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Backed by quality, peer-reviewed published literature, ASHP® Injectable Drug Information™ has been one of pharmacy's most trusted resources for more than four decades. Authored under the editorial authority of AHFS Drug Information® and published by ASHP, it is the global gold standard for IV compatibility and stability information. The 2025 Edition of the industry's go-to guide is newly updated with the latest information, ASHP's Standardize 4 Safety (S4S) concentration standards including new Adult and Pediatric PCA and Epidural standard concentrations, the full list of the AHFS® Pharmacologic-Therapeutic Classification© system, 25 new monographs, and more than 270 new references for a total of over 25,000 total compatibility pairs.

Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.

This new book, drawing on the author's distinguished career in front-line psychiatric practice, describes how to bring patient and prescriber together in an active partnership whereby there is better understanding of the positive and negative elements of drug prescription. At present there is a gap between expectations, with doctors not always able to admit their ignorance of some aspects of drug action, and patients kept unaware of these uncertainties. Balanced decision-making with joint involvement is needed to separate those drugs that are needed regularly to maintain health, those that are only needed when required and those that are mere fashion accessories. Greater care is needed over the explanation of the first prescription, the expected duration of treatment and the plans for eventual withdrawal. The consequence of a better partnership will be less over-prescribing, a reduction of polypharmacy and a lessened need for deprescribing, the planned systematic reduction of drug treatment that has got completely out of control.Concentrating on routine prescribing for psychiatric and mental health disorders rather than unusual conditions and illustrated with real-life anecdotes and case histories, this is essential reading for trainee and practising psychiatrics, general practitioners and pharmacists.

Neurological disorders categorized as neurodegenerative, neuropsychiatric, and neurotraumatic impose a substantial health burden and cause a frail impact on life attributes. The use of synthetic drugs can have undesirable side effects, making neurotherapeutics challenging. Research on neuroprotection aiming for the utilization of safer natural compounds; phytochemicals specifically – is a cutting-edge approach. NeuroPhytomedicine intends to present readers with a wide-ranging and state-of-the-art appearance at the beneficial properties of phytochemicals on various neurological ailments.It additionally contains sections explaining: Applications of phyto-nanotechnology in neurological ailments Phytoconstituents related deep learning and machine learning-based solutions for neurological disorders Epigenetic relevance pertaining to modulation by phytochemicals The goal of NeuroPhytomedicine is to give readers a thorough and up-to-date look at how phytochemicals affect the brain and neurological illnesses in a way that is helpful for research scholars, academicians, scientists, neuroscientists, physicians, and researchers from the pharmaceutical industry.

In pharmaceutical research, solubility plays a key part in the assessment of pharmacokinetic risks. Poor drug absorption, reduced efficacy, excessive metabolism, and adverse reactions are frequently related to issues of drug solubility. During early discovery research at pharmaceutical companies, many thousands of molecules are considered. Most are rejected due to perceived unfavorable properties. Here the author uses the Wiki-pS0TM database, which forms the backbone of this unique handbook. Also discussed is the emerging class of therapeutically promising research molecules called PROTACs (proteolysis-targeting chimeras), showing a propensity for ‘undruggable'targets.FEATURES• A comprehensive and unique listing of measured aqueous intrinsic solubility focusing on drug-like and drug-relevant molecules.• The database can be used to predict the solubility of research pharmaceutical molecules.• Includes downloadable files of the database (.csv format).• The mining of the database can result in a better design of solubility assay protocols, leading to better quality of measurements.• Artificial intelligence and Bayesian statistics will likely be key to this subject area in the future.Alex Avdeef has been an American Association of Pharmaceutical Scientists (AAPS) Fellow since 2014, a former visiting senior research fellow at King's College London, and is the author of Absorption and Drug Development (2nd ed., Wiley, 2012). In 2021, the book was translated into Chinese, by translators affiliated with the China Food and Drug Administration. For nearly 50 years, he has been teaching, researching, and developing methods, instruments, and analysis software for the measurement of ionization constants, solubility, dissolution, and permeability of drugs. His accomplishments in the development of instrumentation include several well-known instruments that are or recently have been manufactured by leading companies in the instrument market, including Thermo Fisher Scientific, Sirius Analytical, and Pion Inc. He has over 200 technical publications in primary scientific journals and book chapters. He has written several comprehensive technical guides and is a co-inventor on six patents. He cofounded Sirius Analytical (UK) in 1989, pION Inc. (USA) in 1996, and founded in–ADME Research (New York City) in 2011. His other positions were at Orion Research, Syracuse University, UC Berkeley, and Caltech.

