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The Teddy Bear Book is the only reference of its kind that focuses on the unique issues that healthcare professionals face when using injectable medications in children, such as limited fluid volumes, maximum concentrations, and rates of administration. The 12th Edition features more than 270 updated monographs (including over 40 monographs new to this edition) that cover the following areas: Safety issues Infusion-related cautions Dosages and conditions requiring dosage adjustments Contraindications and warnings Adverse drug effects Preparation and compatibility Bolus, intermittent, and continuous IV administration Monitoring

To promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function. Failure to enjoin appropriate dosage adjustments in patients with abnormal or rapidly changing kidney function continues to lead to reports of drug toxicity involving a broad array of renally eliminated medications.This updated edition captures nearly 200 new drugs that have been approved by the FDA since the initial publication of Renal Pharmacotherapy. It also covers new evidence that has emerged regarding the need to adjust dosage of certain older medications that are eliminated by the kidneys. Additionally, it presents new data that are being continuously derived in the areas of patient-specific dose individualization for drugs of all types.Comprehensive, convenient, and evidence-based, this reference closes several identified knowledge gaps and will continue to be the leading collection of dosage recommendations for patients with compromised kidney function.

Pediatric Injectable Drugs, also known as “The Teddy Bear Book,” is one of the ASHP's most recognized and trusted resources dedicated to helping pharmacists treat pediatric patients with injectable drugs. For more than 20 years, pharmacists and hospital pediatric teams have looked to Pediatric Injectable Drugs (The Teddy Bear Book) for the most comprehensive research-based information on pediatric intravenous infusions. Now for the first time since 2013, a new edition of this trusted resource is available! The “Teddy Bear Book”, is the only reference of its kind that focuses on the unique issues that pediatric practitioners face when dealing with pediatric injectable drugs, such as limited fluid amounts, limited intravenous sites, and maximum doses. The updated edition of this comprehensive resource by respected editors Stephanie J. Phelps, PharmD, BCPS, Kelley R. Lee, PharmD, Amanda Jill Thompson, PharmD, and Tracy M. Hagemann, PharmD, FCCP, includes 15 new monographs and updates based on the latest evidence-backed literature.

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes. This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.

If you work with children, you must have this book.For more than two decades, Pediatric Injectable Drugs (The Teddy Bear Book), has served an important and continuing need for reliable evidence-based information specific to pediatric injectable drugs.The tenth edition of this invaluable reference has grown to cover 238 drugs commonly used in the treatment of infants and children, including 20 new to this edition. The Teddy Bear Book covers neonates through adolescents, with age-specific dosing and administration guidelines throughout. With three new editors, who collectively bring 75 years of pediatric pharmacy practice experience to the book, the tenth edition is the most thorough and comprehensive reference yet.As with previous editions, the structure of each of the drug monographs covers the following areas: Brand Names Medication Error Potential Contraindications and Warnings Infusion-Related Cautions Dosage (age specific) Dosage Adjustment in Organ Dysfunction Maximum Dosage Additives Suitable Diluents Maximum Concentrations Preparation and Delivery IV Push Intermittent Infusion Continuous Infusion Other Routes of Administration

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is