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The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. - Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations - Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics - Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders. - Explores sex differences in human neuroanatomy and neurophysiology - Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders - Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context

The serotonergic and circadian systems constitute two of the main regulatory signaling networks of the brain. Each of them consists of a highly localized neuronal population that exerts a widespread influence on multiple cognitive, behavioral, physiological and molecular functions. In this book, the authors discuss the evolution, functions and roles in disease of the serotonergic system. Topics include interactions of the serotonergic and circadian systems in health and disease; serotonin's disease-related changes and common clinical disorders; the serotonergic component in Parkinson's disease symptoms and therapy side-effects; co-localization of serotonin and other classical neurotransmitters within the same neuron; and serotonin as a key neurotransmitter in suicide.

Une avancée spectaculaire de la recherche concernant la sérotonine à la fois comme neuromédiateur du système nerveux central et comme neurohormone contrôlant les grandes fonctions organiques à la périphérie a été accomplie depuis la découverte de ses nombreux récepteurs spécifiques il y a une vingtaine d'années.Cet ouvrage, sans précédent en français, fait le point des connaissances biologiques et cliniques sur cette molécule multipotente qui s'est révélée bien plus qu'un neuromédiateur en cause dans la dépression. Il permet de situer précisément où et comment elle agit dans l'organisme afin de faciliter l'utilisation des traitements sérotoninergiques en optimisant son action et en prévenant ses risques de toxicité.La sérotonine participe ainsi à la régulation centrale des états affectifs et dépressifs, des conduites suicidaires, de l'anorexie, des hallucinations, des comportements moteurs entre autres, et au contrôle périphérique de la régulation de nombreuses fonctions jouant un rôle essentiel notamment dans des systèmes aussi variés que les systèmes gastroentérique, cardiovasculaire et immunitaire.L'équipe pluridisciplinaire d'auteurs s'est attachée à'décloisonner'les disciplines médicales, favorisant ainsi les échanges entre spécialistes tels que psychiatres, neurologues, cardiologues, urgentistes, réanimateurs, internistes, médecins généralistes, gériatres et addictologues

The serotonin transporter is a key brain protein that modulates the reuptake of the neurotransmitter serotonin from synaptic spaces back into the presynaptic neuron. This control over neuronal signalling makes it a prime area of neuroscientific study. In this book an international team of top experts introduce and explicate the role of serotonin and the serotonin transporter in both human and animal brains. They demonstrate the relevance of the transporter and indeed the serotonergic system to substrates of neuropsychiatric disorders, and explain how this knowledge is translated into valid animal models that will help foster new discoveries in human neurobiology. Writing for graduate students and academic researchers, they provide a comprehensive coverage of a wide spectrum of data from animal experimentation to clinical psychiatry, creating the only book exclusively dedicated to this exciting new avenue of brain research.

Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

Neurotransmission is a multicomponent process. Transmitters, released by neuronal activity, act on pre- and postsynaptic receptors, and many books detail advances in the receptor field. In addition, after their release from nerve endings, transmitters are removed from the neuronal vicinity by uptake into neuronal or glial cells by specific tra- porter proteins that have been studied intensely over the last 30 years; this information is scattered throughout numerous publishing vehicles. Therefore, the primary aim of this second edition of N- rotransmitter Transporters: Structure, Function, and Regulation is to offer a comprehensive picture of the characterization of neurotransmitter transporters and their biological roles. The transporter field has moved forward in stages. In the first phase, progress came from the use of substrate or blocker ligands selectively targeting transporters, the application of model systems allowing the study of transmitter tra- port shielded from storage, and the development of mathematical models for describing transport phenomena. In the second phase, roughly covering the last decade, advances in DNA techniques allowed the cloning of numerous genes coding for different transporter proteins. In the current, third stage, a wealth of information is being accumulated in studies relating transporter structure with function, experiments addressing regulation by posttranslational transfor- tion, investigations into transport modulation by trafficking processes and genomic influences, characterization of channel properties of tra- porters by electrophysiological approaches, and the creation of transgenic animals under- or overexpressing a given transporter protein.