Search

This book is a multidisciplinary guide to head and neck cancer.Head and neck cancer remains one of the most technically complex cancer subsites to manage. This field involves highly specialized, multidisciplinary management and collaboration amongst surgeons, radiation oncologists, medical oncologists, radiologists, pathologists, and other health disciplines. The clinical and research landscape for head and neck oncology continues to evolve at a rapid pace. This multidisciplinary book provides the latest updates in the contemporary understanding and management of these tumors. The text incorporates updates in surgical techniques (minimally invasive and robotic techniques, reconstructive approaches), radiation medicine (new data on dose and fields, oligometastatic/oligoprogressive disease, retreatment), medical oncology (targeted, immunotherapy and molecular agents), in addition to other overarching topics such as side effects, biomarkers/nanotechnology, and epidemiology. Written by experts in their respective fields, chapters include the most up to date scientific and clinical information with perspectives from each relevant subspeciality. These sections are concise and accessible, yet comprehensive. Palliative medicine, pathologic and imaging principles, and health systems/economics considerations are also described. This book is an ideal resource for clinicians, trainees, and researchers dealing with, and interested in, this challenging malignancy.

This book provides up-to-date guidance that will assist radiation oncologists during the day-to-day management of nasopharyngeal cancer. After discussion of diagnosis and staging, target delineation techniques and treatment planning are described for both intensity-modulated and particle radiation therapy. Detailed information is then presented on the application of radiation therapy in different disease settings, from early stage disease to metastatic disease. Due attention is paid to the role of multimodality treatment and new and advanced technologies in particular circumstances, such as local recurrence. In addition, follow-up and the management of late toxicities are explained and management strategies are documented for special situations and groups, including pediatric patients. The book is published within the Springer series Practical Guides in Radiation Oncology. Like other volumes in the series, it is designed for hands-on use by both radiation oncology residents and practicing radiation oncologists. It will also be of value for head and neck physicians.

This book is an evidence-based guide to current use of radiation therapy for the treatment of malignancies at major disease sites. It is designed to meet the needs of residents, fellows, and practicing radiation oncologists and will assist in selection and delineation of tumor volumes/fields and dose prescription for intensity-modulated radiation therapy, including volumetric modulated arc therapy for stereotactic radiosurgery or stereotactic body radiotherapy. Each tumor site-related chapter presents, from the perspective of an academic expert, informative cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, image-guided treatment delivery, follow-up, and toxicity management. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The expert knowledge and evidence contained in this comprehensive book will give readers the confidence to manage common cancers without outside referral and to meet the clinical challenges faced in everyday practice.

This book provides an overview of the latest advances in head and neck cancer using a multidisciplinary approach. Commencing with a discussion of epidemiological and diagnostic aspects, including the role of vaccination and key pathological features, the book then follows by examining the role of oncogenomics, proteomics, next generation sequencing and homologous recombination function in predicting outcomes. The topics are presented by epidemiologists, pathologists and basic scientists with further contributions from medical oncologists, head and neck cancer surgical specialists (ORL /HNS), and radiation oncologists in chapters that discuss therapeutic approaches for oral, oropharyngeal and thyroid cancer. Special topics such as the development of novel staging classifications, optimal larynx preservation approaches for laryngeal and hypopharyngeal cancer, surgical reconstruction, new surgical approaches in oropharynx cancer, potential for treatment de-escalation, systemic therapyin nasopharyngeal cancer and salivary gland tumors and treatment approaches for tumors of unknown primary site are discussed in detail. Finally, the role of immunotherapy in the field is highlighted. The chapters are based on the latest data presented at the 6th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field. They are written by many of the most internationally acclaimed authors in the field and are therefore an excellent source for all those interested or actively working in the field of head and neck cancer.

