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Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer's and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States'Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century inits third edition serves as a comprehensive resource to students and researchers alike.

Anxiety disorders are not uncommon and are often ‘comorbid'with other forms of mental disorders. This publication provides an update on the origins and the causes of anxiety disorders and their related symptoms. Its focus is on neuroimaging and neuroinflammation and genetics as well as areas where an overlap may exist with abnormal cardiovascular physiology. Further it takes a closer look at the early phases of anxiety disorder and the potential effects of prolonged illness prior to diagnosis and also investigates recent research findings about the neuroimmunology of depression and the immunomodulatory effects of antidepressants. It also examines the neuroinflammatory hypothesis about anxiety disorders and concludes with the succinct but evidence-based and comprehensive reports on the value of pharmacological treatments used for generalized anxiety disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder and obsessive-compulsive disorder. The topics covered in this publication will certainly make it essential reading for both novice and expert practitioners in psychiatric medicine, but its appeal should extend even further and include those researching the neuropsychobiology of anxiety or trying to improve our grasp of posttraumatic stress disorder or obsessive-compulsive disorder.

Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system.In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure – the dorsal raphe nucleus – that structure is not homogeneous from anatomical, physiological and neurochemical points of view, nor are its projections to the cerebral aversive and behavioral inhibition systems.The diverse findings which compose this picture of complexity – whether they arise from developmental neurobiology, electrophysiology, neurochemistry, neuroendocrinology, neuropsychopharmacology or behavioral neuroscience – are integrated in this book. Advanced undergraduate, graduate students, and researchers will benefit from the information. The result sheds light on many important questions regarding the neuroanatomical, pharmacological and functional aspects of the role of serotonin in anxiety disorders, and points to future avenues of research.

In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system. This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness. - Translates the basic science of vagus nerve stimulation into real-world clinical applications - Explains VNS anatomy and signaling through central and autonomic nervous system - Reviews VNS treatment of neurological, psychiatric, and inflammatory disorders - Extends clinical utility to cardiac, renal, and metabolic disorders. - Provides new insights to the disorder of vagus insufficiency syndrome - Explores VNS treatment for headaches, TBI, stroke, seizures, and pain.

Using a practical, easy-to-reference signs and symptoms approach, Fenichel's Clinical Pediatric Neurology, 9th Edition, provides a solid foundation in the diagnosis and management of primary neurologic disorders of childhood while bringing you fully up to date with developments in the field. It offers step-by-step, authoritative guidance that considers each presenting symptom in terms of differential diagnosis and treatment, reflecting real-life patient evaluation and management. Perfect for board exam preparation, office use, or residency reference, this well-organized, revised edition is an ideal introduction to this complex and fast-changing field. - Defines age at onset, course of illness, clinical features, and treatment options for each neurological disease, all logically organized by neurological signs and symptoms in a highly templated format. - Brings you up to date with every aspect of the field, with integrated content on new medications, new topics such as neurological complications of COVID in children, and a new chapter on behavioral neurology. - Includes comprehensive coverage of genetics in relation to epilepsy, autism, and many neurometabolic disorders, with up-to-date coverage of genetic testing, diagnosis, and pharmacogenomics. - Features weighted differential diagnosis tables and treatment algorithms that help you quickly identify the more common and most treatable neurological disorders, as well as evaluate and manage the most difficult neurodegenerative disorders, including those caused by inborn errors of metabolism. - Provides helpful boxes that synthesize symptoms and foundational points, an increased number of imaging examples throughout, and more than 300 illustrations, tables, and charts that support and clarify the text. - Shares the knowledge and experience of clinical neurologist and epileptologist, Dr. Kaitlin C. James, and Dr. J. Eric Piña-Garza, a longtime associate and protégé of Dr. Gerald Fenichel.

This book assembles, for the first time, information required for the recognition, understanding, and treatment of behavioral problems resulting from neurological conditions. Its focus is two-pronged: 1) on conditions where cognitive-behavioral manifestations are major symptoms, such as attention deficit hyperactivity disorder, autism, and developmental language disorder; and 2) on conditions where these symptoms are significant but secondary, such as brain tumors, epilepsy, and AIDS. This multi-authored guide also outlines effective approaches to behavioral therapy for these conditions. Pediatric Behavioral Neurology is an excellent resource for practitioners whose work demands knowledge of the symptoms, signs, and treatment of behavioral and cognitive disorders caused by brain abnormalities. It is comprehensive, yet concise and easy to use.

Designed to be a practical reference guide, chapters succinctly provide a current overview of the relevant area while concise enough to be read in a single sitting. All of the major co-morbidities of epilepsy are reviewed, as well as the impact of anti-epileptic medications and other therapies. In addition, a specific chapter about older patients with epilepsy is also included. This book supplies the reader with a deeper understanding of the relevant co-morbidities in epilepsy as well as providing insights into strategies to help in the holistic treatment of patients. While primarily UK-focused it will also be of interest to medical/nursing practitioners around the globe, including in the developing world, and to epilepsy charities and interested lay- readers/patients.

