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This fully-updated third edition of Scleroderma: From Pathogenesis to Comprehensive Managementbuilds upon the well-regarded approach in the previous editions to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. Comprised of the authoritative work of international experts, the new edition includes extensive updated material reflecting major developments in the field. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive and fully up to date resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud's phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud's is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud's phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch. This fully updated second edition comprehensively discusses various causes of Raynaud's phenomenon including childhood Raynaud's phenomenon, Raynaud's phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud's phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud's phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud's phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors'expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud's phenomenon and the vascular disease of secondary Raynaud's phenomenon. Engaging readers with case vignettes and a plethora of visual aids, Raynaud's Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers.

This volume aims at delivering the state-of-the-art scientific and clinical know-how for the management of patients with Connective Tissue Diseases (CTDs). With contributions from leading specialists from different disciplines, it presents the latest research findings on many aspects of the diseases in a clear, comprehensive way, and describes the most recent trends in treatment, such as the “treat to target” approach. Both basic science and clinical medicine are addressed, with emphasis on the most promising clinical and laboratory-based studies. The coverage is comprehensive in scope, and includes epidemiology, pathogenesis, autoantibodies and biomarkers, disease manifestations, involvement of different organs or systems, the relationships with other disorders, and biological therapy. Readers will find this second volume to be an excellent source of information on the current understanding of CTDs, and clinical approach to CTD, clearly conveying the progress made in recent years. Connective Tissue Disease – A Comprehensive Guide Vol.2 will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these complex diseases.

With its comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, Firestein & Kelley's Textbook of Rheumatology remains your reference of choice in this evolving field. The fully revised 12th Edition retains the user-friendly, full color format, providing in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. New editors, new chapters, and new illustrations keep you fully up to date on recent advances in genetics and the microbiome, current therapies, and other rapid changes in the field. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, physical examination, and disease pathogenesis, manifestations and treatment?including key data on outcomes to better inform clinical decision making. - Includes new or significantly revised chapters on Pre-Clinical Autoimmunity; The Microbiome in Health and Disease; Physical Therapy and Rehabilitation; Nutrition and Rheumatic Disease; Classification and Epidemiology of Spondyloarthritis; Etiology and Pathogenesis of Osteoarthritis; COVID and Rheumatic Disease; Vaccination in Rheumatic Disease; Autoimmune Complications of Immune Checkpoint Inhibitors for Cancer; and many more. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs; many new illustrations highlight diseases among racially diverse patients. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editors Drs. Ted Mikuls and Tuhina Neogi. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints.

The book provides an introduction to the differential diagnosis and decision-making in pediatric rheumatological diseases through typical and real cases. One of the aspects in the discussion of various case scenarios is the avoidance of errors and error management. The casebook is useful for specialists and trainees in pediatrics, young doctors, and anyone on the path to specialization in pediatric rheumatology.The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

​Das Buch gibt anhand typischer und realer Fälle eine Einführung in die Differenzialdiagnostik und Entscheidungsfindung bei pädiatrisch-rheumatologischen Erkrankungen. Ein Aspekt bei der Diskussion unterschiedlicher Fallszenarien ist die Vermeidung von Fehlern und das Fehlermanagement. Das Fallbuch ist nützlich für Fachärzte und Fachärztinnen in Weiterbildung zur Pädiatrie, junge Fachärztinnen und Fachärzte und alle, die sich auf dem Weg zur Spezialisierung in der pädiatrischen Rheumatologie befinden.

Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via textbookscom.support@elsevier.com.

