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This book gathers the consensus recommendations on diagnostic procedures in patients with neck masses by the European Head and Neck Society, European Federation of Cytology Societies, European Society of Hybrid Imaging and International Melanoma Pathology Study Group. Because of the variability of anatomical structures and the richness of histological tissues, the diagnostic process for neck masses is often complex. The diagnostic process depends on the habits of oncological centers, the experience of specialists and particular standards. In reality, there is no international recommendations which would allow to define the optimal and least invasive modalities for carrying out a rapid and accurate diagnosis. Written by the most eminent specialists of different profiles and geographic areas, who present and analyze different technical modalities, the book combines the different points of view and defines the agreed upon optimal technique. Each chapter is short, informative, well referenced and the main messages are placed in tables and boxes. The book is addressed to oncologists, radiologists, nuclear physicians, ENT surgeons, surgical- and cyto-pathologists. This work is under the patronage of the International Academy of Cytoloy (IAC).

This is the third edition of a well-received book that recapitulates the thyroid fine-needle aspiration (FNA) cytology. It covers the basics and critical principles of thyroid cytopathology, addresses technical aspects, and presents the latest breakthrough events in the field, including the new editions of the WHO classification of thyroid tumors and the Bethesda system for reporting thyroid cytopathology.Thyroid FNA Cytology, The Third Edition is a practical handbook for cytopathologists, pathologists, cytotechnologists, endocrinologists, thyroid surgeons, radiologists, thyroid cancer patients, and their families. This edition covers more topics than the previous editions and invites authors from 20 countries from Asia, Europe, and America. It should serve as an individualized guide to readers practicing in various geographic areas with different medical settings and social resources. The book provides multiple chapters on differential diagnosis and pitfalls to show the unique approaches in many countries. The book will broaden their perspectives and serve as a foundation for further advancement in this field.

Cytology evaluates cellular details, and in contrast, histology relates to tissue assessment with rather preserved architecture. During daily cytology practice, we frequently encounter certain situations which are often challenging such as differentiating normal cytology components or non-neoplastic lesions from a neoplastic process, abnormality versus artifact, contaminants from lesional sampling, immunostain expression in unexpected cells, identifying/or characterizing infectious microorganisms and use of special stains. In-depth knowledge about normal tissue cytology, the pattern of immunohistochemical expression in various organs, and recognizing diagnostic pitfalls would help to overcome diagnostically challenging situations. This book presents a detailed and state-of-the-art approach to non-neoplastic cytology. High-yield content, mostly used in daily practice, is in tabular format. The book provides detailed information about cytomorphologic features of infectiousmicroorganisms and the use of special stains, the use of immunohistochemistry along with expression in normal cell types, artifacts/contaminants or incidental findings, and cytomorphologic features of non-tumor related lesions in an organ-based structure. There is a further elaboration of differential diagnosis and mimickers of cytologic material from normal parenchymal tissue, infectious/inflammatory conditions, and benign cystic lesions. The last chapter describes a quick overview of important reference material in tables, which is useful for daily anatomic pathology sign-out. Non-Neoplastic Cytology: A Comprehensive Guide provides practical information about non-neoplastic cytology in one concise format using tables and images. It aims to be a practical resource for cytotechnologists, pathologists, pathology residents, and fellows.

This book is a comprehensive reference work on the multidisciplinary team (MDT) management of colorectal cancer (CRC) patients that will meet the needs of all members of CRC MDTs and those training in the field. Important, up-to-date knowledge is provided on organization of MDTs, early intervention, surgery, oncology, imaging, pathology, and palliation, with special focus on controversies. This second edition has been thoroughly revised. It includes an entirely new section on the principles of treatment of significant polyps and early cancers and a total of 14 new chapters, including one on the early integration of palliative care. Every effort has been made to ensure that each specialty-specific chapter will be approachable for all team members, thereby facilitating an effective interdisciplinary approach to teamwork. The authors are leading European doctors and scientists who have influenced the development of the MDT concept as well as other aspects of individualized treatment ofCRC patients.

