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The complex area of ocular oncology requires adaptable approaches to treatment depending on the type and anatomical region of the tumor, tumor characteristics, the patient's age, co-morbidities, and response to first-line treatment. Through the use of practical, case-based content, Clinical Cases in Ocular Oncology helps you familiarize yourself with clinical decision making in this challenging field, providing expert guidance on diagnosis, management, and treatment planning. - Includes 66 cases covering a range of patient presentations and scenarios that mirror day-to-day practice. - Covers a variety of ophthalmic tumors, including intraocular melanoma, lymphoma of the eye, retinoblastoma, conjunctiva, choroidal melanoma, squamous cell carcinoma, lacrimal gland tumors, and tumors of the eyelid. - Presents each case in an easy-to-read, templated format covering an overview of patient history, questions to ask, assessment, differential diagnosis, multimodal testing and results, management, follow-up care, and key points. - Provides outstanding visual guidance with numerous pathology slides and clinical photos, as well as current diagnostic imaging modalities such as optical coherence tomography (OCT), ultrasound, fluorescein angiography (FA), and indocyanine green angiography (ICG). - Features diagnostic and management algorithms that assist in differential diagnosis and decision making for even the most complex cases.

This new edition elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. This new edition is updated throughout and includes several new chapters, including: palliative radiation therapy for leptomeningeal disease, preoperative treatment for brain metastases, advanced neuroimaging for brain tumors, and MR-LINAC for brain tumors. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

This book offers an overview of the biological basis of 26 different solid cancers for scientists and oncologists to understand the clinical challenges. The book provides a quick, simplified, and updated review of the present genetic or genomic medicine era. With genetic and molecular details to enhance understanding of biological mechanisms underlying disease pathogenesis and treatment response, each chapter covers epidemiology, risk factors, classification, pathophysiology, genetics, and treatment of solid cancers. This book is a beginner's guide for life sciences and medicine graduate students, fellows in training, biomedical sciences researchers, principal investigators, clinician-researchers and oncologists.

The Ultimate OCN Exam Prep Toolkit: Comprehensive Study Guide and Practice Question Bank is your all-in-one resource for mastering the Oncology Certified Nurse (OCN) exam. This essential toolkit provides a thorough and detailed study guide covering all exam topics, along with over 1,000 practice questions complete with detailed rationales to reinforce your understanding and test your knowledge. Key features include: Extensive Coverage of All OCN Exam Topics: Comprehensive chapters that delve into cancer biology, treatment modalities, symptom management, and more. 1,000+ Practice Questions: Test your knowledge with a vast bank of practice questions, each accompanied by detailed explanations to enhance learning. Interactive Study Planner and Progress Tracker: Customize your study schedule, set goals, and track your progress with tools designed to fit your learning style. Expert Tips and Strategies: Benefit from the wisdom and insights of OCN-certified professionals, including study strategies, exam-day tips, and personal anecdotes to keep you motivated and on track. If you're a seasoned oncology nurse or new to the field, this guide is designed to provide the knowledge, tools, and confidence you need to excel on the OCN exam and advance your career in oncology nursing.

Precision pathology of cancer is a new frontier - a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer. Covers both the conceptual bases and the clinical applications Enables pathologists, haematologists, and medical oncologists to apply Precision Pathology to their daily clinical practice Covers the whole range of cancers in practical detail

This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particularinterest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.

Das Buch Umfassender Überblick zu Tumorentitäten und Behandlungskonzepten. -Klassifikation, Klinik, Diagnostik -aktuelle, evidenzgesicherte Behandlungskonzepte -Empfehlungen und gängige Therapieschemata -Onkologische Notfälle, Supportivmaßnahmen und Palliativmedizin -Medikamentenübersicht Verfasst von interdisziplinären Autorenteams. Mit evidenzbasierten Handlungsempfehlungen. Für die tägliche Arbeit in Praxis und Klinik - für konzentrierten Überblick und zum Selbststudium. Online-Version Die Online-Version des Taschenbuchs Hämatologie und Onkologie ist unter www.onkologie2024.de zugänglich.