International Review of Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review of Neurobiology series - Updated release includes the latest information on The Neurobiology of Alcohol Abuse

Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases, Volume 173 in the International Review on Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as A general clinical overview of the non-motor symptoms, Stress/fatigue/cognitive decline Sleep/autonomic failure, A general clinical overview of the non-motor symptoms – psychiatric symptoms, Psychosis, Cognitive Decline, Non-clinical Aspect of non-motor symptoms: Animal Models, Assessment and treatment of cognitive decline in rodent and primate models, Pain in PD models, Affective disorders in PD models, Sleep and circadian dysregulation and EEG disruption in rodent models, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review on Neurobiology serials - Updated release includes the latest information on Translational Approaches to Non-Motor Symptoms of Neurodegenerative Diseases

This innovative book offers a multidimensional exploration of the epistemological foundations of psychiatry and its major disorders. By emphasizing the importance of phenomenology in unravelling the intricate interplay between basic categories of human experience and neurobiological processes, it advocates for a shift in both psychiatric research and clinical practice. Phenomenological Neuropsychiatry presents psychiatry as a hybrid discipline that synthesizes subjective mental experiences with objective neuroscientific findings and forms an integrative and interdisciplinary structure that provides a dialectical bridge between understanding, compassion, and explanation. The first section of the book presents the lived experience of psychosis and argues for a more inclusive approach to mental health issues. The second section examines the ways in which psychiatric knowledge is constructed and the unique challenges posed by combining understanding and explanation of mental disorders. Section three sheds light on how disruptions in bodily experiences, memory processes, and self-perception can contribute to the development and manifestation of psychiatric issues. The following section discusses disorders of mood and anxiety, including the phenomena of depression, obsessions, and depersonalization. The fifth and final section provides an in-depth examination of psychotic disorders. It covers a range of topics, such as timing, intentionality, self-monitoring of action in schizophrenia, and the neurobiology of prodromal psychosis. As a singular work dedicated to revitalizing and advancing cross-fertilization between psychiatry and phenomenology, this groundbreaking book clears the foggy operationalized clusters of mental symptoms that may obscure diagnosis and treatment and argues for systematic integration of patient subjectivity and collaboration in clinical research. It features an authorship of the leading clinicians and thinkers from throughout the world in psychiatry, psychology, neuroscience, social sciences, and philosophy. Phenomenological Neuropsychiatry: How Patient Experience Bridges the Clinic with Clinical Neuroscience is a major contribution to the clinical literature and a must-read for psychiatrists, neurologists, psychologists, and professionals and students from other disciplines concerned with absorbing a deeper understanding of psychiatric disorders.

•It is a first Case Study book on “Headache Disorders” published in India. •A total number of over 81 Cases have been discussed in an interactive manner. •Additionally, 17 Commentaries on topics of current interest related to the cases discussed have been included. •The book is amply illustrated with diagrams and photographs. •All in all, the present volume is a comprehensive textbook on Headache Disorders suitable for General Neurologists, Physicians, Pediatricians, and Trainees.

This book represents a significant advance in the field of evidence-based acupuncture, specifically in regard to neurological disorders. It is a testament to the promising future of acupuncture, integrating the complexities of the human brain with the healing art of acupuncture. Each chapter leads readers to an expanded perspective where past and future, tradition and technology, converge in the pursuit of healing and well-being. In recent decades, technologies like functional magnetic resonance imaging (fMRI) have revolutionized our understanding of the human brain, enabling scientists to observe the brain's response to acupuncture in real-time. Tracing the pathways from acupoint to brain structure reveals fresh insights on the therapeutic function of acupoints and meridians. Participate in this journey to understand how acupuncture influences the brain, exploring new frontiers in the treatment and understanding of brain-related conditions. This book offers a rich blend of traditional healing wisdom and contemporary scientific insight.

This book provides comprehensive and up-to-date general information and evaluation of the diagnostic and therapeutic options available to individuals suffering from neurotologic diseases. Neurotology is a fast-developing area of science. Even fundamental terminology, such as the meaning of vestibular symptoms, has only recently been established due to the rapid development of vestibular research. This volume discusses the fundamental sciences, and the clinical application of treatments in neurotology, as well as the most recent research. It is aimed at assisting physicians in making the most effective judgments regarding the management of care for their patients. Diagnosing patients with vestibular symptoms such as vertigo, dizziness, unsteadiness, and oscillopsia requires consideration of symptoms and indicators of neurotologic illnesses. The majority of diagnoses may be made right at the patient's side. A grasp of important diagnostic concepts is vital for all practicing neurologists, who regularly assess whether such patients merit immediate diagnostic testing or hospital admission. This book emphasizes understanding how to take a focused medical history and perform a thorough physical examination on a patient experiencing vestibular symptoms or suspected of having a neurotologic condition. This up-to-date reference should be part of the collections of all otolaryngologists, head and neck surgeons, audiologists, neurologists, neurosurgeons, and residents interested in providing the best possible care for patients.

This book focuses on the clinical and preclinical research on traumatic brain injuries where age at time of injury (young versus aged) reveals both parallel and divergent findings at the molecular, cellular, and behavioral levels with insights into alterations in brain structure and function and the implications for recovery. The authors address the hurdles that have been overcome, consider new directions inspired by the most recent research, and the value of data sharing and evidenced based-practice. Traumatic Brain Injuries: Tackling the Unique Terrain of the Injured Young and Aged Brain explores the challenges imposed by an injury that not only causes tissue damage but disrupts brain development and may incite pathological events in the aging brain. With the proliferation of the research literature in traumatic brain injuries, this is the time for a book that surveys the landscape and assesses where the field is headed and what is needed moving forward.