Offering the most comprehensive collection of head and neck pathology specimens available in one reference, Gnepp's Diagnostic Surgical Pathology of the Head and Neck, 3rd Edition, is a must-have resource for pathologists in training and practice. This abundantly illustrated volume covers both common and rare disease entities of the entire head and neck area, with particular emphasis on differential diagnosis and diagnostic problems and pitfalls. Detailed text and a highly visual format help you improve turnaround time when diagnosing a specimen and facilitate clear communication of prognosis and therapeutic management options to surgical/medical colleagues. - Covers key topics such as molecular aspects of disease, especially in reference to targeted therapy and personalized medicine; the latest classification and staging systems for head and neck diseases and disorders; and immunohistochemical features that help ensure diagnostic accuracy. - Discusses new diagnostic biomarkers and their utility in differential diagnosis, as well as newly described variants and new histologic entities. - Includes a new chapter on eye pathology. - Incorporates new criteria as established by the 2017 World Health Organization classification of Head and Neck tumors and the 2017 World Health Organization classification of Endocrine organ tumors. - Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. - Features more than 1700 full-color illustrations that capture the pathologic appearance of the full range of common and rare neoplastic and non-neoplastic lesions. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Comprehensive and practical, Mills and Sternberg's Diagnostic Surgical Pathology, 7th Edition, presents advanced diagnostic techniques for differential diagnosis of the surgical specimen and the latest information on all currently known diseases. Led by Drs. Teri A. Longacre, Joel K. Greenson, Jason, L. Hornick, and Victor E. Reuter, a virtual “who's who” of experts in the field provide authoritative guidance on the diagnostic evaluation of every type of specimen from every anatomic site. Visually stunning and thoroughly up to date, this classic two-volume reference is a must-have resource no matter what your level of training or expertise.

This book focuses on Pediatric Head and Neck Surgical Diseases and Pediatric Surgical Pathology. The core objective is to provide the reader the essential background of various head and neck diseases that are common and/or unique to children by highlighting the key diagnostic, clinical, and pathologic features. It encompasses a comprehensive spectrum of pediatric head and neck diseases that are congenital or acquired. Many chapters describe the clinical and radiologic presentation, age-specific differential diagnosis, and diagnostic histopathologic features. The clinical and pathologic aspects of diseases that are unique to children and young adults that are amenable to surgical care are specifically emphasized. Pediatric Head and Neck Textbook: Pathology, Surgery and Imaging is aimed at trainees and specialists in Pediatrics, Otolaryngology – Head & Neck Surgery, General and Pediatric Surgery, Pediatric Radiology and Pediatric Pathology.

This book presents rational diagnostic approaches to common areas of cytopathology, such as thyroid, lymph node and effusion cytology. It discusses differential diagnoses for each site, and describes a systematic approach to narrow down differential diagnoses in a logical manner based on cytomorphology and the judicious application of ancillary tests. Further, it introduces discriminatory panels of immunohistochemical tests, with an emphasis on patient-centred approaches with active clinicopathologic correlations. In addition, it provides practical recommendations for optimizing tissue triage for ancillary testing, in terms of both diagnostic and therapy-related testing. The book also includes sample diagnostic reports to help readers formulate appropriate comments and to aid clinicians in specific clinical scenarios, as well as test cases for readers to apply their diagnostic and specimen triage algorithms. The book equips readers to apply logical approaches tosound cytopathology reporting in daily clinical practice, guiding them through specimen collection and triage to diagnostic workup based on morphologic and clinical features, and writing rational and clinically useful diagnostic cytology reports with a focus on clinicopathologic correlation. As such it is relevant for practising cytopathologists and pathology trainees as well as for cytologists (cytotechnologists) and other clinicians involved in cytopathology diagnostic processes.

