Search

This collection of epilepsy surgical cases illustrates patients with straightforward and challenging pharmacoresistant epilepsy. These cases convey the advancements, investigative strategies, past and modern surgical tools, and sophisticated state-of-the-art of epilepsy surgery and its disciplines. This textbook is organized into four major sections that parallel the contemporary FDA-approved and clinically applicable approaches: resective surgery, disconnection procedures, laser therapy, and neuromodulation. The chapters provide a case-based, interactive, and multidisciplinary integrative approach to pre-operative evaluation, data analysis, and surgical decision-making. In addition, we present alternative approaches to certain diagnostic tools, decision-making strategies, and surgical interventions.This textbook will provide trainees and clinicians with an exhaustive understanding of epilepsy surgery. Moreover, it will be an invaluable resource for preparation for the epilepsy board examination

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

This book is focused on a clinical-based diagnostic approach of autonomic dysfunctions, highlighting main diagnostic tools and pharmacological and non-pharmacological therapies available nowadays. The autonomic nervous system (ANS) is a subcomponent of the peripheral nervous system (PNS) and dysfunction of one or more subdivisions of the ANS, when accompanying other diseases, is linked to a worse prognosis of the latter. In some circumstances or when severe, dysfunction of ANS itself results in symptoms and disability. A myriad of factors can cause autonomic dysfunction and more than one can concur even in the same patient; due to the expansive nature of the ANS, patients can be affected by a wide range of conditions. Each chapter is characterized by a similar structure and is devoted to a different dysfunction. For each pathology, the book offers the essential information on mechanisms of action, treatments and outcomes. Written by experts in the research of these disorders, the volume addresses primarily Neurologists, but will be a useful tool also for Gastroenterologists, Ophthalmologists, Urologists, Cardiologists and Internal medicine specialists.

This book mainly focuses on diversity of brain diseases, such as sleep disorders, major depression disorder, anxiety disorders, epilepsy, cognitive disorders, etc. It introduces the current pathological mechanisms of various diseases from the perspective of basic theories and research; it introduces the clinical evaluation and treatment of the above diseases from the clinical perspective. In addition, the current frontier research on therapeutics of neural stimulation for the above brain disorder was introduced, such as Transcranial electrical stimulation, magnetic stimulation, ultrasonic stimulation, etc., and the therapeutic strategy and stimuli parameters for reference were proposed.This book is aimed at clinical students, doctors and researchers in the field of neurology. Based on major brain diseases, this book systematically proposed the maneuverability, safety and effectiveness of neural stimulation technologies in the treatment of major brain diseases.

This book uses the multiple-choice question (MCQ) format to specifically address the topic related to the cerebral ventricles. The mission of this book is to help readers revise the core concepts and maintain knowledge of the anatomy, pathology, and neurosurgery of the cerebral ventricles. This study companion is structured in five sections, for a total of 18 chapters, including 450 + MCQs in a convenient format to provide a comprehensive and concise overview. Answers and explanations appear immediately below the questions to enhance readability.This book is an adjunct to existing texts and does not intend to be the primary source of information; it rather aims to help readers identify their relevant strengths and weaknesses in the area. The content is based on the most up-to-date best practice evidence, with a style that mirrors the format adopted by most local, regional, and international board examinations.The student of neurosurgery, neurology, neuroscience,neuroanatomy, the residents, the fellows, the younger attending preparing for exams or practice, and even the later-stage surgeons or physicians are the target audience of this book.

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Skull-base surgery is a minimally invasive endoscopic procedure, which involves the surgeon inserting instruments through the natural openings in the skull—the nose or mouth—or by making a small hole just above the eyebrow. This type of surgery requires a team of specialists, which may include ENT (ear, nose, and throat), maxillofacial and neurosurgeons, as well as radiologists. The craniovertebral junction (CVJ) has a unique anatomical bone and neurovascular structure, which not only separates the subaxial cervical spine but also provides a special cranial flexion, extension and axial rotation pattern. As such, a sound knowledge of the basic principles of spine instrumentation and the region's kinematics are essential when it comes to strategic preoperative planning. Skull-base, craniovertebral junction, spine demolitive and reconstructive surgery, neuromodulation, bioengineering and transplantation are recent tools used to improve reconstruction, restoration and rehabilitation – three key words central to the core aim of the Neurorehabilitation and Reconstruction Committee of the WFNS, which is to promte mechanical morphological and functional restoration.