Nanomedicine biotechnology is applied to and used to study drug development, working mechanisms, diagnosis, and therapies. This textbook particularly written for biomedical applications of nanomedicine covers the whole range of disease treatments related to nanomedicine. This book serves the purpose of highlighting the current advancements of nanomedicines-based regimens which may be employed in disease treatment while it also contains the fundamental knowledge for biomedical researchers from all levels. Each chapter starts with an introduction/theory into the specified approaches for various disease states followed by detailed discussions for a comprehensive understanding. This book best suits advanced level students, but also provides an excellent updated material for researchers and healthcare workers related to nanomedicine and diseases treatment.

The aim of this book is to provide insights on the methods currently available to holistically support the bioequivalence assessment. The Bioequivalence assessment has become the cornerstone of generic drug approval worldwide, enabling the introduction of generic equivalents of innovative drugs through appropriate assessment, as required by the various regulatory authorities. Considerations for the planning and design of bioequivalence studies are constantly evolving to create harmonized standards that address the complexity of the technologies that support drug development today. This has led to discussions between regulators and industry, and academy stakeholders seeking updated practices. In this context, this book intends to address these issues cross-functionally in a balanced description between conventional and complex pharmaceutical dosage forms to highlight key recent advances. Special attention is given to the harmonization of biopharmaceutical classification systems based on biowaivers, common shortcomings in generic drug development, bioequivalence statistics, and alternative in vitro and in silico bioequivalence approaches as emerging issues and enhanced science-based trends in the field.

Backed by quality, peer-reviewed published literature, ASHP® Injectable Drug Information™ has been one of pharmacy's most trusted resources for more than four decades. Authored under the editorial authority of AHFS Drug Information® and published by ASHP, it is the global gold standard for IV compatibility and stability information. With over 40 years of precise and accurate detail, nothing else comes close for providing information on compatibility, stability, storage, and preparation of parenteral drugs.

THE #1 Drug Guide for nurses & other clinicians …always dependable, always up to date! Look for these outstanding features Completely updated nursing-focused drug monographs featuring 3,691 generic, brand-name, and combination drugs in an easy A-to-Z format NEW 27 brand-new FDA-approved drugs in this edition—tabbed and conveniently grouped in a handy “new drugs”section for easy retrieval NEW Thousands of clinical updates—new dosages and indications, Boxed warnings, genetic-related information, adverse reactions, nursing considerations, clinical alerts, and patient teaching information Special focus on U.S. and Canadian drug safety issues and concerns Photoguide insert with images of 431 commonly prescribed tablets and capsules

Substance misuse and addictions are a public health issue. They affect the well-being of each community and nation as a whole. It is, therefore, necessary to identify, educate, and treat individuals who are addicted to substances. Policies and procedures go hand-in-hand with public health education and safety. The science behind the public health issues of one drug may be applicable to other drugs as well. However, marshalling all of the aforementioned information into a single source is somewhat difficult due to the wide array of material. The Editors address this by compiling the research in this single reference work that serves as a'one-stop-shopping'approach to everything readers need to know about the scientific basis of public health and addictions and agents of misuse.Apart from active agents that have a plant or chemical basis, there is a need to consider that there are other forms of addiction which may havecommon modes of causality or prevention. These include food addiction, gaming, gambling, and other non-drug addictions. These types of addiction may be related to the addiction of drugs.The Handbook of Substance Misuse and Addictions: From Biology to Public Health offers a holistic understanding of the relationship between public health and substance misuse. The text provides a common platform upon which other forms of addiction or substance misuse can be understood and treated. Addiction processes involve understanding the biological processes as well as behavior, psychology, sociology, and public health, all of which are interlinked. This Handbook is a useful reference for lecturers, students, researchers, practitioners, and other professionals in public health, addiction science, epidemiology, health education, health promotion, and health sciences.

