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This innovative book offers a multidimensional exploration of the epistemological foundations of psychiatry and its major disorders. By emphasizing the importance of phenomenology in unravelling the intricate interplay between basic categories of human experience and neurobiological processes, it advocates for a shift in both psychiatric research and clinical practice. Phenomenological Neuropsychiatry presents psychiatry as a hybrid discipline that synthesizes subjective mental experiences with objective neuroscientific findings and forms an integrative and interdisciplinary structure that provides a dialectical bridge between understanding, compassion, and explanation. The first section of the book presents the lived experience of psychosis and argues for a more inclusive approach to mental health issues. The second section examines the ways in which psychiatric knowledge is constructed and the unique challenges posed by combining understanding and explanation of mental disorders. Section three sheds light on how disruptions in bodily experiences, memory processes, and self-perception can contribute to the development and manifestation of psychiatric issues. The following section discusses disorders of mood and anxiety, including the phenomena of depression, obsessions, and depersonalization. The fifth and final section provides an in-depth examination of psychotic disorders. It covers a range of topics, such as timing, intentionality, self-monitoring of action in schizophrenia, and the neurobiology of prodromal psychosis. As a singular work dedicated to revitalizing and advancing cross-fertilization between psychiatry and phenomenology, this groundbreaking book clears the foggy operationalized clusters of mental symptoms that may obscure diagnosis and treatment and argues for systematic integration of patient subjectivity and collaboration in clinical research. It features an authorship of the leading clinicians and thinkers from throughout the world in psychiatry, psychology, neuroscience, social sciences, and philosophy. Phenomenological Neuropsychiatry: How Patient Experience Bridges the Clinic with Clinical Neuroscience is a major contribution to the clinical literature and a must-read for psychiatrists, neurologists, psychologists, and professionals and students from other disciplines concerned with absorbing a deeper understanding of psychiatric disorders.

Long known to be important for memory, the hippocampus has been a prime focus for neuroscience research for years. This second edition of The Hippocampus Book highlights advances in our understanding of this group of brain structures and includes a new set of translational chapters concerning associated brain disorders. This edition brings together contributions by leading international experts on hippocampal anatomy, physiology, molecular biology and function with other chapters summarizing how disorders of hippocampal function contribute to several neurologic and psychiatric conditions. Concurrently, this text illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, neural and synaptic plasticity, cognition and behaviour, and computational algorithms. Covering theory, experimental data and translational relevance, this uniquely authoritative work vividly illustrates the progress that continues to be made in unravelling the workings of the brain. The Hippocampus Book will be of interest to those working in a range of neuroscientific disciplines, ranging from the molecular biology of neural function and dysfunction, through network physiology to behavior and neuropathology and take pride of place on the bookshelves of all with an interest in the brain and its functions.

Advances in the treatment of neurodegenerative diseases (NDs) are nominal. Currently available therapies are merely symptomatic treatments that cannot prevent the development of the disease. Several herbs have been found very useful for managing neurological diseases. There are immense possibilities to discover a more successful line of ND treatment. Phytochemicals from medicinal plants may play a vital role in maintaining the chemical balance of the brain by affecting the capacity of receptors for the major inhibitory neurotransmitters. A few plants have already gained popularity for the potential treatment of NDs. This volume highlights the therapeutic role of medicinal plants and their scientific validation for improving neuronal health. It presents 15 chapters that cover the herbal treatment of NDs, including Parkinson s disease and Alzheimer s disease. The contents cover a range of pharmaceutical agents like sirtuins, berberine, rosmarinic acid and resveratrol. The book serves as a reference for pharmacology and herbal medicine scholars as well as healthcare workers interested in information about alternative and complementary therapies for neurological disorders.

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

Psychedelic therapies are gaining traction as potential treatments for a wide range of indications, but the structure and delivery of psychedelic therapies are a sharp departure from more traditional models of psychotherapy and pharmacotherapy for psychiatric and other medical disorders. This may be critical to their success. The current volume provides a comprehensive review of the state of the science of psychedelic therapies, including discussion of models and approaches to psychedelic therapies as well as the current status of safety and efficacy data for mood, substance use, trauma, obsessive-compulsive, neurodevelopmental, neurodegenerative disorders, neurological, and inflammatory disorders.