Dieses Referenzwerk bietet dem Allgemeinpädiater, dem angehenden Facharzt und dem (Kinder-)Rheumatologen umfassende Antworten auf alle Fragen der Entstehung, Diagnostik und Therapie von rheumatologischen Erkrankungen bei Kindern und Jugendlichen. Der spezielle Fokus liegt auf der Relevanz und dem Nutzen im Alltag des Pädiaters. Die genauen Angaben zu Therapieempfehlungen und Hinweise zur Evidenz der Therapieverfahren bürgen für einen zuverlässigen und schnellen Behandlungserfolg. Fundierte „State-of-the-Art“-Kinderrheumatologie, praxisbezogen aufbereitet. Ideal zum Nachschlagen für fundiertes Wissen über die Krankheiten, die verwendeten Medikamente und ihre Wirkung im kindlichen Organismus.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. Italso discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. - Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes—including key data on therapeutic outcomes to better inform clinical decision making. - Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. - Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. - Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. - Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease. - Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology. - Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible. - Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today. - Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Auch in den fünf Jahren seit der Erstauflage dieses Bandes hat sich an der Dynamik im Feld der Januskinase (JAK)-Hemmer nichts geändert. Im Gegenteil: Einerseits konnte durch zahlreiche Studien das Potenzial dieser Wirkstoffgruppe eindrucksvoll bestätigt und erweitert werden, andererseits stehen inzwischen so viele Daten zur Verfügung, dass das Nebenwirkungsprofil auch für den einzelnen Patienten sehr exakt eingeschätzt werden kann. Zudem konnten die in der 1. Auflage beschriebenen positiven Signale für eine sehr gute Wirkung der JAK-Hemmer in klinischen Studien über die rheumatoide Arthritis hinaus auch bei weiteren Autoimmunerkrankungen mehr als bestätigt werden. Auf Basis der spannenden Pathophysiologie rund um die JAK-Signalwege hat das Autorenteam dieser Auflage alle notwendigen Daten und Studienergebnisse zusammengestellt, die es ermöglichen sollen, für jede klinische Situation und Fragestellung die passende Antwort zu finden sowie die entsprechende therapeutische Strategie zu entwickeln.

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn's disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight

This book provides a practical guide for managing a variety of problems encountered by the clinician in managing patients with systemic sclerosis. Chapters take a problem-orientated approach to help the reader cut through potential barriers that can arise when working with different medical specialities. Management strategies for a broad range of conditions, including pericardial and pleural effusion, sicca syndrome, calcinosis and watermelon stomach, are presented. ​Practical Management of Systemic Sclerosis in Clinical Practice describes a range of problems and clinical items encountered by a variety of medical professionals who encounter these patients. It is a valuable resource for rheumatologists, immunologists, specialist nurses and primary care professionals.

This book is an up-to-date, comprehensive, clinically oriented guide to the diagnosis and treatment of patients with myocarditis. The opening chapters address the classification, histopathology and molecular diagnosis, as well as the polymorphic clinical presentations, ranging from myocardial infarction with normal coronary arteries; arrhythmias of variable type and clinical severity and fulminant, acute, sub-acute or chronic heart failure; to life-threatening unexplained cardiogenic shock and sudden cardiac death.Including chapters from leading International experts in the field, it covers all key issues from bench to bedside. Topics presented include epidemiology, etiology, pathogenesis, clinical and diagnostic work-up, the role of endomyocardial biopsy and of non-invasive cardiac imaging, risk stratification, and cardiological and etiology-specific management and follow-up. For each topic, a comprehensive review of the current literature is provided and practical suggestions are offered for short- and long-term management. Lastly, future perspectives and gaps in the current knowledge are also addressed. The book also covers a key discovery of last the 2 decades, namely the autoimmune origin of myocarditis in a sizable proportion of patients, discussing in detail the role of immunosuppression and immunomodulation, as well as the need for a multidisciplinary approach to the disease. Mainly intended for cardiologists, general physicians, clinical immunologists and rheumatologists, it is also a valuable tool for residents in Cardiology, Internal Medicine, Clinical Immunology and Rheumatology.

This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

Sjögren-Syndrom, Lupus erythematodes (SLE), Sklerodermie – dies sind nur einige der verschiedenen Formen der Kollagenose. Diese Autoimmunerkrankungen sind äußerst komplex und gehören sehr oft zu den Differentialdiagnosen entzündlicher Erkrankungen. In diesem Buch stellen Experten die einzelnen Kollagenosen vor. Die Thematik des Buchs erstreckt sich von der Epidemiologie bis hin zu Pathogenese, Autoantikörpern/Biomarkern, Krankheitsmanifestationen und Therapie der verschiedenen Organmanifestationen. Verständlich für den Hausarzt und Internisten erläutert sind die klinischen Bilder, die Diagnostik und die Therapie, für den Rheumatologen werden interessante Neuerungen in Diagnostik und Therapie vorgestellt.

