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Psychiatric symptoms (or mood/emotional disturbances) are diverse in patients with neurological diseases, that include depression, anxiety, emotional incontinence, anger, fatigue, and apathy. These symptoms are common; more than 1/3 of the patients suffer from these symptoms. Unfortunately, they have been neglected because 1) unlike other neurological symptoms such as motor dysfunction, speech disturbances or visual field defect, these symptoms are not visible and difficult to be noticed unless they are specifically examined by a physician who is properly educated on this problem 2) they are often not regarded as neurological symptoms either by the patients or their caregivers 3) they are relatively poorly studied by both neurologists and psychiatrists, and accordingly, are unfamiliar to the physicians. Especially, although `depression'is well known to physicians, other symptoms such as emotional incontinence, anger, fatigue or apathy are not appropriately assessed by physicians, and frequently misdiagnosed as depression. Moreover, there are difficulties in diagnosing depression in patients neurological diseases. For example, the individual items included in depression diagnosis such as sleep disturbances, appetite loss, or fatigue can result from neurological diseases or comorbid physical conditions in patients with neurological diseases. Therefore, a diagnosis of `depression'should be made cautiously. Finally, it should be understood that the importance of different mood/ emotional syndromes differ among various neurological diseases; for instance, although emotional incontinence and anger occur in as many as 20-30% of stroke patients, apathy and fatigue are more important symptoms than these for patients with neuro-degenerative disease.In clinical practice, recognizing these symptoms is important because they negatively affect the patients'quality of life, impair the functional recovery, increase the mortality, and increase the caregiver burden. Nevertheless, unlike other neurological symptoms such as motor/sensory dysfunction, and speech disturbances, they are relatively well managed mostly by pharmacological therapy such as selective serotonin re-uptake inhibitors (SSRI).The phenomenology of these neuropsychiatric symptoms and related factors, pathophysiological mechanism, and treatment strategies should be properly educated for neurologists, psychiatrists and other physicians. The book is written by experts in this field to disseminate important knowledges to neurologists, psychiatrists, psychologists and other physicians and will eventually benefit patients with neurological diseases.

Over the past few years, there have been fundamental changes in the diagnosing and treating patients with chronic diseases, significantly affecting management of neurological movement disorders. In addition, the health and fitness sector developed several devices to better classify, track, and potentially treat chronic diseases. Both handling and interpreting these large datasets has been revolutionized, by machine and deep learning approaches, leading to new and more effective therapies, resulting in longer survival rates. Handbook of Digital Technologies in Movement Disorders aims to unite these factors to provide a comprehensive guide to patient focused treatments for movement disorders. This book is divided into five distinct sections, starting with an introduction to digital technologies, concepts, and terminologies. The following section reviews various perspectives on technology in movement disorders, including patient and medical professionals. The third section presents technologies used in detecting, measuring progression, and determining response to treatments. This is followed by reviewing the technology used in various treatments of movement disorders including assistive and robotic technologies. Finally, the last section examines the challenges with technology including privacy and other ethical issues. - Reviews different stakeholders'perspectives on technology in movement disorders - Presents technological advancements for diagnosing, monitoring, and managing Parkinson's disease - Discusses challenges with implementing technology into treatment

The second edition of the'IAN Textbook of Neurology'has been prepared for clinicians who participate in the care of neurological patients, including those who are in training to become neurologists, internists, neurosurgeons, and neuroscientists. The basic structure of this second edition has changed. The book is divided into seven parts. Section 1 discusses the History-taking and the Neurological Examination, inclusive of the systemic examination that helps the neurological diagnoses. Section 2 covers the Applied Neuroanatomy and Neurophysiology aspects that are important to clinicians. Section 3 discusses the clinical Approach to various Common Neurological Symptoms. Section 4 describes Diseases of the Nervous System. Section 5 discusses Investigations, Section 6 the Principles of Management, and Section 7 is about the Counseling and Doctor–Patient Relationship.

This book aims to collect research findings and provide insightful recommendations on various aspects of female epilepsy patients of childbearing age. This book discusses multidisciplinary effort of brain science, reproductive medicine, endocrinology, drug metabolism, genetics, maternal and infant medicine, etc. This book is written by a multidisciplinary team of researchers who had a passion for improving the quality of life of women with epilepsy, to demonstrate the latest scientific discoveries and precise management strategies for women with epilepsy in child-bearing age.

Menschen mit komplexen Behinderungen haben oft nur eine eingeschränkte oder für andere unverständliche Art der Kommunikation und können deshalb kaum oder gar nicht von ihren Beschwerden berichten und bei der medizinischen Anamnese mitarbeiten. Zudem sind atypische Symptome oder ungewöhnliche Komorbiditäten gerade bei speziellen Syndromen häufig. Dadurch gestaltet sich die Diagnostik besonders schwierig. Im vorliegenden Leitfaden ist den am häufigsten vorkommenden Symptomen jeweils ein eigenes Kapitel gewidmet. Ausgehend von konkreten Beispielen erläutern ausgewiesene Expert•innen die besonderen Herausforderungen für die Diagnostik, definieren die Problemstellung und erörtern Differenzialdiagnosen. Konkrete Vorschläge für das Vorgehen bei Anamnese und klinischer Untersuchung runden die Kapitel ab. Mit Beiträgen von Norbert Bohnert, Katharina Bücher, Gloria Dorsch, Thomas Dreher, Guido Elsäßer, Hauke Hermann, Eva Ledig, Markus Knuf, Verona Mau, Christian Münter, Margarete Nowag, Georg Poppele, Martin Rohlf, Petra Rösl, Tanja Sappok, Petra Schulz, Jörg Stockmann, Tatjana Voss, Tobias Wagner und Meike Wehmeyer