Renowned experts in the neuro-oncological field bring their expertise together for Neuro-Oncology Compendium for the Boards and Clinical Practice. This volume reviews the core topics of neuro-oncology including adult and pediatric neuro-oncology, management, central nervous system tumor complications, genetic considerations, and more. With a focus on updated treatments and terminology, this volume is designed to comprehensively review all major facets of neuro-oncology so that physicians-in-training may prepare for the board review and practicing specialists can stay up to date in their treatment of patients. This essential text includes hundreds of figures and tables, succinct review flashcards, end-of-chapter questions and answers, as well as end-of-volume exams so readers can review and test their own comprehension. Each chapter has been reviewed by the editors to ensure cohesive board-level verbiage, emphasizing practical clinical knowledge. Neuro-Oncology Compendium for the Boards and Clinical Practice is up-to-date and comprehensive, eliminating the need for multiple sources of study. Key features of this volume include: -End of chapter flashcards to summarize key content -End of chapter Questions and Answers for review -Practice exams to simulate board questions -Updated terminology and practices -Complimentary images and tables to support learning

Malignome des Kopf-Halsbereichs sind eine heterogene Gruppe bösartiger Tumoren, deren Diagnostik und Therapie ein inter- und multidisziplinäres Konzept erfordern. Ein Team unter anderem bestehend aus Mund-, Kiefer-, Gesichtschirurgen, Hals-Nasen-Ohren-Ärzten, Dermatologen, Onkologen, Strahlentherapeuten, Radiologen, Nuklearmedizinern, Pathologen, Zahnärzten, onkologischen Pflegefachkräften, Physiotherapeuten, Ernährungsberatern und Psychologen sind für die krankheitsgerechte Betreuung der Patienten zuständig.

The book covers all aspects of thyroid and parathyroid surgery, including history and examination, pre-operative workup, and how ancillary specialties like pathology, radiology, radiotherapy, and nuclear medicine impact the outcome of thyroid and parathyroid patients. It offers a step-by-step approach to help the readers manage their cases in their practice. It includes numerous color photographs, anatomical and operative line diagrams for easy understanding. Chapters include flow charts explaining the case management and the decision-making process. The book serves as a valuable resource to endocrine surgeons, general surgeons, endocrinologists, and internists. It also serves as reference material for the exit examination of masters of surgery and the super specialty entrance and exit exam for endocrine surgery. Additionally, it helps consultants and postgraduate students of radiology, pathology, nuclear medicine, and radiotherapy.

This is an open access book.With a wealth of exciting data emerging in this rapidly evolving field this book will review the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches. In addition different disease situations are addressed including different treatment approaches in primary disease and in recurrent and/or metastatic disease as well as new developments in pathology, surgery and reconstruction techniques, new systemic therapies in salivary gland cancer, and supportive care and follow-up.All disciplines involved in the treatment of head & neck cancer are covered with a focus on translation into daily practice. The 8th-THNO is designed for medical oncologists, head and neck surgeons, radiation oncologists, otolaryngologists, and other medical professionals involved in the treatment of patients with head and neck cancer.

CANCER CONSULT New edition covering the specialties of hematology, oncology and cellular therapy, now in two volumes Cancer Consult: Expertise in Clinical Practice, Volume 1: Solid Tumors & Supportive Care, Second Edition includes hundreds of answers to practice-based questions covering the new principles of diagnosis, classification, staging, treatment, and outcomes in the rapidly advancing field of cancer. This textbook series also provides expert guidance in the areas of cancer-related uncertainties and controversies, including experience-based discussions. The book's smaller size allows for easy access during medical rounds. This volume also includes: Up-to-date, clinically relevant information on the very latest topics such as molecular techniques, targeted therapies, immunotherapy, cellular therapy and translational cancer research Sections on head, neck, thoracic, breast, GI, genitourinary, skin, gynecological and hereditary cancers, amongst other topics Streamlined, engaging content to make finding information easier and less time consuming for the reader Concise and practical expert perspectives that reference key studies References to the latest NCCN, ESMO, ASCO, and other national guidelines With its powerful focus on pragmatic clinical diagnostic, therapeutic and prognostic approaches, Cancer Consult: Expertise in Clinical Practice, Volume 1: Solid Tumors & Supportive Care, Second Edition will help keep hematology, oncology and cellular therapy practitioners up-to-date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base. It also offers clinicians, trainees, and fellows an excellent opportunity to enhance their preparation for the ABIM, hematology and oncology fellowship and recertification exams.

