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Since 1898, when Tigerstadt and Bergman first extracted renin from rabbit kidney, the reninrugs, Enzymes and Receptors of the Renin is designed to highlight molecular and clinical approaches to understanding the reninChapter topics have been specifically chosen to cover selected contemporary, controversial and unresolved issues. A novel and uni

Chronic kidney disease is one of the world's major public health problems, and the prevalence of kidney failure is rising steadily. Among the risk factors for a faster progression of renal disease are hypertension and proteinuria, many studies clearly demonstrating that hypertension is both a cause and consequence of chronic kidney disease. Namely, renal blood pressure regulation seems to be involved in five major pathophysiological mechanisms (all closely related to the renin-angiotensin system): Pressure-natriuresis, renal sympathetic nervous system, renal blood flow, intraglomerular pressure and tubuloglomerular feedback. This book reviews experimental data which form the basis of our current understanding of the association between hypertension and kidney diseases: The pathogenesis of increased blood pressure, the mechanisms by which systemic hypertension promotes progressive kidney failure, and the impact of antihypertensive agents on experimental renal mechanisms involved in hypertension. Furthermore, the role of angiotensin II receptor blockers in both the control of systemic blood pressure and the reduction of proteinuria is examined in an attempt to define optimal therapeutic strategies to prevent the otherwise inexorable deterioration of renal function in patients with chronic kidney disease.

This book's focus is on Alzheimer's, the many additional diseases that cause dementia and the reasons for the lack of drugs to treat these neurological dysfunctions. Suggested changes to the USA's Food and Drug Administration (FDA) protocols are offered in order to accelerate the drug development pipeline and reduce the huge costs required to conduct human clinical trials. The importance of the brain renin-angiotensin system is described and possible new directions in drug development are discussed, along with the changing role of academic researchers in identifying and developing new treatment strategies. The book was written for those families touched by Alzheimer's and other dementias, academic scientists interested in neurodegenerative diseases, and would-be entrepreneurs considering beginning a start-up company.

Pulmonary Pharmacology, Volume 98 provides in-depth reviews on the latest progresses about respiratory drug discovery and development. Topics covered in this volume include corticosteroids, monoclonal antibodies, tyrosine kinase inhibitors and phosphodiesterase inhibitors for the treatments of asthma, COPD or pulmonary fibrosis, with perspective on the development of novel therapeutic strategies such as renin-angiotensin system modulators, mitochondrial function modulators, and non-antibacterial macrolides. Part of the volume is devoted to senotherapy for lung ageing in respiratory diseases, and novel pulmonary delivery technologies, including inhaled biologics. Provides accurate reviews from leading experts on the topic of pulmonary pharmacology Each chapter of the volume provides consolidated graphical materials for ease of reading for the audience Provides the latest insights and future perspectives on the drug discovery and development for respiratory diseases

ATj-Rezeptorantagonisten sind eine Substanzklasse, die ähnlich wie die ACE-Hemmer wirken, wenngleich sie unterschiedliche Wirkmechanismen auszeichnen, und die ähnlich erfolgreich sind, obwohl sie erst seit gut drei Jahren auf dem deutschen Arzneimittelmarkt verfügbar sind. Die zweite Aussage ist von der ersten abhängig: die erfolgreiche Behandlung kardio­ vaskulärer Erkrankungen mit Hemmstoffen, die am Renin-Angiotensin-System (RAS) angreifen, nämlich der ACE-Inhibitoren, hat den Weg für die Therapie mit ATj-Antago­ nisten gebahnt. Der voraussehbare Erfolg des Prinzips AT j-Rezeptorenblockade bei Ärzten und Patienten hat dazu geführt, daß sich viele Pharmazeutische Unternehmen mit der neuen Substanzklasse beschäftigten und nun ihre Substanzen auf dem Markt einführen. Innerhalb von nur drei Jahren wurde bereits die sechste Substanz in Deutschland zuge­ lassen, und die ATI-Antagonisten brechen damit den Rekord der ACE-Hemmer. Die antihypertensiven, kardioprotektiven, vasoprotektiven und nephroprotektiven Eigenschaften der ATI-Antagonisten wurden in präklinischen Untersuchungen am Tier­ experiment mit ACE-Inhibitoren aber auch anderen Antihypertensiva verglichen und ein­ drucksvoll belegt, die klinische Wirksamkeit wird zur Zeit in großangelegten Mortali­ tätsstudien für alle protektiven Wirkungen untersucht. Ein Fazit kann bereits jetzt schon gezogen werden: AT I-Antagonisten sind bis heute die Antihypertensiva mit den wenigsten Nebenwirkungen! Das vorliegende Buch faßt die Vorträge eines internationalen Candesartan Kongresses auf Deutsch zusammen, der im April 1998 in Hamburg im ICC stattfand.

Scientific advances over the past two decades have afforded unprecedented oppor­ tunities to understand the structure and function of receptors, receptor-ligand interactions, and receptor signaling. The extent ofprogress in this area is underscored by the recent Nobel Prize for Medicine and Physiology to Alfred Gilman and Martin Rodbell, both of whose work in understanding receptorlG-protein interactions has redefined the way in which we think of how hormones and neurochemicals exert their activity on cellular function. This book is replete with examples of current research approaches to help us better understand the cellular roles in which the renin-angiotensin system and the angiotensin receptors participate. Clearly, defining the structure of angiotensin receptor subtypes is an important first step in cJarifying the mechanisms by which these receptors take part in cellular function. However, the chapters within this book range far beyond structural studies and encompass research on tissue specific expression of the angiotensin receptor subtypes, the genetic regulation ofthese receptors, and the unique function ofvarious angiotensin subtypes in different organ systems, such as the brain, the reproductive system, adipose tissue, the heart, and the kidneys.