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future.Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.

The Indispensable Guide to Interpreting Clinical Laboratory DataBasic Skills in Interpreting Laboratory Data is a comprehensive, in-depth guide to all aspects of lab work that apply to clinical practice. Written by established clinicians and pharmacy faculty members and reviewed by additional experts, it is designed to make all information clear and quickly accessible. Minicases provide clinical scenarios for using tests and managing patients, and quickview charts throughout offer clear interpretations of lab results. Complex but critical skills are required for clinical pharmacists to effectively use lab data in screening for or diagnosing diseases and in monitoring the safety and effectiveness of treatment. As the only book of its kind specifically written for pharmacists by pharmacists, Basic Skills makes it easier to make accurate and critical decisions based on laboratory data.

This book is written for undergraduates of PhramD programs. However, other allied health sciences students may benefit from this work on clinical pharmacy. It provides insights ranging from basic concepts of clinical pharmacy to systemic disease management with an easy-to-understand approach.

This first-of-its-kind handbook offers crucial information on the safety of drugs taken during pregnancy. It covers an exhaustive list of common and less common drugs and provides for each drug the FDA letter categorization and newly approved “Pregnancy and Lactation Labeling Rule (PLLR)” systems for rating drug risks in pregnancy, imposed by the U.S. Food and Drug Administration (FDA). Drugs in Pregnancy: A Handbook for Pharmacists and Physicians covers the pregnancy ramifications of using anti-infective, cardiovascular, hematologic, dermatologic drugs and drugs affecting the endocrine, central, autonomic, gastrointestinal, musculoskeletal systems in addition to herbs, vitamins and dietary supplements. To enable the reader to develop well-informed knowledge about a drug safety profile during pregnancy, three sections of data have been provided for each drug: FDA Category, Risk Summary, and Further Reading.

ASHP's New and Expanded Guide to IV Compatibility & Stability For more than 40 years, ASHP has published the most trusted resource for injectable drug information. Our new ASHP® Injectable Drug Information™ now delivers the same high-quality content that you can expect from ASHP with even MORE of the information you need to make informed patient care decisions. For the first time ever, this gold standard reference is available as an eBook with new and expanded information. The 2021 edition features 18 new monographs, and nearly 200 new references for a total of over 24,000 total compatibility pairs. Backed by quality, peer-reviewed published literature, and authored under the editorial authority of ASHP, ASHP® Injectable Drug Information™ is a must-have resource for every pharmacy.

To promote effectiveness and minimize possible toxicity, the dosage of certain medications must be adjusted in persons with compromised kidney function. Failure to enjoin appropriate dosage adjustments in patients with abnormal or rapidly changing kidney function continues to lead to reports of drug toxicity involving a broad array of renally eliminated medications.This updated edition captures nearly 200 new drugs that have been approved by the FDA since the initial publication of Renal Pharmacotherapy. It also covers new evidence that has emerged regarding the need to adjust dosage of certain older medications that are eliminated by the kidneys. Additionally, it presents new data that are being continuously derived in the areas of patient-specific dose individualization for drugs of all types.Comprehensive, convenient, and evidence-based, this reference closes several identified knowledge gaps and will continue to be the leading collection of dosage recommendations for patients with compromised kidney function.