This new edition fully updates and expands Faro and Mohamed's Functional Neuroradiology, a gold standard, comprehensive introduction to the state-of-the-art functional imaging in neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 12 major sections, including: Diffusion and Perfusion Imaging, Magnetic Resonance Spectroscopy and Chemical Exchange Saturation Transfer Imaging, Multi-Modality Functional Neuroradiology, BOLD Functional MRI, Diffusion Tensor Imaging, Presurgical Brain Tumor Mapping, Emerging neuroimaging techniques, Functional Spine and Hydrocephalus imaging, and Neuroanatomical Gray and Whitematter Brain Atlases. This second edition is fully updated throughout and includes more than 15 new chapters on topics such as: Brain tumor Radiogenomics, CNS Tumor Surveillance and Functional MR Perfusion Imaging, CNS Machine Learning, Focused Ultrasound therapy, TBI Sports Related Injury, and CNS Lymphatic system. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.

MEG-EEG Primer presents the basic A-to-Z of two non-invasive human electrophysiological methods, magnetoencephalography (MEG) and electroencephalography (EEG). These methods are used to study human brain dynamics, tracking the brain's responses to sensory, cognitive, and social stimuli. This book, now in its second edition, remains the only volume of its kind that discusses both MEG and EEG side-by-side, for an integrated understanding of brain function. In 22 chapters with almost two hundred color figures, the book covers the basic physical and physiological foundations of these two methods, the historical background and development of their implementation, instrumentation, recording techniques, data analysis, and interpretation. The new edition includes expanded text on MEG and EEG sensor types and amplifiers, artifacts, new analysis tools, open data repositories, and novel instrumentation. Due to new concerns from the COVID-19 pandemic, general infection control in MEG/EEG laboratories is also discussed. Interoception is introduced as an interesting emerging research field. Moreover, future developments in MEG and EEG are examined with respect to new and evolving technologies, and new applications for their use. Overall, MEG-EEG Primer puts into perspective the role of MEG and EEG in neuroscience research at large, and the future of our understanding of the dynamics of human brain function.

Written and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of the incidental findings of the nervous system, with emphasis on asymptomatic brain and spinal lesions that have the potential to cause illness. It includes very informative chapters, organized into four main groups: first, incidental findings of the brain and cranium, including intracranial, intraventricular and skull base lesions, infarcts and calcification; secondly, incidental findings of the spine and spinal cord, including spinal cord tumors, syringomyelia, arteriovenous malformations and craniovertebral junction anomalies; thirdly, incidental findings of the spinal nerves and peripheral nerves, including tumors of the plexi and peripheral nerves; and fourthly, other lesions, including acquired incidental lesions of the brain and spine as well as the medicolegal and psychiatric aspects related to these lesions. The uniqueness of this compilation lies in the fact that several abnormalities exist in the nervous system that have the potential to cause life threatening illness; yet because they are asymptomatic and incidental, this leads to major management dilemmas related to whether or not to surgically the lesion. The proponents of an early surgical management subscribe to the philosophy that getting rid of an entity earlier on when it is asymptomatic, leads to an early cure and obviates any risk of it becoming aggressive and incurable later on; those opting for a ‘wait and watch'policy subscribe to the view that no intervention (as well as subjecting the patient to the risk of surgery) is mandated until the lesion becomes symptomatic. This may subject a person to a lifetime of anxiety related to how that lesion is going to evolve, when in all likelihood, the subject may remain asymptomatic throughout his/her life. The psychological aspects of the patient who is extremely disturbed by the presence of this incidental lesion; and, who cannot adjust to the reality that the treating doctor actually does not have a well-defined plan for it, are issues that are adequately addressed with clinical illustrations and examples. This comprehensive reference book will be an ideal source for neuroscientists at all levels, from graduate students to researchers in specific disciplines studying this region, including neurosurgeons, neurologists, neuroradiologists, neuropathologists and psychiatrists, who seek both basic and more advanced information regarding the incidental findings of the nervous system.

This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.

The second edition of The Neurologic Examination looks at how to conduct a clinical neurological examination through a pathophysiological approach to the nervous system. This new edition is brought up to date with new data on genetic and immunological disorders and a significant expansion of illustrations of skin manifestations of neurologic disorders. The book provides in-depth instructions for clinicians with a logical order of history and the different parts of the examination. Organized by the functional anatomy of the nervous system, the book provides a bridge from basic science to symptoms and signs of many common and rare neurologic disorders, which will help in making diagnoses. The authors look at how to carry out an examination in different circumstances, from outpatients to patients in respiratory distress, with stroke and epilepsy, and various states of consciousness including coma. Laboratory testing is recommended when appropriate, but the main emphasis is on history and physical examination. The book contains over a hundred discussion boxes with details about neurologic disorders and history. While mainly directed to students and residents learning how to do a neurologic examination, it will still be useful even for more experienced clinicians.

