Search

This book provides a comprehensive and up-to-date overview of general information, along with an evaluation of diagnostic and therapeutic options for individuals suffering from otologic diseases. Covering fundamental sciences, clinical applications of otology treatments, and the latest research, it is designed to aid physicians in making well-informed decisions about patient care management. Divided into seven parts, the book addresses topics such as hearing reconstruction and its acoustic impact, cochlear implants, brainstem implants, genetic causes of hearing loss, including prevention and rehabilitation, sudden deafness, autoimmune inner ear disease, and the molecular basis of otosclerosis. Contributors also explore the contemporary clinical application of genetics and available testing for hearing loss. This volume will serve as an invaluable resource for otolaryngologists, head and neck surgeons, audiologists, neurologists, neurosurgeons, and residents, offering a comprehensive guide to enhance their understanding and practice.

Die 3. Auflage des Handbuchs bietet Klinikern, Laboratoriumsmedizinern, experimentell Forschenden sowie allen, die sich für den Liquor cerebrospinalis interessieren, in der täglichen Praxis eine schnelle und fundierte Orientierung über den aktuellen Wissensstand der Liquordiagnostik. Methoden und Indikationsstellungen zur Gewinnung des Liquor cerebrospinalis sowie die Analyseverfahren, Messparameter und Befundkonstellationen werden im Licht der neuesten Erkenntnisse ausführlich dargestellt. Das Buch ermöglicht eine umfassende Einsicht in methodische und interpretatorische Aspekte aller klinisch bedeutsamen Liquorparameter sowie in den Stellenwert der Liquordiagnostik heute. Neben den aktuellen Entwicklungen in Immunologie, Molekularbiologie und Proteinanalytik sowie der Standardisierung und Qualitätssicherung ist in der Neuauflage erstmals ein 50-seitiger Zytologieatlas mit exemplarischen Fallbeschreibungen Teil dieses Lehrbuches, welcher sich konzeptionell am stufenweisen Erfassen eines zytologischen Präparats orientiert und daher auch besonders für Einsteiger in die Liquorzytologie geeignet ist. Mit Unterstützung der Deutschen Gesellschaft für Liquordiagnostik und Klinische Neurochemie e.V. (DGLN).

Wollen Sie als Fachärztin oder Facharzt die Zusatzweiterbildung Intensivmedizin absolvieren oder in der Intensivmedizin arbeiten? Dann können Sie Ihr Wissen mit diesem Lernbuch oder der App SN Flashcards optimal überprüfen! Über 170 Multiple-Choice-Fragen mit kommentierten Antworten bringen Sie auf den aktuellen Stand von Themen der Intensivmedizin wie Pharmakotherapie, Atmung und Beatmung, Infektiologie, Notfälle und Komplikationen. Plus: Fallorientierte Fragen und Auszüge von über 70 wichtiger klinischer Studien mit Kernaussagen und neu: Aktualisierung bekannter Themen und Ergänzung um „Hot Topics“ der Intensivmedizin aufgrund aktueller Entwicklungen in der Literatur. Ideal für Fachärztinnen und Fachärzte der Anästhesiologie, Chirurgie, Innere Medizin, Neurochirurgie, Neurologie und Wiedereinsteiger•innen in der Intensivmedizin.

In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system. This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness. - Translates the basic science of vagus nerve stimulation into real-world clinical applications - Explains VNS anatomy and signaling through central and autonomic nervous system - Reviews VNS treatment of neurological, psychiatric, and inflammatory disorders - Extends clinical utility to cardiac, renal, and metabolic disorders. - Provides new insights to the disorder of vagus insufficiency syndrome - Explores VNS treatment for headaches, TBI, stroke, seizures, and pain.

