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Most patients diagnosed with reflex epilepsies experience seizures induced by light stimuli or by sudden unexpected noises. In some patients, however, seizures may also be triggered by more complex precipitants such as reading, emotion, or certain movements or activities. The neurophysiological bases and clinical manifestations associated with these conditions are variable and must be distinguished from those related to other commonly observed seizure precipitating factors such as sleep deprivation, alcohol intake, or menstrual cycles whose relationship with the onset of seizures is not directly linked to the specific mechanisms of seizure genesis operating in reflex epilepsies. Reflex Epilepsies for the Practicing Clinician brings together international experts in the field of reflex epilepsies to share their experiences and knowledge. This book explores the rapidly changing genetic scene, characteristic investigations, findings, and appropriate treatments for reflex epilepsies. Focusing on clinical symptoms and signs, diagnostic criteria, investigations, and best therapies available at the present time for these niche epilepsy diagnoses, it highlights the latest findings on the most appropriate work-up of patients with reflex seizures and epilepsies.

Long known to be important for memory, the hippocampus has been a prime focus for neuroscience research for years. This second edition of The Hippocampus Book highlights advances in our understanding of this group of brain structures and includes a new set of translational chapters concerning associated brain disorders. This edition brings together contributions by leading international experts on hippocampal anatomy, physiology, molecular biology and function with other chapters summarizing how disorders of hippocampal function contribute to several neurologic and psychiatric conditions. Concurrently, this text illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, neural and synaptic plasticity, cognition and behaviour, and computational algorithms. Covering theory, experimental data and translational relevance, this uniquely authoritative work vividly illustrates the progress that continues to be made in unravelling the workings of the brain. The Hippocampus Book will be of interest to those working in a range of neuroscientific disciplines, ranging from the molecular biology of neural function and dysfunction, through network physiology to behavior and neuropathology and take pride of place on the bookshelves of all with an interest in the brain and its functions.

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.

This book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary. Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology.

Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.

The fascinating story of glutamate, the neurotransmitter that controls the structure and function of the brain in health and neurological disorders.Sculptor and Destroyer tells the story of a simple, little-known molecule that became a master architect and commander of the human brain: glutamate. Upward of 90 percent of the neurons in the human brain deploy glutamate as their neurotransmitter. Other neurotransmitters can only exert their effects on brain function by subtly modifying the ongoing activity of glutamatergic neurons, but during brain development glutamate controls the growth of dendrites and the formation of synapses. In this eye-opening book, Mark Mattson explains how the neurotransmitter glutamate controls the structure and function of neuronal networks in the brain, thereby mediating the brain's capabilities, including learning and memory, creativity, and imagination. Mattson also delves deeply into the dark side of glutamate, which he calls the “destroyer” side. He shows how relatively subtle aberrancies in the activity of neurons that deploy glutamate may result in behavioral disorders ranging from autism and schizophrenia to chronic anxiety and depression. More dramatically, he describes how glutamate can excite neurons to death, a process that occurs in epilepsy and stroke and, perhaps even more insidiously, in Alzheimer's disease, Parkinson's disease, ALS, and Huntington's disease. Sculptor and Destroyer concludes with a perspective on how knowledge of glutamate's roles in neuroplasticity might be applied to the optimization of brain health throughout our lives. Written inengaging, approachable prose, Sculptor and Destroyer will be of interest to anyone in the fields of neuroscience, neurology, psychiatry, and psychology, as well as to anyone with a curiosity about the human brain.

