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Infertility is an important health problem affecting around 15% of couples worldwide, with profound psycho-social consequences and impairment of patients'quality of life. It has been shown that the male factor is solely and partially implicated in 20-50% of the cases of infertility. Male infertility is a complex issue that can be related to a variety of congenital or acquired factors that lead to a decline in the quantity and/or the quality of semen. Over the recent years, there have been major advances in basic understanding of the factors that regulate male fertility, the diagnostic tests for assessment of male fertility potential, and the therapeutic options for the management of male subfertility/infertility. However, despite advances in technologies and diagnostic methods in the field of andrology, there remains a significant subset of these subfertile men who are classified as having unexplained or idiopathic male infertility. In addition, there are ongoing debates and controversies on the clinical management of infertile men under certain conditions like varicocele, genital tract inflammation/infection or non-obstructive azoospermia. This book discusses advances in cellular, molecular, and genetic aspects of spermatogenesis and sperm evaluation in the context of clinical scenarios. It also addresses clinical dilemmas and controversies through a discussion of the basic science underlying these conditions. The authors form an impressive international collaboration to provide a unique perspective that specializes in all key areas of andrology. Current and Future Advances in Male Infertility provides insights into strategies to reduce the burden of male gonadotoxins, to enhance men's fecundity and to help optimize the care of infertile men. It aims to bridge the gap between researchers and clinicians by integrating basic science and clinical application.

Originally published in 1989, Infertility looks at how fertility treatments fail women. At the time there was disturbing evidence of medical malpractice and invasive technologies which violated women's bodies and took a heavy toll on their lives.Here for the first time, women – from all over the world – tell their own stories about: the pain and stigma of infertility; never-ending cycles of drugs and hormone injections; the trauma of the ‘test-tube baby'method (IVF); their unmet hopes when technology fails – yet again; the damage caused by experimental medicine and surgery; how they have been exploited as so-called ‘surrogate'mothers.These shocking stories shattered the myths of benevolent doctors working in the interests of women.The women who speak out in this book offer support and suggest alternative strategies for other people with fertility problems. Their experiences show that we urgently need to resist the false promise of reproductive technologies if all women are not to become test-sites for medical experimentation and scientific ambition. Still often discussed today it is considered a classic in the field.

First published in 1919 as'Diseases of Women', Gynaecology by Ten Teachers is well established as a concise, yet comprehensive, guide within its field. The 21st Edition has been thoroughly updated by its latest team of'teachers', integrating clinical material with the latest scientific developments that underpin patient care. Each chapter is highly structured, with learning objectives, definitions, aetiology, clinical features, investigations, treatments and key point summaries and additional reading where appropriate. A key theme for this edition is'professionalism'and information specific to this is threaded throughout the text. KEY FEATURES Fully revised – content is entirely refreshed and up to date for this 21st Edition, including the latest imaging and reproductive technologies and current guidelines for best practices Highly illustrated – text supported and enhanced throughout by high-quality colour line diagrams and photographs Clear and accessible – numerous features supplement the narrative text and provide useful queues for revision Illustrative case histories – engage the reader with realistic scenarios that bring obstetric practice to life Digital support material – download and personalise the ebook for fully flexible access and visit [www.routledge.com/cw/mccarthy] for additional resources including questions for self-assessment, video and patient interviews Along with its companion Obstetrics by Ten Teachers, 21st Edition, the books continue to provide an accessible'one stop shop'in gynaecology and obstetrics and for a new generation of doctors.The editors:Emma J Crosbie is Professor of Gynaecological Oncology in the Division of Cancer Sciences at the University of Manchester and Consultant, Manchester University NHS Foundation Trust, Manchester, UK.Louise C Kenny is Professor and Executive Pro-Vice Chancellor of the Faculty of Health and Life Sciences at the University of Liverpool, UK.

The book elucidates a practical method for prenatal screening and detecting Down syndrome in a simple and easy-to-understand language. It provides thorough knowledge on the subject, and each chapter covers a specific topic, making this book an essential quick-reference guide for every antenatal clinic. The book contains chapters on maternal serum screening, noninvasive prenatal testing (NIPT), invasive testing with amniocentesis and CVS, and screening in twins. It also includes advanced chapters on multi-step screening protocols, uncommon aneuploidies, screening for preeclampsia, and open neural tube defects for clinicians interested in fetal medicine. Down syndrome is the most typical genetic condition affecting over 5 million individuals globally. Rapid advances in the medical field make it possible to identify most of these babies before birth. Hence, aneuploidy screening is now offered to pregnant women worldwide. The book aims to helpobstetricians and gynecologists diagnose Down syndrome and other aneuploidies in pregnancy, avoid unnecessary testing, and remain safely within medico-legal boundaries. It is also helpful for fetal medicine students. The book helps the readers address challenging clinical scenarios and confusing test results.

Foundations of Perinatal Genetic Counseling is the first book to provide a practical introduction to the concepts and skills needed to practice genetic counseling with clients before and during pregnancy. In this new edition, the authors provide a revised and updated overview of these concepts including pregnancy basics, information of the perinatal genetic counseling session and family history, testing options and procedures (e.g., diagnostic testing, screening, carrier screening, assisted reproductive technology), common indications, pregnancy management, common counseling situations, and suggested learning activities. With newly expanded material, updated guidelines, and discussions on technological and procedural advancements in the field, Foundations of Perinatal Genetic Counseling: Second Edition is an essential companion for both the classroom and the clinic. Authored by genetic counselors at the forefront of contemporary perinatal practice, this all-in-one reference provides an accessible yet comprehensive overview of the most pertinent information for new learners and practicing counselors. Perinatal genetic counselors will find themselves returning to this unique resource long after their training has come to an end.