This book briefly addresses each and every area of pharmacology, and is both evidence-based and outcome-focused. Healthcare professionals must have a solid understanding of pharmacology to improve patients'quality of life, prevent medical errors, and avoid potentially harmful drug-drug interactions. Pharmacology should be studied by all medical and paramedical students since it provides a solid foundation for understanding the specifics of drugs and the factors that influence them. The book includes relevant flowcharts, diagrams, and tables that present the subject's contents in more understandable way for undergraduate students.

SARS-CoV-2, the coronavirus responsible for COVID-19, wreaked havoc on the world; it could both spread easily and mutate rapidly, leading to the decrease in the effectiveness of newly developed vaccines over time. The detection of these mutated variants and the development of more efficient vaccines requires significant effort and increased knowledge in this field. This new book, SARS-CoV-2 Variants and Global Population Vulnerability: Diagnostic Strategies, Vaccine Development, and Therapeutic Management, provides detailed and systemic information regarding the biology and immunophysiology of SARS-CoV-2 and highlights the global vulnerability of the world population to SARS-CoV-2 infection and COVID-19.The book covers different aspects pertaining to the SARS-CoV-2 variants and their relation to global vulnerability. Chapters discuss the diagnostics, vaccine development, and therapeutic management starting from the zoonotic origin, organization, and transmission of SARS-CoV-2, lifestyle and immunophysiology of the virus, detection and diagnosis techniques, and analytical techniques. The book also observes the global impact of Delta and Omicron SARS-CoV-2 variants. It looks at the drug repurposing and new drug discovery routines for the emerging variants. It presents strategies for fast-track vaccine development, the roles of nasal vaccines and nucleic acid vaccines for COVID-19 management, monoclonal antibody therapy for the diseases management, along with the use of dietary supplements and nutraceuticals, herbal drugs, and other alternative remedies for COVID-19 management. The book also considers the social and environmental impacts of SARS-CoV-2 variants and the current challenges, outlining aspects that can help in developing more efficacious means for controlling SARS-CoV-2 in the future.Key highlights: Discusses SARS-CoV-2 variants, diagnosis strategies, vaccine development, and the therapeutic management of the disease Provides comprehensive coverage of SARS-CoV-2 virus and variants With its unique and thorough take on the subject, this book is an important resource of know-how for investigators working in this area. Professionals from the pharmaceutical industry as well as students, research scholars, doctors, and other healthcare professionals will find this book of particular value.

Pearson Nurse's Drug Guide 2024 helps clinicians administer drugs safely in any health care setting. Drugs are listed alphabetically by generic name and indexed by both generic and trade name, enabling quick, easy lookup. The guide also gives you clinical information for hundreds of drugs, including adverse reactions, interactions, side effects and impact on lab results. Drug monographs deliver the data you need about each drug to adjust diagnoses and interventions. Combine this with detailed administration guidance and dosage information across the lifespan and you have an all-in-one guide to safe, effective drug administration in nearly any medical setting.

An unrivaled reference tool for advanced practice providers and students in clinical practice settings This concise and easy-to-read drug therapy prescribing reference provides critical information for advanced practice nurses and physician assistants in clinical practice settings who are involved in the primary care management of patients with acute, episodic, and chronic health problems, life-altering and life-threatening diseases, and needs for health promotion and disease prevention. Interspersed with clinically useful information, such as monitored laboratory values, patient teaching points, and safety information, this reference draws upon data taken directly from FDA-approved drug labels and patient medication guides, and is organized by diagnosis rather than by drug classification, to provide advanced practice practitioners with the comprehensive, concise, and up-to-date information on drug therapies that they need to help achieve positive outcomes in their daily practice. The first section of this book presents drug treatment regimens for over 700 clinical diagnoses, listed alphabetically by generic name, followed by important information required for prescription decision-making. The second section provides additional information on treatment, organized in a convenient table format. An alphabetical cross-reference index of drugs allows for easy identification of alternate drug names and their location within the text. New to this Edition: Information on over 100 new diagnoses and over 100 new generic drugs indicated for the treatment of quality of life-altering and life-threatening conditions such as chronic kidney disease, genetic diseases, mesothelioma, MS, metastatic cancers, and rare diseases. Updates on drugs used for site-specific cancers, mental health issues, and commonly diagnosed diseases such as diabetes and asthma. Details on new drug approvals including indications, treatment regimens, adverse reactions, drug-drug interactions, warnings and precautions, and use in special populations Key Features: Provides new drug treatment regimens for drugs that are first in class, novel drugs, orphan drugs, new drugs with breakthrough or fast track designation and drugs with new indications and expanded social populations. Includes drug prescribing information on diseases prevalent outside of North America, including endemic diseases with known transmission and treatment interventions. Serves advanced practice providers across the United States and internationally. Consistent with approvals and recommendations for use by the FDA.

Environmental conditions and processes are one of the major pillars on which the human well-being rests. It is the core responsibility of the society to preserve and enhance better conditions for the human well-being. Indeed, there are several evolving unmet needs in public health. Emerging and re-emerging infectious diseases and a surge in the incidence of non-communicable diseases, including cardiovascular diseases (CAD), chronic respiratory diseases, and metabolic diseases have been impediments to sustainable well-being. Many factors are critical in the global surge in the rate and incidence of cardiovascular diseases. These include the shift from acute to chronic conditions, the shift from single risk factor vs. multiple influences, aging population, global health disparities, exposure to lower harmful influences over a longer period, etc. However, the epigenetic factors due to unhealthy environment play a most significant role in the underlying pathogenesis of cardiovascular diseases. Unfortunately, this has been ignored for a long time and realized lately to expand and disseminate knowledge to general population, expand research activities to investigate the cellular and molecular mechanisms, and develop better preventive and treatment strategies. The most significant environmental impoverishment in the pathogenesis of cardiovascular diseases include different genetical, chemical, physical, and biological influences, but not limited to, socio-economic status and lack of nutrients, nutritional aspects including habits, diets and additives, inhaled and ingested pollutants, exhaust gas and gasoline products, tobacco smoke, water pollution, alcohol consumption, soil and mineral pollution, solvents, pesticides, microplastics, non-critical usage of drugs, climate change, extreme atmospheric conditions, extremes in noise and temperature, electromagnetic influences, microwaves and radiation, outdoor light pollution, mental stressors, lack of or over exercise, microbiota and microbiological agents like SARS CoV-2 virus, etc.