This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer's Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson's Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

This textbook provides a state of the art of the knowledge on the prevalence, risk and etiological factors, clinical features, assessment procedures and tools, diagnostic criteria, treatment, and prognosis of the psychiatric disorders encountered in people with intellectual disability (ID) and low-functioning autism spectrum disorder (ASD). ID and ASD represent two meta-syndromic groups of several different conditions, each with particular cognitive and communication features. People with ID/ASD display an increased prevalence of a variety of psychiatric disorders, including psychotic disorders, mood disorders, anxiety and stress-related disorders, somatoform disorders, and obsessive-compulsive disorder, as well behavioral syndromes, personality disorders, and disorders due to psychoactive substance use. This book will enable readers to understand the specificities of psychiatric disorders in the context of ID/ASD. It explains clearly how diagnostic criteria and assessment procedures for psychiatric disorders that were created for the general population have to be modified for use with ID/ASD. Above all, it will enable clinicians to overcome difficulties in diagnosis and to deliver more effective care that meets the particular needs of patients with ID/ASD.

Respiratory Neurobiology: Physiology and Clinical Disorders, Part One, Volume 188 is one of two volumes on the neurology of breathing. This volume focuses on the neurophysiology of breathing, while the second volume focuses on pathologies attributable to abnormalities of the neural control of breathing, breathing problems that may occur in neurological diseases, and the neurological complications of respiratory diseases. - Explores the assessment and treatment of neural disorders of breathing - Identifies neural complications of respiratory diseases - Includes SIDS, stroke, Parkinson's, dementia, epilepsy, muscular dystrophy, and more

Disorders of Emotion in Neurologic Disease, Volume 183 in the Handbook of Clinical Neurology Series, informs clinicians on which neurologic diseases are likely to have a secondary effect on emotion, what to look for in diagnosis, and best practices for treatment. The book begins with an understanding of the neurological basis for emotions in order to better understand what goes awry in neurological disease. It then discusses specific neurologic diseases and disorders affecting emotion. - Reviews the neurology of emotions - Specifies neurologic diseases that affect emotional expression - Informs clinicians on how to diagnose, along with best practices for treatment - Includes coverage of stroke, dementia, epilepsy, Huntington's, Parkinson's, TBI, and more

This extensively revised edition is an essential reference for physicians involved in the diagnosis, referral and treatment of the thoracic outlet syndrome (TOS). TOS is made up of a constellation of problems resulting from pathology at the thoracic outlet in the neck. Busy specialty practice sees multiple affected patients in every clinic, but TOS can often be difficult to diagnosis. Thoracic Outlet Syndrome explores all possible ancillary care issues surrounding this complex condition, including rehabilitation, disability, natural history and medicolegal issues, and aims to stimulate research, discussion and a sense of community between professionals involved in this area. Vascular and thoracic surgeons, neurosurgeons, neurologists, psychiatrists and psychologists, physical therapists, occupational medicine specialists and pain specialists will find this book a must read for successful treatment, referral and diagnosis of TOS in clinical practice.

This ambitious and comprehensive handbook represents an essential contribution to our current understanding of interactions between heart and brain, a research topic generating growing interest. Despite the increasing awareness that neural mechanisms are the primary cause of cardiac disease and its progression, therapy continues to focus on end-organ protection and does not approach the neural core of the problem. Growing public health problems such as heart failure are still treated with autonomic drugs that are 30-40 years old and simply act on cardiac receptors. However, it has now been shown that the progression of ischemic heart disease to heart failure is mainly due to abnormal central responses to incipient cardiac disease, with neural activation the primary cause rather than the consequence of cardiac remodeling. Written by leading international experts in their respective research areas, the book presents a variety of perspectives on the coretopic: from social and philosophical to gender-related aspects.It is designed for a broad readership and includes dedicated sections for cardiologists, psychiatrists, neurologists and psychotherapists looking for a more insightful and targeted approach to neuro-cardiovascular disease.