In der 6. Auflage grundlegend und umfassend neu konzipiert, systematisch und bedarfsorientiert aufbereitet, ist das Standardwerk an die Herausforderungen in der modernen gynäkologischen Endokrinologie angepasst und voll wertvollen Wissens. Es vermittelt gynäkologisch tätigen Ärztinnen und Ärzten wichtige Grundlagen sowie spezialisiertes medizinisches Fachwissen für die optimale Behandlung ihrer Patientinnen. Darstellung aller relevanten Aspekte der gynäkologischen Endokrinologie für die Umsetzung der Theorie in die Praxis Ratschläge zu innovativen Behandlungsansätzen Berücksichtigung nationaler und internationaler Leitlinien Zusammenstellung wichtiger Literatur auf dem neuesten wissenschaftlichen Stand Hilfreiche Tipps für die Beratung der Patientin

First published in 1917 as'Midwifery', Obstetrics by Ten Teachers is well established as a concise, yet comprehensive, guide within its field. The 21st Edition has been thoroughly updated by its latest team of'teachers', integrating clinical material with the latest scientific developments that underpin patient care.Each chapter is highly structured, with learning objectives, definitions, aetiology, clinical features, investigations, treatments and key point summaries and additional reading where appropriate. A key theme for this edition is'professionalism'and information specific to this is threaded throughout the text.KEY FEATURES• Fully revised – content is entirely refreshed and up to date for this twentieth edition, including the latest imaging and reproductive technologies and current guidelines for best practice Highly illustrated – text supported and enhanced throughout by high-quality colour line diagrams and photographs Clear and accessible – numerous features supplement the narrative text and provide useful queues for revision Illustrative case histories – engage the reader with realistic scenarios that bring obstetric practice to life Digital support material – download and personalise the ebook for fully-flexible access and visit [www.routledge.com/cw/mccarthy] for additional resources including questions for self-assessment, video and patient interviews Along with its companion Gynaecology by Ten Teachers, 21st Edition, the books continue to provide an accessible'one stop shop'in obstetrics and gynaecology for a new generation of doctors.The editors:Louise C Kenny is Professor and Executive Pro-Vice Chancellor of the Faculty of Health and Life Sciences at the University of Liverpool, UK.Fergus McCarthy is Senior Lecturer, University College Cork and Consultant Obstetrician & Gynaecologist and Maternal Fetal Medicine Subspecialist, Cork University Maternity Hospital, Cork, Ireland.

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of ‘low prognosis'patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. - Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. - Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. - Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. - Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. - Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. - Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. - Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Supporting readers to perform effectively in urgent or emergency situations that can occur in a hospital, at a birth centre or at home, this fully updated fourth edition presents the necessary knowledge and skills for student and practising midwives.With contributions from highly experienced midwives, this practical guidebook incorporates a new chapter on legal issues for safe practice, as well as additional content on professional issues. It also includes an essential new chapter on cardiac problems, recognising that midwives are often the lead professional caring for women with cardiac anomalies, as many are undiagnosed until the emergency. The book continues to provide key, up-to-date information on high-risk medical and obstetric situations, from serious infection to uterine complications to resuscitation.Emergencies Around Childbirth is essential reading for practising and student midwives and those who teach them.

Clinical scientists, embryologists, and reproductive technologists, at all levels, as well as trainees and students interested in assisted reproductive technology and reproductive medicine, will find here a clear synopsis of the best laboratory practice, clinical biology, assisted reproduction techniques, and advanced practical skills they will need to know as clinical practitioners. Expert embryologists and trainers contributed to the essential material as well as a number of advanced topics.Key features: Offers a clear synopsis of the clinical biology, laboratory skills, and best practice for the trainee embryologist Provides the ideal reference resource for those undertaking postgraduate training to become a clinical embryologist Gives access to the views of expert embryologist and trainers

Die Forschung zu Testosteron und seine Anwendung in der Klinik sind trotz Fortschritten umstritten. Dieses Buch liefert einen umfassenden Überblick über Testosteron, von grundlegenden Merkmalen bis zu neuesten klinischen Erkenntnissen. Es werden spezifische Zustände, in denen Testosteron eine zentrale Rolle spielt, ausführlich besprochen. Dazu zählen zum Beispiel Hypogonadismus, Missbrauch, Pubertät, kardiovaskuläre Effekte und Testosterontherapie. Die Hoden, essenziell für die menschliche Reproduktion und Hauptproduzenten von Testosteron bei Männern, symbolisieren männliche biologische Funktionen. Niedrige Serumtestosteronspiegel korrelieren mit verschiedenen Gesundheitsproblemen. Serumtestosteron gilt zunehmend als wichtiger Biomarker für Männergesundheit. Hypogonadismus, charakterisiert durch verminderte Spermien- oder Testosteronproduktion, kann durch Erkrankungen der Hoden (primär) oder Störungen der Hypophyse/Hypothalamus (sekundär) verursacht werden. Die Diagnose stützt sich auf genaue Tests der hypothalamisch-hypophysär-gonadalen Achse. Das Buch beleuchtet den Einsatz von Testosteron in unterschiedlichen Formen und Applikationswegen, erörtert spezifische Eigenschaften und unterstützt bei der Auswahl geeigneter Behandlungen. Es behandelt auch Risiken des Missbrauchs und bietet Alternativen zur Unterstützung Betroffener.