Comprehensive yet succinct insight into the prevention, diagnosis, and treatment of infectious diseases including COVID-19, mpox, Ebola, and Lyme disease Rising Contagious Diseases provides basic information about preventing and treating threatening infectious diseases from viral, bacterial, and parasitic sources, including 28 emerging or recurring diseases like COVID-19, mpox, Ebola, bird and swine flu, malaria, Legionnaires', and others. The text highlights molecular surveillance and epidemiology (including zoonotic pathogens or their variants), innovative strategies for pathogen detection, drug and vaccine development, appropriate preventive measures, cost-effective diagnostic procedures (assays), and effective therapeutic strategies. The text is unique due to its broad coverage of today's infectious diseases, covering several which are not similarly addressed elsewhere, with detailed insight from experts around the world. Composed of 30 chapters of fundamental facts alongside practical and clinical data, Rising Contagious Diseases covers sample topics such as: Re-emergence of certain diseases in recent decades due to dynamic host-pathogen interactions, anthropogenic selection, and climate change How real-time epidemiological surveillance can improve detection of infectious disease outbreaks or new infections of public health importance Up-to-date insight on transmission dynamics, epidemiology, clinical manifestation, advances in diagnostics, and management of covered diseases Effects of disease outbreaks on the world at large, such as through high morbidity and mortality rates and rising healthcare costs With detailed insight on the prevention, diagnosis, and treatment of infectious diseases, Rising Contagious Diseases is an essential reference for health care professionals, academics in the field of microbiology, immunology, infectious diseases, pathology, pharmacology and public health, and undergraduates and postgraduates in related disciplines.

This book provides an overview on recent progress in anion channels and transporters. It covers multiple scales of analysis ranging from studying the molecular basis of function at atomic resolution to cellular consequences to channel/transporter dysfunction and approaches to correct such processes by pharmacological intervention. Similar anion channels and transporters are expressed in multiple tissues – often fulfilling similar cellular tasks, but also clearly distinct functions. The aim is to combine work on multiple cell and organ systems.

Grunnleggende kunnskaper i klinisk farmakologi og legemiddelhåndtering er nødvendige for sikker og effektiv behandling av pasienter. Denne boka gir deg kunnskapsgrunnlaget for å utføre legemiddelrelaterte arbeidsoppgaver, som å gi legemidler, informere pasienter om bruk av legemidler og effekten av dem, observere og overvåke pasienten og handle raskt dersom det oppstår komplikasjoner, og rapportere om og dokumentere virkning og bivirkninger. For best mulig læringsutbytte anbefaler vi at du først leser del 1, som gir en generell, overordnet innføring i farmakologien, og del 2, som viser hvordan legemidler påvirker ulike sykdomsprosesser. Del 3 handler om legemiddelbehandling ved sykdommer i de enkelte organene og organsystemene. Del 4 tar for seg bruk av legemidler hos spesielle pasientgrupper og ved spesielle tilstander. I denne delen omtales også legemidler til gravide og barn, legemidler mot akutte forgiftninger og plantebaserte legemidler. Boken inngår i kunnskapspakken 37 ºC, som består av fem lærebøker i de naturvitenskapelige fagene for sykepleierutdanningen. Selv om de fem bøkene er utviklet som en helhet, er konseptet fleksibelt, og hver enkelt bok kan brukes uavhengig av de andre bøkene i serien.

Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. The updates to the Third Edition include a new section converting “descriptive” data into “predictive” data through comparison to mathematical models, expansion on enzymes, drug metabolites and drug–drug interactions, and two new chapters. The newly developed companion website hosts further educational resources to complement the book. As in previous editions, this new edition includes numerous valuable chapter summaries, detailed references, practical examples, and case studies throughout.Fully updated, including two new chapters on the science of finding drug moleculesIntroduces the discipline to a scientist new to the areaDemonstrates the value of pharmacology in the drug discovery processPresents a wide variety of techniques in simple termsIncludes interactive exercises in the companion website

This volume provides an overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies. Metabolic disorders occur when metabolic processes in the body are disrupted. They contribute a significant burden to human health globally. They can be congenital or acquired, for example, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, osteopenia, mild-moderate hypovitaminosis D, erectile dysfunction, dyslipidemia, and thyroiditis. Metabolic disorders have gained significant importance due to the exponential increase in obesity worldwide. Early diagnosis of metabolic disorders is important in order to employ lifestyle and risk factor modification.Features: An overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies Describes recent trends in diagnosis of metabolic disorders Discusses management and treatment of metabolic diseases Allows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compounds Suitable globally for graduate and postgraduate students studying metabolic diseases

Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches along with certain key topics related to molecular pharmacology of drugs and therapeutics. Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology. It explains the phenomena of drug-target interactions considering different biochemical systems and cellular strategies. With the advent of technologies, current advances and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will be able to gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology, in a comprehensive and systematic manner with special reference to recent advances in drug discovery research. Highlights the fundamentals of biochemical and molecular aspects, with reference to drug discovery researchDepicts modern drug discovery approaches such as reverse pharmacology, drug repositioning, and CADD in the context of current research updatesSummarizes recent developments in the molecular pharmacology of novel drugs/ therapeutic molecules

