Search

This fully revised and expanded second edition provides a comprehensive and up-to-date overview of nasal rhinitis polyposis, a condition that not only decreases patients'quality of life, but also affects the connections between the upper and lower respiratory tract, making its treatment of critical importance. New research findings, as well as new technical innovations, have changed the conventional medical and surgical approaches to the treatment of nasal polyposis, which has resulted in significant advances in the management of the disease. This reader-friendly and richly illustrated book gathers contributions by authors internationally recognized for their outstanding laboratory research and clinical practice. This second edition includes the latest information, together with new chapters on nasal polyposis endotyping, Asian polyps, epithelial barrier in nasal polyposis, biologics of nasal polyposis, microbiome of nasal polyposis, eosinophil & nasal polyposis, nasal polyposis in children, staphylococcus aureus, superantigens and nasal polyps, and antifungal treatment in chronic sinusitis. It offers comprehensive information to help readers improve the daily management of patients affected by nasal polyposis.

This book evaluates muscle and nerve biopsies. It creates a more analytical view of neuromuscular diseases in the light of clinical findings. Diseases that occur mostly in muscle or nerve tissue may show common clinical findings. Addressing these two issues together will make it easier to understand the diseases. Neuromuscular diseases, normal histology, embryology, and physiopathology of muscles and nerves are discussed with a main focus on differential diagnosis. The book also presents the most cost-effective and easiest-to-follow algorithms for the differential diagnosis of diseases.

This book, which will hold global appeal, adopts a problem-based approach to childhood disorders of the nervous system with the aim of supporting practicing child neurologists, pediatricians, and residents in training in their management of children with neurological disorders. Throughout, the practical assistance that it offers is based firmly on the best available current scientific evidence. The various pediatric neurologic diseases and organ systems are covered by pediatric neurologists and scientists from leading university hospitals and health centers in both the developed and the developing world. In addition to the full range of more frequent disorders, the book spans the neurological aspects of neglected tropical diseases and neurogenetic diagnostic and management algorithms utilizing the power of emerging DNA technology. A further feature is the inclusion of didactic videos relating to epileptic and movement disorders. As an open access publication with a strong clinical focus, the book will be a handy and valuable reference and resource for all practitioners who deal with childhood neurological disorders.

This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

'This book fills an important and unique niche in pediatric neurology, and will be a frequently referenced textbook for all clinicians caring for children with epilepsy. It is well-organized and readable, and provides essential and up-to-date clinical data on these individually rare, but collectively more common, disorders.'-Elaine Wirrell, MD, Neurology'Specialists in pediatric neurology, epilepsy, and biochemical genetics will find this volume to be indispensable for their daily practice. The organized approach to an incredibly complex set of disorders will also benefit trainees trying to make sense of the complex field and developing their own clinical approach, as knowledge about metabolic epilepsies continues to grow.'-Carl E. Stafstrom, MD, PhD, Journal of Pediatric Epilepsy The continued explosion of information in neurogenetics and metabolism mandates increasing awareness of current diagnostic and therapeutic strategies in disease settings where prompt identification and intervention is crucial for a positive outcome. This thoroughly revised and greatly expanded new edition of the first book to bridge clinical epilepsy with inherited metabolic diseases brings together leading authorities to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies, Second Edition contains 15 new chapters, and all existing chapters have been updated to reflect the latest science and clinical advances in this fast-moving field. New sections on basic and clinical science —covering energetics, metabolomics, pathways, the use of novel investigations like transcranial magnetic stimulation, neuropathology, and genomic technologies—supplement the disease-focused sections. Dedicated chapters focus on recently recognized disorders having novel therapeutic implications, pyridoxal-5-phosphate dependency, Menkes disease, and thiamine transporter deficiency. The book also includes new clinical applications of genomics and advanced generation gene sequencing in the diagnosis of inherited metabolic epilepsies. This readable, well-illustrated reference concludes with an updated clinical algorithm to aid physicians in screening and identifying suspected metabolic disorders and a collection of resources for families. Features Synthesizes cutting-edge diagnostic, clinical, and scientific information on epilepsy and inborn errors of metabolism Completely updated and expanded second edition contains the latest knowledge and 15 entirely new chapters Authored and edited by international experts in neurology, metabolic disorders, and genetics A readable and well-illustrated reference for clinicians Essential coverage of the new generation of genetic tests, which were not widely available or utilized when the first edition was published New chapter on inherited metabolic epilepsies in adult

The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.

Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science, diagnosis and treatment of neuromuscular disorders in childhood is a timely and needed resource for all clinicians and researchers studying neuromuscular disorders, especially in childhood. The Second Edition is completely revised to remain current with advances in the field and to insure this remains the standard reference for clinical neurologists and clinical research neurologists. The Second Edition retains comprehensive coverage while shortening the total chapter count to be an even more manageable and effective reference. - Carefully revised new edition of the classic reference on neuromuscular disorders in infancy, childhood and adolescence. - Definitive coverage of the basic science of neuromuscular disease and the latest diagnosis and treatment best practices. - Includes coverage of clinical phenomenology, electrophysiology, histopathology, molecular genetics and protein chemistry

This clinically orientated text by an international group of experts is the first definitive reference book on disorders of the cerebellum in children. It presents a wealth of practical clinical experience backed up by a strong scientific basis for the information and guidance given. The first part sets out the theoretical underpinnings of cerebellar disorders. This is followed by sections on clinical conditions grouped according to common characteristics such as aetiology and symptomatology. The descriptions of the clinical conditions each systematically cover, as appropriate, epidemiology, prevalence, diagnostic criteria, clinical features (including course and prognosis), pathophysiology, genetics, investigations, differential diagnosis, and management and treatment.

Physicians caring for children with rheumatic disease need a varied and highly developed set of clinical skills, including general pediatrics, immunology, musculoskeletal medicine and the management of chronic diseases. With these requirements in mind, this concise handbook emphasizes the most frequently recognized symptom complexes in children. The book first focuses on musculoskeletal diseases that may have multi-organ involvement. It then discusses systemic lupus erythematosis, vasculitis, scleroderma and other auto-inflammatory diseases. The concise text is supported by a wealth of photos and tables.

Nelson Textbook of Pediatrics has been the world's most trusted pediatrics resource for nearly 75 years. Drs. Robert Kliegman, Bonita Stanton, Richard Behrman, and two new editors-Drs. Joseph St. Geme and Nina Schor-continue to provide the most authoritative coverage of the best approaches to care. This streamlined new edition covers the latest on genetics, neurology, infectious disease, melamine poisoning, sexual identity and adolescent homosexuality, psychosis associated with epilepsy, and more.Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Locate key content easily and identify clinical conditions quickly thanks to a full-color design and full-color photographs. Stay current on recent developments and hot topics such as melamine poisoning, long-term mechanical ventilation in the acutely ill child, sexual identity and adolescent homosexuality, age-specific behavior disturbances, and psychosis associated with epilepsy. Tap into substantially enhanced content with world-leading clinical and research expertise from two new editors-Joseph St. Geme, III, MD and Nina Schor, MD-who contribute on the key subspecialties, including pediatric infectious disease and pediatric neurology. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Recognize, diagnose, and manage genetic conditions more effectively using an expanded section that covers these diseases, disorders, and syndromes extensively. Find information on chronic and common dermatologic problems more easily with a more intuitive reorganization of the section.

La pathologie neurologique infantile occupe une place majeure dans la pathologie pédiatrique, en raison de sa fréquence et de la gravité de ses conséquences sur le développement psychomoteur des enfants. La 3e édition de Neurologie pédiatrique, qui paraît 12 ans après l'édition précédente, a été entièrement réécrite afin d'intégrer les progrès extrêmement rapides effectués dans divers domaines tels que la génétique moléculaire, les connaissances des mécanismes physiopathologiques, les méthodes d'investigation, les avancées thérapeutiques. Cette nouvelle édition rend compte de cette fascinante évolution. Ainsi les chapitres consacrés à l'imagerie structurale et fonctionnelle, le développement du système nerveux, les malformations, les maladies neurométaboliques, neurodégénératives, neuromusculaires, les pathologies circulatoires, tumorales, infectieuses, etc., sont entièrement mis à jour. Un nouveau chapitre très complet porte sur le diagnostic anténatal des pathologies neurologiques, qui occupe maintenant une place fondamentale dans la pathologie pédiatrique. Le chapitre consacré à l'épilepsie, pathologie la plus fréquemment rencontrée en neuropédiatrie, a bénéficié d'une refonte complète prenant en compte les nouveaux moyens d'investigation diagnostique et les nouveaux traitements médicaux et chirurgicaux. Les déficiences et handicaps neurologiques sont analysés du point de vue de leurs conséquences médicales, mais également éducatives à la lumière de la loi du 11 février 2005 sur le droit des personnes handicapées. Les fonctions cérébrales supérieures de l'enfant et leurs dérèglements sont étudiés et enrichis des apports sur la connaissance du rôle du cervelet dans la cognition. La place de la pédopsychiatrie dans les maladies neurologiques a été considérablement développée, notamment à travers le problème complexe des pathologies de conversion chez l'enfant. Cette 3e édition de Neurologie pédiatrique constitue actuellement le traité le plus complet et le plus à jour dans le domaine de la neurologie infantile, aussi bien dans la littérature française qu'étrangère.