This book provides readers up-to-date information on various aspects affecting assisted reproduction laboratories and corresponding management approaches, based on latest literatures, clinical practice, and international consensus. Key points of laboratory environment, laboratory operations and quality control measures are presented in details. Last but not least, ethical issues and countermeasures of assisted reproductive technology are discussed. It will be a practical and reader-friendly resource to help reproductive medicine practitioners establish a disciplined risk and control system for assisted reproduction laboratories and techniques.

Cryopreservation of oocytes, sperm, and ovarian and testicular tissues, as well as embryos, is one of the most critical procedures to preserve the reproductive capacity of individuals. It is an indispensable part of assisted reproductive technologies, as nearly all IVF clinics around the world have embraced the freeze-all embryo strategy with no fresh embryo transfers. Advanced platforms, such as automation and artificial intelligence, are making their way into all aspects of assisted reproductive technologies, including reproductive tissue banking process and storage. At the same time, lax regulations and lack of training combined with rapid demands of IVF services have resulted in a climate of frequent disaster and catastrophic incidents from the cryo labs that store thousands of patients'embryos for years. With the onset of malpractice lawsuits against the clinics and awards of large compensation to the patients, regulations are getting stricter in this arena to safeguard the integrity of storage systems, and industry leaders are developing advanced devices and alarm systems to remotely monitor storage systems exploring the power of internet, AI and automation. Therefore, there is an urgent need for a comprehensive text in this field based on the introduction of such a wide array of advanced devices, newer technologies, regulatory frameworks, risks and disaster management options. With contributions from top internationally recognized scientists and clinicians with expertise in cryopreservation and reproductive technology, this book provides a comprehensive overview of the basics of cryobiological processes and a technically detailed presentation on all aspects of cryopreservation of reproductive cells and tissues. It presents the current, well-established procedures, as well as novel techniques with the latest innovations described in detail. Bringing together the latest information with key thought leaders in the field, Cryopreservation in Assisted Reproduction is intended to be the go-to resource for all reproductive medicine clinicians, embryologists, lab technologists, IVF lab directors/managers, and researchers.

South America has one of the greatest riches in the world in terms of biodiversity. Despite all this richness, recent reports warn of different threats to this biodiversity. As a strategy to reduce the rate of loss of animal species, the development and application of assisted reproduction techniques (ARTs) for their conservation currently stands out. Thus, this book compiles information on recent scientific studies regarding the development of ARTs for the conservation of wild mammalian species in South America, thus serving as an important source of reference for professionals and students interested in wildlife conservation.

This second edition offers a unique and focused study of the use of ultrasound during the first trimester, a critical time in a fetus'development. It includes basic examination guidelines as well as cutting-edge ultrasound modalities, including Doppler and three-dimensional ultrasound, for the period immediately preceding conception through early embryology. Fully updated, the text begins with a discussion of the safety and efficacy of diagnostic ultrasound and the use of this modality for the evaluation and treatment of infertility. Recognized experts in the field then explore conditions that may interfere with normal conception or development, including maternal diseases that would benefit from early scanning, elements of teratology, multiple gestations, ectopic pregnancy, gestational trophoblastic disease, fetal anomalies and invasive procedures in the first trimester. This edition includes seven new chapters focusing on the imaging of fetal development, including chapters on the first trimester fetal brain, genitourinary tract, and diagnosis of fetal genetic syndromes. Numerous illustrations, figures, and online videos serve as aides for understanding key concepts. First-Trimester Ultrasound, 2e is a valuable resource for many, in or after training, in obstetrics and gynecology, radiology, emergency medicine, family medicine and genetics.

A concise handbook containing the latest practical guidance on all common contraceptive methods. Contraception Made Easy 3e is an up-to-date handbook for GPs and other healthcare professionals who need easy access to the latest practical guidance on all the commonly used contraceptive methods: combined oral contraceptives (COCs), patches, and vaginal rings progestogen-only pills (POPs), progestogen-only injectables and implants copper intrauterine devices (IUDs) and the levonorgestrel IUS diaphragms, cervical caps, and male and female condoms natural fertility awareness advice/kits emergency contraception male and female sterilisation. This latest edition includes the position on abortion in Ireland and features material on contraception for: women with weight issues, including obesity and eating disorders women taking teratogenic drugs transgender and non-binary people.

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on laboratory topics, including KPIs for the IVF laboratory, Quality control in the cloud, Artificial Intelligence, AI in gamete and embryo selection, Demystifying vitrification, Microfluidics, Gene editing, Disaster management, and Early human embryo development revealed by static imaging. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

The successful book of andrology now in a new edition! This book gives a complete, interdisciplinary overview of the central topics of andrology, infertility, hypogonadism, contraception and erectile dysfunction. It contains detailed information on the clinical practice of couple treatment, andrology-relevant gynecology and modern methods of assisted fertilization, psychological factors of infertility, endocrinology and reproductive functions of the aging man as well as on an important sub-area of ​​andrology, the male contribution to contraception. In addition, the relevant scientific foundations (including molecular biology and genetics) are also covered. Completely revised and updated according to the latest scientific research, the new edition represents a reference for andrology, which no doctor who deals with the topic can miss. For andrologists, practitioners and residents, urologists, dermatologists and internists who deal with the area of​​andrology and male reproductive medicine.