This comprehensive review of research and best practice clinical management of spinal cord, neurodegenerative, and cerebral disorders is intended for both researchers and clinicians. Encompassing hereditary and acquired disorders from disease and accident, the book explores motor control disorders associated with stroke, dementia, seizure, encephalitis, and more. Covering disorders of both children and adults, the book discusses the latest advances in treatments related to neuroplasticity, neural tissue transplantation, and immunotherapy. - Summarizes assessment, disease course, and best practice treatment - Includes hereditary disorders and disorders from disease or accident - Discusses advances in neuroplasticity, tissue transplantation, immunotherapy, and other treatments - Reviews effects of dementia, stroke, seizure, encephalitis, cancer, and more

Parkinson Disease is a comprehensive introduction to the biology and clinical features of Parkinson disease (PD). This book is aimed at clinicians in training, general neurologists seeking a useful guide to PD, and scientists seeking an overview of clinical aspects of PD. Topics covered include nosology of PD, PD epidemiology, pathology and pathophysiology of PD, and theories of PD pathogenesis. Clinical features, including the many non-motor features, natural history of disease progression, clinical pharmacology, and management of PD receive coverage. Important themes are heterogeneity of PD, the multi-focal nature of PD pathology, the diversity of clinical features, dopaminergic signaling and the impacts of dopaminergic deficiency, the importance of non-motor features, limitations of existing treatment modalities, and the necessity of approaching PD as a multi-system disorder. The description and discussion of the many aspects of Parkinson disease (PD) is dogged by the fact that PD is an ambiguous concept. This book intends to be a useful overview, bridging the gap between general textbooks and specific topical reviews.

Das Buch vermittelt aktuell und umfassend das Wissen auf dem Gebiet der Neuro-/Psychopharmakologie. Um ein tieferes Verständnis der Therapieprinzipien sowie der Besonderheiten der medikamentösen Behandlung bei Kindern und Jugendlichen zu erhalten, werden im ersten Teil die Grundlagen der Neuro-/Psychopharmakologie dargelegt. Zudem werden rechtliche und ethische Fragen im Praxisalltag eingehend erörtert. Der zweite Teil behandelt ausführlich die verschiedenen Arzneistoffgruppen. Im dritten Teil wird die störungsspezifische und symptomorientierte Medikation praxisorientiert beschrieben und kritisch bewertet, so dass der Arzt über eine klare Handlungsanleitung verfügt. Die vierte Auflage wurde aktualisiert und auf den neusten wissenschaftlichen Stand gebracht. Dieses Nachschlagewerk besticht durch die komprimierte und einheitliche Darstellung mit vielen zweifarbigen Tabellen, Schemata und Abbildungen. Es wendet sich an Kinder- und Jugendpsychiater und -psychotherapeuten, Pädiater, Allgemeinmediziner, Psychologen, Pflegekräfte und Lehrer.

New ways of understanding the brain – its nature, its capacities, its function, and its dysfunction – hold great promise for human wellbeing. Novel therapeutics spurred by this understanding have important roles addressing many clinical conditions, including Alzheimer Disease, depression, addiction, and obsessive-compulsive disorder. This unique title explores a wide range of groundbreaking sciences and clinical practices for brain-based conditions, including deep brain stimulation, optogenetics, technology-delivered therapies, predictive testing, and new clinical uses of ketamine, cannabis, and other psychoactive substances.An introduction to the imperative to develop new treatments for devastating brain disorders and the state of current therapeutics in psychiatry, addiction, and behavioral disorders is presented, and chapters from leading physician-scientists and neuroethicists outline the clinical and the ethical issues arising in innovation and in the creation of new therapeutics for brain diseases. Written by renowned thought leaders in their fields, the book presents tightly written contributions on novel qualitative and quantitative data from stakeholders in the field, including neuroscientist-clinicians, people living with mental illness and/or addictions, and oversight/policy stakeholders. Concise, anticipatory, and centered on the principles governing human biomedical research and innovation in developing novel therapeutics for brain disorders, Ethics and Clinical Neuroinnovation will be of great value to clinicians, researchers, and students from a vast array of backgrounds, including neuroethics, neuroscience, psychology, psychiatry, philosophy, entrepreneurship, and the law.

The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.

