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This book focuses on rehabilitation demonstrating how translational research may help clinicians in boosting neural plasticity and functional recovery. Translational Neurorehabilitation is a new interesting field that seeks to produce more meaningful, applicable rehabilitation results that directly enhance human health, performance and quality of life. As neurological diseases increase with age and people who survive a brain injury are rising, thanks to the improvement of intensive acute care, the need to appeal to neurorehabilitation will double in the next few years. Motor, cognitive and behavior approaches have changed over the years and novel tools to treat brain and spinal cord injury should be validated before translating them into clinical practice. The book is aimed to expand the current understanding of brain function and disease by evaluating preclinical and clinical trials on neural plasticity and functional recovery after nervous system disorders. Also, it disseminates the knowledge coming from novel therapies, including advanced robotic and ICT-based applications. The book will be of interest to neuroscientists, physiatrists, neural engineers, and clinical neurologists.

Over the past few years, there have been fundamental changes in the diagnosing and treating patients with chronic diseases, significantly affecting management of neurological movement disorders. In addition, the health and fitness sector developed several devices to better classify, track, and potentially treat chronic diseases. Both handling and interpreting these large datasets has been revolutionized, by machine and deep learning approaches, leading to new and more effective therapies, resulting in longer survival rates. Handbook of Digital Technologies in Movement Disorders aims to unite these factors to provide a comprehensive guide to patient focused treatments for movement disorders. This book is divided into five distinct sections, starting with an introduction to digital technologies, concepts, and terminologies. The following section reviews various perspectives on technology in movement disorders, including patient and medical professionals. The third section presents technologies used in detecting, measuring progression, and determining response to treatments. This is followed by reviewing the technology used in various treatments of movement disorders including assistive and robotic technologies. Finally, the last section examines the challenges with technology including privacy and other ethical issues. - Reviews different stakeholders'perspectives on technology in movement disorders - Presents technological advancements for diagnosing, monitoring, and managing Parkinson's disease - Discusses challenges with implementing technology into treatment

Das Praxisbuch der Neurorehabilitation…… komplett aktualisiert und überarbeitet: Das große Praxisbuch bietet Grundlagen- und Praxiswissen, detailliert, kritisch, verständlich und an den Bedürfnissen der Patienten orientiert – ein rundum alltagstaugliches Arbeitsbuch für Teams, ein Lehrbuch für die Aus- und Weiterbildung. Mit neuen Kapiteln u.a. zu Telerehabilitation und der Umsetzung spezieller Therapieformen wie Virtual Reality, musikgestützte Therapie, Natur und Tiere.Umfassend: Mit ausführlicher Darstellung der Grundlagen und der Tätigkeitsfelder, beginnend von der Behandlung auf der Stroke Unit bis hin zur Rückkehr in Familie und Beruf.Interdisziplinär: Die gemeinsame Ausbildungs ​​– und Arbeitsgrundlage für alle Berufsgruppen, die in interdisziplinären Teams zusammenarbeiten: Ärzte, Pflegekräfte, Physiotherapeuten, Ergotherapeuten, Logopäden, Neuropsychologen, Sozialpädagogen, Musiktherapeuten u.a.Aktuell: Wissenschaftlich, evidenzbasiert, durchgängig mit bio-psycho-sozialer Orientierung und von den Prinzipien der ICF (Internationale Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit) geleitet.Kompetent: Fundiertes Fachwissen aus langjähriger Erfahrung, vermittelt von über 50 renommierten internationalen Autoren (aus Deutschland, Schweiz, Großbritannien, Finnland, USA).Informativ: Auch mit Reflexionen über Themen wie „Kontextsensitive Neurorehabilitation“ „Teamarbeit und Zielsetzung“, „Sexualität“, „ Identität und Biografie“, „Holistische neuropsychologische Rehabilitation“.Leserfreundlich: Leicht zugänglich mitEinheitlicher Aufbau der Kapiteloptischer Textstrukturierung: mit Trailers, Praxistipps, Übersichtsboxen, Exkursen („Näher betrachtet“) und mehr…

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.