This book, now in a fully updated second edition, is a comprehensive and up-to-date guide to the use of PET and SPECT for the imaging of neurobiological systems. Diverse aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. A wide range of systems not addressed in the first edition are covered, reflecting the advances made in recent years. The book combines the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuableto all with an interest in clinical and preclinical neuroscience. Companion volumes on the use of PET and SPECT in neurology and psychiatry complete a trilogy.

This book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy.

The book provides a comprehensive reference on the neurobiological understanding of behaviour, how behaviour is regulated by the brain, and how such behaviours in turn influence the brain. The work offers an introduction to neural systems and genetics/epigenetics, followed by detailed study of a wide range of behaviours – temperament and personality, instincts and drives, memory and cognitive function, sex and sexual differentiation, ethology and evolutionary biology, aging, drug abuse and other problematic behaviors, psychophysiology and ultimately the links to biological psychiatry and psychopharmacology. Research findings on the neural basis of social behaviour are integrated across different levels of analysis, from molecular neurobiology and neural systems/behavioural neuroscience to fMRI imaging data on human social behaviour. The content covers research on both normal and abnormal behaviours, as well as developmental aspects. The target audience includes psychiatrists, neurologists, nurses, psychologists and all researchers and advanced students in behavioural, social and developmental neuroscience, as well as clinical neuroscientists.

This comprehensive resource covers a range of women's health issues and their intersection with neurologic and psychiatric disease. Chapters feature high quality, integrated information based on leading-edge research on gender-specific care and are grouped by reproductive years, pregnancy and health, and aging. Emerging science regarding sex differences in neurological and psychiatric illnesses, including anxiety, reproductive health, conversion disorders, depression and ethical issues in pregnancy, stroke risk factors, and successful aging strategies are covered along with clinical application of this knowledge to the delivery of care. In addition, in those medical problems that afflict both men and women, authors will point out the different risks, prevalence, presentations, and responses to treatments or outcomes in women. Written by renowned experts in the field, this textbook will thoroughly address the educational needs of physicians, nurse practitioners, and physician assistants in the areas of neurology, psychiatry, internal medicine, and obstetrics and expanding their understanding of concerns unique to female patients.

Mild traumatic Brain Injury (mTBI or Concussion) is an increasingly common public health issue in sports, military environments, and life in today's active world. Despite a great deal of study and public attention to this disorder, knowledge about optimal diagnostic, prognostic, and treatment information remains lacking. Neurosensory symptoms have been shown to be the most frequent complications of mTBI in both the acute and chronic setting. Neurosensory Disorders in Mild Traumatic Brain Injury brings together both the basic science work as well as the clinical work in mTBI into one volume to provide a comprehensive examination of the neurosensory issues associated with this disorder. Coverage includes chapters on defining mild Traumatic Brain Injury, neurosensory consequences, neurosensory disorders in clinical practice, and diagnosis and treatment for neurosensory disorders in mTBI. This book is written for clinicians, researchers, residents and students in neurology and neuroscience. - Provides a comprehensive examination of the neurosensory issues associated with mild Traumatic Brain Injury and concussion - Brings together both the basic science work and the clinical work in mTBI into a single volume - Helps clinicians understand the best diagnosis and treatment paths and puts current research into perspective for researchers

There are few clinical problems in the sleep medicine field that are more challenging than the sleep difficulties experienced by individuals suffering from post-traumatic stress disorder (PTSD). This book offers a unique, complete resource addressing all the basic concepts and clinical applications in sleep medicine in settings where combat-related PTSD is commonplace. Authored by leading international experts in the field of sleep/military medicine, Sleep and Combat-Related Post Traumatic Stress Disorder is organized in six sections and provides a broad perspective of the field, from the established theories to the most recent developments in research, including the latest neuroscientific perspectives surrounding sleep and PTSD. The result is a full assessment of sleep in relation to combat-related PTSD and a gold standard volume that is the first of its kind. This comprehensive title will be of great interest to a wide range of clinicians -- from academics and clinicians working within or in partnership with the military health care system to veteran hospital physicians and all health personnel who work with war veterans.