For more than 60 years, Merritt's Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today's practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.

“This updated textbook was much needed as there has been increased attention in recent years toward brain injuries. The book provides updated guidelines and clinical practice recommendations that support the intended audience of trainees and current practitioners. This update makes it the current standard text for any brain injury specialist.'---Doody's Review Service, 4 stars This revised and greatly expanded Third Edition of Brain Injury Medicine continues its reputation as the key core textbook in the field, bringing together evidence-based medicine and years of collective author clinical experience in a clear and comprehensive guide for brain injury professionals. Universally praised as the gold standard text and go-to clinical reference, the book covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomes. With 12 new chapters and expanded coverage in key areas of pathobiology and neuro-recovery, special populations, sport concussion, disorders of consciousness, neuropharmacology, and more, this'state of the science'resource promotes a multi-disciplinary approach to a complex condition with consideration of emerging topics and the latest clinical advances. Written by over 200 experts from all involved disciplines, the text runs the full gamut of practice of brain injury medicine including principles of public health and research, biomechanics and neural recovery, neuroimaging and neurodiagnostic testing, sport and military, prognosis and outcome, acute care, treatment of special populations, neurologic and other medical complications post-injury, motor and musculoskeletal problems, post-trauma pain disorders, cognitive and behavioral problems, functional mobility, neuropharmacology and alternative treatments, community reentry, and medicolegal and ethical issues. Unique in its scope of topics relevant to professionals working with patients with brain injury, this third edition offers the most complete and contemporary review of clinical practice standards in the field. Key Features: Thoroughly revised and updated Third Edition of the seminal reference on brain injury medicine Evidence-based consideration of emerging topics with new chapters covering pathobiology, biomarkers, neurorehabilitation nursing, neurodegenerative dementias, anoxic/hypoxic ischemic brain injury, infectious causes of acquired brain injury, neuropsychiatric assessment, PTSD, and capacity assessment Multi-disciplinary authorship with leading experts from a wide range of specialties including but not limited to physiatry, neurology, psychiatry, neurosurgery, neuropsychology, physical therapy, occupational therapy speech language pathology, and nursing New online chapters on survivorship, family perspectives, and resources for persons with brain injury and their caregivers Purchase includes digital access for use on most mobile devices or computers

This book explores connections between music, neural activations and brain plasticity, in order to better understand its associated psychological and physiological effects. The final goal is to focus on the positive effects of music to treat neurological disorders, establishing a new co-ordination between different brain areas to improve both mental illness and wellbeing. A secondary goal is to analyse the role of music at a psycho-sociological level, to understand both the transformation of music into a cultural model and the vision of music as an innate instinct.Music is able to create both emotions and volitional processes. The application of new neuroimaging techniques allows us to explore and evaluate with accuracy what happens in our brain during the creative and artistic performance. A wide range of brain regions are recruited for creative tasks, and music has the opportunity to help in enhance and reset some brain pathological disturbances being also able to ameliorate and restore some rhythmic body activities such as sleep, movement and co-ordination. The book represents a valuable and innovative tool both for neurologists as well as healthcare professionals involved in the management of neurological disorders.

Dieses Buch stellt praxisrelevante Aspekte des Spezialgebietes'Gerinnung'einschließlich Diagnostik und Therapie von Gerinnungsstörungen für die neurologische Intensiv- und Notfallmedizin dar. Im Fokus stehen Gerinnungsstörungen als Ursache zerebraler Ischämien und intrakranieller Blutungen sowie die Thromboseprophylaxe bei neurologischen Patienten und die Differenzialtherapie mit Antithrombotika in der Neurologie.

This textbook addresses the classical use of Transcranial Doppler (TCD) and Transcranial Color-Coded Duplex Sonography (TCCS), focusing on the usefulness of neurological monitoring beyond classical acute brain injuries present in the daily intensive care medical practice. It encompasses a wide range of critical pathologies where neurological impact is part of clinical evolution, offering practical approaches for managing, application and interpretation of neurosonology to assist the physician to making real-time individualized decisions at bedside.It is an academic guide developed and edited by international experts being a very useful resource in daily practice for intensivists, neurologists, neurosurgeons and other specialists involving in critical care.