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.

The purpose of this book is to outline the topics that are critical in the dermatological approach to patients with cancer. This purpose will be accomplished by discussing the value of a multidisciplinary approach, and case examples will be used, including some from the Hospital Sírio-Libanês, a pioneering institution in the treatment of cancer. In all, the book will present and discuss the best global evidence for the dermatologic care of patients with cancer, skin cancer, and solid organ- and bone-marrow-transplanted patients. The clinical, surgical, pathologic, imaging, radiotherapy, oncology and palliative care aspects of the dermatologic care of cancer patients will be covered. The book will also discuss subjects such as genetics, biology, evidence-based medicine, and new diagnostic methods and tools such as dermoscopy and confocal microscopy. Chapters will be based on the following key areas: educating clinicians on how to prevent skin cancer in patients, screening and counseling, diagnosis and treatment of pigmented lesions, melanoma and nonmelanoma skin cancer, cutaneous lymphomas, sarcomas, leukemic and lymphomatous infiltrations, cutaneous metastases, cutaneous paraneoplasic manifestations and cutaneous adverse reactions to chemotherapy and radiation treatment. The primary audiences are dermatologists, oncologists, radioncologists and oncologic surgeons. The secondary audience is residents in these fields. The goal is to prepare and update all specialists on this important clinical and research area.

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Covering all aspects of CNS tumors pathology, this book provides complete information on tumors of the brain and its coverings, sellar region, pineal region, and cranial and paraspinal nerves according to 2021 WHO classification, 5th edition, including new entities, as well as benign cysts and nonneoplastic disorders that are potentially misinterpreted as neoplasms. Throughout the book, emphasis has been placed on histopathologic characteristics and differential diagnosis, which are summarized in tables to make the explanation of certain topics clearer.This valuable text also includes the most recent clinical, pathological, histological, cytological, and molecular knowledge in the field, enabling pathologists to arrive at the correct diagnosis and prepare actionable, useful reports. Since pathology is one of the most visually oriented medical specialties, the myriad of annotated images throughout has been evaluated carefully and include neuroimaging studies, histology, cytology, and immunohistochemical stains that support a morphologic discussion in which differential diagnosis and potential pitfalls are emphasized. Central Nervous System Tumors: Diagnostic Pathology provides a comprehensive guide of the current critical information needed to recognize, understand, and interpret this demanding field of surgical neuropathology. It is designed with the needs of practicing surgical pathologists, pathologists-in training, and clinicians in mind.

This book serves as a hands-on reference for practitioners specializing in oncology, general physicians, medical students and residents engaged at the point of care or'battleground.'The book contains 64 chapters divided into 14 sections, each focusing on individual diseases that are frequently or occasionally encountered in the geographic locations observed (Central and South America, along with the Caribbean). The role of multidisciplinary care is concisely yet thoroughly discussed, including the role of diagnostic physicians (such as pathologists and radiologists), as well as treating physicians including medical, surgical, and radiation oncologists. Attention guidelines for specific cancer entities are likewise developed, including the assessment of oncology care priorities in the context of specific diseases when resources may be scarce. Among many important changes, this third edition includes a brand-new section (Section XIV) proposing training procedures targeted to various roles involved in patient care. There are dedicated chapters for main physician specialties involved in cancer treatment (oncologist, radiologist, surgeon, etc.), presenting an integral starting point to steer and support newly-minted professionals and seasoned physicians alike. This new edition also includes major updates in other areas, and some passages have been revised and reorganized for better comprehension.

The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address'where do we go from here'and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.