Allgemeinverständlich und kurzgefasst stellt dieses Buch die physiologischen Grundlagen der gynäkologischen Endokrinologie und Fortpflanzungsbiologie dar. Hierauf aufbauend werden die wichtigsten Krankheitsbilder und deren Pathophysiologie als auch Bedeutung für den unerfüllten Kinderwunsch dargelegt. Etablierte diagnostische und therapeutische Verfahren werden jeweils weitgehend vertieft und für den klinischen Gebrauch erläutert. Im Buch sind Kapitel zu unterschiedlichen Themenschwerpunkten zu finden:GrundlagenwissenEtablierte diagnostische Verfahren und gynäkologischen FertilitätsstörungenPraxisrelevante Aspekte männlicher Fruchtbarkeitsstörungen, Schilddrüsenerkrankungen im Rahmen des unerfüllten Kinderwunsches, Menopause und KontrazeptionMethoden und Facetten der Kinderwunschbehandlung, von perikonzeptioneller Beratung, natürlicher Familienplanung bis hin zu genetischen und psychologischen AspektenErläuterung von Risiken und VermeidungsstrategienRechtliche und ethische FragenQualitätssicherung in der Reproduktionsmedizin Ziel des Buchs ist die praktische Anwendung und kritische Auseinandersetzung mit den aktuellen Möglichkeiten der modernen Reproduktionsmedizin und gynäkologischen Endokrinologie. Es richtet sich an nicht spezialisierte Gynäkologen, Reproduktionsmediziner sowie Ärzten und Ärztinnen in der Weiterbildung.

This open access book offers a valuable resource for understanding the correct pathways in the context of sexual disorders, couple reproduction, gender identity dysphoria, conditions for which patients commonly ask for consultation and treatment. Based on clinical evidence, international guidelines and experts experience, practical clinical management strategies are presented for each condition. Each clinical care pathway is based on updated algorithm, level of evidence, photos and video-clips that describes the clinical presentations and the best practice management through diagnostic tools and medical or surgical treatment. Leading experts from the most important center of excellence in the field of sexual medicine joined to cover the field of andrology in its entirety, each of them dealing with a single topic from the top of their recognized experience and providing a complete and update textbook that will help urologists and other physicians in their daily clinical practice. This book is thought to be a practical and valuable reference for urologists, gynecologists, endocrinologists, psychiatrics and psychologists, and residents who are not specialty trained in andrology. It is designed for both young fellows training in different specialties and coming into contact with andrological issues for the first time and also more experienced clinicians and surgeons requiring updated guidelines and clear advice on the most controversial issues. This book will represent an invaluable quick consulting tool, updated in its scientific contents and rich in tables, images and video-clips.

Even though research on testosterone is increasing, there is still much controversy regarding its physiology and clinical use. This book provides a broad overview on testosterone, from its basic features to the most recent evidence of clinical applicability. In addition, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. The testes are vital organs for reproduction of the human species, besides being the main source of testosterone production in men. Although not essential for survival, these singular structures represent the essence of male biological function. Testosterone is the most important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Also, there is increasing evidencethat serum testosterone is a major biomarker status of men's health in general. Hypogonadism in a male refers to a decrease in one or both of the two major functions of the testes: sperm production or testosterone production. These abnormalities can result from disease of the testes (primary hypogonadism) or disease of the pituitary or hypothalamus (secondary hypogonadism). Currently, the clinical features of male hypogonadism are sufficiently well-recognized, the causes are well-known, and the tests of the hypothalamic-pituitary-testicular axis are accurate enough for the diagnosis in most patients. Testosterone, the focus hormone of this book, is used in different forms and routes of administration. Several authors unravel its peculiarities and assist in choosing the most suitable form in each case, as well as the possible risks of its misuse or even abuse in men and women, seeking alternatives to help patients in this situation.

Principles and Practice of Assisted Reproductive Technology provides comprehensive information on the modern day approach to all aspects of ART. It is a well-designed and illustrated textbook, which covers the entire armamentarium of ART, in depth, from basic principles of reproductive anatomy, physiology, endocrinology and laboratory aspects of IVF to the latest scientific advances. The book also provides updated optimal information on evaluation and management of an infertile couple, complications of ART, outcomes following ART, ethical and legal issues in ART and ART guidelines. It is a unique compilation where each topic is written by experts who have relevant experience in that field. The third edition not only updates the previous chapters with the latest advances, but brings fresh perspective not only to socially relevant topics like addressing fertility issues in the LGBTQ and gender transformation but also the COVID-19 pandemic and newer advances like rejuvenation therapy. The book portends to be a valuable asset to the entire fraternity of reproductive medicine specialists.

This comprehensive volume covers all aspects of the revolution in prenatal diagnosis brought about by the introduction of non-invasive prenatal testing (NIPT), which primarily relies on the detection of free fetal DNA circulating in maternal blood from the early stages of pregnancy. The book explores the potential of NIPT to provide full genome screening of the fetus and identify many common or rare disorders. The counseling process, as well as the limitations and pitfalls of various techniques used to perform NIPT, are described, evaluated, and critically discussed by renowned international experts. The book also compares the new technology with more conventional tests, preimplantation diagnosis, and the invasive procedures currently in use. This book will be a valuable resource for gynecologists, obstetricians, geneticists, maternal-fetal medicine specialists, pathologists, neonatologists, reproductive medicine specialists, midwives, and anyone interested in prenatal geneticdiagnosis.

