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Chronic rhinosinusitis (CRS) is one of the most common health care complaints, with the prevalence of 5-12% worldwide. This book aims to present the new findings in mechanism, diagnosis and management of this widespread condition to clinical practitioners. All practical information about CRS is compiled; therefore busy clinicians would not have to perform exhaustive literature studies to diagnose CRS.This book firstly presents the advances in the understanding of epidemiology, genetics, mechanisms, phenotypes, and immunology of this disorder. In the following chapters, details in clinical diagnosis of CRS are summarized, especially clinical characteristics in paediatric CRS. Later chapters introduce medical, surgical, and innovative treatments of CRS, with brief case studies. The role of allergies, asthma, allergic fungal rhinosinusitis, and systemic diseases are also discussed. With the illustrative figures, this book is a comprehensive and quick reference to otolaryngologists, paediatricians, family care physicians, allergists, professional clinical staff, and medical students.

This issue of Otolaryngologic Clinics, guest edited by Drs. Abtin Tabaee and Edward D. McCoul, is devoted to Refractory Chronic Rhinosinusitis. Articles in this issue include: Classification of Chronic Rhinosinusitis: Working Towards Personalized Diagnosis; Bacterial Pathogens and the Microbiome; Biofilm and Osteitis; Refractory Chronic Sinusitis with Polyposis; Aspirin-Exacerbated Respiratory Disease; Systemic and Odontogenic Etiologies in Chronic Rhinosinusitis; Genetic and Immune Dysregulation in Chronic Rhinosinusitis; Office Procedures in Refractory Chronic Rhinosinusitis; Topical Therapies and Stents; Revision Functional Endoscopic Sinus Surgery; Extended Endoscopic and Open Sinus Surgery for Refractory Chronic Rhinosinusitis; and An Algorithm for Comprehensive Evaluation and Management of Refractory Chronic Rhinosinusitis.

This volume will serve as a comprehensive and useful guide for ENT physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text will serve to expand management options to physicians already operating on sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.

Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a heterogeneous disease that impacts a significant portion of the population. Specific subtypes of the disease include cystic fibrosis, allergic fungal sinusitis, and aspirin-exacerbated respiratory disease. Unfortunately, the majority of patients with CRSwNP do not fall within one of these subtypes, and have variable responses to medical and surgical treatment. There are rapidly evolving theories describing the etiology of CRSwNP that involve alterations in innate immunity, acquired dysfunction of respiratory epithelial cells, and external or environmental factors. This book provides a comprehensive update on the latest theories on the etiology of CRSwNP as well as a review of innovative and effective medical and surgical therapies. Special thanks go to D.W. Kennedy, Philadelphia, Pa., for contributing the foreword. Otorhinolaryngologists and allergologists, as well as other physicians and medical providers treating patients with CRSwNP, will find this volume to be an indispensable source of current information.

Incidence of invasive fungal sinusitis has been increasing over the years. The understanding of its pathophysiology has improved with newer serological tests and diagnostic methods helping in earlier diagnosis and reducing patient morbidity. It was believed earlier that invasive fungal sinusitis is seen only in immune compromised patients but clinical reports suggest otherwise. More anti-fungal drugs are being added to improve incidence of patient survival. This book aims to compile all practical information about invasive fungal sinusitis into a single volume. Therefore, busy clinicians would not have to perform exhaustive literature studies to diagnose invasive fungal sinusitis. The book aims to provide an overview of diseases which could be mistaken for invasive fungal sinusitis and discuss how the management is different. Book sections consist of clinical, microbiological, serological, pathological, radiological and pharmacological features of the disease and its management. Each section is important in today's context as it dynamically alters the management of the patient. Early clinical suspicion and rapid microbiological, pathological and radiological diagnosis with aggressive treatment with surgical debridement and medical therapy leads to favorable outcomes.

Chronic rhinosinusitis is a widely prevalent condition globally as well as in India. The chronicity of the condition and its multifactorial origin makes the detection of the underlying mechanism of the disease difficult to detect and renders the management challenging. This clinical update handbook put together by the eminent exponents of otolaryngology in India aims to simplify this elusive condition for the benefit of all practitioners involved in the management of this disease. The first chapter highlights socio-economic burden and the impact of this disease on the health related quality of life. The second chapter describes the underlying mechanisms involved in development of the disease. The third chapter showcases the various diagnostic modalities used to detect the disease, differentiate it from other similar conditions and assess its severity. The fourth chapter gives a very succinent overview of the various management modalities. The fifth chapter encapsulates the medical treatment and the sixth offers a lucid description of the latest surgical techniques for this disease. The seventh chapter deals with the other associated conditions that can confuse, complicate or impact the management of the disease as well as affect its prognosis. The eighth chapter describes fungal rhinosinusitis, which is of special importance because of its high prevalence in India.

Now in its fourth edition, this comprehensive handbook features a unique approach—co-authors who specialize in different but companion aspects of treating sinusitis, the most prevalent infection in humans, which affects nearly 25% of the US population.