Since the first edition of this book in 2012, the field of molecular pathology has expanded exponentially. The advent of complete cancer genome sequencing, new diagnostic molecular tests, and biomarkers for targeted therapy and immunotherapy have demonstrated the importance of molecular tools both in patient care and in the practice of pathology. Furthermore, the development of many new molecular technologies has revolutionized the practice of modern pathology. The rapid growth of this field has led to an expansion of knowledge of molecular processes and many more clinical applications in our daily practice of surgical pathology. Thus, this updated second edition of Molecular Surgical Pathology aims to serve as the best available “quick reference” for pathologists, oncologists, geneticists, primary care physicians, and other medical professionals with an interest in this specialty. Molecular Surgical Pathology 2nd Edition focuses on the practical utility of molecular techniques and on molecular biomarkers for the practicing surgical pathologist. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis, as well as its implications for patient management and personalized care. This concise overview of molecular surgical pathology and molecular classification of tumors of different organ sites will help not only practicing physicians, but also those in training, including residents and fellows in various disciplines.

It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes). CTC play a central role in tumor dissemination and metastasis,and have been established as an important evaluative and research tool in advanced cancer, and potentially important in early stage disease. CTC defines tumor cells circulating in blood, while Disseminated Tumor Cells (DTC) refers to tumor cells identified in bone marrow. CTC/DTC are extremely rare events, even in late stage cancer, and their detection has presented enormous technical challenges, with the emergence of multiple technologies developed to address these challenges, including enrichment, identification and sophisticated analytical techniques to evaluate CTC and other cells in circulation that may also be important in the biology of metastasis. As foundational as CTC/DTC has been, the field of liquid biopsy has expanded well beyond these analytes. The relevance of circulating nucleic acids derived from tumor cells has quickly progressed from research to the clinic. There are now well established clinical applications for using ctDNA/RNA to determine therapeutic targets, follow disease progression and detect cancer recurrence long before routine clinical methods. One of the most exciting new areas of work is the possibility of using these circulating tumor derived nucleic acids to detect cancer at its earliest and potentially most curable stages. Another new and burgeoning area is the detection and analysis of ctExosomes. These highly abundant particles which are actively secreted from tumor (and indeed all) cells represent a novel way to detect and define multiple analytes of importance, including proteins, DNA and meDNA, RNA, miRNA, and other cell components that are protected and preserved in these compact structures. This second edition of Circulating Tumor Cells: Advances in Liquid Biopsy Technologies is entirely new and brings together leaders and innovators in the field of liquid biopsy, including basic and molecular biologists, chemists, engineers, statisticians, experts in tumor banking, test developers, research administrators and clinicians. A special feature of this book is that it includes chapters from the members of the US National Cancer Institute Liquid Biopsy Consortium. This edition also includes many of the participants of the latest international meeting on the Advances in Circulating Tumor Cells (ACTC) which is held in Greece every two years and gathers the most important liquid biopsy investigators from around the world. Thus, this edition represents the most comprehensive and up-to-date resource for those who want to further explore the exciting field of CTC and other liquid biopsy technologies. The new edition will be useful to a wide audience including scientists studying metastasis, cancer researchers, translational scientists, oncologic surgeons, medical oncologists, members of the biopharmaceutical industry, and graduate and undergraduate students studying cancer biology.

HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology, Holland-Frei Cancer Medicine combines scientific principles with clinical practice. It contains hundreds of full-color illustrations and photographs, tables, graphs, and algorithms that complement and enhance the complex topics discussed within the book. This book is an invaluable clinical tool that provides readers with overview boxes, additional references, and other pedagogic features designed to make the content easy to access and comprehend. Readers will also find: A translational and integrated approach throughout the book that combines cancer biology with cancer management A strong emphasis on multidisciplinary, research-driven patient care that improves outcomes and allows for the optimal use of all clinically appropriate therapies Discussions of the most current personalized cancer care, including molecular diagnostics and therapeutics Perfect for medical oncologists, radiation oncologists, and internists, Holland-Frei Cancer Medicine, Tenth Edition will also earn a place in the libraries of allied health professionals involved in the treatment of cancer patients. This book is published in collaboration with the American Association for Cancer Research: https://www.aacr.org/