This book provides an in-depth review of knowledge of the corpus callosum, called white matter or terra incognita, with emphasis on anatomical, embryological, diagnostics, and surgical features. It includes very informative chapters from leaders in the field, organized into six main groups: first, the embryology, neuroanatomy, and morphometry of the corpus callosum, and animal studies related to it; secondly, neurophysiological aspects, callosal disconnection and the split brain; thirdly, neuropathology, including clinical disorders such as dementia, Tourette syndrome, and schizophrenia; fourthly, surgical procedures including partial and complete callosotomy and commissurotomy; fifthly, cognitive neuroscience; and sixthly, other features of the corpus callosum, including its medicolegal aspects and statistical shape analysis. This comprehensive reference book will be an ideal source for neuroscientists at all levels, from graduate students to researchers in specific disciplines studying this region including neuroanatomists, embryologists, neurosurgeons, neurologists, neuroradiologists and pediatricians, who seek both basic and more advanced information regarding the distinctive anatomical, physiological and pathological features of the human corpus callosum. ​

Movement Disorders in Psychiatry examines the complex interface between movement disorders and psychiatry, addressing both specific movement disorders in psychiatry and behavioral syndromes associated with diseases categorized as movement disorders. This volume provides an overview of clinical definitions and pathophysiology of movement disorders and reviews specific movement disorders associated with drugs of abuse and psychotropic medications, including tardive dyskinesia, akathisia, and neuroleptic malignant syndrome. Further chapters discuss movement disorders seen in primary psychiatric disorders, such as autism and schizophrenia, as well as diseases with concurrent movement disorder and behavioral symptoms, such as Huntington's disease, Parkinson's disease, frontotemporal dementia, Tourette's syndrome, and autoimmune conditions. Movement Disorders in Psychiatry offers an in-depth perspective on movement disorders with treatment and practical management strategies for related challenges in clinical practice.

The only reference to focus on the must-know aspects of neurology for psychiatrists, Kaufman's Clinical Neurology for Psychiatrists, 9th Edition, brings you up to date with the knowledge you need to excel on the American Board of Psychiatry and Neurology and other examinations. It fully covers the exam topics you'll encounter, along with new content, high-quality illustrations, and multiple-choice questions. In addition, this book prepares you for clinical work in the 21st century. - Discusses timely, clinically-relevant topics such as chronic and acute traumatic brain injury, Alzheimer's disease, correctible causes of dementia, violence, neurologic illnesses that present with symptoms of autism, illicit drug use, stroke, migraine, Parkinson's disease, tardive dyskinesia current treatments, and more. - Includes nearly 2,000 multiple-choice questions both in print and online—all written to help you succeed on the ABPN certifying exam. - Features new content, new and improved clinical illustrations: life-like patient sketches, anatomy line drawings, CTs, MRIs, and EEGs. - Explains each condition's neurologic and psychiatric features, easily performed office and bedside examinations, appropriate tests, differential diagnosis, and management options. - Correlates neurologic illnesses with the DSM-5.

Huntington's disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents adistinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.

Neuropalliative Care, Part Two, Volume 191 covers a type of care that is given when there is no cure for the neurological disorder and the patient is in distress. It provides a scholarly background of neuropalliative care, from historic underpinnings to its practice in various geographical regions, along with best practices for specific neurological disorders. It covers the work of multi or interdisciplinary teams whose care is intended to make the patient as comfortable as possible and includes partners and families in treatment plans. - Summarizes research in neuropalliative care - Identifies current practices in different geographic regions - Provides best practices for specific neurological disorders and patient populations - Includes advanced care planning

Huntington's Disease (HD) is a progressive neurodegenerative disease leading to a variety of neurological and psychiatric symptoms such as chorea, parkinsonism, oculomotor symptoms, cognitive decline, depression, suicidal ideation, and psychosis. Currently, only symptomatic treatment is available. In recent years, there has been a growing number of publications regarding pathophysiology, disease biomarkers, and possible avenues for causal therapy of HD. This book presents an overview of the most important research updates in the pathophysiology and treatment of HD, with particular reference to advances in HD neuropathology, neuroimaging, and biomarkers of HD. We also summarize possible new therapeutic targets, including cannabis-based medicine, cellular, and cell-free therapeutics. Importantly, researchers from different regions of the world have contributed to this volume as we wanted to create a balanced, inclusive, and interdisciplinary review of the topics. We hope that with this book readers will be offered a compact summary of up-to-date trends in HD research which, ultimately, will enable better diagnosis and treatment for HD patients.

There is significant academic interest in the field of art and neurological disorders. Considering how artistic expression may be modified by alterations in neural circuits, as well as in our bodies and everyday lives, associated with a range of disorders and diseases is a rich territory from which to understand the workings of our brains, the unique blend of factors leading to human art making, and disease itself. This book will be an exposé of how different neurological disorders may influence and/or relate to the artistic process, with a particular focus on visual art and painting. The book will interrogate the question of different aspects of neurological disorders and associated brain changes that may impact artistic expression (and vice versa) and will include devoted chapters on Parkinson's disease, Epilepsy, Mood Disorders, Autism, and Schizophrenia. Moreover, we will elaborate on the question from the perspective of the artist themselves, with chapters that highlight the artistic process in the context of lived experience (either directly or indirectly) with disease-mediated brain changes. Finally, engagement in creative acts has been linked to therapeutic benefits in multiple disease processes and neuroplasticity, which is another line of inquiry directly addressed in the book. As a whole, the volume focuses on themes and concepts at the boundary of creativity and neuroscience in such a way as to be relevant to both the medical and broader (artistic) community.