An updated version of the ILAE classification and the differential diagnosis of epilepsies, written by international experts in clinical epileptology and EEG. The book covers the clinical and EEG features as well as the recording protocols of all paediatric and adult epilepsy syndromes, rates diagnostic confidence according to the findings in hand and the available clinical information. The combination of the clinical EEG information, its dynamic layout and the 150 EEGs makes this book a reference guide in daily clinical practice for all electroencephalographers, epileptologists, general and child neurologists, EEG technologists and epilepsy nurses

Atlas of EEG, Seizure Semiology, and Management is a comprehensive yet concise textbook with a focus on practical use of EEG and clinical neurology in the diagnosis and management of epilepsy. It begins with the physiological foundation of EEG, physics and electronics of EEG generation and recording, and technical details of EEG performance. Major sections then discuss seizure and epilepsy diagnoses, normal and abnormal EEG patterns correlated with clinical scenarios, guides to differential diagnosis of seizures, guides to medical and nonmedical management, and lastly teaching case studies. For this edition, there is a separate pediatric EEG and epilepsy section, in addition to discussion of pediatric aspects throughout the rest of the text. Revisions and additions have been made to keep up with the rapid pace of advancement in EEG and epilepsy. This new third edition is authored and edited by four senior faculty of Vanderbilt University Hospital and Vanderbilt Children's Hospital, all trained and board certified in EEG and Clinical Neurophysiology. These experts use their daily experience treating epilepsy in a busy academic medical center to provide a robust core of EEG and epilepsy knowledge to healthcare professionals who diagnose and manage epilepsy, and who are seeking to develop and enhance their knowledge of EEG performance and interpretation. New in this edition: · Compares the new epilepsy classification schemes with the old · Updated status epilepticus management, with new tables and flowcharts · New interpretations for a variety of EEG patterns, some of which have controversial implications

This book offers a detailed account of all aspects of photosensitive epilepsy, including genetic testing, functional imaging (fMRI, MEG), pharmacological studies, animal studies, classification based on the occurrence of photoparoxysmal responses (PPRs) in different epilepsy syndromes, and the available prevention and treatment options. In addition, the comorbidity of and overlap between migraine and epilepsy are discussed. Informative case histories with EEG examples and a helpful glossary are included. In epilepsy, the term photosensitivity is used both for epileptic seizures triggered by flashing or flickering light and for epileptiform discharges evoked by intermittent photic stimulation (IPS) during an EEG recording. Most patients with a clear history of visually induced seizures will show epileptiform EEG discharges during IPS (PPRs). As epileptiform discharges can be evoked in photosensitive patients at any time, without triggering seizures, theycan be considered a useful surrogate marker of the necessity and efficacy of epilepsy treatment. This book will serve as an ideal guide to the subject for pediatricians, (pediatric) neurologists, epileptologists, (child) psychiatrists, clinical geneticists, neuropsychologists, neuropharmacologists, occupational therapists, and basic scientists.

This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.

Das Buch bietet dem Behandler einen Überblick über die gängigen klinisch relevanten Konzepte sowie diagnostischen und therapeutischen Maßnahmen in der Epileptologie. Mit seinem praxisorientierten Aufbau befähigt das Werk dazu, dieses Wissen im klinischen Kontext direkt anzuwenden.Zahlreiche Kasuistiken beantworten über die Kapitel hinweg typische Fragen zu Differenzialdiagnostik, Therapie und sozialmedizinischen Aspekten. Bei den Therapien kommen sowohl medikamentöse als auch operative Ansätze zur Sprache. Ein ballastfreies Buch, geschrieben von Epilepsie-Experten aus Deutschland, Österreich und der Schweiz, das sich den konkreten klinischen Aspekten widmet und dabei die entsprechenden nationalen und internationalen Leitlinien berücksichtigt.

Comprehensive, yet accessible, Wyllie's Treatment of Epilepsy: Principles and Practice has provided a detailed and cohesive overview of seizure disorders and treatment options through six well-regarded editions. The 7th Edition remains the definitive reference in the field with extensive updates from Dr. Elaine Wyllie and her team of world-renowned editors and authors. Ideal for both clinical reference and exam preparation, this single-volume work on contemporary epileptology is an indispensable resource for neurologists, epilepsy specialists and epilepsy neurosurgeons, neurology and neurosurgery residents and fellows, and neuropsychologists.

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuableto all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as wellas clinicians from other specialties who are interested in imaging for their patient care.