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

This book provides comprehensive information of the nanotechnology-based pharmaceutical product development including a diverse range of arenas such as liposomes, nanoparticles, fullerenes, hydrogels, thermally responsive externally activated theranostics (TREAT), hydrogels, microspheres, micro- and nanoemulsions and carbon nanomaterials. It covers the micro- and nanotechnological aspects for pharmaceutical product development with the product development point of view and also covers the industrial aspects, novel technologies, stability studies, validation, safety and toxicity profiles, regulatory perspectives, scale-up technologies and fundamental concept in the development of products.Salient Features: Covers micro- and nanotechnology approaches with current trends with safety and efficacy in product development. Presents an overview of the recent progress of stability testing, reverse engineering, validation and regulatory perspectives as per regulatory requirements. Provides a comprehensive overview of the latest research related to micro- and nanotechnologies including designing, optimisation, validation and scale-up of micro- and nanotechnologies. Is edited by two well-known researchers by contribution of vivid chapters from renowned scientists across the globe in the field of pharmaceutical sciences. Dr. Neelesh Kumar Mehra is working as an Assistant Professor of Pharmaceutics & Biopharmaceutics at the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He received ‘TEAM AWARD'for successful commercialisation of an ophthalmic suspension product. He has authored more than 60 peer-reviewed publications in highly reputed international journals and more than 10 book chapter contributions. He has filed patents on manufacturing process and composition to improved therapeutic efficacy for topical delivery. He guided PhD and MS students for their dissertations/research projects. He has received numerous outstanding awards including Young Scientist Award and Team Award for his research output. He recently published one edited book, ‘Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives', in CRC Press. Currently, he is editing books on nano drug delivery-based products with Elsevier Pvt Ltd. He has rich research and teaching experience in the formulation and development of complex, innovative ophthalmic and injectable biopharmaceutical products including micro- and nanotechnologies for regulated market.Dr. Arvind Gulbake is working as an Assistant Professor at the Faculty of Pharmacy, School of Pharmaceutical & Population Health Informatics, at DIT University, Dehradun, India. He has authored more than 40 peer-reviewed publications in highly reputed international journals, four book chapters and a patent contribution. He has received outstanding awards including Young Scientist Award and BRG Travel Award for his research. He is an assistant editor for IJAP. He guided PhD and MS students for their dissertations/research projects. He has successfully completed extramural project funded by SERB, New Delhi, Government of India. He has more than 12 years of research and teaching experience in the formulation and development of nanopharmaceuticals.

Prescribing Mental Health Medication is a comprehensive text for all practitioners who treat mental disorders with medication. This new (third) edition is fully updated and includes a variety of additional chapters.Prescribing Mental Health Medication covers the latest digital methodologies including Internet-based mental health treatment, electronic medical records and prescriber use of social media. Including information on all psychotropic medications in use in the United States and the United Kingdom, the book incorporates clinical tips, sample dialogues for talking about mental health medications to patients, and information specifically relevant in primary care settings. It looks at:• how to determine if medication is needed, proper dosing and how to start, stop and change medication • specific mental health symptoms and appropriate medication • special populations including non-adherent patients, medication abusers, those mixing alcohol and psychotropics, confused patients, children, adolescents, pregnant women and seniors • management of medication side effects and avoidance of medication risk • prescription of generic preparations• organizing a prescriptive office and record keeping.The additional chapters in this new edition of Prescribing Mental Health Medication cover topics such as combining specific medications, combining medications and psychological therapies, use of'natural'substances in mental health treatment, successfully managing patient relapse, and appropriate prescriptions of potentially controversial medications such as stimulants and benzodiazepines.This practical text explains the entire process of medication assessment, management and follow up for general medical practitioners, mental health practitioners, students, residents, prescribing nurses and others perfecting this skill.

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

In terms of the Good Pharmacy Practice (GPP) of South Africa, pharmacists are required by law to have the following compulsory legislation to comply with the South African Pharmacy Council (SAPC) inspection: The Pharmacy Act 53 of 1974 -Regulations and Rules under the Pharmacy Act 53 of 1974. The Medicines and Related Substances Act 101 of 1965 -Regulations under the Medicines and Related Substances Act 101 of 1965. Rules Relating to Good Pharmacy Practice (GPP).