This book offers a comprehensive overview of the most important neurochemicals and approaches everything from the neurochemical's perspective. It attempts to integrate the biochemical pathways of synthesis and metabolism of these neurochemicals with the disease states and point out the avenues of diagnostic testing and therapeutic intervention. Each chapter focuses on a specific neurochemical and provides a brief history, the biochemical profile, metabolism, physiological functions, and the clinical aspects. The clinical part of each chapter includes a discussion on disease states with either increased or reduced activity of the neurochemical and either activation or inhibition of the relevant receptors. This book is targeted toward practitioners and students of neuroscience and is written to emphasize the importance of these neurochemicals in the brain. With this emphasis on background neurochemical processes, the readers will be pointed towards logical diagnostic studies, laboratory investigations, and therapies based on the neurochemical dysfunction that underlies various disease states.

Primary health care providers such as pediatricians and family medicine physicians commonly encounter children with neurologic symptoms such as headache, double vision, facial weakness etc. Most books currently available in the specialty of pediatric neurology are “condition” or “disorder” based, and most of them are geared towards pediatric neurologists, not generalists who take care of children. A common thread amongst most currently available books in Pediatric Neurology is that the practitioner already knows what “condition” or “disorder” the child is suffering from. This book focuses on symptoms to a large extent. However, children with chronic neurological conditions will follow up with their primary care physicians after their visit with the sub-specialists. They may have questions or ongoing concerns regarding the diagnosis that has been made or being considered. This book attempts to provide information to the primary care physician regarding management and follow upof such children as well. This book serves as a guide for busy clinicians who take care of children presenting with neurological symptoms- with special emphasis on symptoms that are commonly encountered in clinical practice. For each symptom, a brief introduction is given as well as a definition and epidemiologic information for the given symptom. Readers are also instructed on what historical features and physical examinations are essential in narrowing the differential diagnosis. A recommendation on the management of the condition is then established. Instructions on when one should refer the patient to subspecialists for further evaluation and management are clearly laid out. Finally, a list of appropriate resources is provided for families, as well as clinical pearls that can be quickly scanned when one is pressed for time. The overarching goal of this book is to enable the primary care physician to make a confident diagnosis, triage efficiently and initiate treatment if need be.Written by experts in the field, Symptom-Based Approach to Pediatric Neurology is a valuable resource for evaluation and management of children presenting with neurologic symptoms for primary care providers who take care of children.

The second edition of The Neurologic Examination looks at how to conduct a clinical neurological examination through a pathophysiological approach to the nervous system. This new edition is brought up to date with new data on genetic and immunological disorders and a significant expansion of illustrations of skin manifestations of neurologic disorders. The book provides in-depth instructions for clinicians with a logical order of history and the different parts of the examination. Organized by the functional anatomy of the nervous system, the book provides a bridge from basic science to symptoms and signs of many common and rare neurologic disorders, which will help in making diagnoses. The authors look at how to carry out an examination in different circumstances, from outpatients to patients in respiratory distress, with stroke and epilepsy, and various states of consciousness including coma. Laboratory testing is recommended when appropriate, but the main emphasis is on history and physical examination. The book contains over a hundred discussion boxes with details about neurologic disorders and history. While mainly directed to students and residents learning how to do a neurologic examination, it will still be useful even for more experienced clinicians.

This is a clinical and practical oriented textbook that will enable clinicians who have less expertise in the field of movement disorders to make a reasonably accurate diagnosis through a problem-oriented approach. This textbook includes a selective collection of topics that are relevant to practicing neurologists. Some of the best experts in the field of movement disorders from around the world have contributed to this book. Long discussions on pathology and genetics are limited in order to make the book simple, easy to comprehend, and practically useful for the day-to-day management of movement disorders.

International Review on Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review on Neurobiology serials - Updated release includes the latest information on Sex and Gender Differences in Neurological Disease

​Dieses Buch bietet 35 klinische Kasuistiken, die unterschiedliche Symptomatiken, Patientengruppen und Verläufe bei neurodegenerativen Erkrankungen darstellen. Eine Erkrankungsgruppe, die sich sehr heterogen präsentiert und in Diagnose und Therapie gerade für den Anfänger in der neurologischen Weiterbildung komplexe Fallstricke bereithalten kann. Die Fälle sind klar und einheitlich gegliedert. Relevante Informationen zu einer Erkrankung wurden komprimiert zusammengefasst, ergänzt durch Hinweise auf hilfreiche Zusatzthemen wie den Umgang mit Erkrankten oder Tipps zur Diagnose- und Prognosevermittlung. Die Fallgeschichten werden leitliniengerecht besprochen und orientieren sich an etablierten SOPs (Standard Operating Procedures) der Neurologie. Vertiefende Multiple-Choice-Fragen zum Selbstlernen sind über die Springer Flashcards-App zugänglich und regen zum klinischen Nach- und Mitdenken an.