Neurodegenerative diseases, like Alzheimer's, Parkinson's, and Huntington's, cast a long shadow over millions of lives, stealing memories, independence, and futures. The rising tide of these age-related disorders threatens to overwhelm healthcare systems worldwide, prompting an urgent search for effective treatments. While current options offer temporary relief, they fail to halt the relentless march of these devastating conditions. However, a beacon of hope shines at the intersection of cutting-edge neuroscience and the world of small molecules. These tiny chemical warriors, with their inherent advantages of cost-effectiveness, scalability, and diverse functionalities, are emerging as powerful weapons in the fight against neurodegeneration. This book stands as a testament to this increasing revolution. It investigates deep into the intricacies of small molecules, exploring their potential to unravel the mysteries of neurodegenerative diseases and pave the way for innovative therapeutic interventions.Key Features: Provides a comprehensive and accessible overview of the emerging field of small molecules in neurodegenerative diseases. Bridges the gap in current literature by addressing the specific impact of small molecules on these devastating conditions. Offers an in-depth exploration of the various mechanisms by which small molecules can combat neurodegeneration. Serves as a valuable resource for a wide audience, from students to professionals in the field. Lays the foundation for a deeper understanding of neurodegenerative diseases and unlocks new avenues for the development of effective therapies.

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

The book provides a comprehensive exploration of the relationship between nutrition and traumatic brain injury (TBI). Divided into two sections, the book covers various aspects of TBI, from its biomechanics and pathophysiological changes to evidence-based clinical guidelines and experimental models. Section I covers the background of TBI, including the definition and biomechanics of TBI, an understanding of pathophysiological changes that occur in the brain, and the importance of evidence-based clinical guidelines for effective TBI management. The section also delves into experimental models of TBI and the role of biomarkers in diagnosing and assessing TBI. Furthermore, it explores early feeding guidelines following TBI, emphasizing the significance of nutrition in the recovery process. Section II focuses on the connection between nutrition and TBI. It examines the concept of resilience and nutri-protection against TBI prior to the injury, highlighting strategies to enhance the brain's ability to withstand trauma. The book then explores the role of various nutrients and dietary components in TBI, such as antioxidants, branched-chain amino acids, choline, creatine, ketogenic diet, magnesium, polyunsaturated fatty acids (EPA and DHA), polyphenols, vitamin D, and zinc. Each topic is explored in depth, considering their impact on TBI outcomes and potential therapeutic applications. Furthermore, this section delves into nutritional interventions for TBI management. It addresses the selection of appropriate nutritional interventions and mechanistic targets for effective treatment. The section also explores the integration of nutrition into clinical practice guidelines for TBI and the emerging field of nutrigenomics, which investigates the interaction between nutrition and the genetic factors involved in TBI. Additionally, the section discusses the role of pharmacognosy in TBI research and provides nutritional recommendations for TBI management, considering the diverse needs of individuals affected by TBI. The book contributes to advancing the understanding and management of TBI by exploring the background, highlighting the importance of nutrition, and offering insights into nutritional interventions with potential implications for both preventive and therapeutic approaches. The book is a great resource for students and brain/neuroscience researchers.

The World Stroke Organization reports that “stroke has already reached epidemic proportions. Globally1 in 4 adults over the age of 25 will have a stroke in their lifetime. 12.2 million people worldwide will have their first stroke this year, and 6.5 million will die as a result.” Ischemic strokes are the most common type of stroke, with about 87% of all strokes being ischemic strokes.This new volume addresses this epidemic by presenting detailed studies on ischemic injury, with emphasis on the molecular-level mechanisms and the role of signaling pathways in the body, their structure, and their mechanism of action. The book focuses on molecular pharmacology plans and explains the new areas of research on the discovery of therapeutic molecules that can be used for combating this life-threatening disease. The authors discuss stroke occurrence at different stages of life as well as sex-based differences in its treatment. They cover aspects of the clinical treatment and diagnosis of patients with cardiovascular events, including in-depth information on the prevention, evaluation, therapy selection, result projection, and long-term course of the disease in affected patients. They also detail the involvement of platelets, neurotransmitters, renin-angiotensin-aldosterone system, and vitamin D in ischemic injury.

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases. Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these CNS diseases.

