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This book presents extensive and up-to-date information on the anti-proliferative properties of various plant seeds for their application in pharmaceutical industry and medicinal research. This information is imperative for understanding and developing high quality products from the seeds.The book provides insights about anticancer and antitumour activities present in seeds. Different chapters cover the traditional knowledge as well as recent innovations in various seeds, such as prune, pumpkin, grape fruit, sesame, sunflower, bitter gourd, papaya, mango, apple, black plum, cumin, water melon, musk melon, cotton, carambola, pear, cardamon, moringa, wallich, Chinese cabbage, pistachio, etc. and their bioactivities for the applications in cancer and malignancy proliferation. The book introduces the readers to seed as a bioactive compound, and delineates the various health effects. It further explains the relation between the different metabolites and their effect on cell proliferation. Finally the book goes on to explain different seeds and their specific anti-cancer properties. This book is useful for students and researchers of pharmacology, botany and cancer research. It also caters to industry experts in pharmaceutical sciences.

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design.Part 1 of the book set covers these topics:- Heterocyclic anticancer compounds derived from natural sources with their mechanism of action- The role of terpenoids as anticancer compounds: an insight into prevention and treatment- Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents- Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents- Tetrazoles: structure and activity relationship as anticancer agents- Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)

Bentham Briefs in Biomedicine and Pharmacotherapy brings new trends and techniques in pharmacology and medical biochemistry to the forefront through unique volumes. Each volume provides a brief review of selected topics, written by scientific experts. The book series is essential reading for graduate students and researchers in pharmacology and life sciences as well as medical professionals seeking knowledge for research oriented projects.The first volume, Oxidative Stress and Natural Antioxidants, is a compilation of articles about free radicals (which are extremely reactive, short-lived molecules with unpaired electron valency), and antioxidants (which are stabilizing agents of free radicals in the body). The volume presents 17 chapters on the biochemistry of free radicals and antioxidants, with contributions from over 60 scientists. Readers will understand the basic and clinical aspects of free radical biomedicine, the role of antioxidants in neutralizing free radicals through physiological homeostasis, as well as the range of natural compounds which can be used to combat oxidative stress. The chapters also cover special topics such as recent advances in preparation methods of antioxidants, and industrial applications of antioxidants. The range of topics in this volume provide a consolidated reference for a broad set of readers on the subject.

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal is to present a comprehensive collection on most of the therapeutic aspects of plant-derived natural products and molecular mechanisms thereof.

The go-to text/reference for class, clinical, and practice! A who's who of experts and educators brings you practical, in-depth coverage of the most common adult conditions and the corresponding evidence-based occupational therapy interventions. Written for OTAs to meet their unique needs, this approach combines theory with the practical, evidence-based functional content that develops the critical-thinking and clinical-reasoning skills that are the foundation for professional, knowledgeable, creative, and competent practice.

Iatrogenesis is the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one's expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors. This is a huge public health issue: tens to hundreds of thousands of deaths are attributed to iatrogenic causes each year in the U.S., and vulnerable populations such as the elderly and minorities are particularly susceptible. Edited by two renowned cardiology experts, Iatrogenicity: Causes and Consequences of Iatrogenesis in Cardiovascular Medicine addresses both the iatrogenicity that arises with cardiovascular interventions, as well as non-cardiovascular interventions that result in adverse consequences on the cardiovascular system. The book aims to achieve three things: to summarize the available information on this topic in a single high-yield volume; to highlight the human and financial cost of iatrogenesis; and to describe and propose potential interventions to ameliorate the effects of iatrogenesis. This accessible book is a practical reference for any practicing physician who sees patients with cardiovascular issues..

Global health and the increasing incidence of various diseases are a cause for concern, and doctors and scientists reason that the diet, food habits and lifestyle are contributing factors. Processed food has reduced the nutritional value of our diet, and although supplementing foods with various additives is considered an alternative, the long-term impact of this is not known. Many laboratories around the world are working to identify various nutritional components in our daily food and their effect on human health. These have been classified as Nutraceuticals or functional food, and they may have preventive and therapeutic effects in a number of pathologies associated with modern dietary habits and lifestyles. This book addresses various aspects of this issue, revitalizing the discussion and consolidating the latest research on nutritional and functional food and their effects in in-vitro, in-vivo and human clinical studies.

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development• Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.

Be prepared for the latest NBCOT exam! Rely on the guide that has helped thousands of students pass their exams with exactly the practice they need. The 4th Edition mirrors the latest NBCOT exam blueprint and the question formats—multiple-choice and simulation at the difficulty level and in the decision-making style of the actual exam. More than 1,000 questions in five practice exams help you identify your strengths and weaknesses while you improve your test-taking performance.

