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Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders affecting children and adolescents. The condition is characterized by a persistent pattern of behavioural symptoms including inattentiveness, hyperactivity, and impulsiveness associated with substantial impairment in social, academic, and/or occupational functioning. Clinical and research interest in the topic of ADHD has grown substantially in recent years but, despite this, there is still a lack of up-to-date reference texts devoted to the diagnosis, assessment, and management of patients with these conditions. Part of the Oxford Textbooks in Psychiatry series, the Oxford Textbook of Attention Deficit Hyperactivity Disorder attempts to bridge this gap by providing an authoritative, multi-disciplinary guide to the latest research developments in the diagnosis, assessment, and management of patients with ADHD. Organized into eight key sections, this textbook covers the aetiology, pathophysiology, epidemiology, clinical presentation, co-morbidity, clinical assessment, and clinical management of ADHD. Individual chapters address key topics such as the clinical assessment of ADHD in adults, and contain information on best practice, current diagnostic guidelines including DSM-5 and ICD-11, and key up-to-date references for further reading. Edited and written by an international group of recognized experts, the Oxford Textbook of Attention Deficit Hyperactivity Disorder is a comprehensive resource suitable for child and adolescent psychiatrists, adult psychiatrists, and psychiatric trainees, as well as child psychologists, paediatricians, psychiatric nurses, and other mental health care professionals.

In this volume there is a strong emphasis on translational science, with preclinical approaches suggesting new directions for development of new treatments. Individual chapters describe how neuroimaging, neuroendocrine, genetic and behavioral studies use powerful research tools that are offering a completely new understanding of the factors that increase vulnerability to ADHD. The clinical impact of co-morbid problems, especially obesity and substance misuse, are highlighted and explain what such problems can tell us about the etiology of ADHD, more generally. Reviews of the pharmacology of established drug treatments for ADHD justify an exciting novel theory for their therapeutic actions and address questions about the effects of their long‑term use.

Compiling the expertise and research of many of the most widely-cited opinion leaders in the field, this reference spans the etiology, assessment, and management of ADHD and covers all the essential data required to care for patients with this disorder including clinical definitions, psychosocial management approaches, medication dosing ranges, and

Attention deficit hyperactivity disorder (ADHD) is a common neurobehavioral disorder affecting 5–10% of children and adolescents and 3% of adults. Attention Deficit Hyperactivity Disorder: From Genes to Patients aims to provide a comp- hensive, state-of-the-art overview of the critical aspects of ADHD, and hopefully will serve as a quick and up-to-date reference source for professionals with an int- est in ADHD. The book is divided into three major areas that follow an historical survey. The first group of chapters deals with current theories on the pathophysiology of ADHD, and focuses on neurotransmitters and the contributions and validity of animal m- els. The second section emphasizes the evaluation and treatment of patients with ADHD, from the day-to-day approach by the clinical psychologist to the more sophisticated anatomical and functional imaging strategies that have emerged in the last decade. In addition, chapters dealing with specific impairments, such as those pertaining to reading, social interaction, and working memory, are also included for more detailed analysis of these important aspects and their respective contributions to global functioning. The third and final section provides an expanded review on the pharmacotherapy of ADHD and the appropriate methods for selection of specific drugs for individual patients based on drug kinetics and gene expression. David Gozal, MD Dennis L. Molfese, PhD vii CONTENTS Dedication........................................................................................................................................... v Preface............................................................................................................................................... vii Contributors....................................................................................................................................... xi 1 Historical Aspects of Attention Deficit Hyperactivity Disorder................................... 1 Roscoe A. Dykman 2 Scanning the Genome for Attention Deficit Hyperactivity Disorder.........................