​The diagnostic services—pathology and radiology—are the cornerstone for supporting the delivery of high-quality healthcare by providing timely and accurate diagnosis. In this era of precision medicine, it has become increasingly important for these two services to work collaboratively in supporting patients and clinical colleagues by informing and communicating the selection and interpretation of appropriate diagnostic tests, as well as obtaining adequate tissue for diagnosis, prognostication, and therapy at initial presentation and, if required, during disease progression/relapse. This book is aimed at practicing cytopathologists and interventional radiologists as well as trainees in these areas. An essential requirement in the accurate diagnosis of these mass lesion biopsies is the correlation of cytomorphology with the radiological findings and adequate triage of acquired material during the biopsy procedure. The cytologic findings, gross surgically resected specimens, andimaging findings are illustrated to provide a complete pathologic-radiologic correlation of the entities discussed. This Atlas of Cytopathology and Radiology serves as a useful guide for pathologists and radiologists in the appropriate triage and diagnosis of deep seated mass lesions biopsied under ultrasound, CT Scan or fluoroscopic guidance.

Der vorliegende Band „Knochenmark, Lymphatisches System, Milz, Thymus“ ist mehr als 30 Jahre nach Erscheinen der 1. Auflage inhaltlich und strukturell völlig neu gestaltet worden. Er enthält nicht nur die diagnostische Hämatopathologie der anatomischen Bildungs- und Reaktionsorte des hämopoietischen und lymphatischen Systems, sondern berücksichtigt auch alle Organe mit speziellen hämatopathologischen Erkrankungen wie beispielsweise die Lymphome in den Geweben des Mukosa-assoziierten Immunsystems. Eine Betonung erfährt auch die Darstellung organübergreifender gemeinsamer ätiologischer Faktoren, z.B. der Infektionen. Schließlich werden beim Thymus auch alle epithelialen Tumoren und nichtlymphatischen Erkrankungen diskutiert. Dieses Buch richtet sich an Pathologen und Kliniker mit dem Versuch, die diagnostischen Grundlagen eines zielgerichteten therapeutischen Vorgehens für die reale Situation des Einzelpatienten zu definieren. Die Herausgeber hoffen, dass dervorliegende Band diesem Anspruch gerecht wird.

This book offers a comprehensive guide to thyroid fine needle aspiration (FNA) cytology. Borderline/precursor tumors, which were introduced in the 4th edition of the WHO classification of thyroid tumors, are also incorporated. In this second edition, prominent international experts discuss the different approaches to thyroid FNA cytology employed in various countries such as Australia, Canada, China, Korea, Portugal, Switzerland, Taiwan, Thailand, Turkey, Ukraine, the USA, UK, Italy and Japan. The book not only covers key principles of thyroid cytopathology but also addresses technical aspects such as procedural complications, liquid-based cytology, immunocytochemistry, staining procedures, and potential pitfalls. Case-based descriptions and clinical findings, radiologic imaging, cytology, and histopathologic diagnosis – all complemented by a wealth of detailed photographs – will help reader understand and overcome many common dilemmas in daily practice. As such, the book represents an indispensable reference work for all cytopathologists, especially those practicing thyroid cytopathology.

This comprehensive and timely textbook covers all aspects of the evidence-based management of genitourinary cancers and explains the fundamental principles underlying the available diagnostic and treatment approaches, including chemotherapy, radiotherapy, immunotherapy, and surgery. For each type of cancer – prostate, bladder, renal, testicular, and penile, plus rare urologic malignancies – clinical presentation, diagnosis, and treatment strategies are described in detail and information is provided on etiology, epidemiology, risk factors, and pathology, including TNM classification. Careful attention is also devoted to the complications that may be encountered when treating urologic malignancies and to the management of these complications. The text is complemented by the inclusion of numerous high-definition photographs and illustrations. Urologic Oncology will be a valuable reference and source of guidance for all oncologists, urologists and practitioners in related disciplines who treat patients with urologic cancers.