Unveil the next frontier in neurodegenerative disorder research with Integrating Neuroimaging, Computational Neuroscience, and Artificial Intelligence. This groundbreaking book goes beyond traditional approaches, utilizing the power of interdisciplinary integration to illuminate new pathways in diagnosis and treatment. From AI-driven diagnostics to computational neuroscience models, this book showcases the forefront of innovation. Join us in exploring the future of neurodegenerative care, where collaboration and cutting-edge technology converge to redefine possibilities.Key Features: Integrates diverse fields of research, from neuroimaging to computational neuroscience and Artificial Intelligence. Emphasizes the translation of research findings into practical applications, ultimately benefitting patients and clinical practice. Reviews the implementation of Artificial Intelligence and computational models in diagnostic settings. Elucidates the current state of translational neuroscience exploring potential areas for further research and collaboration, including personalized treatments and drug development. Contributions from an international team of experts from diverse disciplines.

Try cutting-edge treatments tested by international experts!Chronic Fatigue Syndrome: Critical Reviews and Clinical Advances presents the latest research and clinical findings of internationally recognized experts in chronic fatigue syndrome (CFS) and myalgic encephalomyelitis (ME). Edited by the organizer of the Second World Congress on Chronic Fatigue Syndrome and Related Disorders, this work focuses on the exciting research presented there. Starting with a thorough review of new literature, the volume continues with scientific reports of research on these mysterious, devastating illnesses. Chronic Fatigue Syndrome dispels some of the mystery and offers new avenues for research and treatment, as well as specific treatment regimes to combat the chlamydia and rickettsiae infections that sometimes underlie CFS/ME.Discover the latest theories on the etiology, physiology, and treatment of CFS/ME, including: links between CFS/ME and rheumatoid arthritis, Gulf War Illness, and fibromyalgia the disease's effects on neurologic function and the immune system the rhythms of fatigue and wellness caused by the disease human herpes virus 6 infection in patients with CFS/ME case reports on stress and hormones in CFS/ME patients role of rickettsiae and chlamydiae in the psychopathology of chronic fatigue The innovative research in Chronic Fatigue Syndrome: Critical Reviews and Clinical Advances will keep your knowledge of these disorders current and up-to-date and enable you to offer your CFS/ME patients the best possible care.

Published in 1997 as the first single-authored book on critical care neurology, The Practice of Emergency and Critical Care Neurology serves as a comprehensive guide to managing all aspects of critically ill neurologic patients. Following patients from the moment they enter the emergency department, this textbook demonstrates how specialists in the neurosciences assume full responsibility for patient care. Edited succinctly for relevance, this book differs from conventional textbooks by following the time course of clinical complexities as they emerge and change, instead of focusing on just the theoretical aspects of the field. Great emphasis is placed on the management of unstable and deteriorating patients. As any patient presents a unique, complex problem, the book pays special care in describing the considerations behind the rapid-fire decisions that comprise the work environment of the neurointensivist. In this new third edition, all chapters have been revised with added information and, in some, new concepts and ideas. Key features of this new edition include: 1. Additional chapters on the basics of neuroimaging and its interpretation; basic pharmacology issues in the intensive care setting (e.g., drug interactions and side effects); intoxications; the principles of critical care ultrasound and its relevance in the NeuroICU and the principles of neuro palliation including neuroethics 2. Rich illustrations using color photos of patients and drawings of important basic concepts of mechanisms in diseases of neurocritical care 3. Fully updated and comprehensive reference list 4. Narrated instruction video of the coma FOUR score

The fifth addition of this classic text that focuses on the diabetic foot continues the tradition of the previous four editions. More specifically, it includes contributions from a distinguished panel of clinicians and researchers, who have either participated in previous editions or are new, who provide up-to-date information on the pathophysiology and management of diabetic foot ulceration. As with the previous editions, it is divided into three sections: the first part focuses on clinical features and diagnosis; the second on pathophysiology; and the third on the management of diabetic foot problems. The main emphasis of the clinical part is on the multidisciplinary approach that has been mainly developed by the world-renowned Joslin-Beth Israel Deaconess Foot Center, which pioneered the management of diabetic lower extremity problems. Also like previous editions, the author panel includes diabetologists, podiatrists, vascular surgeons, infectious disease specialists,orthotists, plastic and orthopedic surgeons, the majority of whom work at the Joslin-Beth Israel Deaconess Foot Center. In addition, the fifth edition not only describes the state-of-the-art current methods in clinical practice but also includes a thorough update of all research progress during the last five years. This updated edition of this timely text will be of significant value to all physicians and researchers with interest in a comprehensive understanding of the diabetic foot.