This book provides a comprehensive overview of the current state of knowledge on autism in females, in order to help understand and clarify gender implications in the autistic female phenotype. Despite the reported higher risk of developing autism in males than in females, few studies have investigated the gender differences at the clinical and neurobiological level. Possible genetic protective factors, as well as differing neurobiological brain trajectories, could be responsible for the male/female discrepancy in prevalence rates (4:1). Moreover, a different clinical phenotype regarding the onset of symptoms, behavioral features and social motivation often skews diagnosis in women. Specifically, the phenomenon of camouflaging or hiding symptoms in high functioning females, due to behavioral coping strategies, contributes to incorrect or delayed diagnosis. In addition to addressing an important gap in the literature, this book provides concrete and specific diagnostic recommendations and intervention strategies. In addition, a dedicated chapter presents clinical case reports and shares the personal experiences of autistic women. Given its scope, the book will appeal to clinicians and practitioners, as well as researchers and students in the fields of child and adult psychiatry, psychology and neuropsychiatry.

Die Behandlung mit repetitiver transkranieller Magnetstimulation (rTMS) wird zunehmend zum Standard bei der Behandlung von Patienten mit Depressionen, unterstützt durch eine rasch wachsende Forschungsbasis. Dieser prägnante klinische Leitfaden dient als Nachschlagewerk und praktisches Werkzeug für Kliniker, die mit dieser Behandlungstechnik arbeiten oder sie kennenlernen möchten. Die einleitenden Kapitel enthalten grundlegende Informationen über die Geschichte und Entwicklung der rTMS-Behandlung und ihren Wirkmechanismus. Die Anwendung der Behandlung bei Depressionen wird dann im Detail behandelt, wobei die Evidenzbasis erläutert und eine Vielzahl klinischer Fragen erörtert wird. Die Nebenwirkungen der Behandlung werden diskutiert, und die Einrichtung von rTMS-Behandlungsprogrammen wird erklärt. Es gibt einen aktualisierten Überblick über den Einsatz von rTMS-Anwendungen bei anderen psychiatrischen Erkrankungen wie Zwangsstörungen. Weitere Kapitel befassen sich mit dem Einsatzvon tiefer TMS, Theta-Burst-Stimulation, beschleunigten Formen der rTMS und was bei Patienten zu tun ist, die nicht auf die erste Therapie ansprechen. Darüber hinaus werden die verschiedenen Ansätze für eine zielgerichtete Behandlung im Detail dargestellt. Dieses Buch vermittelt dem rTMS-Praktiker und jedem Interessierten eine aktuelle und umfassende Übersicht und bietet umfangreiche praktische klinische Ratschläge.

Psychiatric symptoms (or mood/emotional disturbances) are diverse in patients with neurological diseases, that include depression, anxiety, emotional incontinence, anger, fatigue, and apathy. These symptoms are common; more than 1/3 of the patients suffer from these symptoms. Unfortunately, they have been neglected because 1) unlike other neurological symptoms such as motor dysfunction, speech disturbances or visual field defect, these symptoms are not visible and difficult to be noticed unless they are specifically examined by a physician who is properly educated on this problem 2) they are often not regarded as neurological symptoms either by the patients or their caregivers 3) they are relatively poorly studied by both neurologists and psychiatrists, and accordingly, are unfamiliar to the physicians. Especially, although `depression'is well known to physicians, other symptoms such as emotional incontinence, anger, fatigue or apathy are not appropriately assessed by physicians, and frequently misdiagnosed as depression. Moreover, there are difficulties in diagnosing depression in patients neurological diseases. For example, the individual items included in depression diagnosis such as sleep disturbances, appetite loss, or fatigue can result from neurological diseases or comorbid physical conditions in patients with neurological diseases. Therefore, a diagnosis of `depression'should be made cautiously. Finally, it should be understood that the importance of different mood/ emotional syndromes differ among various neurological diseases; for instance, although emotional incontinence and anger occur in as many as 20-30% of stroke patients, apathy and fatigue are more important symptoms than these for patients with neuro-degenerative disease.In clinical practice, recognizing these symptoms is important because they negatively affect the patients'quality of life, impair the functional recovery, increase the mortality, and increase the caregiver burden. Nevertheless, unlike other neurological symptoms such as motor/sensory dysfunction, and speech disturbances, they are relatively well managed mostly by pharmacological therapy such as selective serotonin re-uptake inhibitors (SSRI).The phenomenology of these neuropsychiatric symptoms and related factors, pathophysiological mechanism, and treatment strategies should be properly educated for neurologists, psychiatrists and other physicians. The book is written by experts in this field to disseminate important knowledges to neurologists, psychiatrists, psychologists and other physicians and will eventually benefit patients with neurological diseases.