Practical Head and Neck Pathology: Frequently Asked Questions centers around frequently asked questions, but it is not meant to be comprehensive in its approach. Instead, it aims to touch on all major or commonly encountered entities. Each chapter begins with a list of questions typically ordered from basic histologic knowledge, to inflammatory processes, primary tumors, and secondary tumor types. Strategies for the diagnosis of salivary gland, metastatic head and neck cancers and thyroid disease using ancillary testing is highlighted. Small biopsy dilemmas in undifferentiated tumors of the sinonasal and nasopharyngeal tracts are undertaken with emphasis on differential diagnosis and ancillary techniques. The tables are the foundation of the book, offering a quick reference guide for salient features of various entities and differential diagnoses. A comprehensive set of references after each question can be used to supplement the information provided and give the reader a foundation for further learning. This book answers some of the difficult, prevailing and emerging questions in head and neck pathology that arise in everyday practice. While such challenges may not always be frequent, they have tremendous impact on clinical practice. Clinically pertinent, molecular advances in treatment and diagnosis for the practicing and junior pathologist are covered.

This illustrated volume serves as a handy guide to diagnostic fine needle aspiration (FNA) cytology of thyroid on liquid-based preparations (LBP). It is intended to be a ready resource to accurately diagnose thyroid lesions on LBP using key cytomorphologic features. Key cytologic differential diagnosis, gross, and histopathological correlations accompany the cytological findings. The Atlas of Thyroid Cytopathology on Liquid-Based Preparations is lavishly illustrated with color images of various thyroid diseases that should familiarize pathologists with the differences between conventional smears and LBP, and between the two commonly used LBPs. Authored by leaders in the field, this atlas provides clear, concise, and practical guidance pertaining to cytomorphology and the implications of thyroid FNA diagnoses for patient care in this era of precision medicine.

The new edition of this book highlights the recent advances and state-of-the art in surgical and non-surgical management of thyroid cancer. Readers will learn about the latest advances and recommendations in the field, from molecular studies and biomarkers to the changing epidemiology, kinase inhibition in drug discovery and new surgical approaches, such as intra-operative neural monitoring and robotics. The management of differentiated thyroid cancer as well as childhood cancer, survivorship and clinical trial design and findings and how these fit into cancer management are discussed in detail.This comprehensive volume provides an overview of the current world literature and outlines the practical aspects of management from world leaders in this field and helps clinicians and patients on practical matters. With a selection of authors from around the world it draws on international experience giving a global perspective to the topic. Following on from the success of the firstedition, it uses a multidisciplinary, evidence-based approach centered on the patient, discussing guidelines and how these have improved the quality of care and outcomes. This guide is aimed mainly at thyroidologists of all disciplines, (in training or experts) students, non-specialist clinicians, nursing staff, all the disciplines involved in a multidisciplinary team such as surgeons – Head & Neck or Endocrine and General Surgeons, Oncologists, Endocrinologists, Nuclear Medicine Physicians, Nuclear Medicine Physicists, Radiologists, Pathologists, Specialist Nurses, Geneticists, Clinical Psychologists, Palliative Care Physicians and, of course, patients.

This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care.Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

This book, now in its third edition, aims to promote a deeper understanding of the scientific and clinical basis of nuclear medicine and the new directions in medical imaging. The new edition has been revised and updated to reflect recent changes and to ensure that the contents are in line with likely future directions. The book starts by providing essential information on general pathophysiology, cell structure and cell biology as well as the mechanisms of radiopharmaceutical localization in different tissues and cells. The clinical applications of nuclear medicine are then presented in a series of chapters that cover every major organ system and relate the basic knowledge of anatomy, physiology and pathology to the clinical utilization of various scintigraphic modalities. The therapeutic applications of nuclear medicine are discussed in a separate chapter, and the final chapter is devoted to the biologic effects of ionizing radiations, including radiation from medical procedures.

This issue of Endocrinology and Metabolism Clinics, edited by Dr. Alice Levine, is devoted to Adrenal Disease. This issue will be broken down into 3 sections: Overview of Adrenal Cortical Development, Steroidogenesis, Comparative Anatomy and Molecular Pathophysiology; Benign Adrenal Tumors; and Adrenal Cortical Carcinoma. Articles in this issue include: Adrenal Cortical Zonal Development; Adrenal Steroidogenesis and Congenital Adrenal Hyperplasia; Animal Models of Adrenocortical Tumorigenesis; Genetics of Adrenal Cortical Tumors; Adrenal Incidentalomas; Aldosteronomas – Challenges in Diagnosis and Management; Mild Hypercortisolism Due to Adrenal Adenomas – Definitions and Therapeutic Options; Management of Adrenal Tumors in Pregnancy; Pathology of ACC; Diagnosis and Medical Management of ACC; and Surgical Management of ACC.

