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This book comprehensively reviews various nanodiagnostic approaches for the detection of bacterial pathogens. The initial chapter of the book discusses receptors present on bacterial cell surfaces that can be targeted for diagnostic applications. The book then presents different fluorescent nanoparticle systems that are used for bacterial detection. Further, it covers surface plasmon resonance (SPR), ELISA, and QCM-based nanosensors to detect pathogenic bacteria. It examines different nanosensors used for the microfluidic-based detection of bacterial pathogens, including microfluidic paper-based analytical devices (μPADs), lateral flow devices, and miniaturized PCR devices. The book also covers the current electrochemical, voltammetric, and amperometric nanosensors-based microorganism recognition approaches. Lastly, the book summarizes the current challenges and the futuristic application of nanosensors to detect bacterial pathogens. This book is an invaluable resource for all medical laboratories and clinical institutions dealing with infectious diseases.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

Over the past decade, the potential of the pineal hormone melatonin as a therapeutic agent in a variety of diseases has been recognized. This book is the first to review the effect of melatonin in sleep disorders, its possible use as an immunoregulatory agent and clinical results obtained in cancer immunotherapy. Several papers are devoted to the pharmacological and molecular characterization of melatonin receptors in a variety of cell types. Other contributions further investigate the immunoenhancing effect of melatonin, such as in viral encephalitis and bacterial infections, and consider possible therapeutic indications. Melatonin is also reported to exert important hematopoietic effects by stimulating the production of novel T helper cell opioid cytokines. Other basic studies introduce new perspectives describing melatonin as a potent free radical scavenger. This book should be read by clinicians working in the fields of sleep disorders, oncology and infectious diseases as well as by scientists active in the field of neuroimmunomodulation. It will also be very useful to all those interested in melatonin as a therapeutic agent.

This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and “white paper” that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently, new interventions to medically treat ENT pathology.

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

Hematological cancers or blood cancers are a heterogeneous group of malignant neoplasms, including leukemia, lymphoma, and myeloma, primarily affect the blood and bone marrow. The “Hematological Cancer Pathophysiology: An Interdisciplinary Approach” is the tenth volume of the “Interdisciplinary Cancer Research” series, publishes a comprehensive volume on the pathophysiology of hematological cancers. This volume has an interdisciplinary approach in hematological cancers, including myeloproliferative neoplasms, T-cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, and intraocular lymphoma. Waldenstrom macroglobulinemia and IgG4-related diseases are also discussed in the last chapters. This interdisciplinary series is of special value to researchers working on hematology and oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value to hematologists and oncologists who wish to extend their knowledge on hematological cancers.

This book expands on the work of Dr. Lent Johnson, a major figure in the history of bone tumor pathology and bone tumor radiology, and updates it to provide a comprehensive history of those fields. Dr. Johnson began work on this book in the early 1990s, at the end of his 52-year career at the Armed Forces Institute of Pathology (AFIP) in Washington, DC. Dr. Michael Mulligan worked with him there during his Army service as a Radiologist at the Walter Reed Army Medical Center. Dr. Johnson asked Dr. Mulligan to review his initial draft chapters, but Dr. Johnson died in 1998 and the work was never completed. Dr. Mulligan's intention was to complete it in tribute. The book is structured with Dr. Johnson's initial chapters describing the early history of the development of the specialties of bone pathology and skeletal radiology with an emphasis on the research and teaching programs established at the AFIP. Dr. Mulligan then provides additional information on subsequent developments from the last 30+ years to provide a complete picture of the current state of the field. This is an ideal guide for pathologists, radiologists, and all other medical professionals interested in the history of these specialties.

The General Pathology Student Guide was developed ‘by medical students for medical students'for use in preparing for their pathology course, shelf exams and medical licensing exams. In cooperation with American Educators from Brown University, this book was adapted to the American Curriculum for the USMLEs. The book combines high resolution histological images with condensed related clinical information, and is linked to the AMBOSS learning platform (subscription required), giving access to regularly updated online content, helping students reinforce and deepen their knowledge. The book chapters cover the most relevant basics of pathology, such as infectious diseases, immunopathology, cellular adaptation, and pathologic regeneration. Each chapter includes selected histology slides that show classic findings; these are presented uniformly across chapters to emphasize a stepwise approach to tissue findings and classic disease presentations.The histopathology is displayed in different magnifications and with descriptions, to help students recognize classic patterns of common disease processes. Key histopathologic findings are further integrated with pathophysiology and high-yield clinical knowledge, including imaging, treatment, and clinical outcomes, closing the loop from structure to function to patient impact. This system-based approach highlights pathology's interdisciplinary connections and the impact of the histopathologic diagnosis on patients.This concise volume is ideal for learning and understanding high-yield general pathology concepts in a short period of time. It can be also used as a guide for microscopy in histology slides. This makes learning effective!