Disorders of Emotion in Neurologic Disease, Volume 183 in the Handbook of Clinical Neurology Series, informs clinicians on which neurologic diseases are likely to have a secondary effect on emotion, what to look for in diagnosis, and best practices for treatment. The book begins with an understanding of the neurological basis for emotions in order to better understand what goes awry in neurological disease. It then discusses specific neurologic diseases and disorders affecting emotion. - Reviews the neurology of emotions - Specifies neurologic diseases that affect emotional expression - Informs clinicians on how to diagnose, along with best practices for treatment - Includes coverage of stroke, dementia, epilepsy, Huntington's, Parkinson's, TBI, and more

Offering a state-of-the-art, authoritative summary of the most relevant scientific and clinical advances in the field, Principles and Practice of Movement Disorders provides the expert guidance you need to diagnose and manage the full range of these challenging conditions. Superb summary tables, a large video library, and a new, easy-to-navigate format help you find information quickly and apply it in your practice. Based on the authors'popular Aspen Course of Movement Disorders in conjunction with the International Parkinson and Movement Disorder Society, this 3rd Edition is an indispensable resource for movement disorder specialists, general neurologists, and neurology residents. - Explores all facets of movement disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. - Provides the essential information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. - Reflects recent advances in areas such as the genetics of Parkinsonian and other movement disorders, diagnostic brain imaging, new surgical approaches to patients with movement disorders, and new treatment guidelines for conditions such as restless legs syndrome. - Features a reader-friendly, full-color format, with plentiful diagrams, photographs, and tables. - Includes access to several hundred updated, professional-quality video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses.

Movement Disorders in Childhood, Third Edition provides the most up-to-date information on the diseases and disorders that affect motor control, an important area of specialization within child neurology. In this new edition, each chapter has been fully revised to include all of the latest scientific and therapeutic advances. Updates include new insights in motor development, control, goal-directed and habitual behaviors, classifications of movements and their complex and integrated circuitry. The authors also discuss developments in pathophysiologic mechanisms, immunology and metabolic disorders. New chapters include coverage of genetics of movement disorders and movement disorders in psychiatric conditions.Appendices include an updated and revised drug index and genetic search strategy. An updated Companion website hosts selected educational videos to help diagnose movement disorders. - Provides the only current reference specifically focused on childhood movement disorders - Investigates the underlying etiologies and mechanisms of these disorders - Revised and updated with new materials and a more disease-oriented approach - Contains new chapters on the genetics of movement disorders and movement disorders in psychiatric conditions - Includes new videos of instructive and unusual childhood movement disorders

Comprehensive, yet accessible, Wyllie's Treatment of Epilepsy: Principles and Practice has provided a detailed and cohesive overview of seizure disorders and treatment options through six well-regarded editions. The 7th Edition remains the definitive reference in the field with extensive updates from Dr. Elaine Wyllie and her team of world-renowned editors and authors. Ideal for both clinical reference and exam preparation, this single-volume work on contemporary epileptology is an indispensable resource for neurologists, epilepsy specialists and epilepsy neurosurgeons, neurology and neurosurgery residents and fellows, and neuropsychologists.

Apathy is characterized by loss of motivation, decreased initiative, and emotional blunting. It is highly prevalent in neurological, and psychiatric disorders like Alzheimer's disease, traumatic brain injury, schizophrenia, Parkinson's disease, Huntington's disease, cerebrovascular disorders, and mild behavioural impairment. It has negative outcomes including impairments in activities of daily living, caregiver burden, and higher rates of institutionalization and mortality. The definition of apathy has changed over the years alongside the development of diagnostic criteria and apathy scales and measurements. Apathy is emerging as a treatment target with interest in pharmacological, non-pharmacological, and neuromodulatory treatments for apathy. There is also an increased understanding of the neurobiology of apathy with functional and structural neuroimaging research studies. This book is a comprehensive, in-depth review from experts in neurology and psychiatry. It reviews the current state of apathy in these various disorders while also summarizing apathy diagnostic criteria, scales and measurements, neuropathology, and treatments.

Understanding Tourette Syndrome provides accessible, concise, evidence-based guidelines on this neurodevelopmental disorder, offering parents and professionals a deeper scientific understanding of the condition and its consequences. Zanaboni Dina and Porta explore signs, symptoms and treatment of the disease, with the aim of demonstrating to all those involved in the life of a TS child solutions to manage a range of situations from diagnosis to day-to-day life. Therapies and social intervention, including Habit Reversal Training and Deep Brain Stimulation, are described, allowing caregivers to evaluate the best course of treatment. With a focus on improving quality of life by offering practical recommendations for managing the condition at school and in the family, it places additional emphasis on sibling relationships and the importance of childhood friendship. The authors'expert subject knowledge and extensive experience of working with children and families, makes the topic accessible for any reader, and case studies demonstrate how to apply scientific understanding of the condition to a real-life situation. This unique guide is essential reading for parents and carers, as well as practitioners in Clinical and Educational Psychology, Counselling, Mental Health, Nursing, Child Welfare, Public Healthcare and those in Education. It will also be of interest to postgraduates studying courses in Psychology, Neurology and Psychiatry.