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

This popular textbook, now in its third edition, provides a theoretical framework for understanding why cancers arise, how they develop and how they can be treated.Particular attention is devoted to the origins of cancer and the application of evolutionary theory to explain how mutant cell populations tend to expand and spread. Focused on the genes and signaling pathways involved in the most common tumors, Principles of Cancer Genetics is a highly readable account that will be of interest to anyone who would like to attain a basic understanding of cancer biology. Students who have completed introductory coursework in genetics, biology and biochemistry, medical students and medical house staff will find this book to be a useful starting point toward mastery of this complex but fascinating topic. This updated edition delves into the critical interactions between growing tumors and the immune system, and introduces the concepts of T cell activation, immunoediting and immune evasion. Novel strategies for cancer diagnosis and prognosis, including new roles for next-generation sequencing and liquid biopsies, as well as established and emerging therapeutic modalities are now described in detail.For laypersons, students and researchers in other fields with a general interest in cancer, this book provides an accessible overview, enriched with many easy-to-understand illustrations. For advanced students considering future study in the field of oncology and cancer research, this concise book is a useful guide to the basic principles that underlie our understanding of cancer.

This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.

Principles and Practice of Particle Therapy Although radiation has been used therapeutically for over 100 years, the field of radiation oncology is currently in the midst of a renaissance, particularly with regards to the therapeutic use of particles. Over the past several years, access to particle therapy, whether it be proton therapy or other heavy ion therapy, has increased dramatically. Principles and Practice of Particle Therapy is a clinically oriented resource that can be referenced by both experienced clinicians and those who are just beginning their venture into particle therapy. Written by a team with significant experience in the field, topics covered include: Background information related to particle therapy, including the clinically relevant physics, radiobiological, and practical aspects of developing a particle therapy program “Niche” treatments, such as FLASH, BNCT, and GRID therapy The simulation process, target volume delineation, and unique treatment planning considerations for each disease site Less commonly used ions, such as fast neutrons or helium Principles and Practice of Particle Therapy is a go-to reference work for any health professional involved in the rapidly evolving field of particle therapy.

Based on DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology, Eleventh Edition, this comprehensive review book covers the entire specialty of oncology, including new or expanded coverage of molecular biology; epidemiology and etiology; screen and prevention; genetics; clinical trials; and immunotherapy. Inside, readers will discover hundreds of multiple-choice and case-based questions, along with detailed answers and explanations to help explain the how and why behind each correct response. The ideal way to maximize exam scores for today's student and residents! Learning and review features include: Hundreds of multiple-choice and case-based questions to build comprehension and improve retention. All topics cross-referenced to the latest edition of DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, Eleventh Edition. Material on all aspects of oncology, including medical, radiation and surgical oncology, as well as hematology/oncology issues.

Healthcare has long been on a quest for a ‘magic bullet'to cure the dreaded disease cancer. As this book shows, nanoparticles perfectly fit the bill with their promising characteristics. Meticulously engineered nanostructures, with a useful drug or molecule, target a specific cancer in unique ways. However, as with many targeted systems, the effectiveness of the system needs to be weighed against the adverse effects. The toxicity of nanoparticles has been a worldwide concern, and evidence-based medicine analyses nanostructures for proof of safety and their efficacy in killing cancer cells. This book gives a fresh perspective on a wealth of diverse nanotechnological advances for various cancers.