This expert volume in the Diagnostic Pathology series is an excellent resource for practitioners at all levels of experience and training. Covering all aspects of hospital autopsy in the way it is practiced clinically, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today's practice, helping pathologists accurately determine the cause and mechanism of in-hospital death. Richly illustrated and easy to use, Diagnostic Pathology: Hospital Autopsy, second edition, is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. - Features complete coverage of every aspect of autopsy practice?including clinical presentation with chart review, technical and diagnostic aspects of autopsy performance, and reporting - Presents classic autopsy techniques while also emphasizing the role of molecular studies and other laboratory and ancillary tests not commonly thought of during autopsy practice - Contains new chapters on emerging pathogens and medical entities (deaths from COVID-19 or vaccine complications, multisystem inflammatory disorders in children, adenoviral hepatitis in children, and more), toxicity/pathology associated with new drug therapies (CAR-T, mRNA vaccine-related immune events, etc.), and new cardiac and other medical devices - Features new or updated content on morgue/autopsy suite maintenance, enhanced biosafety techniques, the role of the autopsy practitioner in a pandemic setting, and more - Provides important clinical and diagnostic information through more than 1,100 clinical and gross pathology photographs, histologic images, full-color illustrations, and radiologic images - Includes case presentations highlighting important aspects of reporting that impact clinicians as well as next of kin - Focuses on pathologists in hospital settings, but also provides value to forensic pathologists, private practice pathologists, and others involved in death investigation, such as coroners, medical examiners, law enforcement, and pathology residents - Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

Das Praxisbuch für die tägliche Diagnostik am MikroskopNeben den klinischen und radiologischen Untersuchungen kommt der histopathologischen Untersuchung von Lungengewebeproben eine entscheidungsrelevante Bedeutung zu. In diagnostisch schwierigen oder zweifelhaften Fällen kann durch die histologische Begutachtung betroffener Lungenareale eine Diagnosesicherung erzielt und therapeutisch relevante Differentialdiagnosen ausgeschlossen werden. Die Diagnostik nicht-neoplastischer Lungenerkrankungen ist oft eine große Herausforderung für den diagnostizierenden Pathologen. Unter den knappen Zeitressourcen aber auch angesichts der stetig zunehmenden Anzahl neu definierter bzw. weiter verfeinerter Entitäten, ist es kaum möglich, den Überblick zu behalten oder gar sämtliche wesentlichen Kriterien zur Diagnosestellung aus der Erinnerung abzurufen. Dieses Buch bietet eine kurze, übersichtliche Darstellung der einzelnen Krankheitsentitäten und der diagnostischen Kriterien für die Untersuchung von Lungengewebeproben. Es begleitet den Pathologen bei der täglichen Arbeit am Mikroskop und erläutert kurz und knapp, welche diagnostischen Kriterien im konkreten Fall greifen und welche Differentialdiagnosen zu beachten sind. Die Autoren legen Wert auf eine standardisierte und übersichtliche Darstellung der einzelnen Krankheitsentitäten. Fallstricken, die zunächst die Diagnose in die falsche Richtung lenken können, werden aufgezeigt. Algorithmen erlauben dem Leser, gezielt den korrekten diagnostischen Pfad einzuschlagen und zügig zur richtigen Diagnose zu finden. Ein einmaliges Praxishandbuch für die tägliche Diagnostik des Pathologen.

This new second edition of the successful 2016 Atlas of Adult Autopsy Practice is fully updated and refreshed with novel illustrations, and data refinements. It leads with pictures, focused text, and commentary on the autopsy itself as a specialist pathology subject. The content expands the coverage of specialist techniques with chapters covering post-mortem imaging, toxicology, neuropathology and forensic pathology from practising specialists. The addition of an original chapter addressing post-mortem histology adeptly contributes to the autopsy training literature. The book – a mainstay for the numerous practitioners working in this field, provides a standard for autopsy practice in the UK, Europe and beyond.

This book is unique because it transmits what the authors had learned in more than 40 years dedicated to teaching and studying testicular pathology. The work provides an integrating perspective on aspects of non-tumour pathology of the testicle, on testicular vascular pathology. Apart from the role of varicocele or testicular loss due to torsion of the spermatic cord, references to vascular pathology in Uropathology treatises are very scarce. This book brings together knowledge on arterial, venous, and lymphatic pathology, which have a negative impact on testicular function. Thanks to the high volume of material accumulated over the years in the Pathology Department of the Hospital Universitario La Paz, the authors ensure that the manuscript has an orderly structure that facilitates consultation or its use for teaching purposes. The content is structured in three sections. The first 10 chapters are dedicated to arterial pathology, the following 5 to venous pathology and 4 to pathology of the lymphatic vessels. This structured presentation of vascular pathology of the testis is useful for diagnosis and teaching in the fields of pathology, urology andrology.

This publication is focused on neuronal and glioneuronal tumors of the central nervous system. Overall, these lesions are much less commonly encountered than their glioma counterparts. In the last 4 decades, the number of lesions that have been newly recognized as distinct entities in this arena has grown tremendously, due to the use of immunohistochemistry and most recently molecular studies. As a group, these tumors are important to distinguish from their glioma counterparts in that many of them have a better prognosis. This book will explore the clinical and pathologic features of these entities, including some of the recent molecular findings that have been discovered in some of these neoplasms.

The book offers a comprehensive update on bone tumors and tumor like conditions including clinical, pathological and radiological features. It provides a comprehensive coverage of the topic including molecular biology and provides the readers a solid foundation of knowledge for tumor recognition and evaluation. The book includes chapters on synovial and odontogenic tumors as well. Chapters are uniformly designed and provide systematic approach to various tumors and tumor-like lesions of bone. They are divided according to the predominant cell of origin or the predominant matrix produced, such as osteoid producing lesions, chondroid tumors or giant cell rich tumors, thus assisting the reader, as to how to approach such lesions. Chapters include ample radiology and microscopy images and tables for quick reference.The book is an ideal resource and offers assistance to practicing pathologists, radiologists, clinical oncologists, orthopedicians as well as residents and interns in pathology, radiology, oncology and orthopedics in understanding the approach to bone tumors in a systematic way. The book emphasizes on the need for a multidisciplinary approach for the diagnosis of bone tumors.