This revised, updated, and substantially expanded third edition provides an accessible, practical overview of major areas of research, technical development and clinical application in the field of neurorehabilitation movement therapy. The initial section provides the basic framework and a rationale for technology application in movement therapy by summarizing recent findings in neuroplasticity and motor learning. The following section provides a detailed overview of the movement physiology of various neurologic conditions, illustrating how this knowledge has been used to design various neurorehabilitation technologies. The third section then explains the principles of human-machine interaction for movement rehabilitation. The fourth section provides an overview of assessment technology and predictive modeling in neurorehabilitation. The fifth section provides a survey of technological approaches to neurorehabilitation, including spinal cord stimulation, functional electrical stimulation, virtual reality, wearable sensing, brain computer interfaces, mobile technologies, and telerehabilitation. The final two sections examine in greater detail the ongoing revolution in robotic therapy for upper extremity movement and walking, respectively. The promises and limitations of these technologies in neurorehabilitation are discussed, including an Epilogue which debates the impact and utility of robotics for neurorehabilitation. Throughout the book the chapters provide detailed practical information on state-of-the-art clinical applications of these devices following stroke, spinal cord injury, and other neurologic disorders and future developments in the field. The text is illustrated throughout with photographs and schematic diagrams which serve to clarify the information for the reader.Neurorehabilitation Technology, Third Edition is a valuable resource for neurologists, biomedical engineers, roboticists, rehabilitation specialists, physiotherapists, occupational therapists and those training in these fields.Chapter “Spinal Cord Stimulation to Enable Leg Motor Control and Walking in People with Spinal Cord Injury is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

This book provides a state-of-the art review of this field and demonstrates the basic applications of robotic surgery in the field of neurosurgery, exposing its basic principles, practical technical nuances, and advantages and limitations related to the technology. It also provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information. Robotics in Neurosurgery: Principles and Practice will serve as a valuable resource for clinicians, surgeons, engineers and researchers dealing with, and interested in, this challenging and promising field in robotics applied to neurosurgery.

Transcranial magnetic stimulation (TMS) is a widely used non-invasive brain stimulation technique. It represents an exciting new frontier in neuroscience research and can be used to examine neural processes, providing insights into pathophysiology and treating a variety of neuropsychiatric illnesses. A Practical Guide to Transcranial Magnetic Stimulation Neurophysiology and Treatment Studies presents an overview of the use of TMS as both an investigational tool and as treatment for neurological and psychiatric disorders. The chapters include an overview of the history and basic principles of TMS and repetitive TMS (rTMS), the different types of TMS coils, different stimulation approaches, the use of neuronavigation, and safety considerations. The utility of single and paired TMS techniques to measure cortical inhibition, facilitation, connectivity and reactivity in motor and non-motor brain areas, the different methods of using TMS to induce brain plasticity, and use of TMS in cognitive studies are explored. It also covers TMS and rTMS combined with electroencephalography (EEG) in neurophysiological studies. The authors provide a summary of the clinical applications of TMS in neurological and psychiatric disorders including depression, schizophrenia, stroke, Parkinson disease, and pain. This up-to-date volume provides a compendious review of the use of TMS and rTMS that will help guide the utility of this methodology in both clinical and research settings. This practical guide will be a useful resource for those new to the field, as well as experienced users, for both research and clinical settings.