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer's disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer's disease.Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer's agents Explains the role of phytomolecules and natural products in Alzheimer's therapy Reviews preclinical ways to assess drugs focusing on Alzheimer's disease Covers biomarker analysis for Alzheimer's disease Discusses the onset and progression of Alzheimer's disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.

This volume is an accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system (CNS). Chapters cover the major RNA viruses, their impact on the CNS, and the similarities and differences in pathological outcomes that can be observed. Neuroscientists, be they students, researchers, or clinicians, will benefit from the timely coverage provided.Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers can use the book to understand clearly the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of the human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell type-specific defects affect brain function and cause poor clinical outcomes.The book is aimed primarily at neuroscience students and postgraduates wishing to learn about virology and professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed; however, readers across the disciplines of science, technology, engineering, and mathematics will find this topical and timely publication of value.

Psychiatric symptoms (or mood/emotional disturbances) are diverse in patients with neurological diseases, that include depression, anxiety, emotional incontinence, anger, fatigue, and apathy. These symptoms are common; more than 1/3 of the patients suffer from these symptoms. Unfortunately, they have been neglected because 1) unlike other neurological symptoms such as motor dysfunction, speech disturbances or visual field defect, these symptoms are not visible and difficult to be noticed unless they are specifically examined by a physician who is properly educated on this problem 2) they are often not regarded as neurological symptoms either by the patients or their caregivers 3) they are relatively poorly studied by both neurologists and psychiatrists, and accordingly, are unfamiliar to the physicians. Especially, although `depression'is well known to physicians, other symptoms such as emotional incontinence, anger, fatigue or apathy are not appropriately assessed by physicians, and frequently misdiagnosed as depression. Moreover, there are difficulties in diagnosing depression in patients neurological diseases. For example, the individual items included in depression diagnosis such as sleep disturbances, appetite loss, or fatigue can result from neurological diseases or comorbid physical conditions in patients with neurological diseases. Therefore, a diagnosis of `depression'should be made cautiously. Finally, it should be understood that the importance of different mood/ emotional syndromes differ among various neurological diseases; for instance, although emotional incontinence and anger occur in as many as 20-30% of stroke patients, apathy and fatigue are more important symptoms than these for patients with neuro-degenerative disease.In clinical practice, recognizing these symptoms is important because they negatively affect the patients'quality of life, impair the functional recovery, increase the mortality, and increase the caregiver burden. Nevertheless, unlike other neurological symptoms such as motor/sensory dysfunction, and speech disturbances, they are relatively well managed mostly by pharmacological therapy such as selective serotonin re-uptake inhibitors (SSRI).The phenomenology of these neuropsychiatric symptoms and related factors, pathophysiological mechanism, and treatment strategies should be properly educated for neurologists, psychiatrists and other physicians. The book is written by experts in this field to disseminate important knowledges to neurologists, psychiatrists, psychologists and other physicians and will eventually benefit patients with neurological diseases.

Written in a simple, easy-to-read style. Gives useful tips to practicing physician for managing the patient with neurological disorder. Divided into two sections to help the physicians arrive at a diagnosis and manage it properly. Section 1 includes a practical approach to neurological symptoms such as headache, dizziness, seizures, limb weakness, speech abnormality, and visual symptoms. Section 2 discusses an overview of common neurological disorders such as stroke, autoimmune neurologic disorders, movement disorders, infection of the nervous system, and the importance of dementia. Contains charts, diagrams, and pictures for easy understanding.

