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Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The most up-to-date, comprehensive, and authoritative pharmacology text in health medicine—enhanced by a new full-color illustrations A Doody's Core Title for 2019! Organized to reflect the syllabi in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology, Fourteenth Edition covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors'many years'experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. To be as clinically relevant as possible, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects, and case studies that introduce clinical problems in many chapters. Presented in full color and enhanced by more than three hundred illustrations (many new to this edition), Basic & Clinical Pharmacology features numerous summary tables and diagrams that encapsulate important information. • Student-acclaimed summary tables conclude each chapter • Everything students need to know about the science of pharmacology and its application to clinical practice • Strong emphasis on drug groups and prototypes • NEW! 100 new drug tables • Includes 330 full-color illustrations, case studies, and chapter-ending summary tables • Organized to reflect the syllabi of pharmacology courses • Descriptions of important new drugs

Gain a full understanding of the basic science andclinical use of drugs with the most up-to-date andcomprehensive pharmacology text in the health sciences A Doody's Core Title for 2017! 400 ILLUSTRATIONS--MANY IN FULL COLOR Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors'many years of experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students. Coverage that spans every aspect of medical pharmacology: Encompasses every aspect of medical pharmacology including botanicals and over-the-counter drugs New chapter on pharmacogenomics with important examples Emphasis is placed on discussion of druggroups and prototypes Clinically relevant, the book includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects Full-color presentation with more than 400 illustrations Case studies introduce clinical problems in most chapters Summary tables and diagrams encapsulate important information Includes many new drugs A Generic Name/Trade Name Table appears at the end of most chapters for easy reference when writing a chart order or prescription

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in R

With contributions by numerous experts

Proceedings of the European Neuroscience Association Satellite Symposium held in Fillerval, France, August 27-31, 1989

This volume is dedicated to Professor Ullrich Trendelenburg. It contains the proceedings of a symposium which was held in his honour on the occasion of his retirement and took place March 22-24, 1991 in Wiirzburg. Ullrich Trendelenburg was the head of the Department of Pharmacology at Wiirzburg University from 1968 till the end of March 1991. He is famous internationally for his contributions to the physiology and pharmacology of the autonomic nervous system, and his impact on pharmacology in general throughout the world has been outstanding. The various phases of his life and his career have been delineated recently by Youdim and Riederer (Journal of Neural Transmission; Suppl. 32, 1990). The articles included in this volume reflect a considerable range of current research work dealing with various aspects of neuropharmacology, i. e., the field of research Ullrich Trendelenburg has influenced most. One or more authors of each chapter are either former or present students and coworkers or close friends of Ullrich Trendelenburg. The first section is devoted to the synthesis and metabolism of catecholamines as well as to the mechanisms by which amine transmitters are removed from the extracellular fluid; three chapters deal with the two types of extraneuronal uptake of catecholamines. The second section concentrates on the release of catecholamines in the peripheral and the central nervous system, the regulation of transmitter release and the noradrenaline-ATP co-transmis­ sion. The third section deals with the pharmacology of various receptors, including agrenoceptors, adenosine, 5-HT and glutamate receptors.

Intoxication of humans and animals has become increasingly important in recent years as has contamination of the environment by a variety of chemicals. In order to develop effective means by which such intoxication and contamination can be properly handled, it is imperative to know how these environmental agents act in humans and animals. Despite studies conducted by various investigators, the mechanisms of action of these environmental agents have not been fully elucidated. Insecticides are by no means an exception in terms of the seriousness of the problem and of the urgency of the need for such information. In order to complete a picture of the effects of any particular insecticide, it is of utmost importance that its actions at various levels ranging from those of molecules to whole animals be analyzed and synthesized. To understand the toxicological action on animals or humans, it is not sufficient to know the action at each level only. The actions at various levels must be integrated to construct a picture of the toxic effect on the intact organism. However, in spite of the large body of information that has been accumulated during the past few decades, little or no attempt has been made to integrate experimental data obtained at the molecular, cellular, organ, and animal levels together in order to define the whole picture of insecticidal action.

The purpose of this dictionary is to provide a convenient and affordable personal desk reference resource. The authors, who have many years experience in pharmacological research, teaching and editing, recognized a need for a single up-to-date volume encompassing material that hitherto could be gathered only from a well-stocked library. This book comprises two main sections: an A-Z listing of drugs and their properties; and a descriptive glossary of technical terms. The level and scope of this reference material will make it essential for pharmacologists and medicinal chemists, from the graduate student to established worker. It should also be valuable to workers in allied biomedical diSCiplines, such as biochemistry and physiology, medical students and science writers and editors. Scope The dictionary is centred on pharmacologically active agents. Workers in drug-related diSCiplines need to correctly identify individual agents from an arsenal of pharmacologically active compounds, each with a number of alternative drug names according to the country or naming convention.

Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.

NEUROTOX'91 was the fourth meeting in a series which started in 1979. The'91 meeting, like its predecessors, was held under the patronage of the Society of Chemical Industry, and despite the unfortunate proximity of hostilities in the Arabian Gulf attracted a truly international mix of industrial and academic pesticide scientists. This volume contains the text of invited papers read at the meeting and presents the dramatic developments which so excited those who attended. The potential of molecular neurobiology for gaining knowledge of target sites for neurotoxicants is now starting to be realised. These studies, in conjunction with developments in molecular imaging and modelling, provide new oppor­ tunities for chemists and biologists to gain insights into molecular interactions underlying intoxication. Molecular techniques have also enabled rapid ad­ vances on a second front, where the cloning of genes controlling pesticide resistance should have a profound impact on our understanding of this commercially important problem. The understanding of molecular events will undoubtedly be vital in future developments in chemical control of pests; however, the value of understand­ ing the way in which the nervous system controls behaviour and how behaviour can be modified by chemicals of bath synthetic and natural origins was highlighted. Natural products and their synthetic analogues have continued to provide new and interesting molecules which are already proving their worth as tools for the neuroscientist and may offer leads for commercial synthesis.

Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere withcardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as ‘villains', several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.

While some of the most commonly investigated- and most notorious- chemicals in the world are alkaloids, many modern medicines are also based on alkaloid structures. Chemists continue to explore new synthetic routes and alkaloid derivatives in search of drug candidates for fighting disease. Drawn from the venerable Dictionary of Natural Products, th

Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms.

'A Lange medical book.'

Glutamate receptors are critically important for normal brain function. The preceding decade has seen remarkable advances in our understanding of the physiological function and molecular structure of these proteins. The Glutamate Receptors provides an expansive review of the field with a topical update to two excellent books - The Ionotropic Glutamate Receptors and The Metabotropic Glutamate Receptors. An exciting primer to the study of glutamate receptors and their central role in neurotransmission, The Glutamate Receptors covers the extraordinary research and significant developments in the decade since the previous books were published and gives a snapshot of how prominent scientists look to the future of research in the field. Both insightful and comprehensive, The Glutamate Receptors provides an invaluable reference to students and scientists on nearly every aspect of glutamate receptor structure and function.

When introduced to the human body, bioactive metabolites produced by plants for self defense bind to particular biochemical targets, most notably to proteins involved in signaling by hormones and neurotransmitters. This, essentially, is the basis for the effects of herbal medicine. While herbal medicine preparations may act by complex synergistic i

This thoroughly indexed book summarizes a wealth of information on the biochemical targets of plant defensive compounds, and is an an invaluable reference for all biomedical professionals.

The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover,

Venoms of the Hymenoptera: Biochemical, Pharmacological, and Behavioral Aspects contains papers that deals with the study of the venoms and toxins produced by insects belonging to the order of the Hymenoptera. The book provides a considerable amount of information in the study of the venoms of the Hymenoptera. There are chapters that focus on the history of the research made on the order of the Hymenoptera; the stinging apparatus; venom collection; physiological effects of venoms produced by particular insects belonging to the order; and the pharmacological uses of the venoms and toxins. Entomologists, physiologists, pharmacologists, biochemists, and researchers developing drugs and pesticides will find this text extremely useful.

Internationally acclaimed for more than 40 years, this serial, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine origins, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids, Chemistry and Pharmacology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.

Annual Reports in Medicinal Chemistry

Neuroscience's inherent complexity and rapid growth mean that no one can keep abreast of all the changes across the field. We each bring a necessarily narrow perspective. Neurotherapeutics: Emerg­ ing Strategies is an attempt to provide some diverse perspectives within the hunt for new drugs to treat central nervous system diseases. The book's premise is that the search for new drugs is based on an understanding ofboth clinical and basic sciences. Neurotherapeu­ tics: Emerging Strategies begins with psychiatry and concludes with neurological disorders. Each chapter examines a disease, including clinical features and existing treatments, but the emphasis is on current concepts of underlying causes and novel strategies for drug discovery arising from these possible mechanisms. Participating authors include basic neuroscientists, industry-based pharmacolo­ gists and chemists, and clinicians. The chapters describe the status of the existing disease treat­ ments, and when treatments are lacking, the approach is more basic science oriented. When there is a long history of treatment, there is greater emphasis on those therapies. However, all the chapters seem to reflect the benefits of cloning, since the availability of receptor subtypes now promises the opportunity for greater specificity of drug effects. Modulation of second messengers is another new and recur­ ring theme. And in the chapter on cachexia, cytokines are explored both as drugs and drug targets. Neurotherapeutics: Emerging Strategies reflects the complex­ ity of the nervous system, but the overriding message is hope for new and better drugs to treat those diseases that rob us of ourselves.