In the growing field of neuro-oncology, the past few years have witnessed rapid advances in tumor classification, treatment modalities, and the role of neurologists and neuro-oncologists. Neuro-Oncology for the Clinical Neurologist is a first-of-its-kind resource that focuses on patient-clinical scenarios relevant to the practicing neurologist—bringing you up to date with everything from basic principles and neuro-oncology imaging consults to neurologic complications of radiation, systemic, and immune-based therapies, and much more. - Focuses on the clinical management of patients typically encountered by neurologists and neurology trainees. - Provides clinically relevant updates in five key areas of neuro-oncology: primary CNS tumors, brain and leptomeningeal metastases, inherited tumor syndromes of the nervous system (e.g. neurofibromatosis), paraneoplastic and immune-mediated neurological complications of cancer, and neurological complications of cancer treatments. - Includes a summary of clinical pearls and a reference list of clinical cases. - Anchors each chapter with patient cases and clinical scenarios, provides evidence-based discussion, and explains patient management. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book aims to give the state-of-the-art of intraoperative brain function mapping for resection of brain tumors in awake conditions, and to become a reference for acquiring the fundamental expertise necessary to select the right intraoperative task at the right time of the surgery. The chapters, all focused on a specific brain function, are divided in 4 parts: sensori-motor and visuo-spatial functions, language functions, higher-order functions, and prospects. Each chapter follows the same outline, including a brief review of the current knowledge about the networks sustaining the function in healthy subjects, the description of the intraoperative tasks designed to monitor the function, a review of the literature describing the deficits in that function after surgery, and a critical appraisal of the benefit provided by intraoperative mapping of that function.

Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory,visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain. The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.

This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery. Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options.Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.

This book offers valuable guidance to neurointensivists, other neurocritical care staff, and those desiring to develop a neurocritical care unit via a thorough discussion of neurological emergencies and neurocritical care unit organization.This comprehensive volume begins with a review of acute neurological emergencies as managed clinically in the neurocritical care unit. Topics include acute cerebrovascular, neurological, and neurosurgical disorders. The unique aspect of this book is its description of the organization of the neurocritical care unit. We focus on how other services in the hospital interact with and assist neurocritical care operations, telemedicine/telestroke, and neurocritical care personnel and their roles. A review of expected outcomes of neurocritical care conditions is also included.Neurointensivists, neurocritical care unit staff leadership, hospital administrators, and those interested in developing a neurocritical care unit will find Neurointensive Care Unit: Clinical Practice and Organization to be an invaluable guide.

The second edition of OCT and Imaging in Central Nervous System Diseases offers updated state-of-the-art advances using optical coherence tomography (OCT) regrading neuronal loss within the retina. Detailed information on the OCT imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. Covering disorders like multiple sclerosis, Parkinson's disease, Alzheimer's disease, intracranial hypertension, Friedreich's ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia, readers will given insights into effects on the retina and the and optic nerve. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models.Similar to the first edition, this book is an excellent and richly illustrated reference for diagnosis of many retinaldiseases and monitoring of surgical and medical treatment. OCT allows to study vision from of the retina to the optic tracts. Retinal axons in the retinal nerve fiber layer (RNFL) are non-myelinated until they penetrate the lamina cribrosa. Hence, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.

This encyclopedic reference book on the treatment of intracranial aneurysms offers a case-based approach to the subject that has the benefit of fully reflecting the highly individual technical and clinical challenges encountered in aneurysm patients. The book is structured by aneurysm location, ensuring ease of use. Readers will find solutions for most clinical situations that they may encounter. Different treatment strategies are described, highlighting their respective pros and cons in particular circumstances. The coverage encompasses both basic techniques, such as coil occlusion and parent vessel occlusion, and the latest developments, including extra- and intrasaccular flow diversion, intrasaccular flow disruption, bifurcation stenting, and hybrid procedures combining microsurgical and endovascular elements. Potential procedural complications are identified, and bail-out strategies to anticipate, avoid, and solve major issues are described. The authors are all respected experts inthe field, and the book will be of value to vascular and endovascular neurosurgeons, interventional neuroradiologists and neurologists, stroke neurologists, and other practitioners at all levels of experience.

This book provides a comprehensive overview of the management of brain and skull base tumors. It features detailed insight into the intrinsic molecular biology, anatomical foundation, radiological planning, surgical execution, and the novel therapeutics that guide today's treatment regimens. The first section features concepts related to the epidemiology and pathological basis of disease processes, including relevant cellular and molecular biology. In the second section, integral anatomical foundations and principles are covered including microsurgical anatomy of the cerebrum, white matter tracts, ventricles, brainstem, skull base, advancements in radiological imaging, and cognitive examinations. Surgical approaches and how to execute these procedures are then subsequently discussed in the third part of the work. Principles of Neuro-Oncology: Brain & Skull Base is a practically applicable guide to the latest treatment techniques available to treat these patients. Therefore, it is an indispensable resource for all physicians who utilize these methodologies in their day-to-day practice.

This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author's 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery.