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression, the clinical manifestations, and the development of more effective treatments. This second volume is devoted specifically to clinical and management issues. Readers will find detailed information on a wide range of frequently encountered and more complicated clinical presentations, with examination of risk factors and links to other conditions. Diagnostic aspects, including progress toward biological classification and the role of neuroimaging, are explored. Current trends in therapy are examined at length, drawing on the latest evidence and covering not only antidepressant medications but also the roles of neurostimulation, combined pharmacotherapy and psychotherapy, mindfulness-based cognitive therapy, and complementary and alternative medicine. The companion volume is dedicated to the underlying biomedical and neurobiological basis of depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

This volume covers the gamut of surgical and device-based treatments for psychiatric disorders. Written by experts in the field, this book covers neuroscience advances in the neurobiological underpinnings of psychiatric diseases, emerging surgical and device-based treatments, and advances in the field. Topics include electroconvulsive therapy, transcranial magnetic stimulation, Vagus nerve stimulation (VNS), and many other cutting-edge treatments and techniques.Psychiatric Neurotherapeutics is a valuable resource for psychiatrists, neurosurgeons, neurologists, researchers, and all other medical professionals interested in surgical and device-based treatments of psychiatric disorders.

Recent advances in the understanding of brain functions are reviewed in this text, along with how neurobiological research and brain imaging contributes to identifying and treating neurologic and psychiatric disorders. Chapters focus on consciousness, memory, emotions, language, communication, trauma, pain and resilience, while exploring how stressful events impact mental health and interrupt the continuity of one's sense of self. Clinical vignettes of patients with neurological and mental affections reveal coping and grieving processes in dreams and narratives. This presentation of clinical experience with neuro-scientific evidence provides neurologists, psychiatrists, psychotherapists and psychologists with a coherent picture of the brain-mind relationship.

The development of the brain and nervous system is shaped not just by a genetic program, but also by the effects of multiple environmental stimuli. There are currently no book-length treatments of perinatal neurodevelopment. The proposed book seeks to fill this gap by presenting a collection of chapters from leading experts in the field. It is intended to be comprehensive and will cover all aspects of neurodevelopmental programming in lab animals and in human subjects. The third section of the book will look at ways of translating insights we have garnered from animal studies to human and clinical studies. The primary audience for this work is basic researchers interested in the effects of perinatal imprinting on the development of the nervous system and associated diseases.

This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections - Schizophrenia/Psychotic Disorders and Mood Disorders - deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

PET and SPECT of Neurobiological Systems combine the expertise of authors internationally renowned for their dedication to the development of novel probes and techniques for the investigation of neurobiological systems. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of neuroreceptors, neuroinflammatory markers, transporters and enzymes as well as neurotransmitter synthesis, β-amyloid deposition, cerebral blood flow and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to all with an interest in the field of clinical or preclinical neuroscience. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in neurology'.

Anxiety disorders are not uncommon and are often ‘comorbid'with other forms of mental disorders. This publication provides an update on the origins and the causes of anxiety disorders and their related symptoms. Its focus is on neuroimaging and neuroinflammation and genetics as well as areas where an overlap may exist with abnormal cardiovascular physiology. Further it takes a closer look at the early phases of anxiety disorder and the potential effects of prolonged illness prior to diagnosis and also investigates recent research findings about the neuroimmunology of depression and the immunomodulatory effects of antidepressants. It also examines the neuroinflammatory hypothesis about anxiety disorders and concludes with the succinct but evidence-based and comprehensive reports on the value of pharmacological treatments used for generalized anxiety disorder, panic disorder, social anxiety disorder, posttraumatic stress disorder and obsessive-compulsive disorder. The topics covered in this publication will certainly make it essential reading for both novice and expert practitioners in psychiatric medicine, but its appeal should extend even further and include those researching the neuropsychobiology of anxiety or trying to improve our grasp of posttraumatic stress disorder or obsessive-compulsive disorder.