Updated and expanded, this Second Edition of Essentials of Clinical Radiation Oncology continues to provide a succinct and effective review of the most important studies in the field. Organized by disease topic and grouped by body part, each chapter employs structured sections for targeted information retrieval and retention. Chapters begin with a'Quick Hit'overview of each disease summarizing the most significant paradigms before moving into dedicated summaries on epidemiology, risk factors, anatomy, pathology, genetics, screening, clinical presentation, workup, prognostic factors, staging, treatment paradigm, and medical management. An evidence-based question-and-answer section concludes each chapter, which pairs commonly encountered clinical questions with answers connecting historical context and pertinent clinical studies to better inform decision-making and treatment planning. Providing the latest treatment paradigms and guidelines, this comprehensive second edition now outlines the evidence and must-know considerations for using radiation therapy with immunotherapy, the strategies for metastasis-directed therapy for oligometastatic disease, and much more. Written for the practicing radiation oncologist, related practitioner, and radiation oncology resident entering the field, this'one-stop'resource is the go-to reference for everyday practice. Key Features: Structured sections offer high-yield information for targeted review Cites need-to-know clinical studies and treatment guidelines in evidence-based question-and-answer format Each chapter has been reviewed and updated to include the most recent and relevant studies New chapters on spine tumors, thyroid cancer, sinonasal tumors, cholangiocarcinoma, renal cell carcinoma, multiple myeloma and plasmacytoma, miscellaneous pediatric tumors, and treatment of oligometastatic disease from underlying cancers Designed for quick reference with comprehensive tables on treatment options and patient selection, workup, and prognostic factors by disease site Purchase includes digital access for use on most mobile devices or computers

This book serves as a hands-on reference for practitioners specializing in oncology, general physicians, medical students and residents engaged at the point of care or'battleground.'This new edition has been prepared specifically to include important observations and propose attention protocols for cancer patients within the context of the COVID-19 pandemic, as well as general updates to the previously released chapters. The book contains 58 chapters divided into 13 sections, each focusing on individual diseases that are frequently or occasionally encountered in the geographic locations observed (Central and South America, along with the Caribbean). The role of multidisciplinary care is concisely yet thoroughly discussed, including the role of diagnostic physicians (such as pathologists and radiologists), as well as treating physicians including medical, surgical, and radiation oncologists. Attention guidelines for specific cancer entities are likewise developed, including the assessment of oncology care priorities in the context of specific diseases when resources may be scarce.

This book serves as a hands-on reference for practitioners specializing in oncology, general physicians, medical students and residents engaged at the point of care or'battleground.'The book also bridges the critical gap in clinical knowledge over key elements of multidisciplinary cancer care, focusing on malignant diseases of prevalence in Central and South America as well as the Caribbean, a vast and diverse catchment area in which cancer is emerging as a major health challenge on an individual and population-wide basis. The book contains 55 chapters divided into 13 sections, each focusing on individual diseases that are frequently or occasionally encountered in the geographic locations observed. The role of multidisciplinary care is concisely yet thoroughly discussed, including the role of diagnostic physicians (such as pathologists and radiologists), as well as treating physicians including medical, surgical, and radiation oncologists. Attention guidelines for specific cancer entities are likewise developed, including the assessment of oncology care priorities in the context of specific diseases when resources may be scarce.

Metastatic cancer and costly precision medicines generate extremely complex problems of health care justice. Targeted cancer therapies yield only very marginal gains in life expectancy for most patients at very great cost, thereby threatening the just allocation of limited health care resources. Philosophers have high hopes for the utility of their theories of justice in addressing the challenges of resource allocation; however, none of these theories can address adequately the “wicked” ethical problems that have resulted from these targeted therapies. What we need instead, bioethicist Leonard M. Fleck argues, is a political conception of health care justice, following Rawls, and a fair and inclusive process of rational democratic deliberation governed by public reason. His account makes the basic assumption that we have only limited health care resources to meet unlimited health care needs generated by emerging medical technologies. The primary ethical and political virtue of rational democratic deliberation is that it allows citizens to fashion autonomously shared understandings of how to fairly address the complex problems of health care justice generated by precision medicine. While ideally just outcomes are a moral and political impossibility, “wicked” problems can metastasize if rationing decisions are made invisibly--in ways effectively hidden from those affected by those decisions. As Fleck demonstrates, a fair and inclusive process of democratic deliberation could make these “wicked” problems visible, and subject, to public reason.