The premier textbook of clinical child neurology. Comprehensive descriptions of the neurological disorders of the neonate, infant, child and adolescent. Third edition comprehensively revised and updated.

This book provides a definitive reference work on the developing brain, from conception through the first year of life. Its purpose is to provide the range of specialists involved in the management of the fetus and the neonate with the latest information on the developmental neurology and pathology of the developing central nervous system, so that they can provide prompt and informed treatment of neurological disability – the most feared complication of pregnancy and the early months of the life of the newborn child.A cross-specialty book: brings together the work of specialists on the immature brain from the fields of obstetrics, paediatrics and neurosurgery.An international book: edited and written by an international team of experts.Highly illustrated: includes over 800 images and line drawings that capture the latest investigative techniques.Focused on treatment: key points boxes pick out the most important information for the busy specialist.Evidence-based information: extensively referenced with the latest and most important papers and articles.Includes the latest ultrasound techniques – to reflect the massive improvements since the last edition.Medico-legal issues highlighted – in recognition of the role of specialists as expert witnesses.Covers the latest MR techniques: fast sequences for fetal brain imaging, DWI, tractography.

Primary immunodeficiency diseases (PID) are a group of disorders involving defects in one or more components of the immune system, and are characterized by an increased incidence of infections, autoimmunity, and malignancies. Although PID seem to be rare, the number of patients diagnosed has increased in recent years, and more than 150 different forms of PID have been identified. Nevertheless, because of inadequate medical awareness, a significant number of patients with PID are either not recognized as having a PID or are not diagnosed as early as they should be. Such delays lead to a substantial increase in morbidity and mortality among affected individuals.Our understanding of PID is improving rapidly, which will hopefully lead to more accurate diagnosis and efficient disease management. This book contains the most recent advances in the field, as well as a concise and structured review of previously identified PID. Although the book's primary focus is on practical diagnosis and management, the pathophysiology of PID is also discussed.This book is a comprehensive yet manageable resource for physicians and nurses wishing to learn more about PID, as well as a useful tool for both doctors-in-training and specialists in clinical decision-making and treatment planning.

For nearly three quarters of a century, Nelson Textbook of Pediatrics has been the world's most trusted resource for best approaches to pediatric care. Now in full color for easier referencing, this New Edition continues the tradition, incorporating a wealth of exciting updates and changes—ensuring you have access to today's authoritative knowledge to best diagnose and treat every pediatric patient you see. Whether you're treating patients in the office or in the hospital, or preparing for the boards, Nelson Textbook of Pediatrics, 18th Edition is your comprehensive guide to providing the best possible care.Get an enhanced focus on general pediatrics with editorial contributions from new editor Dr. Bonita F. Stanton.Treat your inpatient and ambulatory patients more effectively with the absolute latest on new topics such as quality improvement and patient care safety •school violence and bullying • preventive measures • vitamin deficiencies • adolescent rape • effect of war on children • and more.Improve your therapeutic skills with the newest knowledge on the principles of antibiotic therapy • antiviral therapy • antiparasitic therapy • antimycobacterial therapy • and others.Understand the principles of therapy and which drugs and dosages to prescribe for every disease.Locate key content more easily and identify clinical conditions quicker thanks to a new full-color design and full-color photographs.