This new edition builds upon the foundational knowledge covered in the first edition, covering the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. The book includes new chapters describing the special considerations for atopic dermatitis in skin of color patients, dedicated chapters on topical and oral prescription management reflected the latest FDA-approved treatments, and also a chapter covering the updated guidelines from the American Academy of Dermatology. A final chapter includes updates on the future of atopic dermatitis treatment. This book provides physicians with insights into the management of atopic dermatitis, such as alternative treatments for pruritus, psychosocial impact on patients and families,assessing patient compliance, and patient resources.

This book focuses on histopathological features of bone and joint infections. Bone and joint infection is a serious health problem that has increased in the past two decades. Their diagnosis requires the collaboration of physicians, radiologists, microbiologists and pathologists. Symptoms of these lesions are nonspecific often resulting in a delayed diagnosis. Radiology is needed for the diagnosis of bone and joint infection, determining the severity and extent of disease. The radiological diagnosis of these infections is challenging because of multiple overlaps with tumor etiologies.Effective antibiotic treatment relies on the detection of the causative organisms and its their susceptibility testing. However, culture is time consuming. Besides, administering antibiotics prior to performing surgery or biopsy, the low virulent bacteria, tissues contaminations and sampling errors limit the reliability of bone culture. Histology is a key tool for the diagnosis of boneand joint infection by evaluating the tissue reaction pattern caused by the pathogen. The histopathological diagnosis is based on the evaluation of the tissue changes and the leukocyte infiltration pattern.The purpose of this book will be to report in detail the histopathological features of bone and joint infections with emphasis on key diagnostic features and differential diagnoses. It will also highlight special stain and other ancillary tests that can be used as an aid in the histological diagnosis.

In Show Me Where It Hurts, Monica Chiu argues that graphic pathography—long-form comics by and about subjects who suffer from disease or are impaired—re-vitalizes and re-visions various negatively affected corporeal states through hand-drawn images. By the body and for the body, the medium is subversive and reparative, and it stands in contradistinction to clinical accounts of illness that tend to disembody or objectify the subject.Employing affect theory, spatial theory, vital materialism, and approaches from race and ethnic studies, women and gender studies, disability studies, and comics studies, Chiu provides readings of recently published graphic pathography. Chiu argues that these kinds of subjective graphic stories, by virtue of their narrative and descriptive strengths, provide a form of resistance to the authoritative voice of biomedicine and serve as a tool to foster important change in the face of social and economic inequities when it comes to questions of health and healthcare. Show Me Where It Hurts reads what already has been manifested on the comics page and invites more of what demands expression.Pathbreaking and provocative, this book will appeal to scholars and students of the medical humanities, comics studies, race and ethnic studies, disability studies, and women and gender studies.

Tutorials in Clinical Chemistry is designed for trainee pathology residents, clinical chemists, medical students, and clinical laboratory scientists, in addition to those preparing for board and postgraduate examination. It is helpful to those in training as well as a teaching aid for mentors, faculty, and directors. The book is organized into 17 system-based chapters covering essential pathophysiology, biochemical investigation, and technical aspects of relevance to results interpretation. Tutorials in Clinical Chemistry is a must-have, didactic and essential knowledge as well as practical resource for learning and review. - Facilitates easy access to troubleshooting common questions within a daily practice - Provides the landscape for the required knowledge and competency in clinical chemistry - Presents concise, direct, practical material for clinicians and clinical practitioners reaching out to the clinical laboratory for advice and interpretation of findings - Covers all aspects of clinical chemistry fellowship curriculum

This book gathers the consensus recommendations on diagnostic procedures in patients with neck masses by the European Head and Neck Society, European Federation of Cytology Societies, European Society of Hybrid Imaging and International Melanoma Pathology Study Group. Because of the variability of anatomical structures and the richness of histological tissues, the diagnostic process for neck masses is often complex. The diagnostic process depends on the habits of oncological centers, the experience of specialists and particular standards. In reality, there is no international recommendations which would allow to define the optimal and least invasive modalities for carrying out a rapid and accurate diagnosis. Written by the most eminent specialists of different profiles and geographic areas, who present and analyze different technical modalities, the book combines the different points of view and defines the agreed upon optimal technique. Each chapter is short, informative, well referenced and the main messages are placed in tables and boxes. The book is addressed to oncologists, radiologists, nuclear physicians, ENT surgeons, surgical- and cyto-pathologists. This work is under the patronage of the International Academy of Cytoloy (IAC).

This updated new edition provides a short, clear, and useful guide to the findings in renal biopsy specimens. The book shows how a diagnosis can be reached, and what clinically significant and helpful information should be reported on a specimen. Each chapter has been updated to incorporate recent advances, with current terminology and information about newly recognized conditions. The latest classification systems and their practical application are also included. Handbook of Renal Biopsy Pathology shows readers how the diagnosis can be made from the clinical indication for the biopsy and interpretation of changes in the specimen. The book is a guide to the differentiation between possible diagnoses, and includes information about eponyms and the origins of words, the pronunciation of names, and a mention of famous people who have had renal disorders. The book is a useful resource for trainee and practicing pathologists and nephrologists, as well as other healthcare professionals specialising in renal disorders, such as transplant surgeons, dialysis and transplant nurses, pharmacists, and medical students.