Das Standardwerk der Andrologie - jetzt komplett aktualisiert! Das Buch gibt einen vollständigen, interdisziplinären Überblick aller Themen der Andrologie, u.a. · der Infertilität, · des Hypogonadismus, · der männlichen Kontrazeption, · der erektilen Dysfunktion und · der Varianten der sexuellen Differenzierung. Der Leser erhält detaillierte Informationen über · die Physiologie der Hoden- und Spermienfunktion · die Diagnostik und Therapie einschl. operativer Verfahren in der Andrologie · die klinische Praxis der Paarbehandlung, · relevante Fakten aus der Gynäkologie, · moderne Verfahren der assistierten Fertilisation · psychologische Faktoren der Sexualität und Infertilität · Umwelteinflüsse auf die Fertilität · Therapie mit Testosteron und Missbrauch · endokrinologische und reproduktive Funktionen des alternden Mannes. · Fertilitätsprotektion · rechtliche und ethische Grundlagen der Andrologie Zusätzlich werden die relevanten naturwissenschaftlichen Grundlagen – einschließlich Molekularbiologie und -genetik – abgedeckt. Komplett nach dem neuesten Stand der wissenschaftlichen Erkenntnis überarbeitet, aktualisiert und praxisorientiert ist der Nieschlag das Standardwerk der Andrologie, an dem keine Ärztin und kein Arzt, der sich mit dem Thema befasst, vorbeikommt. Für Andrologen und Teilnehmer der Zusatzbezeichnung'Andrologie', Urologen, Dermatologen und Internisten, die sich mit dem Gebiet Andrologie beschäftigen. Für Reproduktionsbiologen und Reproduktionsmediziner mit Interesse an der Paarbehandlung.

Human beings have been producing more twins, triplets, and quadruplets than ever before, due to the expansion of medically assisted conception. This book analyzes the anticipatory regimes of making multiple babies. With archival documents, participant observation, in-depth interviews, and registry data, this book traces the global and local governance of the assisted reproductive technologies (ARTs) used to tackle multiple pregnancy since the 1970s, highlighting the early promotion of single embryo transfer in Belgium and Japan and the making of the world's most lenient guidelines in Taiwan.

A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.

••Selected for Doody's Core Titles® 2024 in Toxicology••Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. - Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development - Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis - Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more

This new edition of Sarah Franklin's classic monograph on the development of in vitro fertilisation (IVF) includes two entirely new chapters reflecting on the relevance of the book's findings in the context of the past two decades and providing a ‘state-of-the-art'review of the field today.Over the past 25 years, both the assisted conception industry and the academic field of reproductive studies have grown enormously. IVF, in particular, is belatedly becoming recognised as one of the most influential technologies of the twentieth and twenty-first centuries, with a far-reaching set of implications that have to date been underestimated, understudied and under-reported. This pioneering text was the first to explore the emergence of commercial IVF in the United Kingdom, where the technique was originally developed. During the 1980s, the British Parliament devised a unique system of comprehensive national regulation of assisted reproduction amidst fractious public and media debate over IVF and embryo research. Franklin chronicles these developments and explores their significance in relation to classic anthropological debates about the meanings of kinship, gender and the'biological facts'of parenthood. Drawing on extensive personal interviews with women and couples undergoing IVF, as well as ethnographic fieldword in early IVF clinics, the book explores the unique demands of the IVF technique. In richly detailed chapters, it documents the ‘topsy-turvy'world of IVF, and how the experience of undergoing IVF changes its users in ways they had not anticipated. Franklin argues that such experiences reveal a crucial feature of translational biomedical procedures more widely – namely, that these are ‘hope technologies'that paradoxically generate new uncertainties and risks in the very space of their supposed resolution. The final chapter closely engages with the ‘hope technology'concept, as well as the idea of ‘having to try'and uses these frames to link contemporary reproductive studies to core sociological and anthropological arguments about economy, society and technology.In the context of rapid fertility decline and huge growth in the fertility industry, this volume is even more relevant today than when it was first published at the dawn of what Franklin calls the era of'iFertility'. Embodied Progress is an essential read for all social science academics and students with an interested in the burgeoning new field of reproductive studies. It is also a valuable resource for practitioners working in the fields of reproductive health, biomedicine and policy.

A potential crisis in human fertility is brewing. As societies become more affluent, they experience changes that have a dramatic impact on reproduction. As average family sizes fall, the selection pressure for high-fertility genes decreases; exacerbated by the IVF industry which allows infertility-linked genes to pass into the next generation. Male fertility rates are low, for many reasons including genetics and exposure to environmental toxins. So, a perfect storm of factors is contriving to drive fertility rates down at unprecedented rates. If we do not recognize the reality of our situation and react accordingly, an uncontrollable decline in population numbers is likely, which we'll be unable to reverse. This book will address, in a unique and multi-faceted way, how the consequences of modern life affects fertility, so that we can consider behavioural, social, medical and environmental changes which could reduce the severity of what is about to come.

This practical book focuses on the most recent advances in natural cycle and minimal stimulation in vitro fertilization (IVF).The volume presents the steps that need to be followed to successfully perform these techniques and covers all aspects and competences involved.The book provides information on physiology of folliculogenesis, ovulation, oocytes and luteal phase and based on this information on clinical practice of stimulation, ovulation induction and inhibition, follicle aspiration and luteal phase support in natural cycle and minimal stimulation IVF. In addition costs, risks, success rates and several treatment protocols are provided.An overview of large European, Japanese and American programs and the discussion of clinical cases will complete the coverage of the topic.This practical and easy-to-use guide is a valuable resource for all clinicians performing any kind of IVF techniques.