“This updated textbook was much needed as there has been increased attention in recent years toward brain injuries. The book provides updated guidelines and clinical practice recommendations that support the intended audience of trainees and current practitioners. This update makes it the current standard text for any brain injury specialist.'---Doody's Review Service, 4 stars This revised and greatly expanded Third Edition of Brain Injury Medicine continues its reputation as the key core textbook in the field, bringing together evidence-based medicine and years of collective author clinical experience in a clear and comprehensive guide for brain injury professionals. Universally praised as the gold standard text and go-to clinical reference, the book covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomes. With 12 new chapters and expanded coverage in key areas of pathobiology and neuro-recovery, special populations, sport concussion, disorders of consciousness, neuropharmacology, and more, this'state of the science'resource promotes a multi-disciplinary approach to a complex condition with consideration of emerging topics and the latest clinical advances. Written by over 200 experts from all involved disciplines, the text runs the full gamut of practice of brain injury medicine including principles of public health and research, biomechanics and neural recovery, neuroimaging and neurodiagnostic testing, sport and military, prognosis and outcome, acute care, treatment of special populations, neurologic and other medical complications post-injury, motor and musculoskeletal problems, post-trauma pain disorders, cognitive and behavioral problems, functional mobility, neuropharmacology and alternative treatments, community reentry, and medicolegal and ethical issues. Unique in its scope of topics relevant to professionals working with patients with brain injury, this third edition offers the most complete and contemporary review of clinical practice standards in the field. Key Features: Thoroughly revised and updated Third Edition of the seminal reference on brain injury medicine Evidence-based consideration of emerging topics with new chapters covering pathobiology, biomarkers, neurorehabilitation nursing, neurodegenerative dementias, anoxic/hypoxic ischemic brain injury, infectious causes of acquired brain injury, neuropsychiatric assessment, PTSD, and capacity assessment Multi-disciplinary authorship with leading experts from a wide range of specialties including but not limited to physiatry, neurology, psychiatry, neurosurgery, neuropsychology, physical therapy, occupational therapy speech language pathology, and nursing New online chapters on survivorship, family perspectives, and resources for persons with brain injury and their caregivers Purchase includes digital access for use on most mobile devices or computers

Neurorehabilitation is an expanding field with an increasing clinical impact due to an ageing population. During the last 20 years, neurorehabilitation has developed from a discipline with little scientific background, separated from other medical centers, to a medical entity largely based on the principles of'evidenced based medicine'with strong ties to basic research and clinical neurology. Today neurorehabilitation is still a work in progress and treatment standards are not yet established for all aspects of the field. There are very few books that address contemporary neurorehabilitation from this perspective. This new edition of the Oxford Textbook of Neurorehabilitation provides an understanding of the theoretical underpinnings of the subject as well as a clear perspective on how (and why) to approach treatment decisions on an individualized basis. The book has been thoroughly updated to reflect novel important developments in the field and includes new chapters on vocational rehabilitation, self-management strategies in neurorehabilitation, and music supported therapy in neurorehabilitation. This indispensable book will be of great interest to rehabilitation physicians, neurologists, and allied health care professionals who look after patients requiring neurorehabilitation.

This compilation focuses on spasticity, a condition which results in an abnormal increase in muscle tone caused by injury of nerve pathways within the brain responsible for muscle movement control. The authors assess the effectiveness of extracorporeal shock wave therapy, a promising new non- invasive method, in the reduction of muscle spasticity. Selective dorsal rhizotomy, a successful neurosurgical technique for spasticity treatment, is subsequently described. In the postoperative phase, rehabilitation plays an essential role, supplemented by possible corrective orthopedic interventions. In general, physical therapy methods and rehabilitation techniques constitute suitable non-pharmacological options for spasticity, and they are primary care treatments used in early treatment. The closing study analyzes the effectiveness of upper limb orthosis for the treatment of spasticity, range of motion and functionality issues of persons with cerebral palsy and acquired brain damage.

This book provides a comprehensive review of recent developments in the field of motor neuroprosthetics and brain-machine interfaces. Chapters in this book are provided by leading experts in the field and include topics such as the design and control of multidimensional prosthetics and exoskeletons, deep brain stimulation, functional electrical stimulation, deep learning for brain machine interfaces, biofeedback, and cognitive intent for adaptation of motor prostheses. This book is a great resource for undergraduate and graduate students, researchers, engineers from related disciplines, entrepreneurs, and anyone interested in the latest progress in the field of motor neuroprostheses.

Brain-Computer Interfacing, Volume 168, not only gives readers a clear understanding of what BCI science is currently offering, but also describes future expectations for restoring lost brain function in patients. In-depth technological chapters are aimed at those interested in BCI technologies and the nature of brain signals, while more comprehensive summaries are provided in the more applied chapters. Readers will be able to grasp BCI concepts, understand what needs the technologies can meet, and provide an informed opinion on BCI science. - Explores how many different causes of disability have similar functional consequences (loss of mobility, communication etc.) - Addresses how BCI can be of use - Presents a multidisciplinary review of BCI technologies and the opportunities they provide for people in need of a new kind of prosthetic - Offers a comprehensive, multidisciplinary review of BCI for researchers in neuroscience and traumatic brain injury that is also ideal for clinicians in neurology and neurosurgery