Charakteristische Erkrankungen des ZNS haben durch die Erhöhung des Durchschnittsalters der Bevölkerung erheblich zugenommen und damit die Forschungsaktivität auf diesem Gebiet außerordentlich intensiviert. Schließlich haben Molekularbiologie und molekulare Genetik zur Aufklärung der Ursachen bisher unklarer Erkrankungen des ZNS beigetragen. In insgesamt 17 Kapiteln wird von ausgewiesenen Experten der aktuelle Stand der Forschung, Entwicklung und Anwendung in der medizinischen Praxis und Therapie von Erkrankungen des ZNS vorgestellt. Unter anderem werden die molekularen Ursachen der multiplen Sklerose, der Alzheimer-Erkrankung und der mit der Aids-Erkrankung auftretenden Enzephalopathie, des weiteren die Genetik neurologischer und psychischer Störungen sowie die molekularen Grundlagen der Suchtentstehung und der Depressionstherapie dargestellt.

In der Depressionsbehandlung hat es in den letzten 20 Jahren bedeutsame Fortschritte, aber auch bittere Erkenntnisse gegeben. Zu letzteren zählen hohe Suizidrate, Suizidalität, Chronifizierung bei depressiv Kranken, zu ersteren die Entwicklung neuer Psychotherapiemethoden, neuer Antidepressiva, integrativer Behandlungsansätze, gerade bei schwer und schwerst depressiv Kranken. Depressionsstationen, also die Zusammenfassung depressiver Patienten für ein gemeinsames Behandlungskonzept, sind einer der bedeutsamsten Fortschritte. Die Erfahrungen und die Einrichtungen werden in diesem Buch besprochen, das damit Anregung und Grundlage für weitere Depressionsstationen bietet.

Band III der bekannten Reihe Neuropsychopharmaka stellt in der Neuauflage die aktuellsten medizinischen Präparate und klinischen sowie grundlagenorientierten Ergebnisse zum Thema Depressionssyndrom bzw. Antidepressiva vor. Der Band wurde in Anlehnung an die bereits erfolgten Neuauflagen der Bände IV und V neu gegliedert. Grundlegende Kapitel wurden vorangestellt, die eine Begründung für die im Buch dargestellten Therapiestrategien geben. Der Text wird durch Tabellen, Figuren und einen Medikamentenanhang anschaulich ergänzt. Die Neubearbeitung erfolgte durch eine große Anzahl von renommierten Psychiatern, Pharmakologen und Neurochemikern aus dem gesamten deutschsprachigen Raum, die für eine ausgewogene Darstellung sorgen. Das Buch liefert als einzigartiges Handbuch und Nachschlagewerk rasche Information zu allen Medikamenten. Die leserfreundliche Gliederung (detailliertes Inhaltsverzeichnis, ausführliches Stichwortverzeichnis, Tabellenwerk im Anhang) bietet die Möglichkeit, rasch eine Antwort zu erhalten.

Interdisziplinärer Ansatz für komplexe Syndrome Chronisches Müdigkeitssyndrom (CFS) und Fibromyalgiesyndron (FMS) äußern sich in einer Fülle vegetativer, funktioneller und psychischer Beschwerden. Diagnose und Therapie stellen Ärzte aller Fachrichtungen häufig vor große Schwierigkeiten. Der interdisziplinäre Ansatz schaft Klarheit und hilft Ihnen - die Leitsymptome zu erkennen- das komplexe Krankheitsbild richtig einzuordnen- unnötige aufwändige Untersuchungen zu vermeiden- geeignete therapeutische Massnahmen zu treffen Fundierter Überblick, erfolgreiche Behandlung!

Das Chronische Müdigkeitssyndrom (CFS) und das Fibromyalgiesyndrom (FMS) sind definiert durch eine Fülle vegetativer, funktioneller, aber auch psychischer Beschwerden, für die sich zwar anamnestisch in manchen Fällen präzipitierende Faktoren eruieren lassen, denen aber ein organisches Korrelat nicht zugeordnet werden kann. Die Diagnose basiert deshalb auf dem Ausschluß anderer Erkrankungen. Erhöhte Schmerzperzeption, Myalgien, Leistungsschwäche, schnelle Erschöpfbarkeit sind Leitsymptome beider Beschwerdebilder.CFS und FMS werden im vorliegenden Buch aus der Sicht verschiedener Fachdisziplinen besprochen, wobei es den Autoren vor allem darum geht aufzuzeigen, wie wichtig die Kenntnis dieser komplexen Krankheitsbilder in der internistischen, rheumatologischen, gastroenterologischen, psychiatrischen und neurologischen Praxis ist, um einerseits unnötige aufwendige Untersuchungen zu vermeiden und andererseits geeignete therapeutische Maßnahmen zu treffen.