This book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation.

Now in a completely revised and expanded fourth edition, including two new chapters, this user-friendly textbook offers a succinct overview of both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities. Included here are updated chapters on major reproductive endocrinology and infertility issues, such as polycystic ovary syndrome (PCOS), pubertal disorders, amenorrhea, menopause, management of endometriosis and fibroids (including interventional radiology), laboratory and clinical aspects of assisted reproductive technologies (ART), imaging modalities such as ultrasonography and sonohysterography, hysteroscopic and laparoscopic techniques, an expansion of female infertility and fertility, preimplantation diagnosis and screening, osteoporosis, and contraception and sterilization. Chapters new to this edition discuss third-party reproduction and uterine transplantation. In addition, chapters opens with a list of bulleted key points and end with multiple choice review questions, and most include vibrant clinical case material to illustrate important concepts. Residents, fellows, and new clinicians in obstetrics and gynecology interested in reproductive endocrinology and infertility will find this fourth edition of Clinical Reproductive Medicine and Surgery: A Practical Guide a valuable and focused reference.

Now in a completely newly revised and expanded second edition, this comprehensive text presents the current state of the art in our understanding and management of polycystic ovary syndrome (PCOS), the most common hormonal disorder of reproductive aged women. The numerous bothersome symptoms of PCOS include menstrual irregularities, hirsutism, acne, scalp hair thinning, weigh excess and infertility; additionally, as they age, women with PCOS are at a higher risk for metabolic abnormalities such as diabetes and dyslipidemias, as well as for cardiovascular disease and even certain cancers. Despite improvements in our understanding of this condition, the exact cause/s of PCOS remain elusive; genetic, hormonal, metabolic and environmental underpinnings are all suggested as relevant. All chapters have been updated, with eight new chapters added across seven thematic sections. Part one discusses the epidemiology of PCOS in both adults and adolescents. Part two covers the pathophysiology of PCOS, including genetics, the hypothalamo-pituitary-ovarian and the hypothalamo-pituitary-adrenal axes, insulin resistance, inflammation, and obesity. The next three sections present the various management strategies, medical and surgical, for harnessing the symptomatology, including PCOS-related infertility; these chapters include added case material to provide real-world examples of the treatments in action and their efficacy. Part six covers the comorbidities that women with PCOS commonly encounter, such as issues of mental health, sleep disturbances, endometrial hyperplasia, and cancer, as well as examines the economic burden of PCOS. The final section discusses emerging concepts surrounding possible mechanisms and potential therapeutic approaches to PCOS, including angiogenic dysfunction, the role of vitamin D, future potential therapies to targeted AMH signaling. The closing chapter, by familiarizing the readers with the intergenerational implications ofPCOS and by raising awareness of potential “ripple effects”, aims at alerting the community on a need for vigilance as regards the health of PCOS progeny. With contributions from leaders in the field, Polycystic Ovary Syndrome, Second Edition remains the gold-standard text on this common medical condition and a valuable resource for the wide range of healthcare professionals engaged in caring for the women with PCOS (including but not limited to reproductive endocrinologists, gynecologists, family physicians, dermatologists, mental health professionals), for the aspiring women's health providers of tomorrow, and for the researchers who are striving to unravel the mysteries of the complex entity that PCOS is.

This text has been written as a practical guide, based on the author's experience over the last 40 years of daily clinical practice and aiming to place the modern approach to the management of infertility in the context of sound theory and evidence-based therapy. It provides the reader with a comprehensive classification of the causes of infertility, their investigation, and their management. This new edition covers many advances in the understanding and management of infertility and other updates to practice--for example, a greater understanding of the pathophysiology of ovarian aging and ovarian reserve testing; the classification of disorders of ovulation and management of polycystic ovary syndrome; the refinement of regimens for superovulation, improved embryo culture systems, and the use of artificial intelligence for the selection of embryos; assessments for endometrial receptivity and management of recurrent implantation failure; pre-implantation genetic testing (PGT) as a therapeutic tool opening up the possibility for aneuploidy screening; as well as the latest thoughts on nutritional health, periconception care, and the exciting new world of the microbiome.

This new volume in the Reproductive Medicine for Clinicians series focuses on the practical clinical impact of problems linked to infertility, discussing topics such as luteal support in ART cycles, ovulation induction using pulsatile administration of GnRH, how to deal with the metabolic changes in PCOS, treatment to restore fertility in endometriosis and how to improve implantation, which are common aspects of daily clinical practice.It also addresses significant novel areas like the biological clock in human reproduction, reproduction at advanced parental age and medical and social egg freezing, offering valuable insights for patients and their doctors. Further, the book covers various areas of growing importance, such as how to access the uterine cavity; the future of imaging in reproduction; non-invasive prenatal testing; ART and male infertility; as well as breast cancer and fertility preservation.Last but not least, it examines the medical, ethical and legal aspects of a number of challenges for current and future reproductive medicine, including uterine transplantation and human genetic modification.Bringing together updates on some of the most important problems in reproductive medicine and also covering ethical and legal bases, this book offers an overview of potential treatments for infertility. As such, it is a valuable resource for gynecologists, obstetricians, endocrinologists and all specialists dealing with reproductive health.