The book offers a comprehensive overview of all parathyroid gland disorders both, benign and malignant. It emphases established concepts, presents the ongoing controversies, challenges and debates on diagnosis and treatment of different parathyroid gland disorders, with a view of clarifying some uncertainties, making suggestions to resolve others, and establishing strategies to reach therapeutic success.In addition to general information on parathyroid gland embryology, surgical anatomy, histology and physiology, the chapters explore hyperparathyroidism, osteitis fibrosa cystica, hypoparathyroidism, hungry bone syndrome, the importance of calcium in the human body and differential diagnosis of hypercalcemia. The last chapters investigate post-thyroidectomy hypocalcemia, thyroid cancer, recent intra-operative localizing tools, and illustrate new techniques of parathyroidectomy, as well as parathyroid transplantation. The book will be an invaluable and indispensable source of knowledge and reference for all specialists and trainees entrusted with the care of patients suffering from parathyroid disease.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.

This book provides a simple, step-by-step guide to the identification and sequential management of vascular lesions in the body. Since most vascular lesions occur in the head and neck area, the surgical interventions present challenges with regard to facial growth, airway management and reconstruction options. This book explores the treatment of head and neck vascular malformations and tumors from the perspectives of various specialties, such as otolaryngology, and pediatric, maxillofacial and plastic surgery. It covers surgical anatomy, pathophysiology, molecular basis, medical treatment, current embolization guidelines and surgical resection and reconstruction options for each type of tumor. It also discusses interventional and diagnostic radiological techniques. Written by leading international specialists, the book is a valuable resource for craniofacial, pediatric, maxillofacial, head and neck, and plastic surgeons as well as pediatricians and otolaryngologists.

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

This book provides clinicians, clinicians-in-training and researchers with a unique rapid-access educational resource on the spectrum of issues at the intersection of skin and malignancy. In it, there is clinical detail provided on how the skin reveals systemic malignancy via cutaneous metastases, genodermatoses or paraneoplastic dermatoses. At the same time, it reviews pharmacologic treatment of internal malignancy and how this can result in cutaneous adverse reactions; conversely, therapeutics for skin conditions can increase risk for internal malignancy. As arguably the most significant cutaneous malignancy, melanoma receives specific attention for its metastatic potential, current diagnostic advances, and recent therapeutic breakthroughs. Dermato-Oncology Study Guide: Essential Text and Review serves a critical educational need for clinicians caring for patients with systemic malignancy by creating an easy-to-use resource that provides practical tools to recognize skin signs of internal malignancy. Furthermore it helps in anticipating and managing adverse reactions of therapeutics for systemic malignancy, and gives the reader the opportunity to weigh the risks of malignancy of pharmacologic agents for skin disease.

Treatment of Cancer is a multi-author work and comprehensive guide on modern cancer treatment that aims to give clinician and student alike the framework for an integrated approach to patient care, including radiotherapy, chemotherapy, and surgery. Much information is presented in tables and charts for easy assimilation, and clear algorithms for patient pathways are included to make decisions straightforward while allowing for sound clinical judgement.

This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.

Lanzkowsky's Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks. - Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures - New chapter on Pediatric Vascular Anomalies - New content on'blood avoidance'programs to honor religious preferences - Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders - Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Organized according to the 2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System, Imaging of CNS Tumors is a concise imaging reference for CNS tumors as well as tumor mimics. This unique, heavily illustrated title covers essential imaging features of more than 120 different types of brain and spine tumors, making it a valuable resource for residents and practitioners in radiology, neurosurgery, neuro-oncology, neuropathology, and neurology, as well as for medical and graduate students and research scientists with interest in CNS tumors.

The “world” of soft tissue sarcomas is a highly complex one, due to the large range of tumor types, each of which is characterized by specific features in terms of its epidemiology, pathology diagnosis, clinical behavior, therapy and biomarker pattern (of both diagnostic and therapeutic value). This book offers a practical, clearly structured reference guide, covering all of these aspects for each soft tissue tumor. Thanks to the consistent and user-friendly format, readers can quickly and easily find the information they need; in addition, up-to-date and authoritative literature information helps them to pursue further research. Overall, this book offers professionals and residents in the fields of oncology, surgery, and pathology an essential guide for study, review, and everyday clinical practice.