This volume offers insights into human challenge studies, where adult volunteers are deliberately infected with a pathogen of interest. These studies can broaden our knowledge on infections that have a rather low natural infection rate, but still bear a great threat to global health. The authors also present instances, where no suitable animal model is available to help understand human immune responses to a specific pathogen. The recent SARS-CoV-2 pandemic is another example, where studies that are directly conducted in humans, could save valuable time. Human challenge studies can provide immunogenicity and early efficacy data for vaccine development. However, similar models could be used for studying a wide variety of medical treatments such as monoclonal antibodies, antibiotics, antivirals and bacteriophages. The chapters in this volume cover several pathogens, including viruses, bacteria and parasites, scientific and technical aspects as well as descriptions of regulatory, ethical and manufacturing requirements. The book serves as a valuable resource for scientists and clinicians working on human pathogens.

Writing for Inclusion (WIN) wishes to develop high quality and care systems in childhood education. The priority has been to sensitize very young learners towards care and inclusion. The book shows the learning modules to train teachers to tackle care in education within their classrooms. It also provides students with materials both visual and written to create texts both orally and in writing to advocate for inclusion through stories. As for digital competence, the book explores the possibilities of new technologies to engage in active citizenship. Inclusion practices to create inclusive environments, such as the integration of children with a disability or an awareness campaign for minority students are valuable because they stem from the concept of'Care', fostering empathy in 4th-year primary education students. This book is about building and implementing a methodology that interprets those special needs in four European schools and acts upon them through digital storytelling.

The gold standard in gastrointestinal pathology textbooks returns More than 34 million Americans suffer from pathologies of the digestive system, with over 20 million of these disorders chronic. Treatment of these patients is a complex multidisciplinary area of clinical medicine, drawing upon expertise not only from specialist gastroenterologists but also pathologists, immunologists, endoscopists, and more. Morson & Dawson's Gastrointestinal Pathology has long set the standard for pathology textbooks, with its distinctive balance of clinical gastroenterology and pathology. Now fully updated to reflect the latest research in this vital field of medicine, it promises to bring this subject to a new generation of clinicians and pathologists worldwide. Readers of the sixth edition of Morson and Dawson's Gastrointestinal Pathology will also find: Contemporary recommendations and guidelines for getting the most out of every pathology specimen and producing the best possible report for managing the patientDiscussions of the evolving applications of immunohistochemistry and in situ hybridisationA completely new chapter on lymphoid and other tumours of the large intestine Morson & Dawson's Gastrointestinal Pathology is ideal for gastrointestinal pathologists, general pathologists, gastroenterologists, and any clinicians who work with or in gastrointestinal practice.

This section presents materials in two parts: Part I, Ophthalmic Pathology, and Part II, Intraocular Tumors. The hierarchy of the chapters in Part I moves from general to specific to help clinicians derive a differential diagnosis for a specific issue. Part II is a compilation of selected clinical aspects of importance to the general ophthalmologist—this section contains extensive discussion of intraocular tumors.

In this era of teaching through problem-based learning, this unique book guides approaching patients with anemia through a step-by-step analysis of test results. It explains the rationale for requesting appropriate tests and analyzing them systematically and correlates each answer to the disease-based entity on the latest evidence. The target audience is undergraduate medical students during hematopathology training and the introductory phase in clinical Medicine and Hematology, postgraduate residents in Hematology and Medicine, and undergraduate and postgraduate Allied Health students. It provides a quick reference source for practitioners and teachers in medical and paramedical institutions. Question-answer format for quick review before exams. Hundreds of visual illustrations with microscopic images and tables.Quick reference for students in wards and clinics.

This book equips dental care providers with a thorough understanding of oral maxillofacial pathology and the clinical management of oral lesions and oral biopsies. Readers will learn about the scientific basis of oral maxillofacial pathology, different types of biopsies, when to perfom a biopsy and how to handle it in the dental practice. The book focuses on clinical and radiographical features of oral diseases and guides the practitioner to differential diagnosis using an algorithm that leads to the best treatment for the patient.Emphasis is placed on the successful interdisciplinary work with oral maxillofacial pathologists, the importance of histological descriptions, and explanation on how to read pathological reports is provided. Differential diagnosis of a unilocular radiolucent, multilocular radiolucent lesion and radiopaque lesion in the jaws are discussed for vital teeth, non-vital teeth and the edentulous area.This book will help dentists to deepen their knowledge in oral maxillofacial pathology and guide them through the clinical application of diagnosis algorithms and biopsies in the dental care setting.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of the female genital tract, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Gynecological is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. - Covers all areas of gynecologic pathology, organized into seven easy-to-reference anatomic sections: vulva, vagina, uterine cervix, uterine corpus, fallopian tube and broad ligament, ovary, and peritoneum - Includes all frequently encountered conditions plus extensive coverage of uncommon entities, such as inflammatory diseases of the vulva, discussed by experts in dermatopathology - Provides updated differential diagnoses and diagnostic pearls as well as extensive revisions based on the 2020 WHO Classification of Tumors: Female Genital Tumors, including staging issues and measurement standards - Reflects important molecular updates in endometrial carcinoma classifications as well as updated classifications for squamous and glandular tumors for the lower genital tract, both in situ and invasive - Updates ancillary techniques, newly encountered pitfalls, and advances in the molecular landscape of epithelial and mesenchymal tumors - Features more than 2,500 superb images in print and online, including many new gross and microscopic images as well as diagnostically relevant immunohistochemical and molecular findings - Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

