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This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Bringing together more than over 120 expert contributors from otolaryngology, general surgery, endocrinology, and pathology, Surgery of the Thyroid and Parathyroid Glands, 3rd Edition, presents an interdisciplinary approach to surgical management and treatment of benign and malignant disease. This renowned text/atlas is an ideal resource at all levels of surgical experience: for residents and junior surgeons, it clearly provides all relevant anatomy, surgical procedures, and workup; for experienced surgeons, it details the management of difficult cases, including revision surgery. Highly illustrated and accompanied by dozens of videos, this edition brings you up to date with the full continuum of care in thyroid and parathyroid surgery. - Easy-to-follow, templated chapters cover preoperative evaluation, surgical anatomy, intraoperative techniques, and postoperative management, for a full range of disorders of the thyroid and parathyroid glands. - More than 30 procedural videos walk you step by step through minimally invasive thyroid surgery, surgical anatomy and monitoring of the recurrent laryngeal nerve, surgery for locally advanced thyroid cancer and nodal disease, and more; plus 23 chapter guide videos from the authors with Surgical Text Video Editor-in-Chief Gregory W. Randolph, Jr. - Coverage of cutting-edge topics includes recurrent laryngeal nerve monitoring, minimally invasive surgery and the role of PET in staging and surgical planning. - Expert guidance on thyroid cancer, including multiple chapters on PTC, MTC and HCC, ATC and NIFTP. - New chapters cover medical oncology and TKI therapy. - Extensive coverage of key topics such as FNA mutational analysis, transoral and minimally invasive surgery, recurrent laryngeal nerve monitoring, management of RLN paralysis, all aspects of parathyroid disease, ethics, malpractice, and more. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Surgical Pathology of the Head and Neck, Third Edition is a complete stand-alone reference covering all aspects of head and neck pathology. Providing an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, this source promotes clear communication between pathologists and surgeons. This is the reference o

This well-illustrated monograph presents a comprehensive description of Fine-Needle Cytology (FNC), including technical procedures and ancillary techniques, applied to the lymph node (LN). Possibilities and limitations are highlighted to produce accurate cytological diagnosis of LN and cytological criteria, and to be exploited for extra-nodal lymphoproliferative processes. The normal LN structure and corresponding cytological patterns are described. Cytological, phenotypical, and molecular features are reviewed along with diagnostic criteria for various medical conditions such as lymphadenitis and lymphadenopathies, Hodgkin and Non-Hodgkin lymphoma, pediatric lymphoadenopaties, immunodeficiency-associated lymphoproliferative disorders, extra-nodal lymphoproliferative processes, metastases, and other non-lymphomatous processes. LN-FNC requires knowledge of hemathopathology and imaging techniques, as well as dexterity with FNC performing, smearing, and material management. Rapid on-site evaluation (ROSE), the choice of ancillary techniques and molecular procedures case by case are required to produce accurate and comprehensive diagnosis. This book will help cytopathologists to conduct these tasks in various organs and clinical contexts. LN-FNC requires knowledge of hemathopathology and imaging techniques, as well as dexterity with FNC performing, smearing, and material management. Rapid on-site evaluation (ROSE), the choice of ancillary techniques and molecular procedures case by case are required to produce accurate and comprehensive diagnosis. This book will help cytopathologists to conduct these tasks in various organs and clinical contexts.

The new edition of this book highlights the recent advances and state-of-the art in surgical and non-surgical management of thyroid cancer. Readers will learn about the latest advances and recommendations in the field, from molecular studies and biomarkers to the changing epidemiology, kinase inhibition in drug discovery and new surgical approaches, such as intra-operative neural monitoring and robotics. The management of differentiated thyroid cancer as well as childhood cancer, survivorship and clinical trial design and findings and how these fit into cancer management are discussed in detail.This comprehensive volume provides an overview of the current world literature and outlines the practical aspects of management from world leaders in this field and helps clinicians and patients on practical matters. With a selection of authors from around the world it draws on international experience giving a global perspective to the topic. Following on from the success of the firstedition, it uses a multidisciplinary, evidence-based approach centered on the patient, discussing guidelines and how these have improved the quality of care and outcomes. This guide is aimed mainly at thyroidologists of all disciplines, (in training or experts) students, non-specialist clinicians, nursing staff, all the disciplines involved in a multidisciplinary team such as surgeons – Head & Neck or Endocrine and General Surgeons, Oncologists, Endocrinologists, Nuclear Medicine Physicians, Nuclear Medicine Physicists, Radiologists, Pathologists, Specialist Nurses, Geneticists, Clinical Psychologists, Palliative Care Physicians and, of course, patients.