This acclaimed core text in Dermatology now returns in a thoroughly revised and refocused format. Its clear structuring will enable all readers to find quickly what they need to know and to see how each part fits into the whole, offering a consistent guide for residents wanting a reliable revision aid for the core topics in Dermatology and for physicians in other disciplines interested in individual topics (particularly family physicians specializing in the diagnosis of skin cancer).

This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment, exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

The book covers all aspects of vascular malformations including classification, embryology, genetics, clinical approach, investigations, management, controversies and key points to remember. Chapters cover recent changes in detail in various aspects, such as classification, genetic decoding, minimal intervention, selective approach and investigations for different types. It offers clear guidance on diagnostic protocol and surgical decision making with changing scenario leading to evolving endovascular and radiological interventions. The book is useful for vascular surgeon, pediatric surgeon, general surgeon, plastic surgeon and intervention radiologist as well as clinical research scholars, surgical oncologists and radiologists.

This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology.Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.

Pediatric Surgery provides an authoritative, up-to-date and comprehensive analysis of current practice in the field. It is divided into three topical volumes, with a total of seven sections focusing on general principles, newborn surgery, general pediatric surgery, tumor surgery, trauma, transplantation, and pediatric urology surgery. Detailed descriptions of surgical techniques and pre- and postoperative management are provided by experts from various parts of the world.The result is an international reference on the surgical management of both common and rare diseases of infants and children that will be an ideal source of information and guidance for pediatric surgeons, pediatric urologists, neonatologists, pediatricians, and all those seeking more detailed information on surgical conditions in children.The three topical volumes are as follows: General Principles and Newborn Surgery General Pediatric Surgery, Tumors, Traumaand Transplantation Pediatric Urology

This book provides a detailed overview of the activity and efficacy of new treatments and promising perspectives in the field of cutaneous malignancies. The first part of the book covers the basic molecular and immunological mechanisms. It then goes on to cover specific strategies in melanoma and non-melanoma skin cancers that, starting from the basic mechanisms, translate this information into clinical routine or translational research. This unique handbook comprises very practical structured descriptions of more than 10 new agents used in treatment of melanomas and skin carcinomas together with biological background of their mechanisms of action. It provides structured and up-to-date information about all therapeutics in cutaneous malignancies, making it extremely useful in clinical practice, for clinicians that need timely and focused information. Prepared by a group of international authors from expert melanoma centres in Europe, the book provides knowledge distilled from the diverse perspectives of the contributing authors (pathologists, translational scientists and clinicians). This book is of interest to medical oncologists, oncological surgeons, dermatologists and immunologists as well as biologists and pharmacologists.

This book provides guidance regarding the approach to common scenarios encountered in the frozen section laboratory while underscoring diagnostic pitfalls and providing the proper level of diagnostic information to ensure clear communication. Given the use of frozen section in molecular and research pathology, the text also serves as a guide for morphologic examination. Written by experts in the field, the book is organized according to organ system with additional chapters discussing the roles of digital pathology and molecular assays. Each chapter is extensively illustrated to highlight key points that facilitate interpretation and highlight areas for potential error. The goal of this book is to help trainees understand the need for mastery of this unique diagnostic tool, and to aid pathologists who cover frozen section convert practical information provided into diagnostic improvements.Frozen Section Pathology is a comprehensive and state-of-the-art review and serves as a valuable resource for the general surgical pathologist with frozen section responsibilities as well as surgeons who regularly utilize frozen section.

In the age of genomics, oncogenetics is a growing discipline. It is defined as the identification and management of families where there is a suspected hereditary risk of cancer. This relatively new discipline is part of a modern medicine that aims to be both preventive and predictive. Constitutional Oncogenetics gives precise descriptions of the main syndromes that cause a predisposition for cancer. The first part examines the most common syndromes in the majority of the world, including the heightened hereditary risk of breast and ovarian cancer and Lynch syndrome. The second part introduces less common infracentesimal syndromes, such as Bloom syndrome and Fanconi syndrome. This book is intended for oncogenetic practitioners and other specialists, as well as medical students.