The term ‘carcinoid'entered medical literature over 100 years ago to describe a peculiar intestinal epithelial neoplasm. Since then, a large body of literature has expanded the concept of carcinoid, later replaced by the term ‘NeuroEndocrine Tumor'(NET), defining a wide spectrum of peculiar tumors, potentially affecting all organs and tissues, originating from neuroendocrine cells, sharing, but, at the same time, keeping, pathognomonic pathological, radiological and clinical features. This book provides an authoritative overview of the epidemiological, clinical, genetic, molecular and pathological characteristics of NETs and highlights the most relevant controversial issues in the classification, diagnosis and therapy. Furthermore the new frontiers in the field of medical therapies are presented, through a multidisciplinary and translational approach. Considering the fact that NETs have been recently demonstrated less rare as considered so far,'Neuroendocrine Tumors: A Multidisciplinary Approach'is a must read for endocrinologists, gastroenterologists, endocrine surgeons, as well as pathologists, nuclear medicine physicians and radiologists focused on NET.

For practitioners at all stages of experience, diseases of the parathyroid glands are not easily deciphered. There are many subtleties to its pathology and diagnosis. Today, the wealth of new information from molecular medicine makes it very challenging for the individual practitioner to have a complete picture of these entities. Diseases of the Parathyroid Glands addresses these issues by offering a concise, user-friendly text that provides state-of-the-art background on mineral physiology and its regulation and couples this to a variety of clinical topics of parathyroid gland pathology. Introductory chapters cover calcium regulation and parathyroid gland physiology, drawing upon many of the new aspects of glandular control mechanisms beyond the classical ones associated with calcium alone. The majority of the text covers clinical problems. Although most chapters address problems in adult medicine, three separate chapters are devoted to pediatric problems of hyper- and hypoparathyroidsm and parathormone resistance states. In addition, there are several chapters on less common but equally challenging problems such as parathyroid cancer, calciphylaxis, cystic lesions of the glands, and ectopic glandular disease. The final chapters detail the techniques of parathyroid gland imaging and surgical treatment. Practical and an invaluable addition to the literature, Diseases of the Parathyroid Glands is an indispensable reference for anyone interested in parathyroid disease.

Pediatric pathology has been a recognized sup-specialty of pathology for almost two decades. Today pathology training programs are required to provide education in pediatric pathology. In addition to pediatric pathology specialists, many general and community-based pathologists regularly handle pediatric specimens. A working knowledge of current pediatric pathology is essential for appropriate handling of these cases. The Color Atlas of Pediatric Pathology covers the broad range of pediatric diseases that a pathologist will likely encounter and is written by well-known leaders in this field. Coverage includes both frequent and less commonly seen cases, and each discussion presents a concise summary of the salient features of the disease along with expertly selected, high-quality color images. The Color Atlas of Pediatric Pathology is a practical working resource for every pathologist who sees pediatric cases as well as the pathology trainee. The atlas features approximately 1,100 high-quality images as well as important staging and prognostic (including molecular) parameters. Features of the Color Atlas of Pediatric Pathology include: Comprehensive coverage of pediatric surgical and autopsy pathology Each chapter is presented by a recognized expert Practical presentation: concise text highlights diagnostic features making the atlas an outstanding resource for the practitioner Illustrated throughout with approximately 1,100 full-color images