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Principles and Practice of Stereotactic Radiosurgery, Second Edition serves as the definitive reference textbook for SRS practitioners. It provides a theoretical basis for the use of therapeutic radiation including imaging techniques and radiobiology. The bulk of the textbook contains chapters that are comprehensive in scope on all diseases that are treated by SRS. Lastly, it addresses administrative and technical aspects of running an SRS unit. Each chapter provides an expansive treatment of the subject, with emphasis placed on the technical aspects of SRS so that practitioners in this field can use it as a daily reference.Written by noted experts in the field, Principles and Practice of Stereotactic Radiosurgery, Second Edition is the only reference needed for neurosurgeons, radiation oncologists and medical physicists at all levels of training and practice who are interested in SRS.

Successful clinical use of intensity-modulated radiation therapy (IMRT) represents a significant advance in radiation oncology. Because IMRT can deliver high-dose radiation to a target with a reduced dose to the surrounding organs, it can improve the local control rate and reduce toxicities associated with radiation therapy. Since IMRT began being used in the mid-1990s, a large volume of clinical evidence of the advantages of IMRT has been collected. However, treatment planning and quality assurance (QA) of IMRT are complicated and difficult for the clinician and the medical physicist. This book, by authors renowned for their expertise in their fields, provides cumulative clinical evidence and appropriate techniques for IMRT for the clinician and the physicist. Part I deals with the foundations and techniques, history, principles, QA, treatment planning, radiobiology and related aspects of IMRT. Part II covers clinical applications with several case studies, describing contouring and dose distribution with clinical results along with descriptions of indications and a review of clinical evidence for each tumor site. The information presented in this book serves as a valuable resource for the practicing clinician and physicist.

This evidence-based guide to the current management of cancer cases at all head and neck sites will assist in the appropriate selection and delineation of tumor volumes/fields for intensity-modulated radiation therapy (IMRT), including volumetric modulated arc therapy (VMAT). Each tumor site-related chapter presents, from the perspective of an academic expert, several actual cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, treatment delivery, and follow-up. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The book will be of value for residents, fellows, practicing radiation oncologists, and medical physicists interested in clinical radiation oncology

This is a single, comprehensive handbook for clinical oncology trainees and consultants, covering the basic aspects of stereotactic radiotherapy systems and treatment.

In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

I tumori maligni della testa e collo insorgono in sedi di grande complessità anatomica e funzionale. Proprio per questo rappresentano una sfida per tutti coloro che se ne occupano. Stili di vita che non prevedano l'uso di tabacco e l'abuso di alcolici potranno limitarne l'incidenza così come la vaccinazione contro il papilloma virus responsabile dell'insorgenza di tumori nell'orofaringe. Il fine di ottenere una ottimale possibilità di guarigione con la massima conservazione delle funzioni specifiche dell'organo è stato raggiunto nei tumori in stadio limitato, mentre nei tumori localmente avanzati questo è un punto ancora da raggiungere. Novità nella diagnostica per immagini, la radioterapia, la chirurgia, i nuovi farmaci sono disponibili oggi per migliorare le possibilità di cura, ma è soprattutto la multidisciplinarietà nella decisione clinica, l'accuratezza della programmazione terapeutica, l'efficacia nel controllo delle cure che possono offrire al paziente una vita migliore.

Decision Making in Radiation Oncology is a reference book designed to enable radiation oncologists, including those in training, to make diagnostic and treatment decisions effectively and efficiently. The design is based on the belief that “a picture is worth a thousand words.” Knowledge is conveyed through an illustrative approach using algorithms, schemas, graphics, and tables. Detailed guidelines are provided for multidisciplinary cancer management and radiation therapy techniques. In addition to the attention-riveting algorithms for diagnosis and treatment, strategies for the management of disease at individual stages are detailed for all the commonly diagnosed malignancies. Clinical trials that have yielded “gold standard” treatment and their results are documented in the schemas. Moreover, radiation techniques, including treatment planning and delivery, are presented in an illustrative way. This groundbreaking publication is an essential tool for physicians in their daily clinical practice.