Le Dr P. Aïdan présente dans cet ouvrage la technique de thyroïdectomie robot-assistée. Avec l'avancée des nouvelles technologies la chirurgie devient de plus en plus précise et beaucoup moinsinvasive. Le patient en est le premier bénéficiaire avec une amélioration du geste chirurgical et du confort postopératoire.Les différentes voies d'abord sont décrites, ainsi que la technique robotique de référence. La voie transaxillaire a l'avantage d'être bien adaptée à l'ablation de la glande thyroïde et également des ganglions si nécessaire.Plusieurs équipes internationales (sud-coréennes, américaines, allemandes…) ont participé à l'écriture de ce livre. Un chapitre entier est d'ailleurs écrit par le pionner de la technique le Pr WY. Chung.Enfin, dans un futur proche, de nouveaux instruments robotisés vont faire leur apparition. La miniaturisation ainsi que l'augmentation de la mobilité vont permettre encore de développer d'autres techniques…Cet ouvrage est le premier d'une longue série.

Endocrine surgery is a surgical subspecialty focusing on surgery of the endocrine glands, including the thyroid gland, the parathyroid glands, the adrenal glands, glands of the endocrine pancreas, and some neuroendocrine glands. When surveying the dizzying array of operative approaches, imaging studies, and biochemical and genetic tests that have become routine components of the endocrine surgeon's armamentarium, it is easy for one to forget that this is still a nascent surgical specialty. This third edition of Textbook of Endocrine Surgery aims to provide a comprehensive, up-to-date survey of burgeoning and continually changing field. All of the existing chapters of previous editions have been reviewed and updated, and many new chapters have been added to reflect advancements in the field. This book is divided into 4 sections and comprises of total 109 chapter. The first section covers a broad discussion on thyroid whereas the focus of the second section is to cover parathyroid. The third section aims to cover adrenal gland and the last section of this book discusses on endocrine pancreas.

This text provides a comprehensive, contemporary review of this disease and serves as an important resource for clinicians and researchers with an interest in medullary thyroid cancer. The book reviews the initial management of the patient with thyroid nodules, including risk factors, appropriate genetic evaluation of suspected/known medullary thyroid cancer, and appropriate screening for diseases associated with inherited forms of medullary thyroid cancer, including primary hyperparathyroidism and pheochromocytomas. It includes an in-depth discussion of the optimal surgical management of patients with sporadic and inherited disease, those with locoregional metastases, distant metastases, and recurrent medullary thyroid cancer. The long-term follow-up and management of patients with medullary thyroid cancer is highlighted.Medullary Thyroid Cancer will serve as a useful resource for all providers and researchers interested in this relatively rare and challenging malignancy. It highlights recent guidelines for the management of patients with medullary thyroid cancer and discusses controversies within the literature. All chapters are written by experts in the field and incorporate multiple disciplines, including Surgery (Endocrine Surgery, General Surgery, and Otolaryngology), Endocrinology, Radiology, Medical Oncology and Genetic Counseling.

Thoroughly revised and extensively expanded, this encyclopedic, highly acclaimed title addresses all aspects of the etiology, pathogenesis, diagnosis, initial treatment and long-term management of all varieties of thyroid cancer. Expertly edited by Drs. Leonard Wartofsky and Douglas Van Nostrand, this gold standard reference is divided into 11 Parts: General Considerations on Thyroid Cancer; General Considerations on Nuclear Medicine; the Thyroid Nodule; Well-Differentiated Thyroid Cancer; Variants of Thyroid Cancer, Undifferentiated Tumors: Medullary Thyroid Carcinoma; Undifferentiated Tumors: Thyroid Lymphoma; Undifferentiated Tumors: Anaplastic Thyroid Cancer; New Frontiers and Future Directions; and Additional Resources. With exceptional breadth and depth, the book includes chapters dedicated to isotopes, isotope uptake and scanning procedures such as SPECT/CT, radioiodine ablation (with or without recombinant human TSH), stunning, dosimetry (with or without recombinant human TSH), Octreotide and FDG-PET scanning and other alternative imaging modalities. There is a valuable reference atlas of scan images and illustrations, and a scholarly summary of the side effects of radioiodine and how to avoid or minimize adverse effects of treatment. In addition to an updated section on ultrasonography of the thyroid gland, new sections have been added, including ones on ultrasonography of cervical lymph nodes and imaging for thyroid cancer employing computerized tomography (CT), positron emission tomography (PET) and magnetic resonance imaging (MRI). An indispensable reference source with chapters written by the field's leading authoritative experts, Thyroid Cancer: A Comprehensive Guide to Clinical Management, Third Edition, will be of great interest to not only pathologists, endocrine surgeons, endocrinologists, nuclear medicine physicians, and oncologists but all clinicians with an interest in thyroid cancer.