The March 2020 British National Formulary (BNF 79) is your essential reference book for prescribing, dispensing, and administering medicines.

Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of the chemical basis of drug action. Medicinal Chemistry of Drugs Affecting the Nervous System is the second volume of the series and it presents 8 chapters focusing on a comprehensive account of drugs affecting the nervous system. The volume informs readers about the medicinal chemistry of relevant drugs, which includes the mechanism of drug action, detail structure activity relationships and metabolism as well as clinical significance of drugs affecting autonomic and central nervous system. Chapters in this volume cover cholinergic drugs, adrenergic drugs, antipsychotics, antidepressants, sedatives, hypnotics, anxiolytics, antiepileptic drugs, anesthetics and antiparkinsonian drugs, respectively. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body. The information offered by the book chapters will give readers a strong neuropharmacology knowledge base required for a practicing pharmacist.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A fast, fun, and effective way for pharmacy students to learn essential information about the top 300 drugs McGraw-Hill Education's 2020/2021 Top 300 Pharmacy Drug Cards, Fifth Edition delivers everything pharmacy and nursing students need to know about the top 300 drugs in one easy-to-carry resource. Every card includes: Generic and common name, Class, Dosage Forms, Approved Dose and Indications, Off-Label Use, Contraindications, Adverse Reactions, Drug Interactions, Monitoring Parameters, Medication Safety Issues and Black Box Warnings, and strong focus on patient safety. •Provides photos so students can view tablets and packaging •Includes audio Q&A with detailed discussion for each drug at Top300DrugCards.com •15 bonus cards on key adult and pediatric vaccines •Great for NAPLEX® and course review!

Avec plus de 4600 spécialités et 4000 produits de parapharmacie pour cette 94e édition, le Dictionnaire VIDAL constitue l'ouvrage indispensable des professionnels de Santé dans le cadre de leur pratique quotidienne. Les monographies VIDAL sont rédigées d'après les données publiées par l'Agence nationale de sécurité du médicament et des produits de santé (Ansm), en particulier les Résumés des caractéristiques du produit (RCP), et les informations économiques publiées au Journal officiel. Toutes structurées de la même façon, les monographies permettent une lecture rapide et pratique. Elles sont le reflet de l'information officielle disponible au moment de la publication du Dictionnaire.

This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

The March 2019 British National Formulary (BNF 77) is your essential reference book for prescribing, dispensing, and administering medicines.

The September 2018 British National Formulary (BNF 76) is your essential reference book for prescribing, dispensing, and administering medicines.

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Antimicrobial Drug Interactions,” delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-relatedinfections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.

Written by experts in the field of pharmacovigilance and patient safety, this concise resource provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. Drs. Thao Doan, Fabio Lievano, Mondira Bhattacharya, and Linda Scarazzini provide essential information for health care professionals, clinical researchers, and regulators who need a comprehensive, up-to-date source of information on the principles and practice of pharmacovigilance. - Covers the evolving regulatory landscape, as well as current and future use of digital technologies. - Uses case studies to ensure content is relevant to everyday practice. - Discusses behavioral science and patient perspectives, risk communication, and new frontiers in pharmacovigilance. - Consolidates today's available information on this timely topic into one convenient resource.

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression.The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

Protect Your Patients: A Definitive Guide​ to Drug-Induced Disease A drug-induced disease is the unintended effect of a drug, which results in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical attention and/or require hospitalization. This book, now a modern classic, examines these unintended effects and creates a knowledge base of potentially causal drugs that must be considered in medication monitoring activities. Now in its third edition, this essential and comprehensive resource provides a detailed analysis of how to identify, prevent, and manage drug-induced diseases. Edited by James E. Tisdale and Douglas A. Miller, with contributions from experts distinguished in their respective specialties, Drug-Induced Diseases is organized logically and is easy to use for pharmacists, physicians, nurses, and pharmacy students alike.

