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Oxidative stress plays a prominent role in the development of numerous human diseases associated with animal-based protein, high-carbohydrate diets and excessive fat consumption. Obesity represents the main risk factor for chronic diseases such as cardiovascular disease, cancer, and type 2 diabetes. Extensive research highlights the detrimental impacts of diets high in saturated fat and refined carbohydrates. Type 2 diabetes, cardiovascular disease and obesity are attributed to the sedentary lifestyles, overconsumption of foods high in saturated fats and carbohydrates, and the saturation of nutrient storage. Indeed, the effects of oxidative stress are associated with the absolute quantity and the type of macronutrients; both of these aspects contribute to oxidative stress and may favor the development of obesity-associated diseases and obesity. Nonetheless, the underlying mechanisms of nutritionally mediated oxidative stress are complex and poorly understood. The literature reported on nutritionally mediated oxidative stress and the role of diets in oxidative stress-induced diseases has not well been compiled in a singular source. “Nutrients and Oxidative Stress: Biochemistry Aspects and Pharmacological Insights” explores how dietary choices dampen or exacerbate inflammation and oxidative stress. The implications of oxidative stress in glucose metabolism and adipocyte and obesity-associated non-communicable diseases are also discussed in this brief. Several issues linked to nutritionally mediated oxidative stress, including high carbohydrates, high animal-based proteins, and excessive consumption of fats and oxidative stress, and molecular mechanisms of oxidative stress-induced diseases are covered. The role of diets in oxidative stress-induced diseases is also discussed. By summarizing all the literature in one place, this work provides a cohesive representation of the information and practical reference on the underlying mechanisms of nutritionally mediated oxidative stress involved in the prevention of chronic diseases. The work provides a better understanding of the nutritionally mediated oxidative stress and the molecular mechanisms of oxidative stress in the development of chronic diseases and obesity.

The average life expectancy has increased worldwide in the recent decades. This has presented new challenges as old age brings the onset of diseases such as cancer, neurodegenerative disorders, cardiovascular disease, type 2 diabetes, arthritis, osteoporosis, stroke, and Alzheimer's disease. Studies and research have shown the potential preventive and therapeutic roles of antioxidants in aging and age-related diseases by inhibiting the formation or disrupting the propagation of free radicals and thus increasing healthy longevity, enhancing immune function, and decreasing oxidative stress. This has made an antioxidant rich diet of increasing importance in battling the detrimental effects of the aging process.“The Role of Antioxidants in Longevity and Age-Related Diseases” is the book that compiles research on antioxidants and their biological mechanisms that mediate age-related diseases. This book covers the major issues linked to antioxidants, aging, and age-related diseases, including changes in organ systems over the lifespan, age-related oxidative stress-induced redox imbalance, inflammaging, implications of inflammation in aging and age-related diseases, and the important role of antioxidant-rich foods in their prevention and treatment of various age-related diseases. For researchers seeking a comprehensive single source on antioxidants and their roles in aging and age-related diseases, this novel text provides an up-to-date overview.