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As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications on three popular types of CaPO4: nano-scaled (nano-dimensional), multiphasic (polyphasic) and amorphous CaPO4. Topics discussed include the preparation, structure, composition, properties and biomedical applications of these types of CaPO4 combined with the specific information for each type. Namely, occurrence in the calcified tissue of mammals is discussed for both nano-scaled and amorphous types of CaPO4; both known and potential formulations, as well as their stability are discussed for multiphasic CaPO4, while both the morphology and the available knowledge on amorphous-to-crystalline transformations are discussed for amorphous CaPO4.

As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications of CaPO4 as bioceramics, deposits (coatings, films and layers) and in dentistry. Topics discussed include chemical composition and preparation, forming and shaping, sintering and firing for CaPO4-based bioceramics, chemical composition and preparation, pre- and post-deposition treatments for CaPO4-based deposits, followed by the detailed description of their major properties, biomedical applications and in vivo behavior. The detailed description of current CaPO4 applications in dentistry both for dental caries prevention and as various types of dental treatments is given in the last section of this book.

As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications of CaPO4 as biocomposites and hybrid biomaterials, self-setting formulations, as well as the workings of their dissolution mechanism. Topics discussed include the major constituents of biocomposites and hybrid biomaterials for bone grafting, preparation, properties and the available knowledge on interactions among the phases for various types of CaPO4-based biocomposites. Additionally, the major types, preparation, properties and the available knowledge on the reinforced formulations for various types of self-setting CaPO4-based compositions, followed by the detailed description of their biomedical applications and in vivo behavior are discussed. The comprehensive description of currently available dissolution mechanisms of calcium apatites in acids, followed by the successful attempt to create the general dissolution mechanism is given in the last section of this book.