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapyIncludes the latest international guidelines for nonclinical toxicology in both small and large moleculesIncorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Towards a better understanding of how medicines are used in society Drug Utilization Research (DUR) is a discipline which combines aspects of pharmacotherapy, epidemiology, and health services research into an interdisciplinary set of methods for analyzing and assessing the prescribing, dispensing and consumption of medicines. It combines both qualitative and quantitative approaches to facilitate the safe and effective use of pharmaceuticals. Drug Utilization Research: Methods and Applications provides a comprehensive introduction to this discipline, prepared by an international team of authors with broad experience in numerous fields. Now reorganized and updated to reflect the latest research and global challenges, it is an indispensable resource for understanding the use of pharmaceuticals. Readers of the second edition of Drug Utilization Research will find: New chapters on methods, including more hands-on guidance on how to plan and conduct different types of drug utilizationA section on specific applications in areas such as psychotropics, opioids, cancer drugs, antibacterials, and cardiovascular drugsA new section with case studies illustrating applications of DUR in different continentsDetailed treatment of subjects including DUR and health policy, DUR in specific populations, and many more Drug Utilization Research is ideal for epidemiologists, pharmacists, physicians, nurses and others interested in drug use and its outcomes.

The science of drug safety and pharmacovigilance has rapidly evolved in the 21st century. The knowledge and principles it contains are of increasing importance in clinical and practice settings. The aim of this book is to deal with the gap in knowledge about pharmacovigilance and drug safety, including the application of pharmacovigilance knowledge to individual patient cases in clinical practice. A holistic approach is taken with each chapter written from the perspective of a practitioner, industry personnel, researcher, or regulator, creating a synergy between drug safety, pharmacovigilance, and clinical practice. Chapters offer key material on adverse drug reactions, medication errors, prescribing safety, pharmacovigilance as well as data sources used in drug safety and pharmacovigilance. Each chapter is structured as a self-contained learning resource, with learning objectives, and worked cases. The book is suitable for undergraduate healthcare professions, postgraduate students, researchers, clinical practitioners – including those with prescribing responsibilities. It will also be useful for professionals moving from a clinical practice role to a specialist pharmacovigilance role. For those already in a pharmacovigilance role, the book offers insight into the theory and practice of drug safety and pharmacovigilance in clinical settings.

The book provides a comprehensive exploration of the dynamic field of pharmacology and its fundamental principles. It delves into the intricate interactions between drugs and the human body, focusing on pharmacokinetics, which explains the dynamics of drug actions in the body, and pharmacodynamics, which uncovers the mechanisms through which drugs exert their effects. The book also emphasizes the crucial aspects of therapeutics and gene-based therapy, shedding light on modern approaches to disease treatment. Readers will gain insights into drugs that target the autonomic nervous system, influencing functions beyond voluntary control, and drugs that act on the central nervous system, impacting neurological processes. Additionally, the book examines medications affecting renal and cardiovascular functions, playing a significant role in maintaining homeostasis. Moreover, it explores the realm of drugs influencing gastrointestinal function, essential for digestive health.Furthermore, the book covers pharmacotherapy for microbial diseases, addressing the challenge of infectious agents and their treatment. It also investigates hormones and hormone antagonists, pivotal in regulating various physiological processes. Lastly, it provides a comprehensive understanding of drugs used for immunomodulation, which plays a crucial role in enhancing or suppressing the immune system.The book serves as a resource for students, researchers, and healthcare professionals seeking a deep understanding of drug interactions, therapeutic applications, and cutting-edge approaches in pharmacology.

This book comprehensively covers critically investigated information on medicinal plants prioritized for their anti-allergy properties. It offers insights into strategies related to the distribution, mechanism of action, and assessment of antiallergic medicinal plants, and also delves into crucial aspects of modern biotechnological tools, addressing their implementation challenges, presenting innovative approaches through case studies, and exploring opportunities for nanotechnologies. These elaborated discussions aim to raise awareness and bridge the gap between human health and the biodiversity of antiallergic medicinal plants. As the book navigates the uncertainties of plant-based medicines in the post-COVID-19 era, it provides real-world applications showcasing the specific utility of medicinal plants through advanced biotechnological insights. This book covers several medicinal plants associated with antiallergy, exploring their modes of action, available secondary metabolites,and estimation methods. It also emphasizes all modern biotechnological interventions aimed at propagating, multiplying, and conserving this unique treasure trove of medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. Increasing demand in both developing and developed countries resulted in the expanding trade of medicinal plants and has serious implications for the survival of several plant species, with many under threat of becoming extinct. This book describes various approaches to conserving these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication and cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as allergic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, and other traditional medical practitioners.

Der Arzneiverordnungs-Report ist seit 1985 eine gemeinsame Publikation von Autoren aus Pharmakologie, Klinik, Praxis, Gesundheitsökonomie und Krankenversicherung. Basis sind die Verordnungsdaten von Arzneimitteln für ambulante Patienten der gesetzlichen Krankenversicherung (GKV).