This new edition will grow to three volumes and significantly expand existing sections on medical management of children with cerebral palsy, research, education and therapies. The first volume will cover the cause of CP, the underlying pathology in the brain and the secondary pathologies in different tissues, such as muscle and bone. There are a fair number of controversies and new techniques, such as PET scans, that are getter attention to make earlier diagnosis. It is still not clear whether early diagnosis makes a long term difference. Epidemiology will also be discussed. The second volume will focus on general medical concerns related to CP on each of the medical specialties and the musculoskeletal section - which served as the main focus of the previous edition. This volume will be updated with an emphasis on gait disorders, spasticity, seizures and movement disorders. New research and techniques on the hip and spine areas will be added as well. The third and final volume will be an expanded and comprehensive resource on therapies. More detail on the latest outcome research and techniques will be provided along with sections on orthotics and novel treatments and techniques. This reference work will build on gaps within the first edition and continue to be the definitive guide for rehabilitation physicians, orthopedics, neurologists and therapists who treat children with CP

This 9-volume set covers a wide range of topics, including: childhood vasculitic stroke; anosognosia; stroke-rehabilitation games; electrical stimulation; vasculitis.

This book is the first attempt at bringing together a volume of work from a range of professionals with an interest in spasticity. The framework for the definition was developed in part by the authors contributing chapters that make up this volume. The book represents the current'state-of-the-art'regarding definition, measurement, pathophysiology (all state-of-the-art summaries) and simultaneously gives clinicians guidance on clinical management. This work combines coverage of both spasticity and contractures as these two phenomena are often closely interrelated. Current researchers do not differentiate between these individual impairments and, as such, there is significant confusion in the literature. This book discusses both conditions and then separates them into their respective components. If these two conditions co-exist (which is generally the case), then the management of a patient will need to be customized to individual clinical presentation. The clinical sections of the book are all written by currently practicing, and research active, clinicians, and the earlier chapters are written by researchers currently working on spasticity. In summary, this book: Provides information that is clinically relevant and strongly researched Includes clinical studies covering both spasticity and contractures, which is unique Presents editors and contributors that are world-class experts Takes a cookbook approach to measurements in clinical studies and research Contains extensive references that are included at the end of each chapter

The aim of this textbook is to focus on the neurology. Neurology is a field in medical sciences which has made phenomenal progress over the last two decades. Advancement in technology has changed our understanding of many diseases leading to improvement of patient care. Textbooks provide rapid access to the current status of the diseases and serve as ready reference for the physicians. This textbook consists of 12 sections following as headache, neuroinfections, stroke, epilepsy, movement disorders, central nervous system demyelination, dementia and cognitive disorders, neuromuscular disorders, neurotoxicology, neurorehabilitation, recent advances, and miscellaneous, which are further divided into 111 chapters. Each section is dedicated to one subspecialty of neurology. The book chapters are comprehensive, well-written, and carry information with special emphasis on Indian scenario. It is well documented that prevalence, presentations, genetics, and treatment response of various neurological diseases have significant regional variation. The references quoted are extensive and will guide interested readers for further reading.

This clinically focused book aims to cover for the first time all of the neurological aspects relevant to the diagnosis and treatment of spinal cord disease. Furthermore, innovative neurorestorative therapeutic strategies - aiming for repair of the damaged spinal cord and/or reorganization of the remaining nervous system - with significant potential for translation into clinical routine are presented. The book covers a comprehensive list of topics, including epidemiology, neuroanatomy, etiology of compressive and non-compressive spinal cord injury, imaging, neurophysiology, neurological sequelae, and complications with emphasis on dysfunction of the autonomic nervous system. Both clinically established and preclinical therapies are discussed in detail. The book is suited for trainees and practicing clinicians including neurologists, spine surgeons, rehabilitation specialists, neuroradiologists, and occupational/physical therapists; it will also be of value to neuroscientists involved in research into spinal cord disease.

These proceeding cover new trends presented at the IV Congress of the International Society of Reconstructive Neurosurgery (ISRN), 2015. ISRN is an “open” multidisciplinary society that deals with advances in spine and peripheral-nerve reconstructive surgery, central nervous system revascularization (surgical, radio interventional), neuromodulation, bioengineering and transplantation, which are the latest tools used to promote reconstruction, restoration and rehabilitation.