​Dieses Buch bietet eine Übersicht über ein vernachlässigtes Gebiet der Neurologie: Funktionelle Störungen bedingen jeden sechsten Praxisbesuch und etwa 10% der Notfälle und stationären Aufnahmen an neurologischen Kliniken. Dennoch sorgen sie oft für diagnostische Verunsicherung und therapeutische Ratlosigkeit.Praxisnah und evidenzbasiert erläutert der Autor Untersuchungstechniken und klinische Zeichen, die eine frühe und sichere Diagnosestellung jenseits des Ausschlussprinzips möglich machen. Neue Erklärungsmodelle, die Neurophysiologie und Psychosomatik zusammenbringen, verdeutlichen die Entstehungsmechanismen funktioneller Symptome und die Wirkungsweise verschiedener Therapien. Tipps zur ärztlichen Gesprächsführung sowie konkrete Behandlungsempfehlungen aus der Physiotherapie und Psychotherapie sollen die interdisziplinäre Patientenversorgung erleichtern.

This book discusses the link between the brain and the mind. Adopting an evidence-based neuropsychiatry approach while also touching on philosophical aspects, it examines the association between diseases of the brain and mental health, offering comprehensive insights into the emerging new discipline of psychoneuroendocrinoimmunology and its translation to clinical practice. The book particularly focuses on brain plasticity and on explaining the ability of the brain to learn new pathways in everyday situations and at the same time improve creativity.Written by clinicians and leading experts in the field of brain physiology and pathology, this book is a valuable resource for medical professionals and postgraduate students.

This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supportedby a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.

Rosenberg's Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Provides comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease Presents detailed coverage of genomics, animal models and diagnostic methods, with new coverage on evaluating patients with biochemical abnormalities or gene mutations Includes new chapters on the pharmacogenomics of epilepsy and the most recent updates in molecular genetics, focusing on neurodegenerative and psychiatric diseases

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuableto all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

This book presents the state of the art regarding the use of non-invasive brain stimulation (TMS and tDCS) in the research and treatment of neuropsychiatric disorders. The contributions, all of which were prepared by internationally recognized experts in the field, are divided into two main sections (for TMS and tDCS, respectively) across diagnoses, following an introductory section on the mechanisms of action and neurophysiological background. Neuropsychological perspectives and approaches are provided as well. The book is ultimately intended to offer a unique, integrated approach to the use of non-invasive brain stimulation across the clinical neurosciences, providing a comprehensive and updated perspective that will benefit psychiatrists, neurologists, clinical psychologists and neurophysiologists alike.

Here is a comprehensive overview of the drugs that act on the central and peripheral nervous systems. This volume thoroughly describes the diseases associated with the nervous system and the drugs used for their treatment while also looking at the current status of these drugs and their future potential and challenges.Divided into three sections, the book first focuses on the drugs that affect the functions of the autonomic nervous system to produce therapeutic effects. These drugs may act presynaptically by manipulating the genesis, storage, and secretion, and by blocking the action of neurotransmitters. Some drugs may trigger or impede postsynaptic receptors. Section 2 focuses on drugs that affect the central nervous system, including antianxiety drugs, sedative and hypnotic drugs, antidepressant drugs, antipsychotic drugs, antiepileptic drugs, and many more. It covers the pharmacological management of various diseases, including Alzheimer's, Parkinson's, Huntington's, and others. The last section offers explanations of neurochemical interactions with the aim to develop drugs that have beneficial effects on neurochemical imbalances. This section demonstrates models to assess the transport of drugs across the blood-brain barrier and nanomedicine to treat brain disorders.This rich compilation provides thorough and extensive research updates on the important advances in neuropharmacological drugs and drug therapy from experienced and eminent academicians, researchers, and scientists from throughout the world.

This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments. Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders

This book offers mental health guidelines for all medical professionals facing the emerging challenges presented by an aging population worldwide. The text acknowledges that as the geriatric demographic grows, limited resources and infrastructures demand quality protocols to deliver inpatient geriatric psychiatric care, and that many physicians may not be trained to address these specific needs. This text fills this gap with guidelines assessing, diagnosing, and treating aging patients as they present in the emergency room and other settings. Unlike any other text, this book focuses on how to optimize the use of the inpatient setting by recommending evaluations and treatments, and offering flow-charts and figures of key points, to guide both general workup and continued evaluation and treatment. This approach aims to minimize instances of premature release or readmissions and to improve outcomes. Chapters cover the various issues that clinicians face when working with an older patient, including legal topics, limitations to treatment, prescription-related complications, patients struggling with substance abuse, and various behavioral concerns. Written by experts in the field, the text takes a multidisciplinary approach to deliver high-quality care as needs of the aging population evolve. Inpatient Geriatric Psychiatry is a vital resource for all clinicians working with an aging population, including geriatricians, psychiatrists, neurologists, primary care providers, hospitalists, psychologists, neuropsychologists, emergency room and geriatric nurses, social workers, and trainees.