This book is a toolkit for teaching a course on the pathophysiology of disease and how the most widely utilized laboratory tests can be used to diagnose these conditions. Tests for the major common diseases are presented by organ system. It is also a study guide for students and trainees as they prepare for their respective board examinations. Each topic includes succinct text focusing on a disease topic along with a set of PowerPoint lecture slides and clinical cases (with answers). The toolkit also contains instructions for preparing the teaching laboratories for the course, a comprehensive list of differential diagnoses for the most frequent clinical chemistry abnormalities, discussion of selected cases taken by pathology residents while on night-call, and quiz questions (with answers). Analytical methodology is not presented unless it is important in understanding the test. This third edition includes updated material on tumor markers, Alzheimer's disease markers, markers for pre-eclampsia, additional drugs for which therapeutic monitoring is available, and biomarkers for ethanol abuse, among others. The comprehensive toolkit is the result of more than 40 years of teaching an introductory course in clinical chemistry to second-year medical students at the University of California San Diego. Elements of this book have also been used in teaching UC San Diego clinical laboratory scientist training program students, pharmacy students, clinical chemistry postdoctoral fellows, and pathology residents. This work has been previously published in two editions (2017 and 2021) by the American Society for Clinical Pathology (ASCP) Press under the title “Practical Laboratory Diagnosis of Disease: Clinical Chemistry.”

This book reviews the etiology of major zoonotic diseases, their impact on human health, and control mechanisms for better management. It also examines factors influencing transmission, diagnosis, treatment, management, and prevention of zoonotic diseases caused by different human pathogens, including bacteria, viruses, fungi, protozoans, and parasites. It also introduces zoonoses with a wildlife reservoir and discusses different transmission modes, and factors that influence the epidemiology of zoonoses. It further discusses the holistic strategies for the cost-effective prevention and control of these zoonoses. Towards the end, the book also discusses infections that have spread from non-human primates to humans and strategies to improve disease control and elimination. This book is very useful for students, academicians, and researchers of veterinary sciences, veterinary medicine, and, veterinary public health.

Offering rapid, portable access to key concepts and principles of pathology from Robbins and Cotran Pathologic Basis of Disease, 10th Edition, this up-to-date Pocket Companion makes it easy to locate essential information on the go. The condensed, at-a-glance format, organized to parallel the parent text, is ideal for quick review—anytime, anywhere. - Features cutting-edge information on important topics such as novel therapies for hepatitis C, personalized medicine, the role of microbiome and metabolome in non-communicable disease, and much more. - Includes new gross and microscopic figures for clarity of morphology and new artwork depicting the latest advances in molecular pathogenesis of cancers. - Reflects updated page references and content changes found in to Robbins and Cotran Pathologic Basis of Disease, 10th Edition. - Contains all the key data and principles needed for the USMLE Step 1, in-course exams, and rotations.

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. - Presents updated chapters on systems toxicologic pathology, including new chapter on olfactory - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions to highlight difficult concepts with clear illustrations

This book brings together the expertise of nationally renowned radiologists and pathologists in resolving difficult breast lesions detected on imaging. While there are several separate resources available for radiology residents to study imaging modalities, there are few if any books that illustrate simultaneous radiology pathology correlates. This text will be a useful reference for residents, fellows, and practicing attendings in both disciplines. As the two disciplines of radiology and pathology are interrelated, the scope of the book is to provide and inform readers of not only typical examples of breast lesions that correlate with imaging findings that may or may not require surgical excision but also to resolve problematic lesions that are discordant with imaging findings. This book contains 14 chapters containing hundreds of images supplemented with key references. These chapters include outlines with systematic approaches to each disease entity punctuated by various imaging techniques, key diagnostic points seen on imaging, and pathology followed by differential diagnostic considerations. Finally, a summary of concordant and discordant findings is provided at the end of each section. Written by experts in the fields of radiology and pathology, as well as surgical colleagues that manage patients with breast diseases, Radiology Pathology Correlations of Breast Lesions serves as an easy-to-use reference for radiology and pathology residents and fellows, as well as practicing pathologists and radiologists. This book integrates the radiologic and pathologic appearance of relatively common breast lesions side-by-side with easy-to-understand descriptions and illustrations.

The field of forensic pathology has progressed from its roots in antiquity, with the first documented medicolegal autopsy being performed on Julius Caesar following his murder, to modern day, where it includes molecular autopsy and post-mortem imaging. This evolving field of medicine excites the imaginations of the public, media and physicians. This book provides a comprehensive, state-of-the-art review of this field and contributes to areas that are largely ignored by forensic pathology textbooks. These topics include: death investigation bioethics, principles of courtroom testimony, and the negative medicolegal autopsy.Forensic Pathology serves as a very useful guide for practicing pathologists, trainees, forensic nurses, and clinicians, as well as lawyers, judges and police with an interest in forensic pathology. This book functions as a concise and comprehensive summary of the current status of the field of forensic pathology.