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

For more than 50 years, Dubois'Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. - Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. - Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. - Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). - Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. - Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

This comprehensive book serves as a guide in the day-to-day management of patients with idiopathic inflammatory myopathies (IIM), with a particular emphasis on adult dermatomyositis (DM), polymyositis (PM), juvenile dermatomyositis, necrotizing myositis, and inclusion body myositis. Practical in nature, it presents IIM concepts in a straightforward fashion, with high-quality figures, algorithms, and flowcharts supplementing each of the expertly authored chapters. The book begins with an introduction to myositis, providing an overview of the myositis basics and what type of patient is affected. Subsequent chapters are organized by the sequence in which a physician often manages myositis, from initial presentation and workup, to diagnosis, treatment, and finally prognostic and long-term outcome factors. The key differentials in various diagnostic studies are thoroughly examined, including electromyography, muscle biopsy, and MRI. Managing Myositis: A Practical Guide is an easyto-read, indispensable resource for internists, rheumatologists, dermatologists, pulmonologists, and neurologists.

This practical guide aids clinicians in distinguishing the different dimensions of hand function such as impairment, disability, and handicap. New and updated chapters discuss cerebral palsy, sports injuries, robotics, and assistive technologies. Extensively revised, the book provides a broad overview of the basic principles and examination of hand function. It describes how to evaluate hand function in specific afflicted populations, including the rheumatoid patient, the stroke patient, the trauma patient, the geriatric patient, and the pediatric patient as well as special populations such as diabetes mellitus patients and musicians. It also includes an appendix of hand function scales essential to the assessment of disability. The Second Edition of Hand Function is an ideal resource for all rheumatologists, physiatrists, hand surgeons, orthopedists, occupational therapists, and physical therapists caring for patients with impaired hand function.

The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet's disease, Sjogren's syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

This Atlas examines skin ulcers in patients affected by systemic sclerosis. Although they are not life threatening, digital ulcers cause enormous pain, impact function and quality of life, and can lead to serious local complications such as gangrene, osteomyelitis, and permanent tissue loss. Knowledge and understanding of these ulcers is pivotal in everyday practice in order to arrive at an accurate early diagnosis, a correct analysis of ulcer characteristics, and an appropriate direct and systematic treatment. To that end, this book describes all the major characteristics of skin ulcers in systematic sclerosis, including classification, evaluation, and categorization. Richly illustrated for practical use, Atlas of Ulcers in Systemic Sclerosis: Diagnosis and Management is an essential resource for physicians and related professionals, residents, and graduate students in rheumatology, dermatology, and angiology.

This book is a collection of case-based questions, directed towards and meticulously selected to cover the most common and important aspects of pediatric autoimmune disorders. Autoimmune disorders of infancy and childhood, rheumatological disorders, dermatologic autoimmune disorders, autoinflammatory disorders, and clinical immunology in solid organ and hematopoietic stem cell transplantation are among the topics covered. Each chapter starts with a case description followed by a series of 5-6 multiple choice questions (MCQ), presenting the flow from diagnosis to treatment in a step-wise, logical manner. The text guides the reader through the stream of real clinical practice from initial presentation, differential diagnosis, next best step, lab data, and definitive diagnosis to management and adverse effects of therapy. This MCQ format along with precise, yet detailed answer ensure a quick, reality learning to the reader. The book provides a quick guide and hands-on learning experience for pediatricians, hematologists, immunologists, transplant specialists, pulmonologists, as well as PhD and post-graduate researchers around the world.

This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

This book presents detailed state of the art knowledge on the humoral primary immunodeficiencies (PIDs), i.e., disorders arising from impaired antibody production due to defects intrinsic to B cells or defective interaction between B and T cells. There is extensive coverage of both basic science discoveries and the latest clinical advances in the field. The book is structured in accordance with the most recent classification of PIDs and also covers updates on the B cell immunological synapse. Readers will find comprehensive, in-depth descriptions of novel humoral PID genes and related clinical applications, mucosal B cells, and the various clinical phenotypes of humoral PIDs. Aspects such as differential diagnosis, clinical management in children and adults, and the role of vaccines are also addressed. The authors are all recognized experts from Europe, Australia, and the United States. Humoral Primary Immunodeficiencies will be of high value for immunologists, pediatricians,rheumatologists, oncologists, internists, and infectious disease specialists and will also be informative for MD and PhD students.