Psychopharmacology of Neurologic Disease, Volume 165 in the Handbook of Clinical Neurology series, provides clinicians with an up-to-date, critical review of the best approaches to treatment of neurologic disease as discussed by experienced clinical investigators. The book is organized into sections on dementia, delirium, movement disorders, hereditary degenerative disease, epilepsy and psychogenic seizures, brain vascular disease, pseudobulbar affect, traumatic brain injury, neuro-oncology, multiple sclerosis and other demyelinating disorders, chronic fatigue syndrome/fibromyalgia, pain, headache, sleep disorders, autoimmune encephalitis/anti- NMDA encephalitis, functional sensory neurologic symptom disorders and neurodevelopmental disorders. Each of these diagnostic categories has a significant incidence of behavioral symptomatology that is secondary to the neurologic diagnosis that can serve to complicate other therapeutic interventions, alter the course of illness, and cause distress in patients and family caregivers. - Provides a systematic, evidence-based compendium of best practices in the treatment of behavioral symptomatology relating to neurologic conditions - Integrates state-of-the-art approaches in treating all behavioral symptomatology across all major neurologic disorders - Explores psychopharmacological intervention, non-pharmacological strategies, behavioral symptomatology, and therapeutic interventions

Epilepsy is one of most frequent neurological disorders affecting about 50 million people worldwide and 50% of them have at least another medical problem in comorbidity; sometimes this is a the cause of the epilepsy itself or it is due to shared neurobiological links between epilepsy and other medical conditions; other times it is a long-term consequence of the antiepileptic drug treatment. The Comorbidities of Epilepsy offers an up-to-date, comprehensive overview of all comorbidities of epilepsy (somatic, neurological and behavioral), by international authorities in the field of clinical epileptology, with an emphasis on epidemiology, pathophysiology, diagnosis and management. This book includes also a critical appraisal of the methodological aspects and limitations of current research on this field. Pharmacological issues in the management of comorbidities are discussed, providing information on drug dosages, side effects and interactions, in order to enable the reader to manage these patients safely. The Comorbidities of Epilepsy is aimed at all health professionals dealing with people with epilepsy including neurologists, epileptologists, psychiatrists, clinical psychologists, epilepsy specialist nurses and clinical researchers. - Provides a comprehensive overview of somatic, neurological and behavioral co-morbidities of epilepsy - Discusses up-to-date management of comorbidities of epilepsy - Written by a group of international experts in the field

The one-stop resource on deep brain stimulation for functional neurosurgeons!Deep brain stimulation (DBS) is used to modulate dysfunctional circuits in the brain with stimulation pulses applied to specific target areas of the brain. Globally, DBS procedures have been most commonly performed for Parkinson's disease and essential tremor, but there are now new and growing research efforts studying DBS for psychiatric disorders and epilepsy.Deep Brain Stimulation: Techniques and Practices written by the Society for Innovative Neuroscience in Neurosurgery along with Dr. William S. Anderson and distinguished experts presents the latest DBS approaches. The book begins with a history of DBS, general frame-based techniques, patient selection primarily for movement disorders, multidisciplinary collaboration, and ethical considerations. Subsequent chapters detail diverse technologies and disease-specific treatment for Parkinson's disease, essential tremor, dystonia, OCD, epilepsy, major depression, Tourette syndrome, emerging psychiatric indications, and pediatric applications.Key highlightsLead placement techniques utilizing currently available customized platforms and roboticsMicroelectrode recording and image-based direct targeting with MRI and CT to enhance lead placementLesioning methods including radiofrequency, and MR-guided focused ultrasoundDiscussion of recent innovations in tractography to delineate white matter tracts in the brain and closed loop stimulationDBS has helped thousands of patients with intractable conditions, allowing for a programmable therapy with durable treatment effect. This remarkable guide provides the essentials for functional neurosurgeons to pursue intraoperative research opportunities in this growing subspecialty and incorporate DBS into clinical practice.

This case-based text provides treatment approaches to common and uncommon movement disorders. The first two parts of the book are devoted to the wide spectrum of motor and non-motor problems encountered in caring for people with Parkinson's disease, as well as Parkinsonian syndromes. Next are parts with chapters addressing essential and other tremor disorders followed by management of the various dystonic syndromes and other hyperkinetic disorders including chorea, tics, and myoclonus. Other disorders covered are drug-induced movement disorders, psychogenic movement disorders, Wilson's disease, hemifacial spasm and more. Authored by experts globally, this practical guide will help physicians, other healthcare professionals and trainees care for patients with a wide spectrum of movement disorder related problems.

This book provides a comprehensive, practical, and timely guide to neurorehabilitation for patients affected by tumors of the central nervous system. These patients encounter various physical and psychosocial impairments, due to sensory-motor, psychological and cognitive limitations, as well as depression, anxiety and fatigue. These common tumor and treatment consequences reduce quality of life and produce long-term limitation in functioning and disability that may benefit from rehabilitative interventions.In the early stages of the disease, rehabilitation aims at restoring functioning after tumor treatment, while in the advanced stages, rehabilitation becomes an integral part of palliative care, which aims to increase patients'independence, to prevent complications and to improve quality of life.Based on an interdisciplinary approach, the book is structured in two main parts. The first is devoted to the basics of cancer and to the main clinical features of thetumors of the nervous system, as well as to theessentials of therapeutic approaches. The second part is dedicated to rehabilitation issues, providing the tools for health personnel to take in charge persons affected by neuro-oncological disease. This unique volume is a valuable resource for all health professionals (physicians, psychologists, trainees nurses specialized in neuro-oncology, occupational therapists, physiotherapists, speech therapists) involved in the interdisciplinary management of individuals affected by tumors of the central nervous system.

