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It is almost 120 years since Alzheimer's disease (AD) was first reported, and the concept of managing some of the modifiable risk factors associated with the disease has been present from the outset. Intervening to manage risk factors as a way of tackling AD is not new, but optimizing brain health as a way of minimizing risk and maximizing the potential benefits of revolutionary new treatments for AD is becoming increasingly important. This book, the Handbook of Intervention and Alzheimer's Disease, presents 47 papers exploring factors which may either inspire or inform future treatment and clinical trials. While novel interventions such as anti-amyloid immunotherapy present great opportunities, they may also increase the risk of brain bleeds and edema, which in turn may lead to adverse clinical outcomes. Such adverse outcomes are demonstrably more likely to occur in persons with poor brain health, so improved management of the risk factors which make up the AD preventome will also minimize the risks associated with such novel therapies. The papers in this volume can therefore be thought of as offering insight into those factors that can optimize brain health or providing key insights into interventions which may achieve such outcomes. Together with its companion volume on prevention, the book provides a comprehensive overview of strategies for tackling Alzheimer's disease, and will be of interest to all those working in the field. Cover illustration: Improved hypoperfusion (resolving blue colors) on ASL MRI Z-score maps superimposed on structural MRI scans at baseline and one year in a PET amyloid-positive research participant with cognitive complaints undergoing one year of multi-domain personalized brain health interventions (vascular disease management, dietary optimization, sustained physical activity etc.). Permission to use this figure was granted both by the study P.I. Dr. David Merrill, MD, PhD, of the Pacific Neuroscience Institute and the research participant.

According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease, strokes, and headaches. Neurological disorders also include brain injuries, neuroinfections, multiple sclerosis and Parkinson disease. A Review on Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics covers the major topics related to neurological disorders, current challenges in diagnosis and intervention. This book is organized into four distinct sections, starting with an introduction, providing a general overview of the epidemiology of neurological disorders, pathogenesis and management. The second section presents the aspects of brain diseases due to infection of bacteria, parasite, fungus and viruses. The third section discusses neurodegenerative disorders due to comorbid factors like diabetes, hypertension, hyperlipidemia and post traumatic brain injuries. The last section covers prevention through application of bioactive compounds and neuroprotective agents. - Epidemiology of neurological disorders and pathogenesis. - Explores neuroinflammation, ligand-receptors binding, and neurodegeneration. - Discusses aging and associated disorders in the onset of neurological disorders. - Neuropharmacology and the protective role of bioactive compounds in neuroprotection.

Alzheimer's Disease Research Guide: Animal Models for Understanding Mechanisms and Medications provides researchers with a comprehensive guide, detailing every aspect of Alzheimer's Disease research, including chapters on neuroinflammation, immunotherapy, biomarkers, and animal modeling. This book begins with historical perspectives of both pathological chronology and pathological biochemistry in relation to Alzheimer's disease. Other chapters review Amyloidogenic AB and Non-Amyloidogenic tau and Metabolism of AB major components to the research and understanding of Alzheimer's research. The book concludes with specific treatment chapters including how to develop safe, effective, and inexpensive medications and the application of genome editing to the treatment of Familial Alzheimer's Disease.Written by world renowned expert in Alzheimer's research, this book is a valuable resource for all researchers. - Reviews why familial Alzheimer's disease is vital to understanding sporadic Alzheimer's disease - Describes the latest'game changer'animal models of Alzheimer's disease and frontotemporal dementia in detail - Explains how various Alzheimer's disease medications have failed clinical trials - Discusses pros and cons of therapeutic antibodies, lecanemab and donanemab, that were recently found to be effective in recent clinical trials - Details the application of genome editing as a treatment for familial Alzheimer's disease - Proposes publishing'Journal of Negative Data'for the days of generative AI-assisted publication, AI being unable to distinguish between reproducible and unreproducible data, particularly important in Alzheimer's research

Vitamins and Minerals in Neurological Disorders offers readers a comprehensive reference addressing their relationship to brain health in a wide variety of neurological diseases. Examining various compounds, this broad coverage allows readers to learn about the role nutrient deficiency plays in the pathology of many conditions, as well as their potential in treatment. The book covers diseases including Alzheimer's, Parkinson's, ALS, and MS, along with severe neurological conditions like brain injury, stroke, headache and migraine. This volume provides a platform for research on vitamins, minerals and future investigations of these compounds. - Summarizes vitamin and mineral research for a variety of neurological conditions - Contains chapter abstracts, key facts, a dictionary and a summary - Covers nutraceutical and botanical use in Alzheimer's, Parkinson's, ALS, MS, and more - Includes conditions like migraine, headache, stroke and brain injury

Learn more about how the central nervous system governs human behaviour with an industry-leading text. Biopsychology, Global Edition, 11th Edition by authors John Pinel and Steven Barnes presents a clear, engaging introduction to the topic offering a unique combination of biopsychological science and personal, reader-oriented discourse, ideal for students studying Physiological Psychology and Biopsychology courses. Well-known for its accessible and student-focused approach to the discipline, the book successfully interweaves the fundamentals of the field with clinical case studies, social issues, personal implications, useful metaphors, and memorable anecdotes. The plethora of themed features, and visual illustrations will challenge your critical thinking skills and support your understanding of the concepts introduced. The latest Edition also incorporates two new emerging themes (Thinking About Epigenetics'and'Consciousness') and includes up-to-date coverage of the most recent developments in the field.