Despite efforts to control udder health in cattle, are the causes of mastitis are on the rise. Although at first glance the birth process seems normal in domestic pigs, what could be the problem? What are the clinical aspects of the oestrus cycle and pregnancy endocrinology in mares? What is Lidia cattle breeding and clinic? Does calf gender affect milk yield? Do insecticides reduce fertility? Could boar pheromones be an option to stimulate sow reproduction? Animal Reproduction in Veterinary Medicine is a book with the answers to such questions. It includes ‘Induction and Synchronization of Estrus', which describes the protocol principles and tools. The practical approach this book takes will help students, farmers, veterinarians and academics to build an understanding of the concepts and procedures required to answer real questions by comprehending the basic function of real clinic data. Humans often endure results from the misunderstanding that to be doing well, they should make each thing themselves.

This book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer.Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.

This book provides comprehensive information on Intracytoplasmic Sperm Injection (ICSI), its clinical considerations, outcomes and potential health effects. Male and female infertility is increasing all over the world. The basic techniques of assisted reproduction like ovulation control and intrauterine insemination are ineffective if the sperm quality or number is inadequate. The advanced fertilization techniques are in-vitro fertilization (IVF) and ICSI. In 15% cases of infertility, IVF results in total failed fertilization; therefore, ICSI must be used. Some clinics exclusively use ICSI for all infertility patients due to its reliability of fertilization outcome or to avoid total fertilization failure. ICSI was first used in humans in 1992. Since then, tremendous advances have been made in assisted reproductive technology. ICSI has enabled even those men who have rare sperm in their testes to father a biological child. If no sperm are observed in the ejaculate, in almost all cases, they can be recovered from the testicles. Such retrieved sperm can only be used by ICSI. Therefore, its understanding is essential not only for medical staff but also for patients suffering from infertility. This book is highly recommended for patients suffering from infertility or currently undergoing infertility treatment. It explains the factors affecting ICSI success rate. In ICSI, the embryologist picks a sperm for injection to fertilize oocytes whereas in intrauterine insemination and IVF, one sperm penetrates naturally. This manual selection of sperm has raised concerns especially in those patients suffering from severe male factor infertility. The nature of sperm defects varies and could be congenital, acquired or genetic. Children born through ICSI are, therefore, considered at higher risk of carrying the defect. Many investigations have been carried out to compare incidence of the defects between children conceived naturally and conceived through ICSI. Additional technologies have been developed to ensure the birth of a normal child. These include pre-implantation genetic testing and non-invasive prenatal testing. This book addresses these concerns and explains the health effects on children born through ICSI. This book is very useful for medical students, andrologists, embryologists, nurses or anyone else interested in learning basic or advanced knowledge of assisted reproductive technology, especially ICSI. The authors of the chapters of this book are highly experienced and from different parts of the world. Many of them are directing very busy ART laboratories at leading infertility clinics in the United States of America, Canada and the Middle East.

This new edition of an acclaimed text reviews the evidence for best practice in Maternal-Fetal Medicine, to present the reader with the right information, with appropriate use of proven interventions and avoidance of ineffectual or harmful ones. The information is presented in the right format by summarizing evidence succinctly and clearly in tables and algorithms. The aim is to inform the clinician, to reduce errors and'to make it easy to do it right.'The volume can be purchased separately or together with the companion volume on Obstetric Evidence Based Guidelines (set ISBN 9780367567033).The Series in Maternal-Fetal Medicine is published in conjunction with the Journal of Maternal-Fetal and Neonatal Medicine.From reviews of previous editions:'An excellent resource with quick and easy protocols… this book has a permanent spot on my shelf.'— Doody's Review Service

This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.

The present volume of the book series Advances in Anatomy, Embryology and Cell Biology brings together current reviews from leading experts to address the diversity of placentation by which species establish and maintain pregnancy. Development of viviparity and placentation in rodents, dogs, pigs, cattle, horses, marsupials, primates and elephants are discussed. The development of viviparity in mammals, including some invertebrate species, required the adaptation of the placenta to serve as a functional conduit for interplay between the semiallograftic fetus with the maternal uterus. Although the ‘placenta'protects the fetus from maternal immune rejection and provides oxygen and nutrient flow to support it to term across all the species, structural differentiation of this fetal-maternal interface can vary from simple to very complex. E.C. Amoroso contributed greatly to our early understanding and knowledge of placentation across a great variety ofspecies. His work on placentation provides numerous illustrations and histological sections which are used for teaching and stimulating research today. With this book, we want to pay tribute to his lifetime contributions to the field by reviewing our current understanding of the development of viviparity and placentation in different species. The book is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in placentation and viviparity.