Antimicrobial resistance (AMR) is increasing globally at an incredible rate, and many infectious diseases have already reached an alarming stage of resistance to existing treatments. WHO reports that nearly1.27 million people currently die each year due to resistant infections, and AMR is projected to account for 10 million annual deaths globally by 2050. There is an urgent need for novel approaches to address this issue. Omics technologies are powerful research tools used extensively to study pathogen biology and the activity of microbial agents. These tools, paired with systems biology approaches, can provide novel insights into antimicrobial susceptibility and resistance, and aid in the development of new, more effective measures to combat resistant pathogens. This book provides a comprehensive overview of omics technologies to study pathogen biology, including proteomics, genomics, transcriptomics, metabolomics, and microbiome analysis, and the role of systems biology in developing strategies to combat resistant pathogens. It addresses environmental reservoirs and mobile genetic agents in AMR, host-pathogen interactions and physiology in the development of resistance, drug repurposing and development, and cutting-edge tools such as machine learning, AI for big data analysis, and genomic surveillance. The final section discusses future perspectives on omics-systems biology in AMR, and identifies opportunities for scientific collaboration in the global fight against antimicrobial resistance. This book serves as a comprehensive and accessible resource for researchers in academia and industry focused on immunology, drug development, biotechnology, and systems biology.

This book offers a comprehensive exploration of malaria, a life-threatening disease affecting millions globally, with a focus on the parasitic organisms of the genus Plasmodium that cause it. It discusses the challenges posed by the disease, especially in economically developing regions, and delves into the biology and pathophysiology of the Plasmodium species, including their genetic flexibility and resistance to treatments. Special attention is given to P. falciparum, the most dangerous of these parasites, detailing its complex life cycle, interaction with human hosts, and the severe clinical manifestations it can induce. The book further explores the global health concern of antimalarial drug resistance, highlighting the WHO's efforts in combating the disease and the necessity for novel treatments. Innovative research directions, such as targeting the unique organelles of Plasmodium like the apicoplast and employing proteasome inhibitors, are thoroughly examined as potential strategies in the development of new antimalarial drugs. Additionally, it addresses the critical role of the hemoglobin digestion process in the parasite's lifecycle, presenting it as a promising target for therapeutic intervention. This work is an essential resource for researchers, clinicians, and policymakers involved in malaria control and drug development, providing insights into the current challenges and future directions in the fight against this endemic disease.

This Springer essential explains the theoretical foundations for knowledge-based interpretation of medical laboratory data. Self-organization of biological structure, non-linear dynamics of complex systems and immunological network theories make it possible to describe pathomechanisms and diagnostics, especially of chronic diseases, as an expression of a phenotypic biology and to develop concepts for causal therapies.The book shows how CSF diagnostics with a diagnostic report integrating all laboratory data can identify disease-typical patterns for the differential diagnosis of bacterial, viral, parasitic, oncological, chronic inflammatory, autoimmunological and psychiatric diseases. A CSF app is provided as a tutorial program.The translation from German was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

Written by experts in the field, Precision Molecular Pathology of Aggressive B-Cell Lymphomas contains the most recent revisions from the 5th Edition WHO and 2022 International Consensus Classification diagnostic categories and serves as an important resource for trainees, pathologists, haematologist/oncologists, other clinicians involved in lymphoma care and lymphoma researchers. It provides a comprehensive yet concise synthesis of emerging molecular advances that inform patient care and improve understanding of disease mechanisms. In addition, it provides the necessary background to how molecular techniques are performed to enable the reader to better interpret and critically evaluate relevant and emerging data. As part of the Molecular Pathology Library series, this book focuses specifically on aggressive B-cell lymphomas given the increasing relevance of molecular data for diagnosis and treatment of these disorders. This evidence-based text contains 25 chapters and is divided into 5 parts. Part 1 provides a brief history and background of aggressive B-cell lymphomas. Landmark events in their classification and treatment are given in order to place the substantial advances in the field in context. Part 2 reviews molecular pathology methods, including the increasing use of next generation sequencing techniques in clinical practice. Parts 3 and 4 focus on individual subtypes of aggressive B-cell lymphoma, including a summary of the diagnostic criteria and key pathologic and clinical features for each entity. Finally, Part 5 focuses on emerging molecular technologies that may significantly impact clinical practice.

According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease, strokes, and headaches. Neurological disorders also include brain injuries, neuroinfections, multiple sclerosis and Parkinson disease. A Review on Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics covers the major topics related to neurological disorders, current challenges in diagnosis and intervention. This book is organized into four distinct sections, starting with an introduction, providing a general overview of the epidemiology of neurological disorders, pathogenesis and management. The second section presents the aspects of brain diseases due to infection of bacteria, parasite, fungus and viruses. The third section discusses neurodegenerative disorders due to comorbid factors like diabetes, hypertension, hyperlipidemia and post traumatic brain injuries. The last section covers prevention through application of bioactive compounds and neuroprotective agents. - Epidemiology of neurological disorders and pathogenesis. - Explores neuroinflammation, ligand-receptors binding, and neurodegeneration. - Discusses aging and associated disorders in the onset of neurological disorders. - Neuropharmacology and the protective role of bioactive compounds in neuroprotection.