The March 2018 British National Formulary (BNF 75) is your essential reference book for prescribing, dispensing, and administering medicines.

Sadly, women often feel they have no alternative but to give up breastfeeding, having been prescribed or purchased medication. In many cases, however, this is unnecessary. This book outlines the evidence base for the use of medication during breastfeeding. Breastfeeding and Medication presents a comprehensive A to Z guide to the most frequently prescribed drugs and their safety for breastfeeding mothers. Evaluating the evidence for interventions and using a simple format for quickly identifying medications that are safe or unsafe to use, it also highlights those drugs where there is inconclusive evidence. Additional contextual information makes this the most complete text for those practitioners who support and treat breastfeeding women. It: provides an overview of the anatomy and physiology of the breast together with hormonal influences to better understand how complications, such as mastitis, arise and inform the approach to their treatment; includes a section on conditions that affect women specifically when they are lactating where prescription of medication may be necessary; discusses the importance of breastfeeding and its advantages, as well as its disadvantages; and explores how to support breastfeeding mothers, and presents a counselling model approach. This new edition contains information on more drugs and a chapter on the management of some chronic conditions which may affect breastfeeding mothers. In most cases there are options to support the mother's optimal care whilst allowing her to continue to breastfeed her baby as long as she wishes. This is a topic which raises many questions on social media, which informed the choice of conditions to consider. This is an invaluable reference for all health practitioners and volunteers who work with, support and treat breastfeeding women, including lactation consultants, breastfeeding support workers, health visitors, GPs, practice nurses, pharmacists and midwives.

Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. - Examines the history and recent developments in drug dosage forms for pharmaceutical sciences - Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism - Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A fast, fun, and effective way to learn essential information about the top 300 drugs Includes audio Q&A with detailed discussion for each drug at Top300DrugCards.com and 15 BONUS CARDS ON VACCINES! Everything you need to know about the top 300 drugs in one easy-to-carry resource. Each card includes: • Generic and common name • Class • Dosage Forms • Approved Dose and Indications • Off-Label Use • Contraindications • Adverse Reactions • Drug Interactions • Monitoring Parameters • Medication Safety Issues and Black Box Warnings • Strong focus on patient safety Great for NAPLEX® and course review! Send feedback to the editors: Jill M. Kolesar, PharmD, MS, BCPS, FCCP, Professor, College of Pharmacy, Director, Early Phase Clinical Trials Center, Co-Director, Molecular Tumor Board, Markey Cancer Center, University of Kentucky. Email: jill.kolesar@uky.edu Lee Vermeulen, BSPharm, MS, FCCP, FFIP, Chief, Academic Service Lines, UK HealthCare and Professor of Medicine and Pharmacy, University of Kentucky. Email: Lee.Vermeulen@uky.edu

The BNF for Children (BNFC) 2017-2018 provides essential practical information to all healthcare professionals involved in the prescribing, dispensing, monitoring and administration of medicines to children. It has been revised and revalidated to reflect changes in product availability, emerging safety concerns and shifts in clinical practice. The resource addresses a significant knowledge gap in many areas of paediatric practice by providing practical information on the use of medicines in children of all ages from birth to adolescence.

BNF 74 has been compiled with the advice of clinical experts and continually updated to reflect the latest evidence from credible sources worldwide. It provides up-to-date guidance on prescribing, dispensing, and administering medicines. Access to the latest edition of the BNF is vital for healthcare professionals, as it reflects current best practice as well as legal and professional guidelines relating to the uses of medicines.