Dizziness and Vertigo describes the basic knowledge and practical skills necessary for managing patients presenting with common symptoms of dizziness and vertigo. It provides practitioners with a comprehensive overview of these conditions, steps for diagnosing patients and various treatment options.This revised and updated edition provides a framework for the accurate diagnosis and management of patients with dizziness and vertigo, covering clinical assessments and case studies. It also includes new methods for treating Ménière's disease and benign paroxysmal positional vertigo (BPPV) and in the field of vestibular rehabilitation.Dizziness and Vertigo is an essential reference for all those who manage patients in the outpatient setting, including general practice trainees, ear/nose/throat (ENT) specialists and physiotherapists.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in neurology and allied disciplines.The twelfth volume of this series features these reviews:Chapter 1: Recent Drugs Tested in Clinical Trials for Alzheimer's and Parkinson's Diseases Treatment: Current Approaches in Tracking New DrugsChapter 2: Neurobiology of Placebo: Interpreting Its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in TherapeuticsChapter 3: Role of Gut Microbiota in Neuroinflammation and Neurological DisordersChapter 4: The Role of Age in Pediatric Tumors of the Central Nervous SystemChapter 5: Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related ComorbiditiesChapter 6: Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning.

••Selected for Doody's Core Titles® 2024 in Psychiatry••Anatomy of Neuropsychiatry: The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness, Second Edition, builds upon reprised classic chapters by Lennart Heimer and Gary Van Hoesen describing the cortical and subcortical structure and functional involvements of several functional–anatomical macrosystems in the human forebrain, the existence of which obviates the vaunted heuristic value of the'limbic system'concept in the study of motivation and emotion. New narrative brings in important historical, philosophical, and histotechnical contexts, integration with novel technologies (e.g., optogenetics) and structures (e.g., rostromedial tegmental nucleus), a deeper dive into the interactions of forebrain and prospective cerebellar macrosystems with the reticular core of the brain, and current viewpoints on the essential role of macrosystems in motion, motivation, emotion, cognition, and neuropsychiatric well-being. - Presents discredited concept of the limbic system - Reviews the neuroanatomy of the basal forebrain, greater limbic lobe, and reticular core - Includes Clinical and Basic Science Boxes highlighting specific concepts, structures, and neuronal circuits from functional and clinical perspectives - Features 10 videos of dissections of human brain done by the late Lennart Heimer

​Das Gebiet der funktionellen Störungen hat in der Neurologie inzwischen einen festen Platz eingenommen. Um Behandelnden Sicherheit bei der Diagnostik und handfeste Unterstützung bei der Therapie zu bieten, erläutert dieses Buch praxisnah und evidenzbasiert Untersuchungstechniken und klinische Zeichen, die eine frühe und sichere Diagnosestellung jenseits des Ausschlussprinzips möglich machen. Der Autor erklärt die Wirkungsweise verschiedener Therapien und gibt Tipps zur ärztlichen Gesprächsführung sowie konkrete Behandlungsempfehlungen aus der Physiotherapie und Psychotherapie, um die interdisziplinäre Patientenversorgung zu erleichtern. Die überarbeitete Auflage berücksichtigt aktuelle Entwicklungen aus der klinischen Forschung mit einem Akzent auf praktisch relevanten Aspekten. Neue Kapitel behandeln das pragmatische Management funktioneller neurologischer Störungen in der Notaufnahme und Besonderheiten bei Kindern und Jugendlichen.

This book is a comprehensive guide to pediatric psychopharmacology, detailing medications used to treat a wide variety of childhood and adolescent mental illnesses. Childhood and adolescence represent critically important life stages in cognitive, social, and emotional development. Unfortunately, the prevalence of mental illness has been growing over the last several decades, especially among children. It is estimated that suicide is the second most common cause of death among adolescents and young adults in the United States. A crucial component of evidence-based mental health treatment of youth consists of careful, sophisticated, and compassionate medication treatment. This guide is divided into 18 chapters, with most covering the medications used to treat a specific disorder or group of disorders. Chapters comprehensively cover each medication's history, FDA indication status and context, representation in the media, mechanism, extent of usage and research, and quality of evidence supporting its efficacy and safety. Chapters also cover approaches clinicians can use to discuss medications with patients—including alternative treatment options and integrating patient-level variables when choosing a medication. This book focuses on understanding patient and family perspectives on medication with suggested clinician responses to better communicate about prescription management. Chapters also include tables and figures, list resources and guidelines, and discuss controversies in the media. All prescribers to children and adolescents will find Pediatric Psychopharmacology Evidence to be a timely, comprehensive, and compassionate guide to the pharmacological treatment of young patients with mental illness.

Sensitization is a concept of learning and memory that has grown out of experiments on'simple'animals. Interest in sensitization has grown tremendously in the last several years, fueled mainly by evidence of the molecular basis of sensitization in invertebrates on the one hand and the study of cocaine abuse, which produces behavioral sensitization, on the other. Because the rapid advance of information across such a broad range of research areas has made an integrated approach necessary, this volume combines findings on sensitization across the phylogenetic scale.

Navigating Life with Restless Legs Syndrome provides an overview and evidence-based guidance on a condition that afflicts millions of people around the world and their loved ones. You will learn the most up-to-date treatment approaches to the disorder, the benefits of common medications used to treat RLS, as well as non-pharmacological options such as iron supplements and infusions, along with their potential side effects and long-term risks. RLS during pregnancy and breastfeeding, patients from rural or low-income communities with limited access to health care, and those with dementia, sleep apnea, and insomnia are among the special populations that are also addressed. Periodic limb movements of sleep are discussed to help distinguish between these and RLS. Real patient scenarios and tips for caregivers and loved ones of people battling restless legs syndrome are interspersed throughout. This book serves as a comprehensive yet approachable reference on a complex condition that disrupts life, interrupts sleep, and increases the risk of multiple health problems for so many people.