This innovative book examines what can be learnt about the brain mechanisms underlying religious belief and practice from studying people with neurological disorders, such as stroke, epilepsy and Parkinson's disease. Using a clinical case study approach, the book analyses the interaction of social influences, religious upbringing and neurological disorders on lived religious experience in a number of different religions. The interdisciplinary contributors to the book ensure a variety of perspectives to help understand how the religious life is affected when different cognitive functions are impaired; how faith modifies the effects of neurological disorders; and how awareness of faith practices may assist in the treatment of these conditions.

Functional MRI: Basic Principles and Emerging Clinical Applications provides an overview of the basic principles of fMRI for clinicians with minimal knowledge of the imaging technique and its research potential and clinical applications. The text is divided into two parts, with Section I covering the primary signal measured in fMRI (BOLD), the correlation between neuronal activity and the BOLD signal, and how the data is analyzed and interpreted in fMRI. Section II explores applications of fMRI in cognitive neuroscience and common psychiatric disorders, surgical planning in neurosurgery, anesthesia and the intensive care unit, and more. Timely and highly accessible, this book is a valuable resource for researchers and clinicians interested in understanding what fMRI is, how it works, and its applications.

Epilepsy is a prevalent and serious neurological disorder. This vital textbook addresses the role of neuroimaging as a unique tool to provide in vivo biomarkers aimed at furthering our understanding of causes and consequences of epilepsy in a day-to-day clinical context. Unique in its approach, this translational book presents a critical appraisal of advanced pre-clinical biomarkers that allows capturing epileptogenesis at molecular, cellular, and neuronal system levels. The book is divided into four sections. Part I includes a series of chapters focused on imaging of early disease stages. Part II discusses lesion detection and network analysis methods. Part III focuses on imaging methods used to predict response to antiepileptic drugs and surgery. Finally, Part IV presents imaging techniques used to evaluate disease consequence.

Since 1984, the year of the publication of its first edition, the famous “Blue Guide” has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents. This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases. The different backgrounds of the contributors - coordinators and authors – ensure that the book's longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved. This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.

This book describes the developments and improvements in electroencephalography (EEG). In recent years, digital technology has replaced analog equipments, and it is now possible to easily record and store EEG tracings and to quickly recall previously acquired material for subsequent analysis. In addition, not only static figures, but also electronic supplementary materials can be included in books, enabling EEGs to be viewed in real-time.In clinical practice, EEG still represents the most important functional examination in the study CNS development and its anatomical and physiological integrity throughout life. In the pathological context, EEG provides indispensable diagnostic information for classification of epileptic syndromes, and it is also valuable in all the other CNS diseases (infectious, cerebrovascular, neurodegenerative, etc).Furthermore, monitoring EEG can be widely used in emergency settings, such as emergency departments or intensive care units. In comatose patients, EEG provides information regarding prognosis and evaluation of the sedative effect of anesthetic drugs.Written by a group of leading national and international experts, it offers a substantial, yet practical, EEG compendium, which serves as a reference resource for physicians and neurodiagnostic technologists as well as physicians-in-training, researchers, practicing electroencephalographers and students.

Translational research connects science and clinical medicine from'the bench to the bedside.'In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good'brain-gymnastics'for reconsidering the ideas on epilepsy. - It provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsies - Treats major epilepsies as system epilepsies of brain networks - Reveals the interrelationship of sleep, epilepsy and cognitive impairment showing how epileptic manifestations became facilitated in NREM sleep and interferes with sleep plastic functions

Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Clinical Neurophysiology includes sections that provide a summary of the basic science underlying neurophysiological techniques, a description of the techniques themselves, including normal values, and a description of the use of the techniques in clinical situations. Much of diagnostic neurophysiology is essentially pattern recognition which is illustrated throughout the text using audio and video examples. Divided into four key sections, this book begins with the scientific basis of clinical neurophysiology (Section 1) before exploring specific techniques including Electromyography, Intracranial EEG recordings, and Magnetoencephalography (Section 2). The final two sections explore clinical aspects of both the peripheral nervous system (Section 3) and the central nervous system (Section 4).