TRP Channels as Therapeutic Targets, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. The Editor lined up a team of worldwide experts in academia and corporate R&D to provide diverse views into these promising drug development targets. Following the research development happened in the past ten years, since the first edition published, the revision includes seven new chapters. All remaining chapters are completely updated. New topics included in the book are TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. TRP Channels as Therapeutic Targets, Second Edition is a reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline, will find in this book their biologic principles of action.Presents the perspectives of several life science research specialties on the topicProvides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practiceRepresents an updated and complete reference

This book provides recent advances in the understanding of the central processes in the resolution of inflammation. It also describes the active, specialized pathways that bring the resolution of inflammation. Further, the book examines the key molecular and cellular events that are involved in the resolution of inflammation processes involved in tissue repair and regain of physiological function. Importantly, it sheds light on the cellular and molecular processes through which conventional inflammatory cytokines control mammalian tissue repair and regeneration. It also explores the perturbation of processes that are involved in the resolution of inflammation with aging and reviews clinical trials of anti-inflammatory and immunomodulatory therapies. Towards the end, the book discusses the role of inflammation in the development and progression of cancer. This book is an invaluable resource for scientists, academicians, and research scholars interested in the latest cutting-edge knowledge in the field of immunology, inflammation, inflammation resolution, and inflammatory diseases. ​

In today's fast-paced and modern world, our lifestyles have undergone a dramatic shift. The conveniences and comforts that accompany our technological advancements have come at a cost – an increased prevalence of lifestyle diseases. Lack of physical activity, stress, sedentary habits, and poor dietary choices have become leading causes of a spurt in varied health complications such as obesity, diabetes, and cardiovascular diseases. Various health awareness programmes organized by central/state governments, private organizations, and NGOs from time to time have generated interest among common people in exploring organic foods that are free from chemicals and full of nutraceuticals. There has been a growing interest in exploring the potential of nutraceuticals to address lifestyle diseases.Recognizing the urgent need to address this global health crisis, this book delves into a realm of science that offers immense potential for improving our health and well-being. Nutraceuticals, which combine'nutrition'with'pharmaceuticals,'offer a promising strategy for treating certain conditions caused by a particular way of life. They include a variety of bioactive substances obtained from plants, including fruits, vegetables, herbs, and marine organisms. Certain substances have therapeutic qualities and have shown significant promise in treating and even preventing certain disorders.Features: The chapters in this book have been meticulously curated to provide readers with a diverse range of perspectives. Provides a comprehensive exploration of nutraceuticals and their potential benefits. Examines the impact of specific nutraceuticals on various lifestyle diseases to discuss their synergistic effects and potential adverse reactions. Each chapter offers valuable insights and practical guidance for healthcare professionals, researchers, and individuals seeking to enhance their overall well-being. A systematic overview of the state-of-the-art in nutraceuticals with recent research results. This book will certainly be a valuable resource for researchers engaged in studies on nutraceuticals to develop a depth of understanding of the latest trends and tools in this field. Additionally, it can serve as a comprehensive textbook for graduate-level courses in food and nutrition, biomedical, and health sciences.

Advancement of Phenolic Acids in Drug Discovery: Fundamental and Applications offers comprehensive coverage of the ADMET profiles of phenolic acids, their extraction method and prospects for drug design and development. Chapters overview phenolic acids and their characterization, discuss the role of phenolic acids in plant systems, present sources and detailed extraction methods of phenolic acids, and cover phenolic acid mechanisms of action as it relates to several key diseases and health conditions, including their role as antioxidant agents, anti-inflammatory and analgesic drugs, anti-microbial drugs, anti-viral drugs, anti-cancer drugs, diabetes and metabolic dysfunctions, neurological disorders, cardiovascular diseases. The book's final chapters cover nanoscience aspects of phenolic acids, biomedical applications, and concludes with challenges and opportunities presented by phenolic acids. This is the ideal reference for researchers in the fields of drug development, both in academia and corporate settings. Researchers of related areas like food science and medicinal chemistry will also benefit from this in-depth profiling of therapeutical properties of phenolic acids.Highlights fundamental concepts with advanced exploration of phenolic acidsProvides in-depth coverage on the design and development of novel drugs from natural phenolic acidsReviews the changing role of phenolic acids

The Chemistry inside Spices & Herbs: Research and Development brings comprehensive information about the chemistry of spices and herbs with a focus on recent research in this field.Experts in phytochemistry have contributed chapters with the aim to give the reader deep knowledge about phytochemical constituents in herbal plants and their benefits. These in-depth reviews cover the biochemistry and biotechnology of spices and herbs, herbal medicines, biologically active compounds and their role in therapeutics among other topics. Chapters which highlight natural drugs and their role in different diseases and special plants of clinical significance are also included.Volume 4 covers these topics: the potential use of Indian spices in managing viral infections, the chemical, functional, and nutritional properties of Coriander, traditional uses, chemical components, and pharmacological properties of Sphaeranthus indicus, Copaiba oleoresins phytochemisty and the pharmacological properties of oils from Copaifera species. Additionally, the pharmacognostic profile of Nardostachys jatamansi is discussed, along with insights into the medicinal herb Bush Onion (Afrostyrax lepidophyllus) and its nutritional and medicinal values. Various aspects of plant essential oils, including their chemistry, extraction methods, and medicinal properties, and plant proteases are also covered in detail.This book is an ideal resource for scholars (in life sciences, phytomedicine and natural product chemistry) and general readers who want to understand the importance of herbs, spices and traditional medicine in pharmaceutical R & D and clinical research.

Reference pocketbook containing common medications prescribed to patients to facilitate identification and revealing potential interactions, overdose symptoms, and common call outs Easy to navigate and truly pocket-sized, the Paramedic Pocketbook of Prescription Medications covers common medications and their possible presentations, highlights risk of causing harm, and goes over mechanism of action, use, and potential risks for each. Key features: Concise presentation of a wide range of medications, accessible even to those with a limited pharmacological background Brief overview of drug legislation and paramedic practice Includes special circumstances in paediatrics, the elderly, and individuals experiencing kidney injury and disease, hepatic failure, pregnancy and breastfeeding, and palliative care Highlights which conditions or medications have different prevalence or effects in different ethnic groups Paramedic Pocketbook of Prescription Medications is an essential guide for emergency services personnel and first responders to carry with them for easy reference and peace of mind.