A full-color, easy-to-understand introduction to anatomy, physiology, and pathology that's designed to provide a comprehensive understanding of the human body without overwhelming readers.Anatomy, Physiology, and Pathology is the ideal introduction on the topic for students of complementary and physical therapies. Designed for ease of learning both as an independent study resource and in the classroom, this textbook is suitable for anyone requiring detailed knowledge of these subjects and has been adopted by colleges worldwide.Author and therapist Ruth Hull provides a thorough understanding of anatomy, physiology, and pathology with clear, accessible language and helpful learning tools. It's designed for easy comprehension, with more than 300 clearly labeled color images; flow charts, diagrams, and tables to help visualize complex ideas; study tips; practice questions in each chapter; and more.Chapters outline the following systems:Skin, hair, and nailsSkeletal, muscular, and nervous systemsEndocrine and respiratory systemsCardiovascular, lymphatic, and immune systemsDigestive systemUrinary systemReproductive systemThis book also serves as an effective refresher for current healthcare and bodywork professionals.

Understand and diagnose pathologies of the bladder with this essential reference With emphasis on the scientific validation of current diagnostic methods and their direct application in clinical practice, Bladder Pathology is a cutting-edge resource that offers contemporary, comprehensive, and evidence-based practice information for pathologists, urologists, oncologists, and other medical professionals. Readers of the second edition of Bladder Pathology will also find: Detailed discussion of bladder anatomy, benign and malignant conditions, treatment effects, and much moreAn evidence-based approach to diagnosis and patient management in specific clinical settingsOver one thousand lavish color illustrations to aid in diagnosis and treatment planning Fully updated to reflect the latest research and evidence, Bladder Pathology is an indispensable resource for pathologists, urologists, and other clinicians.

•Competency-based curricular changes recommended by NMC incorporated as core/must-know, and non-core/desirable-to-know and their corresponding new assessment methods included. •Updated text in academic and diagnostic pathology includes current definitions, additional causes, contemporary mechanisms, up-to-date international classifications of diseases (including WHO classifications of neoplasms, 5th edition) and modern approach to diagnosis and prognosis, in a simple, lucid, easily understandable and reproducible, user-friendly format. •Newer content includes a new chapter on ‘Blood Banking and Transfusion'and another on ‘Clinical Pathology'incorporated in Appendix I along with Basic Diagnostic Cytology. Pathology of COVID-19 and its impact on different organ-systems incorporated in different chapters. •Labelled gross and photomicrographs of high quality and better resolution added and amended, many of these were generously contributed by Prof Ivan Damjanov in previous edition, several schematic illustrations updated and amended. •New tables added at several places for enhanced learning. •Key points as gist at the end of every topic in bulleted points for a rapid revision of the subject in an ultra-short time. •Chapter orientation paragraph given at the beginning of every chapter to peek through the entire chapter and meant to aid the user in systematic and organised learning. •Revised companion book prepared exclusively on the pattern of competencies/outcomes as recommended by the NMC is given for free to the user of the textbook for a quick review of the subject. •Complimentary online learning resource includes high-yield questions (long-answer type, short-answer type, MCQs, clinical scenario-based and image-based) and clinical cases along with key and explanatory notes. •Cheers! No overburdening!! With all these additions and insertions, girth of the book remains unaltered, care having been taken not to overburden the already stressed students.

Ten years have elapsed since the printing of the second edition of this book. Since then there's been a veritable explosion of information coming mainly from the field of molecular diagnostics, which bear particular importance in the classification and treatment of Infantile enteropathies, disorders associated with immunodeficiencies, the classification of intestinal polyps and polyposis syndromes in childhood, cholestatic and metabolic disorders of childhood, liver tumors and transplantation pathology, all of which were major subjects explored in our previous editions. In this updated third edition, most of the chapters have been extensively revised to incorporate updated understanding in pathogenesis and terminology. For example, the widespread use of genetic panels and next generation sequencing in the diagnosis of cholestatic disorders of infancy and childhood, not widely available when the last edition was being prepared, prompted the writing of an entirely new chapter reflecting these advances by a new set of authors. Similarly, progress in diagnosis and classification of liver tumors justified an entirely new chapter on liver tumors that incorporates newer patient stratification in treatment protocols and reflects the new WHO classification of liver tumors. Pathology of Pediatric Gastrointestinal and Liver Disease 3rd Edition provides the pediatric pathologist, the GI or general pathologist, and the pediatric gastroenterologist with the most complete and current reference on the subject. It includes in-depth discussions on disorders and issues that are frequently encountered but for which up-to-date information is often not readily available, as well as infrequent disorders unique or specific to children that are not covered in standard texts.

This book covers the full scope of fundamental oral and maxillofacial surgery, while supporting readers to focus on the essential information and disorders which are the most common, or have significant implications for modern clinical practice. It presents an overview of the most common clinical presentations, physical examination findings, diagnostic tools, complications, treatments, and discussions of differential diagnosis and related issues. Detailed illustrations including clinical photographs, radiological images and pathological slides provide a visual guide to conditions, techniques, diagnoses and key concepts. The most current clinical information also cover the minor and major complications which may occur in all facets of oral maxillofacial surgery. Readers can focus on the prompt recognition of each diagnosis, and consider differential diagnosis as well as precise management strategies in preventing complication and relapse. Case-based approach discussion can actively engage and raise the reader interest and retention of the information. Overall, the book provides a uniquely contemporary approach, reflecting the exciting developments of technique and instrumentation within this surgical field, built on technical innovation and state-of-art clinical practice. It is a readable resource, identifying commonalities and shedding light on controversies through reasoned discussion and balanced presentation of the evidence.