This book is a practical reference and educational tool that teaches headache specialists and neurologists about the comorbid illnesses they will encounter in their patients.Headache Medicine is increasingly recognized as a dedicated specialty with an emerging cohort of physicians focused on treating these patients. Given the high prevalence of headache globally, patients often have comorbid conditions, which affect treatment decisions and outcomes in innumerable ways. This easy-to-use reference of comorbid conditions facilitates an understanding of the complete patient with a headache. Each chapter discusses the longitudinal illnesses organized by body system, in addition to chapters on general internal medicine and the treatment of special populations. Headache clinicians will benefit from building knowledge of general internal medicine topics as an overlay to their headache practice.This reference book on comorbid conditions supports a holistic approach to the patient with a headache. In addition to headache specialists, it will benefit a wide range of health-care providers, including neurologists, primary care physicians, pediatricians, obstetricians, and gynecologists.

Drug Addiction Mechanisms in the Brain explores the fascinating world of drug substances and their effects on the brain. This book provides a comprehensive overview of the ten major substances that contribute to drug addiction Information about each substance is presented in a specific chapter, shedding light on their biochemical mechanisms and physiological effects. From the stimulating effects of cocaine to the sedative properties of heroin, and the hallucinogenic experiences induced by LSD, the book takes the reader through the intricate pathways of addiction. Other substances covered in the book include alcohol, nicotine, MDMA, METH, morphine, ketamine, and fentanyl. Readers will gain an understanding about neurochemical alterations in the brain Anyone looking for interesting knowledge about the addictive nature of common drugs and their complex interplay with the brain will find this book informative.

Epilepsy is the most common neurological condition in children and young people, and is more likely to begin in childhood, with approximately 50–60% of cases remitting before the young person enters adulthood. This concise resource focuses on the investigation, diagnosis, treatment, and management of epilepsy in children and young people, and discusses the transition through to adult services.

The book offers a must-have tool primarily for psychiatrists, geriatricians, neurologists, and psychologists, but will also be of interest to general practitioners for first line assessment. The aim of this book is to establish a gold standard: a reference work to be used as a clinical guide to the assessment of mental illness in older persons in the field. Psychogeriatrics is generally a very specific field in the midst of different disciplines, where there is hardly a clinical consensus on how to best assess and treat elderly subjects with mental or behavioral symptoms, possibly resulting from psychiatric disorders. This book provides clear and practical indications, prepared by a panel of international experts in the field with extensive scientific and clinical experience. Boxes with first and second line actions for assessing and treating mental illness in the elderly are included, and all chapters are uniformly divided into sections on epidemiology, etiopathogenesis, differential diagnosis, assessment, and treatment.

This textbook presents real-world cases and discussions that introduce the various psychiatric syndromes found in the aging population before delving into the core concepts covered by geriatric psychiatry curricula. The text follows each case study with the vital information necessary for physicians in training, including key features of each disorder and its presentation, practical guidelines for diagnosis and treatment, clinical pearls, and other devices that are essential to trainees in geriatric psychiatry. With the latest DSM-5-TR guidelines and with rich learning tools that include key points, review questions, tables, and illustrations, this text is the only resource that is specifically designed to train both US and Canadian candidates for specialty and subspecialty certification or recertification in geriatric psychiatry. It will also appeal to audiences worldwide as a state-of-the-art resource for practice guidance. The text meets the needs of the future head on with its straightforward coverage of the most frequently encountered challenges, including neuropsychiatric syndromes, psychopharmacology, elder care and the law, substance use disorders, psychiatric comorbidities in systemic medical illness, consultation-liaison psychiatry, palliative care, climate change and health, and equity/diversity/inclusion matters in the care of older adults. Written by experts in the field, Geriatric Psychiatry: A Case-Based Textbook, 2nd edition will be the ultimate resource for graduate and undergraduate medical students and certificate candidates providing mental health care for aging adults, including psychiatrists, psychologists, geriatricians, primary care and family practice doctors, neurologists, social workers, nurses, and others.

This book describes the theoretical background of the different forms of tinnitus (ringing in the ears) and detailed knowledge of state-of-the-art treatments of tinnitus. Tinnitus has many forms, and the severity ranges widely from being non-problematic to severely affecting a person's daily life. How loud the tinnitus is perceived does not directly relate to how much it distresses the patient. Thus, even tinnitus very close to the hearing threshold can be a disabling symptom. It can reduce the quality of life by generating anxiety and concentration problems, impairing the ability to do intellectual work, making it difficult to sleep, causing depression and sometimes even leading to suicide.Textbook of Tinnitus has filled a void by providing a comprehensive overview about the different forms of tinnitus, their pathophysiology and their treatment. However, since the publication of the first edition of the Textbook of Tinnitus in 2011, tinnitus research has dramaticallyevolved. In view of the substantial increase in knowledge, most chapters in this second edition are newly written and a few original chapters have had major updates. This edition has nine sections, covering the basics of tinnitus, the neurobiology of tinnitus, pathophysiological models, animal research, diagnosis and assessment, various forms of management and treatment, and finally, a look at the future of tinnitus and tinnitus research. The book will be of great interest to otolaryngologists, neurologists, psychiatrists, neurosurgeons, primary care clinicians, audiologists and psychologists, and students. Because of its organization and its extensive subject index, Textbook of Tinnitus, Second Edition can also serve as a reference for clinicians who do not treat tinnitus patients routinely.