Stroke is a condition that predominantly affects older people, often leading to death, disability and dependency as well as occupancy of hospital and nursing-home beds. Older stroke patients are similar in many ways to their younger counterparts, but at the same time exhibit several key differences. Their outcome and care are complicated by delayed diagnosis, polypharmacy, difficult rehabilitation, ageism, false assumptions of poor outcome, multiple co-morbidity, social issues including implications for independent living, ethical dilemmas, and many others. The proportion of older people is increasing every day and with it the burden of disease and disability. The implications this has for health services are immense, especially for long-term conditions. Despite this there is limited literature available to clinicians on stroke with a particular focus on this age group. Traversing the whole stroke pathway, Stroke in the Older Person brings together key discussions on every aspect of the disease as it affects the older person, including its general aspects and those very specific to the older populations. All chapters are written by highly experienced clinicians that offer up-to-date evidence-based information as well as practical tips to promote excellent, empathetic care to older patients. Over 30 chapters, this resource addresses the epidemiology, aetio-pathogenesis, clinical presentation, diagnostic work-up (including imaging), primary and secondary prevention, and rehabilitation of older people. There is a special focus on intracerebral haemorrhage, carotid re-vascularisation, transient ischaemic attack, cognitive impairment, research, ethical and moral dilemmas including DNAR, advanced directives and end-of-life care.

This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supportedby a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.

This comprehensive, evidence-based book is intended to serve as a reference for medical practitioners involved in the perioperative care of neurosurgical patients. Fundamental aspects of neuroanesthesiology and neurocritical care are thoroughly examined across 101 chapters, outlining key elements that are crucial to a care provider's knowledge of the practice. These elements include specific diagnostic procedures and treatment options, concepts and applicable details of the available neurosurgical interventions and techniques, and mechanisms necessary to provide top of the line care for patients. Each chapter features definitive and distinct areas of this multi-specialty discipline, and is designed to guide the reader from problem to solution in situations that can arise in the clinical setting.Essentials of Neurosurgical Anesthesia & Critical Care, 2nd edition is a problem-oriented approach textbook that will aid a wide variety of readers in handling day-to-day issues and developments relevant to the perioperative care of neurosurgical patients.

This ambitious and important second edition of the Handbook of Medical Neuropsychology takes an in-depth approach to the medical conditions and methods of neurorehabilitation. Comprehensive in scope and highly detailed in its coverage, the second edition, like the first, characterizes the effects of disease and the impact of interventions in the current state of advanced medicine at a level appropriate both for researchers and for clinicians. Featuring the most up-to-date information and quantitative research on cognitive neuroscience of autism, HIV/AIDS, cancer, head injury, respiratory diseases, endocrine diseases, early birth injury, dementia, and other disorders, the book handles theory, historical background, practical considerations, and controversial areas with evidence based disease indicators, clinical expertise, and real-world insight. It seeks to critique diagnostic and assessment tools specific to disorders. The new chapters in this inclusive second editionreflect the changes in prominent problems found in the clinic and provide worthy insights for research investigation in their review of: Substance use disorders.Nutrition in neurocognition and mental health.Hypothyroidism and Hashimoto's thyroiditis.Traumatic brain injury in very early childhood.Cognitive functioning in asthma.The role of mindfulness in neurorehabilitation. The Handbook of Medical Neuropsychology, 2nd Edition continues to be an essential resource for the neuropsychology clinician, researcher, practitioner or graduate student. It will be stimulating and relevant reading for years to come.

This two-volume book offers a comprehensive guide to anesthetic management and critical care management in neurosurgical and neurological patients. This first volume focuses on neuroanesthesia. The book begins with basic information on neuroanesthesia, extensively discussing the anatomy of the brain and spine, physiology and relevant pharmacology. Special considerations for pregnant, pediatric and geriatric patients are covered in separate chapters. Each neurosurgical condition is discussed in a standard format relevant for neurosurgical patients, and each chapter, prepared by experts in the field, includes ample illustrations and flowcharts. Information is also provided on the latest evidence-based approaches, robotic surgery and gene therapy. The book offers a valuable resource for all residents, fellows and trainees in the fields of neuroanesthesia and anesthesia; it will also benefit practitioners and consultants.

This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging. In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN.SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering.SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity.This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists. Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, USA. Dr. Claudia Sommer is a professor of Neurology at the Department of Neurology, Würzburg University Hospital, Germany.