Climate change is the biggest threat to the fertility of mammals across the globe through its potential effects on heat stress, nutrition security, extreme weather events, vulnerable shelter, and population migration. Climatic variables, such as temperature and humidity, are common environmental stressors as well as nutritional stress, which reduces fertility. Besides climate and nutritional stressors, another major factor responsible for reduced fertility discovered within the past decade is the exposure to potential hazardous substances such as chemical, radiation, physical, biological, and occupational hazards. This exposure includes anything from heavy metals and gases to pathogens and toxins and any substance that interferes with natural biological functions of the exposed workers, pregnant and breast-feeding workers, and young working population. There also must be research focused on developmental hazards that alter the structure and function of the developing embryo as well. The different climatic factors in the era of climate change need to be explored to discuss the impacts on fertility. Climate Change and Its Impact on Fertility highlights the issues and concerns that address the latest impact of climate change and mitigation strategies for enhancing early embryo survival and uterine potential. This book covers the effects of climate change on both the biological parents and the embryo by discussing the negative impacts, providing an overview of the variety of climate changes currently affecting fertility, and exploring possible solutions. This book is ideally intended for medical scientists and doctors, reproductive biologists, experimental toxicologists, mammalian cell biologists, clinicians, embryologists, health and safety agencies/regulatory authorities, public health officials, and policymakers along with practitioners, stakeholders, researchers, academicians, and students interested in climate change and its link to embryo growth, developmental risk, implantation failure, and fertility.

A concise handbook containing the latest practical guidance on all common contraceptive methods. Contraception Made Easy 2e is an up-to-date handbook for GPs and other healthcare professionals who need easy access to the latest practical guidance on all the commonly used contraceptive methods: combined oral contraceptives (COCs), patches, and vaginal rings progestogen-only pills (POPs), progestogen-only injectables and implants copper intrauterine devices (IUDs) and the levonorgestrel IUS diaphragms, cervical caps, and male and female condoms natural fertility awareness advice/kits emergency contraception male and female sterilisation. This new edition covers the new position on abortion in Ireland and features new material on contraception for: women with weight issues, including obesity and eating disorders women taking teratogenic drugs transgender and non-binary people.

Major advances in genetics, immunology, and endocrinology have necessitated a new edition of this best-selling text. However, despite the advances, recurrent pregnancy loss presents a frustrating clinical problem. There is still disagreement about the number of pregnancy losses which warrant investigation and treatment and about which investigations should be performed. This third edition provides an authoritative and comprehensive update on advances in the understanding and management of this troubling phenomenon, covering both basic scientific topics such as genetics and cytokines, and profiles major advances in immunology, endocrinology, and thrombotic mechanism. Clinical research is discussed, as is assessment of results when applying an evidence-based approach or a more personalised approach, which is now becoming possible due to advances in the diagnosis of cause. There are lively debates on the role of progestogens and immunotherapy, which remain controversial.Designed for specialists working in reproductive medicine clinics and those involved with maternal-fetal care, the book is also ideal for generalists and gynecologists seeking a comprehensive view of developments in the field.

This richly illustrated book focuses on one of the specific and crucial steps of the Medically Assisted Procreation techniques that is often overlooked: the oocyte pick-up. Enhanced by a large number of high-quality pictures, this atlas of oocyte retrieval comprehensively describes important aspects such as the setting of the ultrasonic equipment, the choice of needle, the layout of the devices in the room and the technique to be used, which, if not properly handled, can lead to erroneous behaviors. The original and detailed illustrations, mainly microscopic images and explanatory drawings, help readers to better understand how to manage all the phases of the ovarian pick-up and oocyte management. This practical atlas provides a valuable guide for all specialists who want to improve their skills and gain confidence with the MPA techniques.

With the increased prevalence of subfertility (any form of reduced fertility with prolonged time of unwanted non-conception) and the number of subfertile patients turning to assisted reproductive clinics for help, Subfertility: Recent Advances for Management and Prevention is a much-needed resource for today's health care providers. Written by doctors with extensive expertise in the areas of reproductive physiology and endocrinology, it provides a description of the methods for achieving conception, an overview of the causes of subfertility and how to detect them, a review of the psychological impact of subfertility, guidelines for the treatment of subfertility, and a look at assisted reproductive technologies. - rovides a holistic approach to the causes and treatment of subfertility, with guidance on selecting patients on the basis of ovarian reserve/sperm parameters and the management of special endocrine abnormalities like polycystic ovarian syndrome, endometriosis, and thyroid disorders. - Offers a concise review of the most recent advances for improving assisted reproductive techniques. - Covers reproductive physiology and the causes of subfertility, with special focus on endocrine abnormalities that lead to subfertility. - Consolidates today's available information on this timely topic into a single, convenient resource.

A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility.World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book's appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successfulspermatogenesis Covers comprehensive information about Spermatogenesis atone place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell developmentand fertility Highlights the translational opportunities in molecular signalingin testis

This book brings together the most current research and the latest clinical approaches to the management of diminished ovarian reserve (DOR), one of the largest segments of the IVF patient population, both in the advanced reproductive age group as well as poor responders. Opening with a review of the definition and scope of the problem, as well as the current understanding of the natural history of DOR, subsequent chapters in part I outline dietary, hormonal, traditional supplements and conventional methods used to stimulate ovaries and improve ART outcomes. The main segment of chapters, comprising part II, present minimal and mild stimulation protocols and alternatives, frozen embryo transfer preparation, trigger agents and post-trigger testing, embryo culture and endometrial considerations, and a review of clinical outcomes. Part III discusses the utilization of contemporary technologies in the treatment of DOR, including fresh vs. frozen embryo transfer, cryopreservation and comprehensive chromosomal analysis. Future prospects are presented in part IV, such as the artificial oocyte and ovary development, early-age oocyte freezing, ovarian cortical tissue freezing and activation of the ovarian cortex. Utilizing the latest evidence and authored by an international array of thought leaders, Diminished Ovarian Reserve and Assisted Reproductive Technologies is an excellent resource for reproductive medicine and REI specialists, IVF lab professionals, and students and residents in these areas.