Nasopharyngeal Cancer - Multidisciplinary Management provides a comprehensive account of the current state of knowledge on nasopharyngeal cancer and its multidisciplinary management. The first ten chapters document contain essential background information on subjects such as epidemiology, pathogenesis, molecular biology, pathology, and the use of imaging in diagnosis and staging. Subsequently, the various treatment options and combinations in a range of settings are examined in depth. Detailed attention is given to the roles of concurrent, adjuvant, and neoadjuvant chemotherapy and advanced radiotherapy techniques. Further chapters then explore surgical treatment, follow-up, treatment of metastatic disease, treatment-related complications, and nasopharyngeal cancer in children. This is an important book that will prove essential reading for the radiation oncology community worldwide and meet the need for substantial improvements in knowledge of modern techniques.

Why a book dedicated to rare cancer management? Given the large variety of rare cancers,they take up a significant part of our daily practice. Therefore, we owe it to our patients with rare tumours that we use the knowledge gained in the treatment of the more common cancers to provide them with a better future. This knowledge comes from recent developments in molecular diagnostics, systemic treatments with new drugs and targeted therapies together with advanced technologies in the areas of radiology and radiation therapy. Our authors have analysed the literature and recommend treatments for rare cancers based on results from past studies. We hope that this book will be an aid to those treating rare cancer cases about which, up to now, little has been published, and will reassure our patients that they have not been forgotten.

There are more than 100 types of cancers In Part II, head and neck cancer is d- affecting all parts of the human body. cussed. The global number of annual new More than 11 million people are diagnosed cases of this malignancy is ~500,000. These with cancer every year, and it is estimated malignancies include oral squamous cell that there will be 16 million new cases by carcinoma, salivary gland tumors, tons- the year 2020. In 2005, 7. 6 million peo- lar cancer, tongue cancer, nasopharyngeal ple died of cancer, that is, 13% of the 58 carcinoma, and retinoblastoma, which are million deaths worldwide. It is estimated detailed. In Part III, diagnosis, therapy, and that 9 million people will die from can- prognosis of thyroid carcinoma are d- cer worldwide in 2015 and 11. 4 million cussed. The global number of new cases of will die in 2030. More than 70% of all thyroid cancer is ~141,000, and the number cancer deaths occur in low and middle of worldwide thyroid mortalities is ~35,375. income countries. These statistics underlie The number of new cases of this cancer in the fact that cancer is the deadliest of all the United States is ~33,550. Molecular human diseases. The enormity of the glo- genetics of thyroid cancer, gene expr- bal healthcare costs as a result of cancer sion markers for diagnosis, papillary t- cannot be overemphasized.

The emphasis on cancer management in the past was based primarily on control rates from multidisciplinary input in management. There has always been a recognition that one would like to achieve the best result with the least complication, but never has there been any major emphasis on evidence-based outcome studies, nor on functional preservation and quality of life. The authors of this book have dealt very effectively with the various tumor types in head and neck cancer with the experts in the? eld of management. The contents range from epidemiology and treatment outcome, treatment techniques with the potential impact on the quality of life such as dysphagia, to the various options relative to high technology radiation therapy programs for mana- ment. The potential for improving form and function through surgical care as an integrated part of the program is dealt with very effectively as well as the potentials for chemotherapy and the use of targeted agents have on quality of life issues. The volume also addresses toxicity, quality of life, and techniques for prevention of adverse effects, as well as the potentials for rehabilitation and supportive care. The authors have clearly done an extraordinarily good job in addressing the mul- plicity of problems that impact upon the functional preservation and quality of life in head and neck radiation therapy. Philadelphia Luther W.

Over recent decades, combined modality treatment has drastically improved the cure rates for various malignant tumors. Further progress is expected through the design of sound combinations involving recently developed drugs. The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. The text, written by acknowledged experts, is specifically designed to be accessible to professionals from the various disciplines involved in multidisciplinary cancer care and to residents in radiation oncology training programs.