Neurotrauma and Critical Care of the Brain, 2nd edition by renowned neurosurgeons Jack Jallo and Christopher Loftus incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on traumatic brain injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery provide a concise review of a complex and evolving field.The book lays a solid foundation with discussion of TBI classification, pathophysiology, key blood biomarkers, noninvasive neuromonitoring in severe TBI patients, multimodality monitoring in neurocritical care, and brain imaging modalities. From the prehospital setting to intensive care, top experts share clinical pearls and core guidelines on the management of mild, moderate, and severe TBI and complications. Chapters new to this edition include concomitant injuries, orbital/facial fractures, vascular injuries, spine fractures, autonomic dysfunction, and temperature management.Key HighlightsSpecialized topics include wartime penetrating injuries, cardiovascular complications of TBI, venous thromboembolism prophylaxis, ethical considerations, TBI costs in the U.S. and the financial return on helmetsManagement of pediatric brain injuries in the NICU with illustrative casesNearly 200 high quality illustrations facilitate understanding of complex anatomy and techniquesSummary tables provide a handy overview of injury type, causes, characteristics, and recommended imaging modalitiesThis remarkable resource is essential reading for neurosurgeons, neurologists, trauma physicians, critical care and rehabilitation medicine specialists, and residents in these specialties. Paired with Neurotrauma and Critical Care of the Spine, 2nd edition, this dynamic duo is the most up-to-date neurocritical care reference available today.

The purpose of this textbook is to enable a Neuroscientist to discuss the structure and functions of the brain at a level appropriate for students at many levels of study including undergraduate, graduate, dental or medical school level. It is truer in neurology than in any other system of medicine that a firm knowledge of basic science material, that is, the anatomy, physiology and pathology of the nervous system, enables one to readily arrive at the diagnosis of where the disease process is located and to apply their knowledge at solving problems in clinical situations. The authors have a long experience in teaching neuroscience courses at the first or second year level to medical and dental students and to residents in which clinical information and clinical problem solving are integral to the course.

No other neurological condition allows the same opportunities for an intracranial electrophysiological study of the human brain as epilepsy does. Epileptic surgery is designed to remove the epileptic focus from the human brain, thereby effecting either cure or substantial reduction of seizures in an individual with an otherwise intractable condition. Its use as a treatment modality dates from the late 19th century, and it has become a widely used treatment option throughout the world in the last 20-30 years. The complexity of epilepsy cases in surgical centres, and the need for invasive electrode studies for pre-surgical evaluation, are both greatly increasing. Invasive Studies of the Human Epileptic Brain is the definitive reference text on the use of invasive electroencephalographic (EEG) diagnostic studies in human epilepsy. Written by some of the most renowned epilepsy experts of the 20th and 21st centuries, the authors provide their expertise and insights into the identification and mapping of intracranial epileptiform and non-epileptiform activity, mapping of the human brain function, and approaches in the use of invasive electroencephalography in a variety of clinical situations. The book is organized into an easily readable series of chapters and is brilliantly illustrated with case studies; each providing an intuitively comprehensive approach to invasive brain studies.

Die operativen und interventionellen Verfahren der Schmerztherapie sowie die Therapie der wichtigsten Schmerzsyndrome sind systematisch und detailliert in diesem Buch dargestellt. Technik und Ausführung der einzelnen Methoden werden ausführlich beschrieben, dabei sind sowohl neuroläsionelle und neuromodulierende Verfahren als auch die neurochirurgischen Therapieoptionen bei Gesichts- und Kopfschmerzen berücksichtigt. Zahlreiche Hinweise auf Tipps und Tricks erleichtern die Durchführung und erhöhen die Sicherheit der Anwendung. Aus den publizierten Behandlungsergebnissen wird der Stellenwert der Verfahren für die möglichen Indikationen abgeleitet. Therapieempfehlungen für die einzelnen Schmerzsyndrome beziehen alle Behandlungsmodalitäten ein und ermöglichen so ein indikationsspezifisches, patientenorientiertes Vorgehen.

This book aims to provide an overview of the basics of anesthesia for neurotrauma. It showcases how management of different neurotrauma cases may differ, especially those involving spine and or polytrauma. It provides quick and easy access to understand anesthesia for neurotrauma.

The aim of this unique book is to provide an overview of recent advances bridging the gap between psychiatry and neuroscience, allowing a fruitful dialogue between both sciences. The emerging interactions and mutual contributions between neuroscience and psychiatry are here recognized. This book is designed to identify the borders, trends and implications in both fields today.Comprehensive and developed by a renowned group of experts from both fields, the book is divided into four parts: Epistemological Considerations About the Study of Normal and Abnormal Human Behaviors; From Basic Neurosciences to Human Brain; Neurosciences, Learning, Teaching and the Role of Social Environment; and Explaining Human Pathological Behaviors: From Brain Disorders to Psychopathology. A unique and invaluable addition to the literature in psychiatry and neuroscience, Psychiatry and Neuroscience Update – Vol. II: A Translational Approach offers an important and clearer understanding of the relationship between these two disciplines. This book is directed to students, professionals and researchers of medicine, psychology, psychopedagogy and nursery.