Early identification and diagnosis by type and stage is the key to high survival rates with thyroid cancer. To present the pathologist with current clinical information on diagnosis, differential diagnosis, staging, and prognosis of thyroid cancers, topics presented are: Poorly differentiated thyroid carcinoma; Paraganglimoa; Immunohistochemical markers for evaluation and prognosis in thyroid carcinoma; Familial endocrine syndromes; Parathyroid enoplasia; Inflammatory lesions of the thyroid associated with cancer; Assessing biological aggression in adrenal cortical neoplasia; Pituitary neoplasia; and Pancreatic endocrine neoplasia. Peter Sadow, whose clinical practice and research involve studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasms, primarily of the thyroid and adrenal glands, leads this issue.

Moderne endokrine Chirurgie erfolgt immer in enger interdisziplinärer Zusammenarbeit mit Internisten, Nuklearmedizinern und Pathologen. Die chirurgisch relevanten Erkrankungen der endokrinen Organe sind mit allen Aspekten umfassend in diesem Buch dargestellt: Physiologie und Pathophysiologie der endokrinen Regelkreise, Diagnostik und interdisziplinäre Therapie, praxisorientierte detaillierte Empfehlungen zum Vorgehen und zur Verfahrenswahl. Alle Beiträge wurden dem aktuellen Stand angepasst und sind, wie in den Vorauflagen, von renommierten Autoren der beteiligten Fachgebiete verfasst.

This book describes in detail the various techniques of minimally invasive thyroidectomy that have emerged in recent years and presents the new supportive equipment, including intraoperative monitoring and energy devices. In addition, the basic preoperative techniques that are a prerequisite to successful thyroidectomy are covered, and individual chapters are devoted to complications, outcomes, and post-thyroidectomy quality of life. Important related topics are also discussed, including guidelines for managing papillary and medullary thyroid cancer and the surgical management of metastatic lymph nodes. Both the editors and the authors are internationally renowned experts, and they include the founders of several of the techniques described. The up-to-date text is supplemented by many color pictures and medical illustrations, making the book very user-friendly and ideal for the busy surgeon or endocrinologist who is interested in the management of thyroid diseases.

'Surgical Pathology of the Head and Neck, Third Edition'is a complete stand-alone reference dealing with head and neck pathology. Providing an interdisciplinary approach to the diagnosis, treatment, and management of head and neck diseases, and covering all aspects of general pathology - this is the reference of choice for head and neck pathologi

Cancer of the thyroid gland may be a less common condition than carcinoma of the breast, lung, or colon, but it occurs with suf?cient frequency to constitute a major problem that is of concern to general practitioners, physicians, and particularly s- geons.Some idea of the frequency of thyroid carcinoma is given by its incidence in the United States. Every year some 26,000 patients are diagnosed there as suffering from thyroid cancer.Comparable?gures apply to most countries in Europe although the in- dence does vary somewhat from country to country,perhaps depending on the endo- nous iodine intake.Of the 21,000 patients diagnosed annually in the United States,two thirds will be women,and some 800 will die of the disease during the year. This book should do much to improve the outcome in the treatment of thyroid cancer. First because it is written by a small team of experts of international repute. Secondly their wide experience of the condition allows them to write with authority and thirdly they express their views in clear and commendable English.

Management of Thyroid Cancer and Related Nodular Disease is an authoritative, readable book covering all aspects of thyroid cancer. The text is extensively referenced and includes personal experience of 35 years working with patients with thyroid disorders, including thyroid nodules and thyroid cancer. The chapters are supplemented with many illustrations including pathology, thyroid and whole-body scans, ultrasounds and other nuclear medicine and radiological studies. Important questions that patients may ask their physicians are highlighted, indicating the topics the physician should cover. Thyroid anatomy and physiology, as well as the management of thyroid nodules are covered. There are several pathological varieties of thyroid cancer and these are reviewed with examples. A chapter about the etiology and pathogenesis of thyroid cancer covers the role of radiation and gene abnormalities. Chernobyl is referred to in this chapter as well. Management of Thyroid Cancer and Related Nodular Disease is designed for physicians, including primary care doctors, endocrinologists, nuclear medicine physicians, general and head and neck surgeons, oncologists and radiation oncologists. Others groups who will find an interest in part, or all of the book are residents, medical students, and nurse practitioners when they research a patient-related problem.

Containing colour figures whcih depict minimally-invasive methods, this reference illustrates cutting-edge techniques and modern technologies in endocrine surgical management, encompassing traditional and emerging concepts in physiology, molecular endocrinology, imaging and surgery to anchor and assist professionals in all areas of this burgeoning discipline.