Höhere kognitive Leistungen ebenso wie psychische Erkrankungen sind ohne Beteiligung der Frontallappen nicht denkbar. Dieses Buch liefert eine kompakte Übersicht aktueller Erkenntnisse über die Leistungen und Störungen einer Hirnstruktur, die als ein Charakteristikum des Homo sapiens gilt und Philosophen, Psychologen, Neurowissenschaftler sowie Nervenärzte seit langem fasziniert.

This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.

Die 4. Auflage der Psychiatrie der Gegenwart ist völlig neu konzipiert; sie umfaßt jetzt 6 Bände. Beibehalten hat man den editorischen Leitgedanken, der auch die Vorauflagen prägte: Nicht enzyklopädische Vollständigkeit, sondern der aktuelle Erfahrungsstand der Psychiatrie wird - paradigmatisch - vermittelt. Das Werk bringt zu jedem Thema eine Übersicht des wissenschaftlich gesicherten Wissens, dessen Anwendung in der Praxis sowie Brennpunkte, Entwicklungstrends, Zukunftsperspektiven des Fachs. Wesentliche Akzentsetzungen der 4. Auflage sind die internationale Vielfalt der Beiträge, die Gewichtung von'Migration, Postraumatischer Belastungsstörung - allgemein: Spezifischen Lebenssituationen', die Integration neuer Erkenntnisse etwa in der Molekularbiologie, im Bereich bildgebender Verfahren oder in der Neuropsychologie. Neu und leserfreundlich ist das zweifarbige, mit Mariginalienspalte versehene Innenlayout.

In der klinischen Medizin müssen psychische Beschwerdebilder und Erkrankungen in Behandlungskonzepte für körperliche Erkrankungen mit einbezogen werden, denn inadäquate Diagnostik und Therapie psychischer Störungen bei primär körperlich Kranken führen zu ungünstigen und chronifizierten Krankheitsverläufen. Angesichts neuer technologischer Möglichkeiten bei der Behandlung körperlicher Erkrankungen muss dafür gesorgt werden, dass die erreichbaren Fortschritte nicht durch ein Nichtbeachten zusätzlicher psychischer Störungen in Frage gestellt werden. Gerade die Aspekte psychischer Erkrankungen werden in diesem Buch herausgearbeitet, die in der ambulanten und stationären Versorgung körperlich Kranker von besonderem Interesse sind. Praxisbezogen werden Diagnostik und Therapie wie auch spezielle Behandlungssituationen dargestellt, dabei wird auf schwierige Problemkonstellationen und Gefahrenquellen hingewiesen.

Die 4. Auflage der Psychiatrie der Gegenwart ist völlig neu konzipiert; sie umfaßt jetzt 6 Bände. Beibehalten hat man den editorischen Leitgedanken, der auch die Vorauflagen prägte: Nicht enzyklopädische Vollständigkeit, sondern der aktuelle Erfahrungsstand der Psychiatrie wird - paradigmatisch - vermittelt. Das Werk bringt zu jedem Thema eine Übersicht des wissenschaftlich gesicherten Wissens, dessen Anwendung in der Praxis sowie Brennpunkte, Entwicklungstrends, Zukunftsperspektiven des Fachs. Wesentliche Akzentsetzungen der 4. Auflage sind die internationale Vielfalt der Beiträge, die Gewichtung von'Migration, Postraumatischer Belastungsstörung - allgemein: Spezifischen Lebenssituationen', die Integration neuer Erkenntnisse etwa in der Molekularbiologie, im Bereich bildgebender Verfahren oder in der Neuropsychologie. Neu und leserfreundlich ist das zweifarbige, mit Mariginalienspalte versehene Innenlayout.