La herramienta de referencia para la epilepsia clínica y teórica. La epileptología se desarrolla. El enfoque sindrómico se complementa con un enfoque etiológico, basado sobre todo en los avances de la genética. Nuevas entidades han surgido, y un enfoque puramente electro-clínico no es ya suficiente en numerosas situaciones. Al igual que sus predecesores, la quinta edición de la Guía Azul incluye las recientes proyecciones que hicieron progresar nuestra comprensión de las epilepsias. Nos pareció necesario justificar los enfoques fisiológicos, epidemiológicos, genéticos y terapéuticos, y colocarlos en el contexto de los recientes esfuerzos de reclasificación de las epilepsias. A pesar de todo, la descripción de los síndromes epilépticos constituye siempre el corazón de esta obra. Un contenido ricamente ilustrado, con imagines de EEG, IRM, tablas comparativas,... Un DVD incluso, con más de 100 secuencias de video e EEG, para completar e ilustrar los diversos síndromes.

The second edition of Neurobiology of Disease includes nearly 200 articles surveying all major disorders of the nervous system in both adults and children, focusing on relevant diagnosis and treatments from the perspective of cutting edge clinical and basic neurobiological research. Akin to an encyclopedia of every neurologic disorder, this comprehensive work is ideal for graduate and medical school students, residents, and candidates preparing for their board certification examinations. Each chapter is illustrated with detailed figures, supplemented with descriptive and diagnostic tables, and thoroughly referenced for further investigations. The book's editors, Michael V. Johnston, Harold P. Adams Jr., and Ali Fatemi bring their unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this new edition, the following Section Editors provided oversight of their respective sections: · Movement Disorders-Joel Perlmutter, Washington University · Dementias-David Knopman, Mayo Clinic · Motorneuron Diseases-Merit Cudkowicz, Massachusetts General Hospital · Paroxysmal Disorders-Solomon Moshe, Albert Einstein College of Medicine · Pediatric Neurology and Developmental Disorders-Tanjala Gipson and Deepa Menon, Kennedy Krieger Institute and Johns Hopkins University · Neuroimmunological Diseases-Carlos Pardo-Villamizar, Johns Hopkins University · Cerebrovascular Diseases-Harold P. Adams Jr., University of Iowa · Peripheral and Autonomic Nervous System Disorders and Pain-Nicholas Maragakis, Johns Hopkins University · Neoplastic and Paraneoplastic Diseases-Lisa DeAngelis, Memorial Sloan-Kettering Cancer Center · Infectious Diseases of the Nervous System-Karen L. Roos, Indiana University · Sleep Disturbances-Mark Dyken, University of Iowa · Substance Abuse and Toxicology Disorders-Barry E. Kosofsky, Weill-Cornell University Medical Center · Neurologic Manifestations of Medical Disorders-John C. Probasco, Johns Hopkins University

Wyllie's Treatment of Epilepsy: Principles and Practice, 6th edition provides a broad, detailed, and cohesive overview of seizure disorders and contemporary treatment options. Written by the most influential experts in the field and thoroughly updated to provide the most current content, Wyllie's Treatment of Epilepsy assists neurologists and epilepsy specialists, neurology residents and fellows, and neuropsychologists in assessing and treating their epileptic patients with the latest treatment options. Dr. Wyllie is once again joined by associate editors Drs. Gidal and Goodkin, as well as newcomers Dr. Joseph Sirven of the Mayo Clinic and Dr. Tobias Loddenkemper, Assistant Professor of Neurology at Harvard Medical School, who specializes in epilepsy research and treatment, particularly for the pediatric population. In-depth review of the subspecialties of epileptology, i.e., neuroimaging, epilepsy surgery, antiepileptic medications A comprehensive single-volume text on epileptology Clinically oriented, evidence-based reference Online bank of over 500 board review-style questions highlight key concepts for board examinations and clinical practice

Greenfield's Neuropathology, the world's leading neuropathology reference, provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The book's detailed advice on pathological assessment and interpretation is based on clear descriptions of molecular and cellular processes and reactions that are relevant to the development of the nervous system, as well as its normal and abnormal functioning. The information is presented in an accessible way to readers working within a range of disciplines in the clinical neurosciences, and neuropathological findings are placed within the context of a broader diagnostic process. New for the Ninth Edition: Features online and downloadable digital formats with rapid search functions, annotation and bookmarking facilities, image collections, and live reference links Contains many color illustrations and high-quality clinical photographs to help with interpretation and understanding Includes more than 1000 new photographs and drawings Incorporates new design elements, such as alternate colour coding of chapters for easier navigation Known for its thorough yet practical approach, Greenfield's continues to provide trusted information to all neuropathologists and those in related specialties, including neurologists, neurosurgeons, general pathologists, neuroradiologists, and clinical neuroscientists.