This ground-breaking title begins with an introductory overview of the Lower Extremity Gait Systems (LEGS) project, identifying concerns and observations as context for the reader to consider topics and challenges detailed in later chapters. Next are chapters that explore relevant military and civilian needs, and an essential historical context of the capabilities and limitations of contemporary prosthetics. The section concludes with an overview of essential components used in passive and active lower limb prosthetics, including sockets, foot, ankle, and knee systems, as well as emerging bionic systems. A second section considers research and development in orthotics, synthetic and biological materials, volitional control, and wearable robotics (also known as exoskeletons). Finally, expert authors explore advanced science and emerging medical perspectives in research related to limb salvage, osseointegration, limb transplantation, and tissue engineering. Designed for medical practitioners, engineers, students, and researchers who use or develop prosthetic technology for civilian or military amputees, Full Stride: Advancing the State of the Art in Lower Extremity Gait Systems will be of great interest to trauma specialists, orthopedists, rehabilitation specialists, nursing staff and physical therapists, as well as researchers and scientists who specialize in fields that shape and inform advanced prosthetic device development such as materials sciences, engineering (electrical, mechanical, biomedical), robotics, and human physiology.

This revised, updated second edition provides an accessible, practical overview of major areas of technical development and clinical application in the field of neurorehabilitation movement therapy. The initial section provides a rationale for technology application in movement therapy by summarizing recent findings in neuroplasticity and motor learning. The following section then explains the state of the art in human-machine interaction requirements for clinical rehabilitation practice. Subsequent sections describe the ongoing revolution in robotic therapy for upper extremity movement and for walking, and then describe other emerging technologies including electrical stimulation, virtual reality, wearable sensors, and brain-computer interfaces. The promises and limitations of these technologies in neurorehabilitation are discussed. Throughout the book the chapters provide detailed practical information on state-of-the-art clinical applications of these devices following stroke, spinal cord injury, and other neurologic disorders. The text is illustrated throughout with photographs and schematic diagrams which serve to clarify the information for the reader. Neurorehabilitation Technology, Second Edition is a valuable resource for neurologists, biomedical engineers, roboticists, rehabilitation specialists, physiotherapists, occupational therapists and those training in these fields.

Neurological early rehabilitation following injury to the nervous system has continuously evolved since the 1990s into a highly specialised discipline. This practice-based work represents both a manual and a guide for doctors, nurses and therapists, and summarises the experiences of staff at the Schön Hospital in Bad Aibling. The book escribes neurological syndromes that can be rehabilitated, as well as differential diagnoses, therapy options, treatment rocedures and socio-medical aspects.

Dieses Buch enthält den Artikel: Motorische Rehabilitation aus dem Sammelband: Therapie und Verlauf neurologischer Erkrankungen. Das große Referenz- und Facharztbuch zur klinischen Neurologie liegt hiermit unter der Federführung der international renommierten Herausgeber und der Mitarbeit von über 140 Fachexperten als eine vollständig überarbeitete und erweiterte Neuauflage vor. Durch die thematische Neuausrichtung einzelner Beiträge, z. B. zur transienten globalen Amnesie oder zu Tropenkrankheiten, und acht zusätzliche Kapitel, nämlich zu Antikörper-assoziierten Enzephalopathien, mitochondrialen Erkrankungen, atypischem Gesichtsschmerz, craniomandibulärer Dysfunktion, Hypophysentumoren, Tic/Tourette und ADS, Apraxie sowie ethischen und rechtlichen Aspekten in der Neurologie, hat die 6. Auflage viel Neues zu bieten. In bewährter Form werden systematisch die aktuellen Erkenntnisse zum Stand von Klinik, Therapie und Verlauf neurologischer Erkrankungen zusammengefasst und für die pragmatische Anwendung gewichtet.