Over the past decade, significant advances in research methodology have stimulated dramatic progress in the field of child psychiatry in general, and in pediatric anxiety disorders, more specifically. Pediatric Anxiety Disorders: A Clinical Guide is a comprehensive and vital addition to the literature at an exciting time in the field of psychiatry. This state-of-the-art reference aims to bridge the most up-to-date research findings with relevant clinical perspectives, making it a unique and essential resource for established clinicians and researchers, as well as for students and trainees. The book is organized into four sections, each of which includes chapters on a specific area of interest. The first section reviews the current research regarding etiological mechanisms of pediatric anxiety. The second section provides in-depth descriptions of the anxiety disorders that affect children and adolescents. The third section summarizes the literature on empirically supported assessment tools and evidence based cognitive-behavioral and pharmacological interventions. Of special practical note, the authors of these chapters have included comprehensive summary tables that can serve as quick reference tools. The final section of the text is dedicated to understanding how anxiety manifests in two special populations, children with chronic medical illnesses and those with autism spectrum disorders. Pediatric Anxiety Disorders: A Clinical Guide is an authoritative new volume developed by a renowned collection of clinicians and researchers in the field of childhood anxiety disorders.

Die Erforschung der neurobiologischen Aspekte von Suchterkrankungen dient dem Verständnis der Krankheitsursachen, deren spezifischer Behandlung und der Entstigmatisierung der betroffenen Menschen. Der Band stellt die Leitsymptome von Abhängigkeitserkrankungen vor, bezieht diese auf ihre neurobiologischen Grundlagen und diskutiert die Übereinstimmungen und Unterschiede zwischen den verschiedenen Suchterkrankungen. Ausführlich werden Störungen im sog. dopaminergen Belohnungssystem und ihre Auswirkungen auf die GABAerge und glutamaterge Neurotransmission beschrieben. Weiterhin werden Störungen der serotonergen Neurotransmission und ihre Bedeutung für die Affektivität ebenso wie Veränderungen der Opioidrezeptoren diskutiert. Kapitel zu den genetischen Grundlagen der jeweiligen Suchterkrankungen und den therapeutischen Implikationen der neurobiologischen Befunde runden das Buch ab.

This book explores the pharmacology, treatment and relapse prevention techniques relating to cocaine abuse. Topics discussed include incentive sensitization and loss of top-down control in cocaine addiction; cocaine abuse and dependence in schizophrenia; prenatal cocaine exposure and the associated adverse effects on pregnancy; and the clinical efficacy of medications with glutamatergic mechanisms of action for the treatment of cocaine addiction.

This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact,'brain diseases,'this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. - Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment - Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders - A'must have'reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Nuclear Medicine in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. Psychiatric disorders are discussed both from categorical and functional psychopathological viewpoint and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a psychiatrist and a nuclear medicine expert, and each contains a section'Clinical Aspects', to link research data with clinical routine. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist.

Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological organization of the serotonergic system.In this book, the author summarizes the latest findings regarding the role of serotonin in modulating the activity of brain regions which organize behavioral patterns associated with fear, anxiety and stress. The emergent picture is one of far greater complexity than previously thought: while the serotonergic innervation of those brain regions arises from the same structure – the dorsal raphe nucleus – that structure is not homogeneous from anatomical, physiological and neurochemical points of view, nor are its projections to the cerebral aversive and behavioral inhibition systems.The diverse findings which compose this picture of complexity – whether they arise from developmental neurobiology, electrophysiology, neurochemistry, neuroendocrinology, neuropsychopharmacology or behavioral neuroscience – are integrated in this book. Advanced undergraduate, graduate students, and researchers will benefit from the information. The result sheds light on many important questions regarding the neuroanatomical, pharmacological and functional aspects of the role of serotonin in anxiety disorders, and points to future avenues of research.