A comprehensive collection of the most recent knowledge on the biological bases of various kinds of epilepsies and modern clinical approaches to their treatment. Epilepsy affects about 0.5-1% of the world's population (about 50,000,000 individuals) and the main goal of its treatment is to eliminate seizures without creating side effects. Despite numerous advances in the treatment of epilepsy and the approval of several new antiepileptic drugs, about 30% of patients continue to experience recurrent seizures which are medically, physically, and/or socially disabling. The editor of this volume hopes that by bridging the gap between the fundamental biology of epilepsy and its clinical implications he might spur further research and treatment options.​

PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

This compendium is set against the background of new findings about the mechanisms involved in epilepsy, considered from different perspectives. It provides a historical overview of what has been achieved and presents the current state-of-the-art treatments in clinical practice. Regional differences in the treatment of the contributing specialists from various European countries and the United States have been taken into account; their respective guidelines are presented. This includes recommendations for children and adults, and also for the treatment of status epilepticus. Furthermore, a number of chapters deal with the mechanisms of classical and newly developed antiepileptic drugs as well as the therapeutic perspectives that arise from current research. This book is intended for current clinical practice, as a source of background information about the mechanisms of epilepsy and antiepileptic drugs, and also gives an outlook for the potential future therapeutic advances for this common disease.

Dieses Kompendium entstand vor dem Hintergrund neuer Erkenntnisse über die Mechanismen bei Epilepsien aus verschiedenen Perspektiven. Es vermittelt einen historischen Überblick über das bisher Erreichte und stellt den aktuellen Stand der modernen Behandlung in der heutigen klinischen Praxis dar. Dazu werden regionale Unterschiede in der Therapie durch Beiträge von Spezialisten aus verschiedenen europäischen Ländern und den USA berücksichtigt, die ihre jeweiligen Leitlinien vorstellen. Dies schließt Empfehlungen für Kinder und Erwachsene sowie auch zur Behandlung des Status epilepticus ein. Weiterhin befasst sich eine Reihe von Kapiteln mit den Wirkmechanismen klassischer und neu entwickelter Antiepileptika sowie mit den therapeutischen Perspektiven, die sich aus der aktuellen Forschung ergeben. Das Buch ist gedacht für die aktuelle klinische Praxis, als Quelle für Hintergrundinformationen über die Mechanismen von Epilepsien und Antiepileptika sowie als Ausblick für die potenziellen künftigen therapeutischen Fortschritte, die bei dieser häufigen Erkrankung von Nutzen sind.

Epilepsy is the most common serious neurological condition, affecting children and adults, and can occur in a variety of medical settings. It has many causes and many forms, and a variable prognosis. Mortality and morbidity are high, social and legal consequences can stretch well beyond the purely medical, and its management is often poor. Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures. Written by internationally-renowned specialists, each chapter comprehensively covers the current knowledge and evidence base related to each aspect of the disorder, with an emphasis on the personal experience of the authors. The print edition of the Oxford Textbook of Epilepsy and Epileptic Seizures is complemented by an online version, which allows access to the full content of the textbook, contains links from the references to primary research journal articles, enables full text searches, and provides access to figures and tables that can be downloaded to PowerPoint®. This textbook will prove a useful clinical reference for neurologists and senior trainees in neurology, an educational manual for trainees, and will offer practical assistance to all physicians advising people with epilepsy.