​Dieses Buch erleichtert dem Leser den Weg vom Symptom zur Diagnose bei rheumatischen Krankheitsbildern: Abgebildet ist das gesamte Spektrum der international den rheumatischen Erkrankungen zugeordneten muskuloskelettalen Schmerzen und Krankheiten in ihren differenzialdiagnostischen Aspekten. Einer ausführlichen Darstellung der Grundlagen folgt eine detaillierte Beschreibung aller wichtigen Differenzialdiagnosen mit über 200 Tabellen und Übersichten. Die fünfte Auflage dieses Standardwerks wurde von neuen Autoren komplett überarbeitet und aktualisiert.

Mit diesem Praxisbuch können klinisch tätige Neurologen über die aktuellen therapeutischen Strategien in der Neuroimmunologie und in den Nachbardisziplinen informiert bleiben. Der interdisziplinäre Ansatz erleichtert differenzialdiagnostische Überlegungen, da auch internistische Systemerkrankungen berücksichtigt sind. Die 2. Auflage wurde thematisch u.a. ergänzt um Kapitel zu endokrinen Erkrankungen, limbischer Enzephalopathie, neuralgischer Amyotrophie und rheumatoider Arthritis. Besonders praktisch für die Anwendung in der Klinik: zahlreiche Übersichten und Tabellen sowie eine Aufstellung der Immuntherapeutika mit Angaben zur Dosis, zur Durchführung der Therapie, zu begleitenden Untersuchungen und Maßnahmen sowie Begleittherapien.

This book explores comorbidity in patients with rheumatic diseases and details both care and treatment options in standard clinical practice. Patients with rheumatic diseases are clinically complex, and the interplay of their disease activity with associated conditions may lead to increased morbidity and mortality. Recently there have been major advances in the management of rheumatic diseases, however, without addressing the potential comorbid conditions, including cardiovascular disease; pulmonary disease; and depression; outcomes remain poor. ​​​ With its 19 chapters, covering the management of major rheumatic diseases (e.g. rheumatoid arthritis, systemic lupus erythematosus, and osteoarthritis), potential comorbidities and treatment recommendations, as well as possible interactions between conditions; this book addresses the gap between textbook medicine and day to day patients'care. Authors also discuss the new hot issue of the comorbidity index, comparing the standard tools to the recently developed indices and how they can assist the rheumatologists in determining disease burden, prognosis, and comorbidity probability. This book is an ideal clinical guide and reference that enables rheumatologists, internal medicine physicians, and residents to address the full clinical expression of these rheumatic diseases with views towards prevention or early management of comorbid conditions.

Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

Dieses Fachbuch macht mit den wichtigsten chronisch entzündlichen Gelenk- und Wirbelsäulenerkrankungen vertraut. Anhand von über 40 instruktiven Fallbeispielen werden anschaulich diagnostisches Vorgehen, therapeutisches Ansprechen und der Verlauf der Erkrankung beschrieben. Jeder Kasuistik folgt ein Kommentar des Rheumatologen, der differenzialdiagnostische Aspekte und notwendige Behandlungsansätze erörtert. Weitere Schwerpunkte liegen auf dem gezielten Einsatz der Basis- und Begleitmedikation mit möglichen Nebenwirkungen. Das Buch richtet sich insbesondere an Allgemeinmediziner und Internisten in Praxis und in Weiterbildung, an Fachärzte für Orthopädie und physikalische Medizin, und auch an interessierte Studenten der Medizin.

This book on rheumatology in children is intended to be a handy tool for all professionals interested in this field. It is divided into five sections: General considerations, arthritic problems, connective tissue diseases, systemic vasculitides and finally a section that covers miscellaneous issues such as Immunodeficiencies, bone heath and uveitis.The book has an easy format with each chapter having one or more clinicalvignettes at the start of the chapter. In addition each chapter outlines the learning objectives and key take home messages. At the end of each section a collection of cases to highlight important issues in the clinic are included. The colorful charts, pictures and tables make reading this book an easy task. The authors are leading experts in their fields working at best practices centers globally to provide the reader with state-of-the-art information.

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.