The Oxford Textbook of Neurohaematology is a single source of knowledge on the diverse neurological conditions associated with malignant and classical haematological diseases. The book covers the full range of haematological diseases, both malignant and classical, that impact the central, peripheral, and autonomic nervous systems. The book is divided into three sections. In the first section, neurological conditions associated with malignant haematological diseases are presented. This section begins with chapters on primary haematological malignancies of the nervous system including primary central nervous system lymphomas, vitreoretinal lymphoma, and other rare primary malignancies such as Hodgkin disease and lymphoproliferative disorders. Next, a chapter on histiocytic tumours of the central nervous system presents the neurological conditions associated with the Langerhans and non-Langerhans histiocytoses. This is followed by chapters covering the neurological complications of systemic myeloid and lymphoid malignancies. The second section of the book covers neurological complications of the treatments used in the management of haematological malignancies such as chemotherapy, radiation, and immunotherapy including chimeric antigen receptor T cells. The third and final section of the book features chapters on the neurological complications associated with classical haematological diseases including disorders of red blood cells (e.g., sickle cell anaemia), disorders of platelets and coagulation (e.g., immune thrombocytopenia), and disorders of white blood cells (e.g., hyperviscosity syndrome). Edited by leading authorities in the field, this book will serve as a useful resource for neurologists, haematologists, and oncologists, as well as for subspecialists and allied health professionals involved in the management of haematological diseases and their neurological manifestations.

The second edition of the'IAN Textbook of Neurology'has been prepared for clinicians who participate in the care of neurological patients, including those who are in training to become neurologists, internists, neurosurgeons, and neuroscientists. The basic structure of this second edition has changed. The book is divided into seven parts. Section 1 discusses the History-taking and the Neurological Examination, inclusive of the systemic examination that helps the neurological diagnoses. Section 2 covers the Applied Neuroanatomy and Neurophysiology aspects that are important to clinicians. Section 3 discusses the clinical Approach to various Common Neurological Symptoms. Section 4 describes Diseases of the Nervous System. Section 5 discusses Investigations, Section 6 the Principles of Management, and Section 7 is about the Counseling and Doctor–Patient Relationship.

This book focuses on the clinical and preclinical research on traumatic brain injuries where age at time of injury (young versus aged) reveals both parallel and divergent findings at the molecular, cellular, and behavioral levels with insights into alterations in brain structure and function and the implications for recovery. The authors address the hurdles that have been overcome, consider new directions inspired by the most recent research, and the value of data sharing and evidenced based-practice. Traumatic Brain Injuries: Tackling the Unique Terrain of the Injured Young and Aged Brain explores the challenges imposed by an injury that not only causes tissue damage but disrupts brain development and may incite pathological events in the aging brain. With the proliferation of the research literature in traumatic brain injuries, this is the time for a book that surveys the landscape and assesses where the field is headed and what is needed moving forward.

Richly illustrated with figures and examples and supplemented with a glossary of terms, The Evolutionary Roots of Human Brain Diseases assembles recent findings in clinical neuroscience, evolutionary biology, anthropology, and cellular biology to elucidate the origins of human brain diseases and how evolution has given rise to exclusive impacts on brain health only in humans. The book is succinct, up-to-date, and written by researchers across numerous disciplines, making it a compulsory read for clinical neurologists, psychologists, and all medical researchers interested in the brain. The book's 22 chapters cover basic science concepts behind cerebral cellular specificities or human-specific network developments, detailed discussions of neurological or psychiatric diseases and their clinical expression with an evolutionary focus, the newest imaging techniques to study the brain, future medication developments, as well as cultural and societal repercussions. Evolutionary concepts ranging from genetic pleiotropic antagonism to disease remnants of ancient behaviours crucial for survival are also presented. Insightful and innovative in its approach, this book offers a fascinating interdisciplinary dialogue on the potential repercussions of ongoing human brain evolution.