Now in its fourth edition, this best-selling book is fully updated to address the ever increasing demands on healthcare professionals to deliver high-quality patient care. A multitude of factors impinge on healthcare delivery today, including an ageing population, more sophisticated medicines, high patient expectation and changing health service infrastructure. Time demands on primary care doctors have caused other models of service delivery to be adopted across the world, leading to ongoing changes in the traditional boundaries of care between doctors, nurses, and pharmacists. Certain medical tasks are now being performed by nurses and pharmacists, for example prescribing. Healthcare policies to encourage patients to manage their own health have led to more medicines becoming available over the counter, allowing community pharmacists to manage and treat a wide range of conditions. Further deregulation of medicines to treat acute illness from different therapeutic areas seems likely. Government policy now encourages chronic disease management as a self-care activity, and could well be the largest area for future growth of reclassification of medicines. Pharmacists, now more than ever before, need to be able to recognise the signs and symptoms, and use an evidence-based approach to treatment. Community Pharmacy is intended for all non-medical prescribers but especially for pharmacists, from undergraduate students to experienced practitioners. Key features - Guidance for arriving at a differential diagnosis - Practical prescribing tips - Trigger points for referral boxes - Other hints and tips boxes - Specific questions to ask boxes - Case studies - Self-assessment questions Consistent approach gives: - Anatomy overview - History taking and physical examination - Prevalence and epidemiology - Aetiology - Arriving at a differential diagnosis - Clinical features - Conditions to eliminate Likely causes Unlikely causes Very unlikely causes - Evidence base for OTC medicine - Practical prescribing and product selection - More on the examination of eyes, ears and mouth - New sections on future-proofing (vaccinations etc.) - New material covering inter-professional education for clinical skills. Now with a free accompanying e-book on StudentConsult which also gives additional material on: - evidence-based medicine - videos on physical examination - additional written case studies - more multiple-choice questions

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects ofdrug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.

BNF 73 (March 2017) is the authoritative guide to prescribing, dispensing and administering medicines for all healthcare professionals.

An A-Z pocket book containing concise and practical pharmaceutical information for busy clinical pharmacists.

Adverse Drug Interactions: A Handbook for Prescribers assists clinicians by providing key information on potential adverse effects that can result from prescribing two or more drugs for simultaneous use. Interactions that are likely to give rise to life-threatening conditions, and which must therefore be completely avoided, are clearly highlighted.

Rivolto ai farmacisti preparatori, agli studenti e a tutti coloro che vogliono allestire un laboratorio galenico presso la propria struttura, a oltre venti anni dalla prima pubblicazione del 1995, il Manuale delle preparazioni galeniche è diventato l'autentico punto di riferimento per il settore. La IV edizione estende l'orizzonte dei preparati officinali a tutte le Farmacopee e Formulari Ufficiali in vigore nell'Unione Europea: Farmacopee Britannica, Tedesca, Austriaca, Ceca e Rumena; Formulari Nazionali Spagnolo, Francese, Belga, Ungherese e Slovacco. Offre quindi al farmacista la più ampia possibilità di attingere alle varie realtà europee; notevolmente ampliate anche le sezioni dedicate alle formulazioni magistrali e fitoterapiche. L'opera affronta inizialmente le problematiche relative all'organizzazione del laboratorio galenico, l'applicazione delle Norme di Buona Preparazione della F.U.I. XII, nonché gli aspetti legislativi legati alla preparazione dei medicinali in farmacia, aggiornando al 2016 la normativa in tema di doping, stupefacenti, impiego terapeutico della Cannabis e applicazione della Legge di Bella. Nei capitoli successivi l'autore descrive approfonditamente le singole forme farmaceutiche, analizzando gli specifici eccipienti, le tecniche di esecuzione, le apparecchiature manuali o automatiche appositamente studiate per il laboratorio di farmacia e parafarmacia, le tecniche di stabilizzazione dei medicinali e i controlli da effettuare. Completano la trattazione tre ampie Appendici: I – Elenco sostanze e preparati vegetali ammessi negli integratori alimentari; II – Lista T.M. della Farmacopea Omeopatica Tedesca; III – Esempi di etichettatura.

The September 2016 British National Formulary (BNF 72) is your essential reference book for prescribing, dispensing, and administering medicines.