Quinta edición de la conocida obra'Neurología', dirigida por el profesor Zarranz, en la que participan renombrados expertos en campos tan relevantes como las cefaleas, enfermedad de Alzheimer, epilepsia o enfermedad del sueño, entre otras. Tradicionalmente recomendada para estudiantes de últimos cursos de Medicina, ha evolucionado y resulta de interés también para residentes en Neurología. Como novedad, incluye contenidos en línea en www.studentconsult.es para el estudiante: 248 preguntas de autoevaluación, tablas y figuras del libro y adicionales, y bibliografía del libro y, aproximadamente, 15 vídeos. Asimismo, incorpora recursos exclusivos para docentes, que consisten en 48 casos clínicos.Quinta edición de la conocida obra'Neurología', dirigida por el profesor Zarranz, en la que participan renombrados expertos en campos tan relevantes como las cefaleas, enfermedad de Alzheimer, epilepsia o enfermedad del sueño, entre otras. Tradicionalmente recomendada para estudiantes de últimos cursos de Medicina, ha evolucionado y resulta de interés también para residentes en Neurología. Como novedad, incluye contenidos en línea en www.studentconsult.es para el estudiante: 248 preguntas de autoevaluación, tablas y figuras del libro y adicionales, y bibliografía del libro y, aproximadamente, 15 vídeos. Asimismo, incorpora recursos exclusivos para docentes, que consisten en 48 casos clínicos.

Un DVD inclus avec des séquences vidéos inédites pour chaque chapitre! L'épileptologie change, et les approches syndromiques sont maintenant complétées par une approche étiologique fondée sur les progrès considérables en génétique. Une approche purement'électro-clinique'n'est plus adaptée aujourd'hui dans bien des cas. Cette 5e édition du'Guide bleu'fait le point sur les plus récents progrès. Ainsi, la structure du livre a un peu évolué, laissant plus de place aux approches : physiologiques épidémiologiques génétiques thérapeutique Néanmoins, la description des syndromes épileptiques reste au coeur de cet ouvrage. La diversité des contributeurs - coordinateurs et auteurs - confère à ce livre des qualités d'objectivité et de sérieux qui en font la réputation depuis maintenant près de 30 ans.

Epilepsy, Part II, Treatment, Volume 108, provides a full description of epilepsy pathology and etiology, antiepileptic drug treatment, the approach to surgical evaluation and alternative procedures to be considered, in both children and adults, as well as brain stimulation and diet treatment. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, establishes the scientific and practical diagnosis of epilepsy. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy. - A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology - International list of contributors including the leading workers in the field - Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care

Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part II, Treatment, Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy. - A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology - International list of contributors including the leading workers in the field - Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care

Clinical case studies have long been recognized as a useful adjunct to problem-based learning and continuing professional development. They emphasize the need for clinical reasoning, integrative thinking, problem-solving, communication, teamwork and self-directed learning - all desirable generic skills for health care professionals. Epilepsy is amongst the most frequently encountered of neurological disorders. There are important emerging clinical management issues (e.g., first seizure, therapy-resistant seizures, ICU, pregnancy) but also differential diagnosis of non-epileptic seizures (syncopy, pseudo-seizure, paroxysmal dystonic syndromes, sleep disorders, psychosis, inborn errors of metabolism, etc.). This selection of epilepsy case studies will inform and challenge clinicians at all stages in their careers. Including both common and uncommon cases, Case Studies in Epilepsy reinforces the diagnostic skills and treatment decision-making processes necessary to treat epilepsy and other seizures confidently. Written by leading experts, the cases and discussions work through differential diagnoses, treatments and social consequences in pediatric and adult patients.