Dieses Buch enthält den Artikel: Motorische Rehabilitation aus dem Sammelband: Therapie und Verlauf neurologischer Erkrankungen. Das große Referenz- und Facharztbuch zur klinischen Neurologie liegt hiermit unter der Federführung der international renommierten Herausgeber und der Mitarbeit von über 140 Fachexperten als eine vollständig überarbeitete und erweiterte Neuauflage vor. Durch die thematische Neuausrichtung einzelner Beiträge, z. B. zur transienten globalen Amnesie oder zu Tropenkrankheiten, und acht zusätzliche Kapitel, nämlich zu Antikörper-assoziierten Enzephalopathien, mitochondrialen Erkrankungen, atypischem Gesichtsschmerz, craniomandibulärer Dysfunktion, Hypophysentumoren, Tic/Tourette und ADS, Apraxie sowie ethischen und rechtlichen Aspekten in der Neurologie, hat die 6. Auflage viel Neues zu bieten. In bewährter Form werden systematisch die aktuellen Erkenntnisse zum Stand von Klinik, Therapie und Verlauf neurologischer Erkrankungen zusammengefasst und für die pragmatische Anwendung gewichtet.

Brain Injury Medicine - which includes free ebook access with every print purchase - is a clear and comprehensive guide to all aspects of the management of traumatic brain injury-from early diagnosis and evaluation through the post-acute period and rehabilitation. An essential reference for physicians and other health care professionals who work with patients with brain injury, the book focuses on assessment and treatment of the wider variety of clinical problems these patients face and addresses many associated concerns such as epidemiology, ethical issues, legal issues, and life-care planning. Written by over 190 acknowledged leaders, the text covers the full spectrum of the practice of brain injury medicine including principles of neural recovery, neuroimaging and neurodiagnostic testing, prognosis and outcome, acute care, rehabilitation, treatment of specific populations, neurologic and other medical problems following injury, cognitive and behavioral problems, post-trauma pain disorders, pharmacologic and alternative treatments, and community reentry and productivity. Brain Injury Medicine, 2nd Edition Features:The acknowledged gold standard reference-brings together knowledge, experience, and evidence-based medicineComprehensive and current-completely revised, updated, and expanded to include emerging topics and the latest clinical and research advances Multi-disciplinary focus-expert authorship from a wide range of specialties promotes a holistic team approach to a complex, many-faceted condition Covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomesNew to the Second Edition:Three new Associate Editors from related disciplines provide added expertise Five new sections: acute rehabilitative care, pediatric TBI, special senses, autonomic and other organ system problems, post-trauma pain disorders 25 new chapters running the gamut from health policy to biomechanics, to military TBI to pediatric issues and more Print + Digital Access: Purchase price includes enhanced e-book containing the complete and fully searchable text plus additional digital-only content

Neurorehabilitation Technology provides an accessible, practical overview of the all the major areas of development and application in the field. The initial chapters provide a clear, concise explanation of the rationale for robot use and the science behind the technology before proceeding to outline a theoretical framework for robotics in neurorehabilitative therapy. Subsequent chapters provide detailed practical information on state-of-the-art clinical applications of robotic devices, including robotics for locomotion; posture and balance and upper extremity recovery in stroke and spinal cord injury. Schematic diagrams, photographs and tables will be included to clarify the information for the reader. The book also discusses standard and safety issues and future perspectives.

Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. - Comprehensive coverage of the latest scientific understanding of spinal cord injuries - Detailed coverage of current treatment best practices and potential future treatments - Connects leading edge research programs to future treatment opportunities

The book provides a comprehensive review and update of the newest diagnostic and therapeutic tools in paediatric neurology. Special attention is paid to neuroradiologic and neurophysiologic techniques and to their clinical application, with guidelines and suggestions on how an integrated approach can be used to reach diagnosis. Some of the chapters focus on the newborn infant and the first years of life, highlighting the most appropriate MRI, clinical, and EEG techniques to investigate the developing brain. Techniques used in older children are also presented, including state-of-the art insights that afford a better understanding of the correlation between function and brain structure in young patients with brain lesions. New genetic discoveries are particularly emphasized, as is the possibility of performing accurate phenotype-genotype correlation by combining latest methods such as muscle MRI and genetic information in order to identify diagnostic MRI patterns associated with specific genetic disorders. In all chapters an effort is made to combine technical data with clinical applications in order to highlight, when possible, how these novel procedures can also be used in rehabilitation. This book will be of interest to paediatricians, paediatric neurologists, neonatologists, and, indeed, to all those who are involved in the diagnosis and care of children with neurologic disabilities. Available in print version and eBook.