This volume answers the question: Why do we believe what we believe? It examines current research on the concept of beliefs, and the development in our understanding of the process of believing. It takes into account empirical findings in the field of neuroscience regarding the processes that underlie beliefs, and discusses the notion that beyond the interactive exploratory analysis of sensory information from the complex outside world, humans engage in an evaluative analysis by which they attribute personal meaning and relevance to the probabilistic representations of objects and events. Beliefs exert a strong influence on behaviour, decision-making, and identifying and solving problems. Despite their importance, beliefs have until recently not been at the centre of scientific interest. In fact, “belief” is an ill-defined phenomenon. From a transdisciplinary perspective the actual approaches to understanding belief seem incompatible as they attempt to highlight such different topics as “belief – religion”, “belief – spirituality”, “belief – faith”, “belief – knowledge”, “belief – attitude”, “belief – disbelief”, “belief – illusion”, and “believing – brain function”. This situation contradicts the idea that belief is close to pathological phenomena and that it should be eliminated from scientific discussions. Rather, believing is fundamental for understanding the many problems of every-day life. In fact, the book shows that beliefs are relevant for politics, international affairs, economy, law, or religions also in modern societies. This book presents the increasing scientific interest in beliefs and believing, and reflects the change in focus from the content aspect of belief towards the fluid nature of believing.

These proceeding cover new trends presented at the IV Congress of the International Society of Reconstructive Neurosurgery (ISRN), 2015. ISRN is an “open” multidisciplinary society that deals with advances in spine and peripheral-nerve reconstructive surgery, central nervous system revascularization (surgical, radio interventional), neuromodulation, bioengineering and transplantation, which are the latest tools used to promote reconstruction, restoration and rehabilitation.

This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.

This Atlas is the first reference Atlas covering exclusively all aspects of this multifaceted topic. It is designed to serve as a succinct appropriate resource for neurosurgeons, spinal surgeons, radiologists, neurologists, microbiologists, researchers and infectious disease specialists with an interest in cranio-cerebral and vertebro-medullary infections especially encountered in neurosurgery and spinal surgery. This Atlas is designed to deliver more information in less space than traditional texts, allowing for quick review of the essential facts of this complex infectious topic through pictures. Pertinent imaging and laboratory information are combined with intraoperative photographs and illustrations to help readers visualize variable presentations and enhance their perioperative management. The comprehensive content of this richly-illustrated book covers different infectious diseases seen on neurosurgical and spinal practices. The Atlas is divided into five sections, after a general introduction, the second section focuses on infections of the brain and its coverings. The third section focuses on vertebromedullary infections. The fourth section includes infections following cranial and spinal surgery, and the fifth section provides a description of the most important specific pathogens and other particular conditions. The format makes it easily accessible and includes a definition of each infection and its epidemiology, main clinical presentations, imaging features and laboratory findings, treatment options, and prognosis information. It will help the reader in choosing the most appropriate way to manage this multipart problem. In addition, the book supplies clinicians and investigators with both basic and more sophisticated information and procedures relating to the complications associated with neurosurgical andspinal infections.

With the recent development of new technology and practices in the field of ambulatory EEG (aEEG), the time is right for a practical reference on the application of aEEG in clinical practice. This authoritative guide to prolonged EEG recording outside the hospital or clinic is a valuable resource for anyone involved in long-term EEG monitoring and interpretation. Bridging the gap between routine scalp EEG and in-patient video EEG monitoring, aEEG has evolved to provide cost-effective, high-yield, high-tech recording for evaluation of epilepsy diagnoses, nonepileptic attacks, quantification of seizures or epileptiform burden, and other issues requiring extended EEG observation for paroxysmal neurological events in any environment. Bringing together top experts from leading epilepsy centers, the book covers equipment, technical aspects of recording, instrumentation and polygraphic event monitoring, artifacts, clinical use in adult and pediatric patients, sleep recording, short-term and chronic ambulatory EEG, and reimbursement. The concluding chapter offers representative case presentations with relevant findings to further enhance the reader's understanding and implementation of key concepts. This'start to stop'survey of current applications is essential reading for a wide range of clinicians practicing in the field of clinical neurophysiology and epilepsy management, whether seasoned or in training.Key Features:Fills the void of when and how to use aEEG in evaluating patients with paroxysmal neurological events and epilepsyIncorporates aEEG into clinical management at all stages of diagnosis and treatmentContains numerous aEEG illustrations and graphics to emphasize key pointsIncludes a chapter on common artifacts that can complicate the interpretation of an aEEGDetails the evolving use of chronic intracranial aEEG and wearable devicesIllustrative case studies provide pearls and reinforce best practices in aEEG monitoring