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a'better understanding of the epilepsies and seek more rational methods of their prevention and treatment.'Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the'bible'of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

The single-best resource available for learning how to perform and interpret video EEG Companion DVD shows real-time Video EEG in practice! The Atlas of Video-EEG Monitoring explains the essentials of video EEG for use in all settings. This full-color atlas thoroughly covers the basics of performing video EEG for diagnosis along with how to use video EEG for the diagnosis and interpretation of first and/or repeated seizures, during treatment of epilepsy, in the emergency department and intensive care unit, and during surgery. Features Over 340 full-color images and EEGs Detailed overview of epileptic seizures, from simple partial seizures and primary generalized tonic-clonic seizures to epileptic spasms In-depth survey of seizure mimics, including psychogenic non-epileptic spells; panic spells; dissociative spells; movement disorders; sleep disorders; and syncope Thorough review of status epilepticus, including epilepsia partialis continua, non-epileptic movements in coma, and other syndromes Cutting-edge guidance on intracranial video-EEG monitoring, including placement and interpretation of grid and strip electrodes, and depth electrodes DVD contains videos linked to EEG patterns in the book—-allowing you to see each problem in real time

A disorder which affects 4 percent of children and 1-2 percent of the general population, epilepsy is one of the most common neurological disorders. The original edition of C.P. Panayiotopoulos'guide proved to be the only one of its kind, covering many important aspects of diagnosis and treatment. Due to the continued advances being made in the subject, a second edition is now due. The text includes detailed diagnostics, concise descriptions of syndromes, a wealth of practical tips, and is supported by useful tables to enable clear diagnoses. Building on the sell-out success of the first edition this thorough revision reflects the latest report of the ILAE classification core group and the significant progress made in the diagnosis, classification and treatment of the epilepsies. This new edition is indispensable reading for all those who care for patients with epileptic seizures.

Make your way through the epilepsy maze Epilepsy is a complex neurological condition. There are many modern treatment options, and treatment should nowadays be tailored to an individual patient. But identification of the best therapy can be a labyrinthine process. The Handbook of Epilepsy Treatment provides a practical pathfinder for treating epilepsy based on published evidence and the author's 30 years of specialist clinical experience. Direct in style but comprehensive in content, with ample tables and summaries, the Handbook of Epilepsy Treatment covers: Treatment of the different forms and causes of epilepsy Treatment in the different commonly encountered clinical situations Treatment in children, in adults, in the elderly, in women, in epilepsy syndromes and in those with special needs and requirements Epilepsy drugs – their pharmacology, kinetics, side effects, effectiveness and practical usage in the clinic Epilepsy surgery – the various types, the indications, assessment and outcome A succinct pharmacopeia summarizes the entire range of anti-epileptic medications with emphasis on effective prescribing in the clinical setting. The Handbook of Epilepsy Treatment will help you and your patient find the best path to control epilepsy for each individual's situation.

A practical reference to the medical and surgical treatment of epilepsy The third edition of The Treatment of Epilepsy has been thoroughly updated. It is a reference work, but has a strong practical bias, and is designed to assist neurologists, neurosurgeons and other clinicians at all levels who are involved in the treatment of patients with epilepsy. It is a definitive source of clinical information to guide clinical practice and rational therapy. Written and edited by leading experts, many actively involved with the International League Against Epilepsy, this new edition: covers the recent advances in the principles and approaches to epilepsy therapy, the introduction of new drugs and the development of new surgical techniques contains 26 completely new chapters and 61 new contributors includes pharmacological properties and prescribing information for all drugs used in the treatment of epilepsy features the important contribution of a new editor Jerome Engel Jr, Professor of Neurology at the University of California School of Medicine in Los Angeles.

Textbook of Epilepsy Surgery covers all of the latest advances in the surgical management of epilepsy. The book provides a better understanding of epileptogenic mechanisms in etiologically different types of epilepsy and explains neuronavigation systems. It discusses new neuroimaging techniques, new surgical strategies, and more aggressive surgical approaches in cases with catastrophic epilepsies. The contributors also analyze the improved statistics of surgical outcome in different epilepsy types. This definitive textbook is an invaluable reference for neurologists, neurosurgeons, epilepsy specialists, and those interested in epilepsy and its surgical treatment.