This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world's foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Advocacy is a broad term that covers activities aimed at increasing attention, awareness, information, nursing, treatment, and support to improve the outcome of patients. These actions can be focused directly towards patients or indirectly via third parties. Although advocacy is present in all medical specialties, neurology in particular finds itself in need of strong advocacy tools as the diagnosis, treatment, long-term care and associated resource, and social issues have become increasingly complex. While some physicians implicitly or explicitly act as advocates, there is a lack of holistic research in order to clarify the meaning of advocacy along with concrete methods and strategies. Advocacy in Neurology provides an integrated approach to the concept of advocacy in neurology. Structured in five sections, the book begins by explaining the term'advocacy'in general before elaborating on the areas of interest within neurology. The text goes on to offer concrete strategies and tools for clinicians to deploy advocacy in their daily work, and then discusses specific neurological diseases to point out and explain where advocacy is, or could be, beneficial. The book ends with an outlook, presentation of results, and an ending conclusion. Advocacy in Neurology offers a practical perspective on advocacy activities in neurology, aiming to show when and why they are important for neurology.

This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases

The aim of this book is to focus on the Neurological Examination: A Structured Approach. Neurological examination is the assessment of sensory neuron and motor responses, especially reflexes, to determine whether the nervous system is impaired. Clinical neurology has received a well-deserved attention in the recent years, with reputed journals discussing and debating its relevance in modern neurology. This book consists of 18 chapters, which include assessment of higher mental functions, examination of a patient in coma, cranial nerves, motor system, examination of the sensory system, reflexes, examination of coordination, examination of gait, examination of movement disorders, clinical evaluation of seizures and epilepsies, examination of a patient with vertigo, autonomic nervous system, neurological examination of a neonate, and pediatric neurological examination. Each chapter is divided into 4 fixed components following as physiological basis, methodology, interpretation, and caveats. These represent the 4 levels where clinical errors can creep in. This book is an attempt to present neurological examination in a fixed, structured format that minimizes this variability and to encourage uniformity. This book can be used by neurologists, neurosurgeons, physicians, pediatricians as well as postgraduate trainees from these fields.

Lekarz POZ jest pierwsza osobą, do której zgłasza się pacjent ze swoimi dolegliwościami. Jego zadaniem jest rozpoznać chorobę i zastosować właściwe leczenie. Czasami konieczne jest określenie czy istniejące objawy mają swoje źródło w psychice pacjenta czy odwrotnie – są związane z jego stanem somatycznym. Zespół autorów pod kierunkiem prof. Marka Jaremy (byłego konsultanta krajowego w dziedzinie psychiatrii) podjął się przygotowania cyklu publikacji, które będą wparciem dla lekarza POZ w jego codziennej praktyce w takich sytuacjach. Zawarta w książce wiedza pomoże podjąć decyzję czy leczyć samemu, czy skierować pacjenta do lekarza psychiatry. „Zaburzenia nerwicowe w praktyce lekarza POZ” jest kolejną w cyklu. W książce obok: - niezbędnych informacji z zakresu etiologii i patogenezy schorzeń - uproszczonego opisu objawów oraz obrazu klinicznego - podstawowych wiadomości z zakresu leczenia farmakologicznego - opisu działań poza farmakologicznych (np. psychoterapii) Czytelnik znajdzie ponadto: - klasyfikację zaburzeń nerwicowych - kilka słów o częstości występowania - podstawowe wiadomości na temat współchorobowości w zaburzeniach nerwicowych.

Imaging in Movement Disorders: Imaging in Atypical Parkinsonism and Familial Movement Disorders, Volume 142, addresses the use of imaging modalities across the spectrum of movement disorders and dementias. Over the last decades, advances in neuroimaging tools have played a pivotal role in expanding our understanding of disease aetiology and pathophysiology, identifying biomarkers to monitor disease progression, aiding differential diagnosis and in the identification of novel targets for therapeutic intervention. This updated volume covers PET Molecular Imaging in Atypical Parkinsonism, SPECT Molecular Imaging in Atypical Parkinsonism, Structural MRI in Atypical Parkinsonism, Functional MRI in Atypical Parkinsonism, and more. - Offers a complete review of the applications of neuroimaging tools in Atypical Parkinsonism, familial Parkinson's disease and Huntington's disease - Discusses the role of neuroimaging modalities, including SPECT, PET, and structural and functional MRI - Includes sections on potential clinical applications and future directions

Antiepileptic drugs are among the most commonly prescribed medications by both neurologists and psychiatrists, as they exert a number of effects which extend far beyond their anticonvulsant properties. There is growing evidence that each antiepileptic drug is characterised by a specific behavioural profile. Behavioural Neurology of Antiepileptic Drugs: A Practical Guide offers a user-friendly guide to the use of antiepileptic drugs and their behavioural effects on patients with epilepsy and primary psychiatric conditions. Written over 18 chapters, this practical handbook guides the reader through the breadth of medications used in modern epilepsy and psychiatry practice alphabetically, including information on each drug's indications, contra-indications, side-effects, and important interactions. This resource covers practical information on prescribing and monitoring to ensure the reader has the most up-to-date evidence-based guidance at their fingertips, and diagrams are used throughout to aid visual learning. With up-to-date content and a practical approach, Behavioural Neurology of Antiepileptic Drugs: A Practical Guide is an invaluable resource for consultants and trainees in neurology, psychiatry, and neuropsychiatry, as well as to pharmacists and specialist epilepsy nurses.