The current technology and its applications in flow cytometry are presented in this comprehensive reference work. Described in explicit detail are the instrumentation and its components, and applications of the technology in cell biology, immunology, pharmacology, genetics, hematology and clinical medicine. Methods for data analysis, including both hardware and software, and explicit experimental techniques for making specific measurements are presented.Material is divided by topic into two volumes: Volume I covers instrumentation, genetics, and cell structure; Volume II contains material on cell function studies by flow cytometry.This reference is essential for both the novice and the experienced investigator using flow cytometry in research, and for students of cell biology, biomedical engineering, and medical technology.

This book is an accessible, evidence-based, succinct and practical reference for those providing hands-on care to patients with acute pancreatitis. It represents the most updated results of clinical science and offers the frameworks that underpin the disease and its management. The first part of the book presents the latest clinical science and illustrates a clear indication of what is known, and what are the gaps in our understanding of the disease. The second part provides practical clinical management guidelines. The chapters are designed to bring recommendations, practical points to facilitate navigation, easy access of knowledge, and highlights key decision points and options.Acute Pancreatitis - A Practical Guide for Clinicians is relevant to not only clinicians involved in patient care but medical, nursing and dietitian students, surgical and gastroenterology researchers, companies and agencies. The book comprehensively covers acute pancreatitis, associating it with local pancreatic complications, systemic inflammation and organ failures, also providing management algorithms. This practical reference book is an introduction to disease management, indicating why topics addressed in each chapter are essential, providing valuable guidance for day-to-day treatment by professionals globally.

This book describes the pathologic conditions of drug-induced lung injuries, monitoring strategies, and guides on how to interpret the evidence. It also dives into particular drugs that caused the disorder, such as EGFR inhibitors, anti-EGFR antibodies, mTOR inhibitors, proteasome inhibitors, immune checkpoint inhibitors, neoangiogenesis inhibitors, and other molecular targeted drugs. It outlines the analysis and interpretation of the post-marketing survey on surveillance of each drug for inducing pulmonary lesions presenting diffuse haziness. The data and analysis from this survey are valuable since a guideline is yet to be established due to limited clinical evidence and cases. As new drugs are developed, establishing treatment and event management is crucial. Thus, Drug-induced Pulmonary Disorder in Medical Oncology - Expert Opinion to Decipher Big Data summarizes the accumulated information to provide a foundation for further research advancement. The book offers a refreshing alternative to current approaches to medical oncology and respiratory diseases professionals and will also attract medical affairs members in global pharmaceutical companies.

This encyclopedia volume covers the complete field of gynecologic pathology – from Abnormal Villous Lesions to WHO Classification of Tumors of the Vulva. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Understanding Kidney Diseases makes accessible a medical specialty that is commonly regarded by students as difficult. The target audience is undergraduate and non-specialist postgraduate students. The book is unique in combining the reference material normally found in a nephrology textbook with the everyday clinical applicability of a medical handbook. The chapters are structured on the approach that a clinician should take when assessing someone with a possible kidney problem. The factual content is brought to life by over 60 case studies and is illustrated by a high density of figures, many displaying information in a graphical form that avoids off-putting data and text. It is an authored book, written in a consistent style that is deliberately clear, concise and easy to follow. Nonetheless, it is referenced in as much detail as would be expected in a conventional textbook. It explains principles and concepts that help students understand and interpret clinical problems. No other textbook of nephrology combines these features. The book emphasises a patient-centred approach to practice. Students'knowledge can be put it into practice by answering a bank of questions that patients frequently ask, and tested against traditional multiple-choice questions. In summary, Understanding Kidney Diseases gives students confidence in helping someone with a kidney problem. Praised by leading nephrologists, it is the book the authors wish they could have read when they were students.

This textbook is a step-by-step, at the bench, real-world approach to grossing a wide variety of surgical cases. Each figure is produced directly from the bench during the grossing process with the associated dictation. These specimens contain the imperfections of real-life cases with ample illustrations drawn by renown medical illustrationist Kyle Cunningham. This book is not a bullet-point list of what to do but rather a step-by-step, illustrated approach to grossing each specimen. This manual can be utilized at the bench with any specimen at any time. Key features include step-by-step photographic documentation of optimal methods for handling gross specimens commonly seen in the pathology laboratory, medical illustrations that highlight key anatomic features, and tips and tricks to produce optimal diagnostic sections for pathologic diagnosis. Each chapter also includes multiple choice questions to help apply the knowledge and skills learned in the readings. This text is not just a reference manual. It is a deliberative teaching manual meant to be taken into the lab and used at the bench providing consultative support. The text is specifically focused on pathology residents learning grossing skills when no one is around to answer questions. Currently, there are four main surgical grossing texts on the market. Those texts contain drawings and characterizations of the perfect organ and a list of sections needed for each specimen. These books do not focus on the methodology for taking the most appropriate sections with a focus on handling imperfect specimens. Manual of Pathologic Grossing is the only text that includes photographs of each step in the grossing process. The photos are accompanied by a step-by-step text of demonstrating how and why each section was taken.

This book introduces the basic knowledge about pathologic anatomy, which covers the the etiology, pathogenesis, pathological changes and outcomes of diseases. It will help the student to understand and master the nature of various diseases and the theories in occurrence and development.This book consists of 18 chapters, including 6 chapters in general pathology and 12 chapters in systematic anatomy. In each chapter, it starts from the most important ‘Key Concepts'to learn, which will guide the student during the learning stage and review stage.This book is a useful textbook for graduate and undergraduate students in medical schools, including MBBS (Bachelor of Medicine and Bachelor of Surgery) student.