The second edition of the'IAN Textbook of Neurology'has been prepared for clinicians who participate in the care of neurological patients, including those who are in training to become neurologists, internists, neurosurgeons, and neuroscientists. The basic structure of this second edition has changed. The book is divided into seven parts. Section 1 discusses the History-taking and the Neurological Examination, inclusive of the systemic examination that helps the neurological diagnoses. Section 2 covers the Applied Neuroanatomy and Neurophysiology aspects that are important to clinicians. Section 3 discusses the clinical Approach to various Common Neurological Symptoms. Section 4 describes Diseases of the Nervous System. Section 5 discusses Investigations, Section 6 the Principles of Management, and Section 7 is about the Counseling and Doctor–Patient Relationship.

Hone your clinical reasoning and diagnostic skills with a new series of case-based topic-specific studies. This compilation of twenty neurology-related cases includes presenting clinical manifestations and a discussion of the broad range of possible diagnoses, with a reveal of the actual diagnosis at the end. Does this child have a classic presentation of a rare condition or an atypical presentation of a common diagnosis? Does the patient have a primary neurological condition or a neurological manifestation of a systemic disease? Several patients in this collection presented with ataxia, but their final diagnoses range from the unsurprising cerebellar tumor to uncommon conditions like heavy metal poisoning and rare genetic disorders. Does the child with diffuse weakness have a classic condition such as Guillain-Barré syndrome, a vitamin deficiency, one of the periodic paralyses, or an autoimmune disorder such as myasthenia gravis? Cases also include relatively new conditions such as autoimmune encephalitis or genetic disorders but remind us not to overlook well-known but now uncommon conditions like vitamin deficiencies or remote neurological dysfunction due to cancer in another organ.

How to Build a Human Brain takes a developmental approach to understanding brain structure and function. It guides readers through the evolution of the human brain, from its cellular building blocks, up to hind brain structures and functions, and through to neocortex and associated functions. In doing so, it enables students to develop a comprehensive knowledge of the relationship between brain networks and functions, neural underpinnings of functional problems seen after neuropathology, and neuroanatomy.Written in an engaging style, each chapter follows a blueprint format with subsections on issues like'damage and repair'and'faulty wiring'as the brain is ‘built'across the course of the book. The author includes illustrative case studies and entertaining fast fact boxes to highlight the real-word relevance of each brain structure being examined. This textbook offers an accessible reference for students of neuroscience, cognitive neuroscience, neuropsychology,and biological psychology.

This practical, case-based book offers an approach to diagnosis and treatment of movement disorders in the outpatient setting. The major hypokinetic and hyperkinetic disorders are considered in turn, with more than 1,000 videos illustrating the role of phenomenology in the diagnosis and treatment of these conditions. Discussion of the role of ancillary testing (imaging, genetic testing) and treatment options with medications, botulinum toxin injections, and surgical intervention are woven in to the discussion of cases throughout the book. Special attention is directed to pitfalls and perils of office-based practice. This volume will be of interest to movement disorders neurologists and trainees, general neurologists, neurology residents, and any healthcare professional with an interest in exploring the application of the many treatments that have transformed movement disorders into a therapeutic field. Rather than a textbook of movement disorders, thisvolume will help the practicing clinician in guiding the thought process for evaluation and management of patients in the clinic.

This monograph serves as an expert in selective topics of Neurology and their clinical applications pertaining to the Indian context. As the monograph deals with practical realistic problems; it is surely efficacious in decision-making of the general physicians and the neurologists in their everyday clinical practice. It also serves as an essential resource for all the postgraduate students of medicine and neurology. This monograph is a comprehensive amalgam for all the readers. It consists of three sections; namely Stroke; Epilepsy; and CNS infections. Each section comprises an almost equal set of questions.

This collection of epilepsy surgical cases illustrates patients with straightforward and challenging pharmacoresistant epilepsy. These cases convey the advancements, investigative strategies, past and modern surgical tools, and sophisticated state-of-the-art of epilepsy surgery and its disciplines. This textbook is organized into four major sections that parallel the contemporary FDA-approved and clinically applicable approaches: resective surgery, disconnection procedures, laser therapy, and neuromodulation. The chapters provide a case-based, interactive, and multidisciplinary integrative approach to pre-operative evaluation, data analysis, and surgical decision-making. In addition, we present alternative approaches to certain diagnostic tools, decision-making strategies, and surgical interventions.This textbook will provide trainees and clinicians with an exhaustive understanding of epilepsy surgery. Moreover, it will be an invaluable resource for preparation for the epilepsy board examination