Examples of plant-derived pharmaceuticals that have become the focus of continuous and exponential research and development interest have, to date, been somewhat scarce. After a long period, the last two decades have been characterized by a 100-fold increase in the number of scientific articles published annually that are of relevance to the use of curcumin in biomedicine. Today, the already-wide spectrum of potential clinical applications of this natural drug and its synthetic derivatives continues to grow, including chemoprevention and the treatment of cancers, inflammatory and immune diseases, diabetes, bacterial and viral infections, parasitosis, and cardiovascular and neurodegenerative diseases. Over the last two decades, numerous findings have confirmed the safety of curcumin, both in preclinical and clinical studies. Its physicochemical properties, low bioavailability and rapid metabolism have, however, somewhat limited its potential therapeutic applications. To overcome these limitations, the last few years have seen an impressive development of research on analogs, prodrugs and nanostructured systems, a number of which are already demonstrating improved properties compared with the parent structure. In parallel, new administration routes have been explored, and additional pharmacological properties have been documented, leading in particular to promising prospects for pain management. This is the first book devoted to all of these aspects of research. It comprises 20 chapters (by 71 contributors) with 32 tables, 100 figures and about 2000 references, organized into three sections, with a progression from basic sciences to clinical applications. The first section relates to photophysical and photochemical properties, structure-activity relationships, the design of curcumin derivatives, its biological targets and pharmacology, prodrug concepts, and the development of nanoformulations of curcumin. The second section covers the exploration of the antinociceptive role of curcumin and its clinical applications for pain management, treatment of neurological diseases and burn wounds, its anti-inflammatory and immunomodulatory properties, and its pharmacological effects for the treatment of parasitosis. The third section describes various aspects of the antitumor activities of curcumin and emerging therapeutic strategies using this drug and its many derivatives. The various chapters of this book have been written by experts from five continents, representing 15 countries and 33 teams, who have agreed to present their viewpoints and experience in this field. It provides a systematic reference source for scientists, clinical researchers and students who wish to become familiar with the different areas of investigation in the subject.

Massage and Remedial Exercises: In Medical and Surgical Conditions describes the principles of certain forms of massage and remedial exercises for specific medical and surgical condition. This book is composed of 23 chapters. Considerable chapters are devoted to treatment of fractures, along with suggestions of approximate dates on which to begin the movements. Other chapters cover the treatment options for central nervous system, motor and sensory neurons, and muscle diseases. Different forms of deformities and constitutional, heart, blood, respiratory organ, abdominal, and pelvic diseases are considered in the last chapters. This book is directed primarily toward medical gymnasts.

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. - Timely and critical reviews of important topics in medicinal chemistry

A natural product is a chemical compound or substance produced by a living organism - found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. A natural product can be considered as such even if it can be prepared by total synthesis. In this book, the authors present current research in the study of the structure, bioactivity and applications of natural products. Topics discussed include the in-vitro assessment of chromones and alkaloids from Caribbean plants as potential anti-tuberculars and chemopreventors; natural products as inhibitors of ubiquitin and ubiquitin-like protein-proteasome pathways; the biological activities of red propolis; nanoencapsulation of natural products; and natural products as a source of potential drugs for the treatment of fungal infections.

The most effective and comprehensive pharmacy review for the NAPLEX® The ultimate pharmacy review covering every topic tested on the exam 1,500+ NAPLEX-style Q&As deliver unmatched preparation for the exam Build confidence and test-taking skills with more than 1500 NAPLEX®-style questions and tried-and-proven tips for boosting exam performance Learn from detailed explanations why answers are correct or incorrect Improve in every essential competency: pharmacology, pharmaceutical calculations, pharmacy, pharmaceutical compounding, biopharmaceutics and pharmacokinetics, health care equipment and supplies, and pharmaceutical care Recognize all frequently dispensed drugs, including the 200 generic drugs most likely to be dispensed by pharmacists EVERYTHING YOU NEED TO EXCEL ON THE NAPLEX® Questions that cover every topic found on the exam An entire chapter devoted to patient profiles, with each profile accompanied by a series of questions An informative description of the computer-based examination Two valuable appendices: frequently dispensed drugs and trade names versus generic names

Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.

Toxicology: Mechanisms and Analytical Methods, Volume II provides an account of the general methods of chemical analysis available to the toxicologist, discussion of the principles on which they are based, and a survey of the material to which they are applied. The volume supplements the methods presented in the first volume. It provides specific examples of general procedures; considers the important groups of poisons; arranges the order of extraction from biological material; and discusses the methods for identifying and determining the members of each poison group. The book will be invaluable to toxicologists, clinical chemists, and biochemists.