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This book explores the relationship between the gut microbiome and cancer, illuminating various facets from fundamental roles to personalized therapies. It provides a comprehensive overview of the impact of the gut microbiome on cancer development, offering potential for innovative diagnostic and treatment approaches. The book discusses the role of dysbiosis in cancer development, the influence of the microbiome on treatment responses, and strategies to modulate the microbiome for enhanced therapies. It reviews the influence of the gut microbiome on immunotherapy resistance and chemoresistance in cancer patients. Additionally, the book presents gut microbiome biomarkers for cancer diagnosis and prognosis, the implication of the gut-brain axis on cancer development and progression, and the impact of diet and lifestyle on the microbiome. Towards the end, the book investigates the role of the gut microbiome in pediatric cancer and provides an outlook on the future challenges, technological advancements, and ethical considerations of gut microbiome research in the context of personalized cancer therapies. This book is intended for cancer researchers, medical oncologists, clinicians, pharmacologists, translational investigators, and medical students.

Research on the therapeutic efficacy of cannabinoids has demonstrated that cannabidiol (CBD), either alone or in 1:1 mixtures with delta-9-tetrahydrocannabinol (THC), can effectively treat animals in experimental models of neuroinflammatory, demyelinative, neurodegenerative, neuropsychiatric, and neoplastic diseases. Short-term, small-scale, human cohorts, observational studies, randomized, non-randomized, placebo-controlled, and uncontrolled clinical trials have provided low-certainty and moderate-certainty evidence that medical marijuana can reduce spasticity, neuropathic pain, neuroinflammation, anxiety, sleep disturbance, urinary bladder dysfunction, frequency and duration of seizure, tumor size, and metastasis as well as promote overall cancer survival. Medical Cannabis and the Effects of Cannabinoids on Fighting Cancer, Multiple Sclerosis, Epilepsy, Parkinson's, and Other Neurodegenerative Diseases presents the findings from clinical and basic medical scientists who are investigating the cellular and molecular mechanisms of cannabinoid-mediated inhibition of innate and adaptive immune responses, mobilization of myeloid-derived immunosuppressive cells, enhancement of neuroprotection, facilitation of oligodendrocyte survival, promotion of CNS progenitor cell differentiation to support regeneration and remyelination, arrest of tumor cell proliferation, decrease in tumor cell adhesion, disruption of tumor angiogenesis, inhibition of endothelial cells, and prevention of cancer metastasis by inhibition of cell migration. The chapters further discuss pharmacologic challenges and precisely how the delicate balance between the opposing effects of various types of cannabinoid receptors can be controlled by manipulating specific membrane channels and signaling pathways to achieve favorable long-term clinicopathologic outcomes in oncology and neurology. Covering topics such as neurodegenerative diseases, spectroscopic applications, and ethical issues, this premier reference source is an essential resource for medical professionals, pharmacists, hospital administrators, government officials, students and faculty of higher education, librarians, researchers, and academicians.

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.