Les biomédicaments et les thérapeutiques ciblées immunomodulatricess sont, ces dernières années, un des thèmes privilégiés de la recherche médicale et ont fait l'objet de nombreuses études scientifiques.Les progrès sont rapides. Ainsi, Immunothérapies ciblées – Maladies inflammatoires et auto-immunes a pour objectif de présenter et de faire le point sur les traitements disponibles et surtout les perspectives dans de nombreuses grandes disciplines médicales comme la rhumatologie, la neurologie, la médecine interne, la dermatologie, la gastro-entérologie, la pneumologie et la pédiatrie.En abordant le sujet par des chapitres de connaissances générales, puis par une approche molécule par molécule, et enfin pathologie par pathologie, les auteurs permettent d'avoir accès à toutes les informations nécessaires pour comprendre et utiliser le plus efficacement possible ces nouveaux traitements immunomodulateurs.Rédigé par les principaux spécialistes du domaine, abondamment illustré et documenté, cet ouvrage innovant est à la fois un text-book, un thésaurus de connaissances synthétiques, mais aussi un document pratique qui constitue une véritable référence répondant aux besoins des étudiants, des médecins de nombreuses spécialités et même des médecins généralistes les plus curieux.

Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. Hardening of the skin is one of the most visible manifestations of the disease. It's estimated that about 300,000 Americans have scleroderma. About one third of those people have the systemic form of scleroderma. Since scleroderma presents with symptoms similar to other autoimmune diseases, diagnosis is difficult. This issue will cover: The Genetic Basis of SSc: Genetics, Epigenetics, Mechanisms of Pathogenesis – linking fibrosis, vasculopathy and immune dysregulation, The Role of Autoantibodies in Diagnosis and Prognosis/survival; Managing Raynaud's phenomenon and ischemic ulcers, managing SSc Lung Disease, Monitoring for and Managing Pulmonary Arterial Hypertension, and many more!

Systemic sclerosis is a chronic autoimmune disease with a complex pathophysiology and potential involvement of multiple organs. The second edition of this textbook gives a practically oriented overview on epidemiology, pathophysiology, classification, disease manifestations and treatment options. Particular attention is paid to novel developments in the classification criteria, molecular targets for therapy and recently approved treatments for organ manifestations. It gives a comprehensive overview for both the experienced clinician and younger colleagues.

Was soll der Arzt tun, wenn er von Patientinnen und Patienten mit'kalten Händen'und'merkwürdigen Hauterscheinungen'konsultiert wird, die bei ihm um Rat und Hilfe nachsuchen? Diesem weiter hochaktuellen Problem widmet sich intensiv auch die inzwischen 3. Auflage des Buches zum Raynaud-Syndrom, der systemischen Sklerose und zu den zahlreichen verwandten Erkrankungen. In guter Tradition hat das nur wenig veränderte Team von Experten aus der Rheumatologie, Dermatologie, Pulmonologie, Angiologie und Pathologie die aktuelle Literatur und die neuesten Entwicklungen im Detail aufbereitet und mit persönlichen langjährigen Expertisen zu einem sehr informativen und praxisnahen Ganzen zusammengefügt. Die Entwicklungen reichen hierbei von neuen Erkenntnissen zur Pathophysiologie über die ganz aktuellen neuen Klassifikationskriterien hin zu deutlich überarbeiteten Therapieempfehlungen insbesondere der Organmanifestationen.

A Visual Guide to Scleroderma and Approach to Treatment offers a focused analysis of the diagnosis and management of scleroderma. Specifically designed to enlighten and update students and trainees, practicing rheumatologists and general practitioners on the various forms of systemic sclerosis, the book is designed to be an easily accessible tool that also covers potential complications and the latest treatment developments. A Visual Guide to Scleroderma and Approach to Treatment emphasizes recognition of common clinical features by focusing on and illustrating severe and less severe forms of the disease that can involve internal organs such as the gastrointestinal tract, heart, lungs and kidneys. Photos and radiographs introduce each chapter and are accompanied by a guide to workup and treatment. A comprehensive and invaluable addition to the literature, this text is not only a necessary resource for students, trainees and primary care physicians; it will also be of significant interest to specialists in the fields of rheumatology, dermatology, pulmonology, cardiology, gastroenterology and nephrology.

Raynaud's Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike. In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud's Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies. Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular perturbation that mimics RP, this title provides a wealth of new information available on normal and abnormal thermoregulation and helps physicians identify the best therapeutic approaches to treating RP. The work offers differential diagnosis options, reviews potential causes such as autoimmune disease, industrial trauma, drugs, and metabolic causes and provides clear recommendations for therapy. Engaging readers with case vignettes and a plethora of visual aids, Raynaud's Phenomenon: A Guide to Pathogenesis and Treatment is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to physicians, patients, and individuals dealing with these disease processes.