Differential Diagnosis in Surgical Pathology, 2nd Edition, by Paolo Gattuso, MD, Vijaya B. Reddy, MD, Odile David, MD, and Daniel J. Spitz, MD, is skillfully designed to help you confidently sign out your most complex and challenging cases. Covering a complete range of tumors and tumor-like conditions in all organ systems, it provides a user-friendly road map to the main criteria you should consider in order to differentiate between a variety of potential diagnoses that all have a very similar appearance. Over 1,350 new full-color macro- and microphotographs provide a realistic basis for comparison to what you see under the microscope. Quick checklists cover all diagnostic possibilities to make sure nothing falls through the cracks.A concise, bulleted textual format facilitates quick retrieval of essential facts. A consistent approach to diagnosis and interpretation expedites reference. Coverage of all relevant ancillary diagnostic techniques addresses all of the investigative contexts needed to formulate an accurate diagnosis. Expert'pearls'offer practical tips on what diagnostic criteria to consider or exclude. A comprehensive, yet manageable size allows for quick consultation.Over 1,350 new full-color macro- and microphotographs provide a realistic basis for comparison to what you see under the microscope. Immunohistochemical and molecular techniques throughout enable you to review all of the latest diagnostic considerations in one place. Expanded coverage of non-neoplastic entities assists you in recognizing benign lesions that may mimic the appearance and characteristics of malignant ones. Extensive updates include the latest classification schemes and relevant diagnostic techniques. A brand-new, color-coded layout highlights key points more clearly and helps you turn to the sections you need more speedily.

The past two decades have seen an ever accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Mole- lar diagnostics, molecular targeted therapy, and genetic therapy are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, medical oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical inves- gators, pathologists and medical laboratory directors, and radiologists require a basic understanding of the fundamentals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice.

This resource is the authoritative guide to problematic areas of the head and neck for the surgical pathologist. With particular emphasis placed on diagnostic problems and differential diagnosis in addition to coverage of more common diagnostically straightforward lesions, you'll get the most complete diagnostic picture possible. The updated second edition features new coverage and a more user-friendly layout.Features the most comprehensive collection of head and neck pathology specimens in one reference for comparison with your findings. Covers rare as well as common diagnoses to help you identify even the most obscure disease entities. Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. Emphasizes differential diagnosis and avoiding diagnostic pitfalls so you can overcome difficult diagnostic challenges.Covers FNA cytology, molecular genetic techniques, and immunohistochemistry to present the most compete diagnostic picture possible. Presents a brand-new chapter on specimen handling to ensure effective processing and reporting of head and neck specimens. Features more than 1700 full-color illustrations that capture the pathologic and cytopathologic appearances of the full range of common and rare neoplastic and non-neoplastic lesions.

With increasing emphasis on the early diagnosis and management of urologic tumours, it is imperative that the practising urologist comprehend the relevance of the morphology for the clinical diagnostic and therapy. Moreover, the clinician should be fully informed of the importance of modern morphological methods (PCR, FISH, CGH etc) for the diagnos

The second edition of this book has been significantly expanded to meet the demands of the increasing new trend of molecular imaging. A separate chapter on the basis of FDG uptake has been added. New to this edition are the more clinically oriented details on scintigraphic studies, their strengths and limitations in relation to other modalities. It further contains many new images, illustrations and tables.

Hematologist/oncologists rely heavily upon the discipline of hematopathology for the care and management of their patients. Whether interpreting a lymph node or bone marrow biopsy, directing a high throughput automated hematology laboratory, or translating testing modalities from the research bench to the clinical laboratory, hematopathologists and other laboratory medicine specialists provide a steady stream of critical data for the clinical practitioner. Recently the rapid advances in diagnosis and treatment of hematological disorders including the need to evaluate patients'eligibility for and monitor responses to rapidly evolving targeted therapies have made the close collaboration between pathologists and clinician practitioners even more essential. Our goal is to provide outstanding reviews of selected topics in hematopathology in a format that provides both general and historical background, as well as an overview of the state-of-the-art in diagnostic hematopathology, with an eye on future potential and future developments.

Atlas of Selective Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer emphasizes a multidisciplinary approach combining the experiences of a nuclear medicine physician, surgeon, and pathologist. This is an important reference also for researchers and clinicians who want to become familiar with sentinel lymph node mapping. The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin. Therefore, the logical approach is to harvest that specific SLN for thorough analysis.