neurology A fully updated and authoritative neurology resource The Queen Square Textbook has established itself as a favourite companion to clinical neurosciences training and teaching around the world, whilst retaining its role as an invaluable reference guide for physicians and other healthcare professionals working in neurology, general medicine and related specialties. The book continues to reflect the core values essential to the practice of clinical neurology in the 21st century. The third edition has been extensively revised and updated to take account of the rapid pace of progress in the neurosciences and patient care. Contemporary neurology has been changed by the COVID-19 pandemic, the climate emergency and the growing inequalities in healthcare resources. The new edition has been extensively revised to reflect these challenges and affords a greater emphasis on management and rehabilitation whilst continuing to reflect the coherence of a text produced from a single, closely-knit, centre of excellence. Highlights of the new edition include: An updated approach to clinical examination, decision-making and diagnosis New developments in neuroimmunology, pathology and genetics Neuropalliative care Ethical and legal issues in clinical neurology The latest developments in the understanding and management of stroke, movement disorders, epilepsy, cognitive impairment, multiple sclerosis, infections, myelopathy, anterior horn cell disease, disorders of nerve and muscle, neuro-oncology, neurological disorders of hearing, balance and vision, and the neurological care of critical illness, sleep, neuropsychiatry, pain, autonomic and urological disorders. An emphasis on treatment and rehabilitation of the person with a neurological disease The new edition marks a significant transition to reflect contemporary neurological practice during uncertain times. It mirrors the enormous changes in investigation, diagnosis and treatment that have occurred in recent years whilst maintaining the underlying principle that we do not treat diagnoses but, rather, we care for people affected by neurological disease.

Cannabidiol in Neurology and Psychiatry, Volume 177 in the International Review in Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topic such as Historical perspective on the therapeutic potential of cannabidiol, Cannabidiol: pharmacodynamics pharmacokinetic, Cannabidiol and Alzheimer's disease, Cannabidiol on anxiety disorders, Cannabidiol on psychosis, Cannabidiol on autism spectrum disorders, Cannabidiol in Epilepsy, Cannabidiol in Ischemia/stroke, Cannabidiol in Depression, Cannabidiol and Abuse of drugs, and much more.Additional chapters cover Cannabidiol in fear response and PTSD, Cannabidiol and Pain. and Cannabidiol and Parkinson's disease. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review on Neurobiology series - Updated release includes the latest information on Cannabidiol in Neurology and Psychiatry

Migraine Management, Volume 196 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable, are also critically reviewed. Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness is also explored. - Summarizes evidence-based best treatment for migraines - Differentiates treatment based on patient population, migraine type, and clinical setting - Includes pharmacological, biobehavioral, and physical treatments - Provides specialized treatments for children, the elderly, and pregnant patients

This title primarily focuses on the functional mechanisms and roles of Ca2+ channels in the central nervous system, and the effects of Ca antagonists on cytosolic CA2+ by blocking voltage sensitive channels. These findings are an important contribution to understanding the mechanisms of brain dysfunctions, including Alzheimer's disease, cerebral ischemia and affective disorders, as well as the effects of cytosolic CA2+ modulators on neuronal cell death. In addition the results of clinical trials are reported using typical and atypical Ca antagonists in the treatment of neuropsychiatric diseases.An essential reference to some of the most current and vital research into Ca antagonists as therapeutic agents, this monograph is invaluable for all clinical and pre-clinical researchers active in the multidisciplinary fields of neuroscience, including: psychopharmacology, molecular biology, behavioral pharmacology, neuropharmacology, and electrophysiology and immunology. Investigators of Ca2+ dynamics and brain dysfunction especially will find this book useful in the development of novel drugs to treat neuropsychiatric diseases.

Wie kommt es, dass Menschen von unangenehmen Emotionen und Wahrnehmungen überschwemmt werden, ohne die Kontrolle darüber zu haben? Woher kommen Panikattacken? Warum gibt es plötzlich auftretende körperliche Schmerzen – an Stellen, die scheinbar nicht erklärlich sind? Es gibt Menschen, die behaupten, das Trauma-Thema sei maßlos überbewertet, aber ist das wirklich so? Was sagen Statistiken? Was sagen Wissenschaftler/innen, Behörden, Organisationen? Was ist Trauma überhaupt? Gibt es unterschiedliche Arten von Traumata? Was hat Trauma mit dem Geschlecht zu tun? Wirkt sich manches Trauma je nach Geschlecht anders aus? Hat Trauma nur mit der Psyche zu tun? Macht Trauma etwas mit dem Gehirn, dem Körper – oder gar etwas mit unser Fähigkeit zu sprechen? Kommt Trauma nur im Krieg vor? Hat Trauma auch mit nachteiligen Kindheitserfahrungen zu tun? Und wenn ja – können wir in Folge von Trauma krank werden? Wird das Immunsystem beeinträchtigt? Verändert Trauma unsere Gene? Und: Heißt das etwa, dass Trauma von einer Generation auf die nächste weitergegeben werden kann? Fragen über Fragen, auf die es Antworten gibt. Auch auf die Fragen, wie es mit unserer Erinnerung aussieht – und warum. Womit wir bei den Emotionen wären. Diese spielen bekanntermaßen ebenfalls eine Rolle bei Trauma. Denn: Sie erfüllen eine wichtige Funktion. Welche? Lesen Sie und schauen Sie, auch auf Farben, Grafiken und Bilder im Anschluss an jedes Kapitel. Am Ende dieses Buches werden Sie wissen, warum Ihr autonomes Nervensystem so selbstständig ist, dass Sie froh darüber sein können. Und weshalb Erstarrung (Freeze) manchmal das Beste war, was Betroffenen geschehen konnte. Dieses Buch lädt Sie ein zu einem Plädoyer für Verständnis für uns selbst, für Selbstmitgefühl und für Selbstliebe sowie für die Entwicklung neuer Kraft. Am Horizont dämmert es: Was wollen wir eigentlich, gesellschaftlich, menschlich? Es wird Zeit, dass wir zur Kenntnis nehmen. Sind Sie bereit für Antworten?