The spectrum of systemic rheumatologic disease (often termed connective tissue disease) is characterized by autoimmune-mediated organ dysfunction, and the lungs are a frequent target. There are numerous pulmonary manifestations associated with connective tissue diseases, and all patients with rheumatologic disease are at risk of developing associated lung disease. Pulmonary Manifestations of Rheumatic Disease covers the comprehensive management of rheumatologic lung disease, which requires a multi-disciplinary approach and is optimized by active engagement by rheumatologists working closely with pulmonologists and other specialists. The book offers a practical reference using a case-based approach for practicing clinicians in the ongoing assessment and understanding of rheumatologic lung disease, and presents the science and pathophysiology underlying rheumatologic lung diseases. The first text of its kind specifically dedicated to describe diverse, commonplace, and challenging aspects of rheumatologic lung diseases, Pulmonary Manifestations of Rheumatic Disease serves as an invaluable tool for the practicing clinician.

Accurate assessment of hand function is critical to any treatment regimen of the hand compromised patient. Hand Function is a practical, clinical book which provides the knowledge needed to distinguish the different dimensions of hand function, particularly impairment, disability and handicap. Beginning with an overview of basic principles and examination, subsequent chapters evaluate the hand function in specific afflicted populations, including the rheumatoid patient, the stroke patient, the trauma patient, the geriatric patient and the pediatric patient, as well as special populations such as diabetes mellitus patients and musicians. An appendix containing hand function scales essential to the assessment of disability is also included. Rheumatologists, physiatrists, hand surgeons, orthopedists, occupational therapists and physical therapists will all find Hand Function a useful and valuable addition to their clinical references.

This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.

Differentialdiagnose rheumatischer Erkrankungen stellt das gesamte vielfältige Diagnosespektrum der rheumatischen Erkrankungen von der Methodik bis zur endgültigen Evaluierung und Abgrenzung zu anderen Erkrankungen dar. Neben Früh- und Spätdiagnose der häufig vorkommenden Erkrankungen werden auch selten vorkommende Formen ausführlich beschrieben. Dem Leser werden Entscheidungswege zur vollständigen Differentialdiagnose gegeben, die ihm erlauben, die notwendigen Therapien einzuleiten. Somit ist das Buch ein wertvolles Referenzwerk für Rheumatologen aber auch für Orthopäden, Radiologen und Sportmediziner.

Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea­ cher, and the unswerving commitment of the investigator. Fass­ bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam­ ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor­ mous achievements made in molecular biology, genetics, struc­ tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis­ eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century.

Das Buch mit namhaften Autoren soll Medizinstudenten und Allgemeinmedizinern ebenso wie niedergelassenen und klinisch tätigen Internisten und Rheumatologen den derzeitigen Wissensstand über molekulare und zelluläre Grundlagen rheumatischer Erkrankungen und den sich daraus entwickelnden Therapieprinzipien vermitteln.

Die Krankheiten des rheumatischen Formenkreises erlangen immer mehr Bedeutung in der Medizin. Die Kenntnisse über Molekularbiologie, Immunologie, medikamentöse und chirurgische Therapie haben in den letzten Jahren rasant zugenommen. Es ist den Herausgebern und Autoren gelungen, die Rheumatologie mit all ihren Randgebieten auf dem letzten Stand des Wissens zu präsentieren und gleichzeitig für die Tätigkeit am Krankenbett eine praxisbezogene Hilfe anzubieten. Im allgemeinen Teil wird u. a. auf die Bausteine des Bindegewebes, Immunologie, Genetik und Epidemiologie eingegangen, gefolgt von einem Teil über Diagnostik und Krankheitsbilder und einem therapeutischen Teil, der alle medikamentösen, nicht-medikamentösen und chirurgisch-orthopädischen Aspekte beinhaltet. Besonders in den klinischen Kapiteln wird durchgehend eine übersichtliche Gliederung nach folgendem Muster eingehalten: Definition, Häufigkeit, Ätiologie und Pathogenese, Krankheitsbild und Verlauf, Labor, bildgebende Verfahren, Komplikationen, Differentialdiagnose, Therapie und Prognose. Das Lehrbuch ist damit eine geglückte Synthese von fundiertem Handbuch und praktischer Checkliste.