This textbook highlights the exciting field of nanoneuroscience and its potential to transform how we diagnose and treat neurological disorders.'The Textbook of Nanoneuroscience and Nanoneurosurgery,'dives deep into this emerging field, exploring the latest tools and techniques currently being developed at the nanoscale level. Key areas of focus include: Nanoplatforms: The book explores how scientists utilize materials on a near-microscopic scale for neurosurgery, neurology, and brain imaging applications. Bridging the Gap: Regulatory hurdles for translating research from the lab to real-world use are addressed, paving the way for future advancements. The Future is Now: The book showcases recent breakthroughs already impacting patient care alongside promising areas with significant potential. Collaboration is Key: Insights from over 220 researchers and 5000+ references, along with illustrative figures in B/W and color, provide a comprehensive overview of this dynamic field. With its focus on minimally invasive procedures and the latest regulatory considerations，'The Textbook of Nanoneuroscience and Nanoneurosurgery'equips researchers and medical professionals with the knowledge to develop groundbreaking treatments for neurological conditions. The text also reviews the latest regulatory guidelines that influence the translation of nanotechnological research from the laboratory to the clinic and the most recent information on biodevices and pharmaceutical spinoffs. It highlights presidential and congressional initiatives and programs that may impact the field soon. Some reviews of the First edition of the textbook.'…a significant contribution to the field of nanoneuroscience and nanoneurosurgery … the reader will come away with a deeper understanding of the history of nanotechnology and medicine.'—Neuroscience'This is a monumental first textbook on nanoneurosurgery. … recommended reading for neurosurgeons, neurologists, neuroradiologists, and neuroscientists involved in research on new techniques for application in neurosurgery. Biomedical engineers and various companies developing instruments and devices would benefit from the wealth of information about trends for the development of new technologies for neurosurgery.'K. K. Jain, MD, Basel, Switzerland'Phenomenal body of knowledge in this book that would take eons to collate by myself. Every answer to every one of my questions plus heaps more. Essential reading for everyone interested in the field. A must-have!'Albert Deme'This is an amazing foray into the future of a largely unexplored, but increasingly critical medical domain…..I have learned much from every page of this captivating text, and I highly recommend it to any medical student, researcher, medical professional in the neurosciences, or anyone who has an interest in the human brain and the future of medicine, to gather a glimpse of the incredible and beneficial paradigm shifts that will soon impact the field of neuroscience.'Frank Boehm, British Columbia, Canada

This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive volumes. The Editors of this second volume present a comprehensive textbook that incorporates best practice/evidence-based medicine and performance improvement, while it champions the three characteristics needed in our neuro–ICUs: patient and family centered high-quality care, education, and discovery. This volume concentrates on perioperative management, monitoring and pharmacotherapy, examining the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery and critical features of the management of patients. General issues are discussed across the textbook, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states. Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. Textbook of Neurointensive Care Volume 2: Perioperative Management, Monitoring, Pharmacotherapy provides the reader with a detailed resource for studying this most complex area of medicine. It is thus essential reading for all trainees and professionals in critical care, neurosurgery, anesthesia and neurology.

This book covers experimental theory and practice of yoga that have enhanced its neuroscientific understanding. This is an excellent handbook for the researchers in the field of evidence-based integrative health. It encompasses traditional and modern tools used in neuroscience. It also provides information for the modern biologists, physicians and policymakers, of how mind-body complexities in neuroscience, mental health and preventive healthcare can be useful for health and disease. It serves as a guide for integrative health practitioners, patients, educationists, philosophers, graduate students and faculty pursuing research in the field of biology, complimentary medicine, and other alternative therapies. The chapters in this book also serve as a comprehensive resource for clinical trials in Yoga. In addition, flow charts and illustrations have been provided to understand how healthy brain ageing can be achieved.

Nanotechnology is revolutionizing medicine and neuroscience. However, with this innovation comes the concern of the potential risks posed by nanomaterials to the human nervous system. As scientific research progresses, so does the urgency to understand and mitigate these risks. This book offers a multidisciplinary approach to tackle the complexities of nanotechnology's impact on neurological health. Amidst the excitement of scientific advancements, Nanomaterials and the Nervous System provides a critical analysis of nanoparticle-induced neurotoxicity. By dissecting the hazards associated with nanomaterials, it guides researchers, policymakers, and healthcare professionals in developing safer alternatives and regulatory frameworks. Moreover, it delves into speculative theories and conspiracy narratives, prompting crucial discussions on the ethical and societal implications of nanotechnology. Beyond addressing these challenges, this book also provides pertinent knowledge for those navigating the landscape of nanotechnology, neuroscience, and transhumanism. Through its comprehensive exploration of scientific advancements, speculative theories, and ethical considerations, the book equips readers with the tools to understand, evaluate, and shape the future of nanotechnology's role in neurological health.