The World Stroke Organization reports that “stroke has already reached epidemic proportions. Globally1 in 4 adults over the age of 25 will have a stroke in their lifetime. 12.2 million people worldwide will have their first stroke this year, and 6.5 million will die as a result.” Ischemic strokes are the most common type of stroke, with about 87% of all strokes being ischemic strokes.This new volume addresses this epidemic by presenting detailed studies on ischemic injury, with emphasis on the molecular-level mechanisms and the role of signaling pathways in the body, their structure, and their mechanism of action. The book focuses on molecular pharmacology plans and explains the new areas of research on the discovery of therapeutic molecules that can be used for combating this life-threatening disease. The authors discuss stroke occurrence at different stages of life as well as sex-based differences in its treatment. They cover aspects of the clinical treatment and diagnosis of patients with cardiovascular events, including in-depth information on the prevention, evaluation, therapy selection, result projection, and long-term course of the disease in affected patients. They also detail the involvement of platelets, neurotransmitters, renin-angiotensin-aldosterone system, and vitamin D in ischemic injury.

This book offers a comprehensive and authoritative review of bioactive substances found in plant underground stems, roots, rhizomes, corms, and tubers from all around the world. Tubers and starchy roots are plants that store edible starch content in underground stems, roots, rhizomes, corms, and tubers. They are a key source for both human and animal consumption and are rich in carbohydrates. They are widely used as industrial crops as well. Phytochemicals found in tubers and roots, such as phenolics, terpenoids, and alkaloids, have anti-inflammatory, anti-cancer, hypoglycemic, hypocholesterolemic, and antibacterial properties. Except for common potatoes, sweet potatoes, and cassava, the nutritional and health benefits of many tuberous crops have not yet been adequately investigated. This book sheds new insights into these topics by addressing several plant metabolites found in storage organs, which can be seen as scientifically neglected even though they have a high economic relevance as food and pharmaceutical sources. Divided into 6 parts, this book discusses how bioactive chemicals found in plant storage organs are synthesized and how their bioactive principles are specifically expressed in underground stems, roots, rhizomes, corms, and tubers. Additionally, each chapter includes background information on the plant, its parts, its nutritional makeup, chemical components, and biological functions. Given its breadth, the book appeals to a wide readership, from scholars through graduate and post-graduate students to professionals in the industry.

This book provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.

This book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology.

The book delves into the intricate interplay of stress and adaptive responses, and their multifaceted dynamics influenced by stress type, exposure duration, genetic factors, and lifestyle elements. It unveils the complexity of stress management, unveiling how adaptive strategies evolve in response to stressors. By harnessing scientific breakthroughs in stress response comprehension, the book navigates the path to effective stress mitigation. Through avenues such as pharmacological interventions, dietary adjustments, psychological enhancement, and more, the book advocates for achieving adaptive resilience—a state where the system effectively copes with stress. The text encapsulates an array of stressors, including extreme stress, oxidative stress, and genotoxic stress, dissecting their impact on systemic equilibrium and health. The book's focal point rests on adaptive mechanisms that vary with stressor types, while also spotlighting how these mechanisms can be calibrated through pharmacological and alternative means. This is an invaluable resource for understanding, mitigating, and harnessing the power of adaptation in the face of stress-induced challenges.

Hayes'Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I.'Principles of Toxicology'), major classes of established chemical hazards (Section II.'Agents'), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III.'Methods'), as well as toxicology of specific target systems and organs (Section IV.'Organ- and System-Specific Toxicology'). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

In the past years, COVID-19 caused millions of deaths and severely damaged not only public health, but also the global economy. New variants continue to threaten human health. Thus, natural compounds for retarding infection are in high demand. This book summarizes the emerging research with flavonoids, whose application holds great promise of antivirus, anti-inflammation, antioxidative stress, and immunomodulatory. Topics include the role of flavonoids in preventing an inflammatory storm and how flavonoids interact with critical protein targets that are involved in the infection stages of COVID-19.Key Features• Highlights anti-SARS-CoV-2 drug discovery on natural products and medicinal plants• Includes all major subclasses of flavonoids that promisingly combat COVID-19 • Proposes molecular mechanisms of flavonoids against protein targets of SARS-CoV-2• Contributions from an international team of leading researchers• Provides recommendations with respect to the future research

This dictionary of toxicology provides curated and authentic information on the terminologies used with their description as per modern toxicology and associated declines. It aims to have a collection of over 3500 terminologies with their basic information and roles with relevance in toxicology and associated disciplines in alphabetical order. This book has a flow of information in alphabetical order starting from word A to Z. The contents cover all the possible facets of contemporary. It is an unparalleled reservoir of information with a practical understanding of the subject for undergraduates, post-graduate, doctorate and post-doctorate, researchers of toxicology, medical and dental sciences, veterinary sciences, pharmacy sciences, life sciences, forensic sciences, etc. Besides this, target readers would also be personnel working in academia, pharma industries, contract research organizations involved in regulatory studies, regulatory agencies and implementing agencies, and people having an interest in toxicological sciences.

In the intricate tapestry of nature, the potential of kitchen spice seeds remains largely untapped, despite their rich history as sources of natural compounds with diverse benefits. The scientific community faces a challenge in fully comprehending and harnessing the phytochemical, ethnobotanical, and pharmacological dimensions of these seeds, which hold promise in medicine but play pivotal roles in cultural, historical, and culinary spheres. Researchers, scientists, and enthusiasts find themselves surrounded by a fragmented landscape of knowledge, with limited resources to uncover the hidden potential of kitchen spice seeds. The lack of a cohesive repository that integrates scientific insights with cultural, historical, and culinary perspectives hinders the exploration and understanding of these natural wonders. This fragmented approach impedes progress in unlocking the multifaceted benefits and applications embedded within these seeds. Therapeutic and Pharmacological Applications of Ethnobotany is an all-encompassing compendium meticulously crafted to bridge these knowledge gaps. By presenting a synthesis of phytochemical analysis, ethnobotanical insights, pharmacological studies, botanical descriptions, industrial and culinary applications, biogenic synthesis, and innovative uses, this book provides a holistic exploration of kitchen spice seeds. Tailored for researchers, scientists, botanists, pharmacologists, ethnobotanists, and culinary experts, it serves as a beacon guiding readers through the scientific intricacies and cultural significances of these seeds, unlocking a wealth of knowledge that transcends disciplinary boundaries.

This reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.​

Eco-toxicology, an offshoot of toxicology, is a multidisciplinary science that integrates toxicology and ecology by drawing knowledge and procedures from both fields. It analyses the effects of toxic chemicals or biological agents on living organisms at different levels of organization. Eco-toxicology classifies different contaminants, their characteristics, release and ecological fate, and predicts their effects so that timely action can be taken to prevent or minimize any detrimental effects. Environmental Toxicology starts with the basics of toxicology, briefly touching on the sources of toxic compounds, classification of toxicants, and factors affecting toxicity, and then elaborates on heavy metal toxicity. The individual chapters on various heavy metals and radioactive metals discuss the sources and routes of exposure, aetiology, pathophysiology, clinical manifestations, and mechanisms of toxicity, toxicological effects, diagnosis, treatment, management, and ecological impact. The book covers the field in its greatest width and provides an insight into pesticide and radiation toxicity, and recent advances in eco-toxicology, with special focus on the removal of HMs and the latest bioremediation techniques. This book serves as a reference work for advanced students pursuing degrees in environmental toxicology and across various disciplines, such as biomedical and environmental sciences, toxicology, eco-toxicology, pharmacology, public health, etc. and all interested in learning the concepts of eco-toxicology. Features: A systematic overview of the key concepts of eco-toxicology, its relationship with other disciplines, and recent advances in the area Detailed classification of toxicants, types of toxicity, and mechanism of the action of toxicants An in-depth coverage of topics on the mechanism toxicity of HMs, in addition to exclusive sections on pesticide and radiation toxicity A fact file in each chapter, highlighting its key points Flow charts, tables, diagrams, and illustrations in easily understandable language

Progress and Prospect of Nanocarriers: Design, Concept, and Recent Advances examines the different nanocarriers that are currently being developed for specific applications in biomedical drug delivery, disease management, diagnosis and therapy. Nanosized drug delivery systems have gained tremendous amounts of clinical interest due to their effective bio-distribution and enhanced pharmacokinetic and selective targeting capability which results in high therapeutic potential, low side effects, and the generation of cost-effective drug delivery systems. Numerous effective nanocarriers have been evolving, including polymeric nanoparticles, liposomes, microspheres, dendrimers, and carbon nanotubes.This book is a helpful reference for scientists and students in the fields of drug delivery, biomaterials and nanomedicine, as well as scientists and engineers in industrial disciplines of drug delivery and drug formulation.Focuses on multiple nanocarrier platformsExamines the different technologies that have improved drug delivery and suggests where the technology is headedWritten for researchers and students by diverse experts in biomaterials, drug delivery and nanomedicine

Adrenoceptors have been at the forefront of physiological and pharmacological research for a century. They served as prototypes for rationale drug design as recognized by a Nobel Prize to Sir James Black and for the molecular understanding and structure of G protein-coupled receptors as recognized by a Nobel Prize to Brian Kobilka and Robert J. Lefkowitz. Drugs directly or indirectly targeting adrenoceptors have become guideline-recommended treatments for more than 30 human and various animal diseases. This volume assembles leading experts on various types of adrenoceptor research to provide concise insight into the current standing and future direction of uses of adrenoceptor-targeted drugs and research in this field.

This textbook is built around patient presentation, advancing from symptoms through diagnosis to treatment as anticipated in clinical practice. As a result, this textbook provides concise, focused information on pharmacological treatments and mechanisms of action related to specific symptoms and patient presentation. Each chapter is followed by relevant cases and questions with answers and detailed explanations. The book will be of use to medical, pharmacy, pharmacology and physiology students, practicing physicians and pharmacists, and pre-medical students preparing for a Medical College Admission Test (MCAT) in the United States and similar tests offered in other countries. The readers are given a guided presentation of how practicing physicians think when facing symptoms and determining treatments.

Natural Products and their Bioactives in Antidiabetic Drug Discovery Enables researchers to effectively understand and use bioactive compounds to target, prevent, and manage diabetes Natural Products and Their Bioactives in Antidiabetic Drug Discovery provides readers with an overview of recent research in new drug discovery against diabetic complications based on bioactives from NPs, bridging the gap between the public research institutes and private companies working to find drugs to treat diabetes. To aid in reader comprehension, the text includes case studies and illustrated examples in relevant chapters. Part one presents chapters on fundamental concepts of diabetes mellitus (DM) and recent drug discovery progress along with the various druggable targets and challenges. Part two covers bioactive compounds targeting Type-1 Diabetes. Part three focuses on Type-2 Diabetes. In Part four, the contributors address gestational DM prevention and management with natural compounds. Written by a global team of experts in the field, Natural Products and their Bioactives in Antidiabetic Drug Discovery covers sample topics such as: Obesity risk factor in patients with T1DM and possible role of nutritional therapy in its management Use of natural non-insulin drugs as a novel approach to enhance therapeutic outcomes against T1DM Effectiveness of functional foods in intervening the diabetic complications and realistic results in clinical trials Implementation of nanotechnology in improving the bioavailability and reducing the threshold dose of bioactive compounds Various antidiabetic mechanisms of action of different polyphenols and immunomodulatory role of NPs bioactives relevance in T1DM therapy Effects of natural products on genetics of gestational diabetes With comprehensive coverage of recent research in new drug discovery against diabetic complications based on bioactives from NPs, Natural Products and Their Bioactives in Antidiabetic Drug Discovery is an essential resource for researchers and professionals involved in drug discovery and development, health care, medicinal chemistry, phytochemistry, plant science, and toxicology.