Kelley's Textbook of Rheumatology delivers the state-of-the-art scientific and clinical know-how you need to offer your patients the most effective diagnosis and care. This rheumatology book's sweeping updates highlight current advances and breakthroughs that impact your practice. With Kelley's Textbook of Rheumatology, you'll be ready to handle the toughest clinical challenges you face.Search the entire contents online at www.expertconsult.com, download all of images, and watch videos demonstrating the complete musculoskeletal exam, including abnormal findings and the arthroscopic presentation of diseased joints. Review basic science advances and their clinical implications in one place and get dependable, evidence-based guidance with the integrated chapter format that readers of Kelley's Textbook of Rheumatology have always appreciated. Gain a thorough understanding of the'whys'and'hows'of rheumatic disease management with detailed coverage of the very latest breakthroughs and the newest clinical algorithms. Apply the latest therapeutic advances through new chapters in bioengineering and tissue engineering, as well as up-to-date coverage of gout and disease-modifying drugs. Learn how the study of biomarkers across populations can help you detect diseases earlier and with greater accuracy with a new chapter on epigenetics. Diagnose, monitor, and manage rheumatic disease more effectively with expanded information on the use of ultrasound and other imaging modalities.

Perioperative care of the patient with a multisystem inflammatory (rheumatic) disease has become increasingly complex and perioperative medicine has evolved into its own subspecialty. Physicians who have expertise in managing patients with rheumatic disease infrequently spend significant time also managing patients undergoing surgical procedures, and the reverse is equally true. Despite the burgeoning literature on the medical management of the surgical patient, scant data have been generated regarding patients with complex rheumatic disease. Perioperative Management of Patients with Rheumatic Disease fills a conspicuous gap in the literature and aims at providing a paved path for rheumatologists--who infrequently manage surgical problems--and medical consultants--who only seldom encounter patients with rheumatic diseases--to tread as they care for patients in the perioperative period. The book addresses discrete management issues from the perspective of the medical subspecialist and also offers concise descriptions of surgical procedures. Written from the surgical perspective for the internist, the surgical procedure chapters include a brief description of relative contraindications, time to recovery, rehabilitation suggestions, and comments regarding common and severe procedure specific postoperative complications.

A huge number of therapeutic studies has been published in rheumatology and clinical immunology. This number grows substantially by the year. As such, it becomes increasingly difficult to keep track of this multitude of studies and the ensuing therapeutic trends. Further to this, a particular study can be referred to in a variety of ways, either as a shortened version of the title or an acronym, adding to the confusion. The book Clinical Trials in Rheumatology, Second Edition, provides an updated summary of the important studies in the field for easy reference. Every study is shown with name, acronym (if in existence), authors, complete citation, study design, and a short overview of the trial's data and main conclusions. An acronym finder is supplied at the beginning of the book. This book is a valuable reference tool for rheumatologists and other clinical specialties, as well as for research scientists interested in immunomodulatory and selected other drug therapies in rheumatologic diseases.

Recognized for more than 45 years as the definitive text in the field, Dubois'Lupus Erythematosus and Related Syndromes strikes the perfect balance between basic science and clinical expertise, providing the evidence-based findings, treatment consensuses, and practical clinical information you need to confidently diagnose and manage SLE. Broaden your understanding with comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.Experience clinical scenarios with vivid clarity through a heavily illustrated, full-color format which includes fundamental images of lupus rashes as well as graphs, algorithms, and differential diagnosis comparisons.Discover the latest in systemic lupus erythematosus with new chapters on important emerging topics such as socioeconomic and disability aspects; and rigorously updated chapters that include expanded coverage of the nervous system, and the most in-depth discussion of immunity and regulatory cells.Learn from the very best. World-renowned rheumatologists Drs. Daniel Wallace and Bevra Hannahs Hahn, along with new associate editors Drs. Michael Weisman, Ronald Van Vollenhoven, Nan Shen, and David Isenberg, present definitive coverage on new and rapidly changing areas in the field.Rely on it anytime, anywhere! Access the full text, image bank, and bonus online-only chapters at www.expertconsult.com.Dubois'Lupus Erythematosus was first published in 1966. For the past forty years, the product has distinguished itself internationally as the go-to reference on lupus and related diseases. For rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on systemic lupus erythematosus (SLE) and related disorders, this product delivers a complete arsenal of information on SLE, connective tissue diseases, and the antiphospholipid syndromes.