The new edition of the highly popular, The Fractal Geometry of the Brain, reviews the most intriguing applications of fractal analysis in neuroscience with a focus on current and future potential, limits, advantages, and disadvantages. It brings an understanding of fractals to clinicians and researchers even if they do not have a mathematical background, and it serves as a valuable tool for teaching the translational applications of computational fractal-based models to both students and scholars. As a consequence of the novel research developed at Professor Di Ieva's laboratory and other centers around the world, the second edition will explore the use of computational fractal-based analysis in many clinical disciplines and different fields of research, including neurology and neurosurgery, neuroanatomy and psychology, magnetoencephalography (MEG), eye-tracking devices (for the fractal computational characterization of “scanpaths”),deep learning in image analysis, radiomics for the characterization of brain MRIs, characterization of neuropsychological and psychiatric diseases and traits, signal complexity analysis in time series, and functional MRI, amongst others.

Neuropsychological & Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues, Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as wel as current practices for rehabilitation and targets for essential future interventions in vulnerable populations. This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology. - Discusses the neurocognitive implications of brain and systemic cancer treatments - Examines the foundations of neuropsychological testing and daily life implications, including caregiver support - Covers the psychosocial implications of brain cancer, psychotherapeutic interventions, and cognitive rehabilitation

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

This book is a collection of the latest data and papers on neurological disorders during pregnancy. These complicated and difficult conditions require a multi-disciplinary approach to treatment, which may either be surgical intervention or medical management. For women in the reproductive age group, the diagnosis of neurological disorders during pregnancy or post-partum creates further challenges Taking motivation from the Editor's successful management for pregnant cases with neurological disorders, this book is intended to guide the neurosurgical community towards better management of treating neurological disorders in pregnancy.

Seit Jahrzehnten der unangefochtene Bestseller für die Psychopharmakotherapie!Verlässlichkeit und Kompetenz zeichnet auch die 14. Auflage des Kompendiums aus. In der Neuauflage wurden sämtliche Inhalte sorgfältig überarbeitet und auf den neuesten Stand gebracht. Selbstverständlich finden Sie alle neuen Präparate mit den aktuellsten Empfehlungen und Bewertungen und die Berücksichtigung der DSM-5 Klassifikation.Das „Kompendium der psychiatrischen Pharmakotherapie“ ist der unverzichtbare Leitfaden für die Psychiatrie. Nirgendwo sonst findet man so komprimiert alles Wissenswerte rund um die Psychopharmakotherapie PLUS alles Wesentliche zu den einzelnen psychischen Störungen.

This second edition title provides medical students and residents with the information to build skills that will aid them in studying for any level of their board exams. It also prepares students with the ability to look at a patient's neurological signs and symptoms, logically think through the various tracts, and determine where a lesion is located.This 2nd edition book is a systematic approach to learning neuroanatomy by studying various lesions to the nervous system and their subsequent signs and symptoms. If you are a medical student, this is not the time for simply memorizing a list of symptoms that go along with the name of a syndrome. Forget memorizing random isolated factoids with a series of flash cards. This is the point in your education when you need to understand the lesion scenarios. To do this you need to put everything together and develop a big picture view of the nervous system. When you can do this, then the details will make a lot more sense. With that said, everything that follows in the text is related to clinical scenarios. Fully updated and greatly expanded with content (including a neuroanatomy atlas) this unique and comprehensive textbook received outstanding reviews in the first edition. Including 100 high-yield neuroanatomy key phrases and a cross section of images with lesion test questions, this title specifically fills a gap in the literature for medical students studying for their board exams and those about to go on a neuro-related rotation. Written by a renowned professor with over 25 years of teaching experience specific to board exam preparation, chapters are crafted with the goal of aiding students in understanding concepts by explaining the reasoning behind signs and symptoms, rather than pure memorization.Medical Neuroanatomy for the Boards and the Clinic, 2nd edition, is the go-to book for students seeking a practical yet nuanced reference for board exam preparation.​Provides 100 high-yield neuroanatomy key phrasesFeatures cross section images with lesion test questionsWritten with the medical student in mind who is studying for board exams

Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.

This textbook is designed for use in medical and paramedical training and is also suitable for programmes in nursing, human movement sciences, and medical biology. It serves as a reference for doctors and paramedics such as physiotherapists in clinical practice. This 2nd edition was written parallel with the 19th edition of the Dutch textbook, that has been used in medical and paramedical curricula in the Netherlands and Belgium for many years. The authors used their broad experience in medical education and encorporated many comments of students to come to a practice-based textbook for the education of undergraduate students and young residents in Neurology. It is in line with the most recent international thinking, guidelines and research findings in the field of neurology. The treatment guidelines used in Europe have been taken into account. The reader is guided from basic concepts to complex physiology. The first eleven chapters are devotedto the basic neurological sciences and provide a glimpse of clinical practice. The ensuing nineteen clinical chapters are based on the illness model, thus giving the reader an overview of a large number of neurological disorders. Each chapter starts with a case study which provides a practical context for the theory. The textbook also includes many tables and diagrams to clarify the concepts discussed. The Textbook of Clinical Neurology is also available online. Readers will find the entire content on the website, along with test questions, case studies, guidelines and other additional material.

This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.