This book is being published as we mark the end of the first 50 years of the modern antidepressant era. This era began with the chance discovery that tri- clic antidepressants and monoamine oxidase inhibitors had antidepressant p- perties. That discovery had three consequences. First, it brought simple and effective treatment to patients suffering from major depressive illnesses. Second, these discoveries, together with the discovery of lithium and chlorpromazine, began the remedicalization of psychiatry by making it clear that the treatment of many of the major psychiatric illnesses can be approached in the same way as other medical conditions. However, the most far-reaching effect was to provide the first clue as to what mechanisms might underlie antidepressant efficacy, a development that has led to an explosion in the number of available an- depressants and to their widespread use. The goal of this book is to provide a thorough review of the current status of antidepressants—how we arrived at this point in their evolution and where we are going in both the near and the long term. The book employs both a scientific and historical approach to accomplish these goals. The book is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that the book provides a comprehensive and logical approach to this important group of medications. The importance of the book is a function of its topic.

The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.

Praise for the First Edition:--'This instructive text will serve as a reference for specialists in the care of patients with these disorders and for general neurologists and others to whom a patient with Stiff-Person syndrome or Wilson's disease is a rarity. The emphasis on the neuroscientific basis for the disorders presented and their study and treatment will also make the book academically useful....This excellent and timely book will provide a valuable resource for those involved in the academic and clinical aspects of movement disorders. 5 STARS!'--Doody's Review Service

Expanded to include detailed information on pharmacologic and non-pharmacologic treatment, the Handbook of Sleep Medicine continues to offer a concise overview of the field for trainees and practitioners in the many disciplines that deal with sleep disorders. Chapters provide a broad introduction to sleep disturbances and associated comorbidities and discuss the major sleep disorders in terms of epidemiology, diagnostic criteria, differential diagnosis, assessment tools, management, and follow-up. Of special value are algorithms that provide a logical approach to evaluating sleep-related complaints. All chapters adhere to the new International Classification of Sleep Disorders (ICSD-2), which is outlined in an appendix with ICD-9 codes.

An informative and comprehensive review from the leading researchers in the field, this book provides a complete one-stop guide to neuroimaging techniques and their application to a wide range of neuropsychiatric disorders. For each disorder or group of disorders, separate chapters review the most up-to-date findings from structural imaging, functional imaging and/or molecular imaging. Each section ends with an overview from a internationally-renowned luminary in the field, addressing the question of'What do we know and where are we going?'Richly illustrated throughout, each chapter includes a'summary box', providing readers with explicit take-home messages. This is an essential resource for clinicians, researchers and trainees who want to learn how neuroimaging tools lead to new discoveries about brain and behaviour associations in neuropsychiatric disorders.

Sleep in Childhood Neurological Disorders addresses the myriad sleep-wake issues associated with neurological disturbances from the newborn period through adolescence. The editors and contributing authors are internationally recognized authorities who cover everything from sleep and ADHD, headaches, restless leg syndrome, parasomnias, hypersomnias, autism, brain tumors, epilepsy, traumatic brain injury, and other primary disorders to sleep co-morbidities, assessment, testing, interventions, pharmacology and more. The first book devoted to the growing field of pediatric neurosomnology, Sleep in Childhood Neurological Disorders is an invaluable text for clinicians looking for current information and practical guidance to successfully manage their pediatric sleep patients.Sleep in Childhood Neurological Disorders features Dedicated focus on neurologically-based sleep disorders in children Diagnostic tables, key points, clinical pearls, and treatment algorithms throughout to enhance clinical utility Directions for'Future Research'in each chapter highlight promising studies and new therapies Broad-based coverage of the full range of common sleep disorders and co-morbidities

Questa terza edizione, interamente rivista, aggiornata e ampliata, tratta in modo completo ed esauriente i disturbi del comportamento secondari a lesioni e disfunzioni cerebrali acquisite, che occupano un vasto territorio intermedio tra la neurologia, la psichiatria e la psicologia. L'elevata e aggiornata qualità delle informazioni contenute fa di questo volume un punto di riferimento indispensabile per neurologi, psichiatri, psicogeriatri, neuropsicologi e psicologi, per gli studenti in formazione nelle discipline neuropsichiatriche e psicologiche, per gli esperti in neuroriabilitazione e per tutti coloro che sono interessati ad approfondire le attuali conoscenze sulle basi neurobiologiche del comportamento umano, sui rapporti fra mente, cervello e ambiente e sui disturbi che si possono manifestare quando lesioni o disfunzioni cerebrali alterano tali rapporti.

Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.