The dentate gyrus (DG) is one of the most sensitive regions to various brain insults due to the occurrence of neurogenesis in its subgranular zone. Thus, it may serve as a brain sensor to radiation exposure, chemical and biological toxins, alcohol abuse, smoking, drug treatments, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition and aging. DG is also involved in the pathogenesis of multiple neurological and neuropsychological disorders including intractable temporal lobe epilepsy (TLE), Alzheimer's disease (AD), major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and schizophrenia. Over decades of research, our understanding regarding the function and physiology of the DG is ever-changing. While it is commonly believed that the dentate granule cells are primarily responsible for executing higher brain functions such as learning and memory, there is increasing evidence demonstrating that the glial cells, particularly microglia, astrocytes and oligodendrocytes, are also involved in memory formation. Therefore, a book that systematically reviews DG structure, function and health implications is needed to update clinicians and researchers with state-of-the-art knowledge. In the first three chapters of this book, the recent progresses in the study of DG development with relevant molecular mechanisms, the cytoarchitectonics of DG with laminar and sublaminar distribution of different types of neurons and glial cells, as well as afferent and efferent of the DG and their neurophysiological roles will be described respectively. In Chapters 4 and 5, DG as a brain sensor to radiation exposure, and pre- and post-natal radiation-induced DG damage and cognitive impairment will be reviewed accordingly. The involvement of DG in pathogenesis of neurological disorders including TLE and AD will be discussed in Chapters 6 and 7. Finally, in the last two chapters, i.e., Chapters 8 and 9, the roles of DG in the development of neuropsychological disorders including MDD, PTSD and schizophrenia will be presented.

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a'one-stop'source for everything you need to know about dementia

Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer's disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. - Offers comprehensive coverage of a broad range of topics related to dementia - Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations - Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations - Serves as a'one-stop'source for everything you need to know about dementia

Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems. - Features leading experts in various subfields as section editors and article authors - Contains articles that are peer reviewed to ensure accuracy, thoroughness and scholarship - Covers mechanisms which control regional specification, regulate proliferation of neuronal progenitors, control differentiation and survival of specific neuronal subtypes, and control the development of non-neural cells

Geriatric Neurology, Volume 167, serves as an update on the basic biological and behavioral mechanisms underlying the aging process, with an emphasis on neurological aging and state-of-the-art reviews on our understanding of vascular, cognitive, neurodegenerative and neuropsychiatric diseases in the elderly. Developed with an eye to providing both the basic underpinnings of age-related changes and the clinical information necessary to aid in diagnostics and treatment, the book serves as a useful volume for students, basic and translational scientists, and practicing clinicians on how to understand and treat common neurological disorders in the elderly. - Reviews the foundations of geriatric neurology, including the fundamentals of age associated changes in molecular biology, altered pharmacokinetics and psychopharmacology that make drug therapy in the elderly different from younger patients - Contains major advances in our understanding of neurodegenerative diseases - Features contributions from world leaders in geriatric neurology–the broadest, most expert coverage available

Alzheimer's Disease: New Beginnings focuses on the future promise for therapeutic breakthroughs in light of notable clinical trial failures. The volume editors used a combination of scientometric evaluations to determine the most promising new approaches as well as soliciting insights from leaders in each of the major areas of Alzheimer's disease research. By combining these two approaches, they recruited authors from the entire outlook spectrum, from those who feel an elusive breakthrough might still be a few, well-placed tweaks away to those who feel that they are launching entirely new investigative paradigms. These scholars present an open-eyed path forward. Now is the most exciting period in this field as old dogmas make way for new insights, from new approaches to clinical trials, improved biomarker-based diagnostics, population-based studies, prevention, metabolism, to further refinement of the role of inflammation, genetics, tau, and amyloid-β.

Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differentiation, neuronal plasticity, and learning and memory. - Discusses the unique features of neural miRNAs - Details functional investigation of miRNA actions and current experimental approaches - Includes extensive coverage of miRNA biology, developmental and postnatal neurogenesis, and computational challenges for miRNA target identification - Contains thorough discussion of the transcriptional control of miRNA expression in forebrain development and in specific neuronal subtypes, as well as miRNA function in neurogenesis, neuronal network maturation, plasticity, gliogenesis, and dysfunction - Provides an overview of miRNA roles in neurodevelopmental disorders and their possible role in the evolution of the neocortex

This three-volume collection of essays provides a comprehensive review of state-of-the-art clinical phenomenology, mechanisms, and treatment strategies for the major dementias—particularly the neuropsychiatric disorders involved.Dementia presents a very significant problem: a recent study by Alzheimer's Disease International estimates that the number of people with dementia worldwide will exceed 35 million by 2050. Neuropsychiatric disorders of the dementias are a major source of stress for the family members of those afflicted and a primary reason for nursing home placement, resulting in the high cost of treatment for every major dementia.Dementia is the first comprehensive treatment of neuropsychiatric approaches to both onset and treatment of the major dementias. Within these three volumes, leading experts on brain science and research explain details, developments, and emerging treatments for one of the most widespread, devastating disorders worldwide—dementia. This title provides mechanistic accounts of dementia onset that take into account neuropsychiatric disorders of dementia and reviews of the latest treatments for both patient and caregivers.

International Review of Neurobiology