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Alcohol is one of the major risk factors for negative health outcomes worldwide. It accounts for more than 60 alcohol-related diseases, ranging from addiction, through liver cirrhosis, to cancer. Collectively, these conditions account for mortality and morbidity that make alcohol use one of the leading preventable causes of disability adjusted life-years (DALYs) lost globally. In this book, an international faculty covers all aspects of alcohol-related disorders, ranging from addiction/alcohol use disorders (AUD) to alcohol-related diseases of other organs such as liver, heart or cancer. A special focus is to reach out to primary care physicians who are in the front line of this major health problem. The book also provides an update for addiction specialists, as well as specialists in internal medicine, gastroenterology and hepatology. The book is divided into sections that include epidemiology, alcohol use disorders and addiction, alcohol-related liver disease, alcoholic hepatitis,primary care and interdisciplinary approaches and other alcohol-related diseases. Besides current diagnostic measures and treatment strategies, the book deals with the many underlying molecular and genetic mechanisms of alcohol toxicity. Novel insights include prospective data on all-cause mortality and the emerging major role of alcohol-mediated hemolysis and enhanced red blood cell turnover. The book also aims at guiding policy makers to handle the topic of alcohol in our society more responsibly.

This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.

Neurobiology of Addiction highlights some of the most promising research areas of the rapidly expanding field of addiction. It will be useful as a practical tool for clinicians, research investigators, and trainees-both in addiction and in other illnesses with overlapping mechanisms-as well as an informative resource for non-technical readers who are interested in addiction or mental health policy. The editors have combined their areas of expertise to provide a unique perspective into the prevention and treatment of addictive disorders. Their approach addresses addiction in the broader context of behavioral processes and survival-related adaptations, focusing on its neurobiological precursors and drawing parallels between addictions and other recurrent or progressive psychiatric disorders. The book also emphasizes resilience, clinical contexts of addictive behavior, and treatment strategies that target its underlying neurobiological mechanisms.

Clinical Manual of Addiction Psychopharmacology is a comprehensive guide to the pharmacology of drugs of abuse and the medications used to treat dependence on those substances. This new, second edition provides a thorough update on a broad range of addictive substances, along with enhanced coverage in areas where significant advances have been made since publication of the first edition. Clinicians, including psychiatrists, psychiatric residents and fellows, and other mental health practitioners who encounter individuals with substance-related disorders in the course of their clinical work, will find the manual to be well-organized, exhaustively referenced, and current.The book is structured for ease of use and completeness of coverage, with an abundance of beneficial features: • Material is presented in a systematic fashion, addressing epidemiology, pharmacology of the abused substance (including pharmacokinetics and pharmacodynamics), psychopharmacological treatments, and issues of dependence, tolerance, withdrawal, and abstinence.• Both basic science and clinical dimensions are addressed, and these different perspectives, including pharmacotherapy and the psychosocial aspects of treatment, are integrated to allow clinicians a more holistic and effective treatment approach.• Coverage of the pharmacology of drugs of abuse is thorough and reflects the latest research findings, providing a necessary background for understanding the clinical effects and treatment of dependence on these substances.• Coverage of pharmacotherapy for dependence on these drugs is equally comprehensive, with meticulously detailed findings and evidence-based recommendations for the clinical care of patients dependent on a variety of substances.• Tables are used strategically to present complex information in a logical and accessible way; for example, the table on management of alcohol withdrawal syndrome includes detailed information on the symptom-triggered approach, fixed dose schedules, and delirium in a condensed, yet easy-to-understand format. The book is well written and edited for clarity and accuracy by editors and contributors at the forefront of the psychopharmacology of addiction. As new drugs come into the market and old drugs find new applications, clinicians must stay current to provide the best care. Clinical Manual of Addiction Psychopharmacology helps them to do just that, offering both sound science and clinical wisdom to meet the complex challenges of treating individuals with substance-related disorders.

The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.