Focusing on the spinal cord and its role in motor control, Restorative Neurology of Spinal Cord Injury details the clinical and neurophysiological assessment process and methods developed throughout the past half century by basic and clinical scientists. Then, through the use of specialized clinical and neurophysiological testing methods, conduction and processing performed within the surviving neural circuitry is examined and characterized in detail. Based on the results of such assessment, treatment strategies, also described in this book, are applied to augment, rather than replace, the performance of surviving neural circuitry and improve the functional capacity of people who have experienced injury to their spinal cords.

In a specialized field such as neurosurgery, highly specific knowledge is required. Training programs in the EU vary, making it difficult to standardize medical training. This manual forms the basis for a European consensus in neurosurgery. It is written for residents, students and physicians with a special interest in neurosurgery. Diagnostic and therapeutic procedures are detailed according to localization (cranial, spinal, peripheral nerves) with special consideration given to congenital defects and pediatric neurosurgical disorders, functional and stereotactic neurosurgery, as well as critical neurosurgical care. Each chapter contains the basics of anatomy and physiology. The book is well-organized and clearly structured according to each entity and its neurosurgical treatment options. A better understanding of specific neurosurgical problems will help practicing neurosurgeons provide better medical care for their patients, and will also provide the neurosurgery resident with a reliable European standard for step-by-step management of neurosurgical problems, which will prove useful when preparing for the board examination.

Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field. The two volumes present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. The immense therapeutic potential is highlighted which arises from the close collaboration of biomedical scientists and biotechnological engineers in this area and signifies the transition from the conventional'resective'surgery to functional neuroprosthetic surgery (Vol. I) and neural networks surgery (Vol. II) which uses neuro-engineering to improve impaired neural function. Volume I describes techniques and procedures applied in internal contact with non-neural tissues surrounding the nervous system (dura or cerebrospinal fluid), as in the case of epidural stimulation for pain, etc. or intrathecal drug application for the treatment of spasticity and pain. There is also a special section on non-invasive functional neuroprosthetic systems, which are usually applied by transcutaneous contact with the nervous system.

This reference provides a clear understanding of the basic mechanisms of synaptic transmission and information processing and illustrates potential clinical applications for the recovery of lost function as a result of gene defects, injury, or disease-relating the most recent advances in the design of new therapeutics, the treatment of neurological

The Second Edition of this single-authored volume integrates multiple disciplines of basic and clinical research to help clinicians further develop the best possible care for the rehabilitation of patients with neurologic diseases. From the readable descriptions of the structures and functions of pathways for movement and cognition, the reader comes to understand the potential for training induced, pharmacologic, and near-future biologic interventions to enhance recovery. Dr. Dobkin shows how functional neuroimaging serves as a marker for whether physical, cognitive, and neuromodulating therapies work and how they sculpt the plasticity of the brain. Themes, such as how the manipulation of sensory experience can serve as a formidable tool for rehabilitation, run throughout the text, built from the level of the synapse to behaviors such as grasping, walking, and thinking. From illustrating how we may one day repair the brain and spinal cord to how to retrain spared and new pathways, Dr. Dobkin draws insights from a broad swath of fundamental research to give clinicians tools they can translate into bedside practices. The book treats the medical complications and therapeutic approaches to neurologic diseases as an interconnected matrix. The management of common medical issues, impairments, and disabilities are described across diseases. Special problems posed by patients with stroke, myelopathies, brain injury, multiple sclerosis, degenerative diseases, and motor unit disorders receive individual comment. Short-term and delayed pulse interventions for patients, along with clinical trials, are dissected and put into perspective. The First Edition of this book was titled Neurologic Rehabilitation. The title has been changed to reflect Dr. Dobkin's sense that fundamental research now drives the field of neurologic rehabilitation even more than it could in 1996 when the First Edition was published. The Second Edition features entirely new chapters on functional neuroimaging of recovery; neurostimulators and neuroprosteses; integration into the book of many new clinical and neuroscientific observations relevant to the clinician; and extensive updating and expansion of all chapters. Readers, whether clinicians serving the rehabilitation team, or students or researchers in neuroscience, neurology, physical medicine, allied health, or bioengineering, will acquire new insights and tools for creative pursuits that aim to lessen the disabilities of patients.