Taurine, or 2-aminoethanesulfonic acid, is one of the most abundant sulfur-containing amino acids in the human body. It is found in the heart, brain, retina, and skeletal muscles, and is synthesized in the pancreas. Studies have revealed that taurine is of high physiological importance: it protects against pathologies associated with mitochondrial diseases, and linked processes like aging, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders. It is also used as a nutritional supplement. Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as a pharmacological agent for treating different diseases. Readers will gain an insight into the crucial role it plays in human physiology and the benefits of taurine supplements.Topics covered in this reference include- Synthesis of taurine and its dietary sources- The Role of taurine in mitochondrial health- Taurine as a neurotransmitter- Beneficial effects of taurine in physiological systems such as the reproductive system, renal system, and the gastrointestinal tract- Hepatoprotective and anti-inflammatory properties of taurine- The anti-aging promise of taurine supplementation- Role of taurine supplementation in obesity

Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The editors lined up a group of worldwide experts to contribute to the book. Following a consistent chapter structure, the authors cover the foundational aspects of pharmacogenomics in the first four chapters of the book that include basic concepts, drug metabolism, drug discovery and development, and testing. The second part of the book is dedicated to detailed studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. Pharmacogenomics: From Discovery to Clinical Implementation is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. Researchers and graduate students in the related fields of Genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit of the structured approach of the book.Provides an in-depth review of pharmacogenomics and its role in drug discovery/metabolism and its clinical impactsDescribes the practice of pharmacogenomics in the treatment of diabetes, cancers, cardiovascular diseases, psychiatric disorders, pulmonary diseases, infectious, gastroenterology, and autoimmune diseasesUses a consistent chapter structure to support understanding of the fundamental concepts in the area

Frontiers in Clinical Drug Research Diabetes and Obesity is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of two metabolic diseases diabetes and obesity. The scope of the series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs affecting endocrine and metabolic processes linked with diabetes and obesity. Reviews in this series also include research on specific receptor targets and pre-clinical / clinical findings on novel pharmaceutical agents. Frontiers in Clinical Drug Research Diabetes and Obesity is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of diabetes and obesity research.The seventh volume of this series features 6 reviews on diabetes related topics for both medical specialists and pharmacologists.- Clinical and diagnostic implications of glycated albumin in diabetes mellitus.- Development of novel therapeutic groups and bioactive compounds from herbs for diabetes management- Aspartame as a sugar substitute- Mental health, adherence, and self-management among children with diabetes- Cardioprotective effects of new generation anti-diabetic and lipid-lowering agents- Epidemiology, pathophysiology, and treatment of diabesity

••Selected for Doody's Core Titles® 2024 in Ophthalmology••Nanotechnology in Ophthalmology is a comprehensive and up-to-date reference on the role and applications of nanotechnology in ophthalmology, from drug delivery and treatment of ocular diseases to toxicity issues. Written by experts from the nanotechnology, ophthalmology, and pharmacology fields, this book has a unique, broad and diverse scope, including chapters on nanosensor-based diagnostic tools, delivery of nanobiomaterials, implantable materials and devices, delivery of nanobiomaterials, nanotechnology for medical and surgical treatment, regenerative medicine, and more. This book provides a valuable reference to researchers working in the areas of ophthalmology, nanoscience and pharmacology, and clinical fellows who are interested in nanoophthalmology as a reference for their practice and research.Provides a comprehensive review of the literature in the area of nanoophthalmologyDiscusses regenerative medicine, drug delivery, imaging, and medical device applicationsAnalyzes treatment strategies for emerging and multidrug-resistant ocular pathogens

This completely updated and expanded 2nd Edition provides all the information needed in order to understand the complex molecular, cellular and genetic mechanisms that underlie normal and abnormal cardiac rhythms. Its goal is to help physiologists and clinicians alike develop better preventive and treatment strategies. The respective chapters cover a broad range of topics, including the role of specific ion channels and transporters, gap junctions, intracellular Ca2+ handling in pacemaker activity, impulse conduction, and the activity of atrial and ventricular myocardium. Special emphasis is placed on the unique electrophysiology of specialized pacemaking cells and conducting fibers. In turn, several types of inherited and acquired ventricular arrhythmias are presented in detail. Clinicians will especially appreciate the updated information on even common disorders like atrial fibrillation and their impacts on human physiology. In closing, the book goes “one step further” and considers future prospects, e.g. novel antiarrhythmic agents and new concepts like optogenetics, in the context of heart rate regulation. Accordingly, it offers readers a solid reference guide to everything they need to know about human heart rate and rhythm.

Placebo Effects Through the Lens of Translational Research is an Open Access book integrating current knowledge on placebo research in healthcare to develop comprehensive and adequate strategies for better symptom management and treatment responses. This edited collection features the work of experts in placebo studies, including women, people of color, and international scholars, helping to diversify the existing scholarship in the field. It presents the latest research findings while also considers theoretical aspects of placebo. Together, the chapters in this volume help bridge the gulf between research and ideas in placebo studies and their day-to-day application in clinical practice in order to improve healthcare and health outcomes. Responses to placebos can be as significant as the observed results of active treatments in Phase II/III randomized clinical trials. These results have led to a stagnant era in new drug development since the effect of these potential therapeutics have similar, measured effects as the placebos used in the same trials. This book sheds light on translational aspects related to placebo and drug treatment methods. It also evaluates the clinical implications of a much-needed integration of pharmacological and nonpharmacological treatments in healthcare. Placebo Effects Through the Lens of Translational Research concludes with a discussion of the most innovative developments in placebo research, which will be of interest to a wide readership, including clinicians, senior scientists, trainees, and patients. In a single volume, Placebo Effects Through the Lens of Translational Research provides readers with an overview of current perspectives on placebo research and translational applications.