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Pediatric Neuro-Ophthalmology, 3rd edition provides the single authoritative resource on the pathophysiology, diagnostic evaluation, and treatment of neuro-ophthalmologic disorders in children. This book is encyclopedic in scope, incorporating extensive references for each condition, numerous diagrams and pictures, and a detailed analysis of the clinical disorders included in the differential diagnosis of each condition. The third edition builds upon this format to incorporate new discoveries about mechanisms of disease, new diagnostic modalities, advances in treatment in the field of pediatric neuro-ophthalmology, and updated neuroimaging figures. ​

This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson's disease, Alzheimer's disease, intracranial hypertension, Friedreich's ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.

Whereas most book about the neurologic examination are disease and anatomy oriented, The Neurologic Examination: Scientific Basis for Clinical Diagnosis focuses on a pathophysiological approach to the nervous system. The authors emphasize that the scientific interpretation of symptoms obtained from carefully taking the patient's history and noting signs found during physical examination are essential in the diagnosis of neurologic diseases, even if laboratory testing, such as electrophysiology and neuroimaging, are more widely used. This book aims to provide a bridge from the basic sciences such as anatomy, physiology, pharmacology, and molecular biology to the neurologic symptoms. Neurologic examinations provide the foundation for diagnosis, and only after a thorough and expertly executed examination can one begin to incorporate laboratory testing and treatment. The Neurologic Examination: Scientific Basis for Clinical Diagnosis, based on the widely successful Japanese book Diagnosis of Neurological Diseases (Igakushoin, Japan, second edition 2013) by Dr. Shibasaki, hopes to revitalize the use of neurologic examinations before jumping into laboratory testing. Doing so can help cut down on time, patient and physician anxiety, and unnecessary testing expenses. This book is a must-read for all practicing neurologists, residents, and medical students. Key Features Include · The chapters are arranged in order of the actual steps in a neurologic examination; · Highly illustrated with figures and tables indicative of the neurologic signs and symptoms that may appear during the given step; and · 99 discussion boxes are inserted throughout to provide a more in-depth look at particular topics without interrupting the reading flow of the text.

In 1851, Heinrich Müller discovered what he called “radial fibers” and what we now call Müller cells, as the principal glial cells of the vertebrate retina. Later on, other glial cell types were found in the retina, including astrocytes, microglia, and even oligodendrocytes. It turned out that retinal glial cells are essential constituents of the tissue. For instance, Müller cells appear to constitute the “core” of columnar units of clonally and functionally related groups of neurons. Their primary function is to support neuronal functioning by guiding the light towards the photoreceptor cells, removing excess neurotransmitter molecules from extracellular space, and performing efficient clearance of excess extracellular potassium ions. The latter two functions are also crucial for neuronal survival and are coupled to water clearance which is also essential. Müller cells are capable of “sensing” neuronal activity and modifying it by the release of signal substances (gliotransmitters). In cases of retinal injuries the Müller cells become reactive, and all above-mentioned functions are impaired. However, such de-differentiated Müller cells may proliferate, and may even serve as stem cells for the regeneration of a damaged retina. As well as the Müller cells, retinal astrocytes and microglial cells are important players in retinal development and function. This book gives a comprehensive survey of the present knowledge on retinal glia.

The Human Auditory System: Fundamental Organization and Clinical Disorders provides a comprehensive and focused reference on the neuroscience of hearing and the associated neurological diagnosis and treatment of auditory disorders. This reference looks at this dynamic area of basic research, a multidisciplinary endeavor with contributions from neuroscience, clinical neurology, cognitive neuroscience, cognitive science communications disorders, and psychology, and its dramatic clinical application. - A focused reference on the neuroscience of hearing and clinical disorders - Covers both basic brain science, key methodologies and clinical diagnosis and treatment of audiology disorders - Coverage of audiology across the lifespan from birth to elderly topics

Pain is the most common reason people seek medical help. The treatment of chronic pain is a major unmet clinical need and its impact on health, well-being, society and the economy is immense. Pain is an integrative, whole-systems (patho)physiological phenomenon and behavioural neuroscience plays a key role in advancing our understanding of pain. This volume brings together a series of authoritative chapters written by leading experts in preclinical and clinical aspects of pain neurobiology. Behavioural approaches to the study of persistent or chronic pain in animal models or humans are at the core of the volume, but the anatomical, physiological, neurochemical and molecular mechanisms that underpin behavioural alterations are also emphasized. ​