'The second edition of the treatment of Epilepsy is a vital contribution to the field. The book's primary focus is on the medical and surgical evaluation and treatment of the disease. Experts around the globe who have made seminal contributions to the treatment of epilepsy have contributed to the book, which preserves its flow and focus extremely well...This book is highly recommended and is a solid reference for anybody who is involved in the evaluation and medical care of patients with epilepsy.'New England Journal of Medicine 352;7 There is a wide variety of different types of epilepsy and seizures and a large array of available treatments suited to differing clinical situations. Consequently, the successful treatment of epilepsy is a complex process involving careful and rational analysis of a large number of variables and is rarely achieved. In recent years, there have been rapid advances both in medical and surgical treatments and and the complexity of treatment has increased still further. There remain important unresolved issues and controversies. Most of the existing large books on the subject either concentrate too much on the biology and phenomenology of epilepsy at the expense of therapy or else fail to balance the medical and surgical treatments available. This book aims to be the definitive textbook on medical and surgical treatment of epilepsy and to act as a clinical reference book with a strong practical bias. It will take the form of a detailed review and distillation of the literature rather than a presentation of individual research and will provide answers to the diversity of questions encountered in day to day clinical practice. In this way, the clinician will be guided through the difficult decision-making processes involved in the successful diagnosis and therapy. After a concise summary of the recent scientific developments in epileptology and discussion of the classification and diagnosis of epilepsy, the large medical will cover in detail the indications, clinical pharmacology, pharmacokinetics, toxicity and outcome of drug treatment. The surgical section will cover indications, patient selection, pre-surgical assessment, surgical technique, anaesthesia, complications and outcome.

Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.•Provides a crucial update of recent advances in imaging techniques•Timely publication as subject of neuroimaging is a very'hot'area in both clinical epilepsy and basic neuroscience research•Editors are well-respected in this field

Epilepsy is the most common neurological disorder of childhood, occurring both in children whose physical and cognitive states are otherwise normal as well as being a facet of a more generalised and severe brain disease. There are many manifestations of epilepsy and, therefore, a diversity of factors in underlying pathology, responses to treatment

This reference text provides an insightful and unified synthesis of cognitive neuroscience and behavioral neurology. The strong clinical emphasis and outstanding illustrations will provide neurologists, psychiatrists, neuropsychologists, and psychologists with a solid foundation to the major neurobehavioral syndromes. With backgrounds in behavioral neurology, functional imaging and cognitive neuroscience, the two authors are in an ideal position to cover the anatomy, genetics, physiology, and cognitive neuroscience underlying these disorders. Their emphasis on therapy makes the book a'must read'for anyone who cares for patients with cognitive and behavioral disorders.

Reflex epilepsies can provide qualitative and quantitative insights into the complexities of ictogenesis. This is what the chapters of this book are about, dealing with such varied modes of precipitation as hot water, eating, touch and movement, music, and emotions. The relation of several reflex epileptic mechanisms to Juvenile Myoclonic Epilepsy is discussed as well as the meaning of their occurrence across syndromes for our present nosological understanding of epilepsy. Our traditional dichotomy seems out-dated as functional studies of trigger mechanisms rather point to central nervous subsystems acting as pathological networks generating seizures in both generalised and localisation-related epilepsies. This book makes the point on research for a better comprehension of the current nosology of the epilepsy. A reference work written by the best international specialists in epilepsy.

This is a thorough revision of one of the landmark books in the field of neuropsychiatry. The authors, one a distinguished neurologist and the other an eminent psychiatrist, provide a clear, well-integrated account of the behavioral aspects of neurological conditions and the neurological aspects of psychiatric disorders. Earlier editions presented the view, then provocative, that disordered brain function underlies psychiatric illnesses. A more balanced view characterizes the Fourth Edition, in which the authors discuss the most recent data from the neurosciences and molecular biology, including changes in the brain induced by the environment and by emotions. There is also a valuable new clinical chapter on differentiating the etiologies of disturbed behavior. Avoiding the deluge of information in multi-authored volumes, this very readable text provides a consistent approach to the understanding and diagnosis of disturbances of behavior. While the book is directed toward medical students, residents, psychiatrists, neurologists, psychologists, and psychology students (particularly those taking abnormal psychology courses), it has also been used by a wide variety of health professionals and attorneys.

'The First Solvay Pharmaceuticals Conference on'Parkinson's Disease'was held in Como from October 25 to 27, 2000'--Pref.