The recent high-profile murders of George Floyd, and other African American individuals, along with the prevailing coronavirus disease (COVID-19) pandemic have reinforced the notion that certain marginalized populations have worse health outcomes than other populations, likely due to unequal and unjust policies and practices. Neurological processes and prognoses frequently vary by sex/gender, race/ethnicity, socioeconomic status, and geographic location. In particular, individuals of lower socioeconomic status and from minority racial and ethnic backgrounds have worse neurological health and often receive a lower standard of neurological care. These inequities in neurological outcomes are attributed to wider societal social influences, which impact how people live and how neurology is practiced. Published evidence suggests that healthcare providers and the healthcare system contribute to inequities in neurological care for vulnerable and underserved populations. However, educating neurology care providers about these issues and training them to provide equitable care for these patients can potentially improve neurology care access, delivery, and outcomes. In this book we provide the theoretical background, scientific evidence, and experiential knowledge warranted to properly care for vulnerable, underserved patients with neurological diseases at the levels of the provider and system. This book examines the root causes of neurological health inequities across a broad range of topics and offers possible solutions for achieving neurological health equity. Initial chapters help to frame the overall issue of neurological health equity. Subsequent chapters evaluate neurological health equity from the clinical practice standpoint, with a focus on select populations and subspecialty care delivery settings. Lastly, we discuss the bigger picture with regard to the pipeline of practitioners and purview of policy makers. This text is relevant for neurology residents and fellows, multidisciplinary neurological care practitioners (neurologists, neurosurgeons, advanced practice providers, hospitalists, emergency physicians, critical care physicians, pharmacists, and allied health personnel), and public health researchers and health policy makers. The book is divided into three sections: Principles, Neurological Conditions, and Priorities. The first section establishes the framework and explains various key terminologies and concepts, which undergird the care of vulnerable and undeserved patient populations. The second section, Neurological Conditions, covers key neurological diseases by sub-specialty describing published evidence of care and outcome disparities, gaps in knowledge, practical techniques for bridging these disparities on provider and system levels. The third section, Priorities, identifies important areas of focus and improvement targeting trainees, researchers, community partners, stakeholder organizations and policy makers, which would be crucial for implementing sustained societal-level enhancements in the neurological health of these vulnerable populations.

This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive volumes. The Editors of this first volume present a comprehensive textbook that incorporates best practice/evidence-based medicine and performance improvement, while it champions the three characteristics needed in our neuro–ICUs: patient and family centered high-quality care, education, and discovery. This volume concentrates on neuroanatomy, diagnostic assessment and disease management, examining the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery and critical features of the management of patients. General issues are discussed across the textbook, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states. Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. Textbook of Neurointensive Care Volume 1: Neuroanatomy, Diagnostic Assessment, Disease Management provides the reader with a detailed resource for studying this most complex area of medicine. It is thus essential reading for all trainees and professionals in critical care, neurosurgery, anesthesia and neurology.

This book describes the theoretical background of the different forms of tinnitus (ringing in the ears) and detailed knowledge of state-of-the-art treatments of tinnitus. Tinnitus has many forms, and the severity ranges widely from being non-problematic to severely affecting a person's daily life. How loud the tinnitus is perceived does not directly relate to how much it distresses the patient. Thus, even tinnitus very close to the hearing threshold can be a disabling symptom. It can reduce the quality of life by generating anxiety and concentration problems, impairing the ability to do intellectual work, making it difficult to sleep, causing depression and sometimes even leading to suicide.Textbook of Tinnitus has filled a void by providing a comprehensive overview about the different forms of tinnitus, their pathophysiology and their treatment. However, since the publication of the first edition of the Textbook of Tinnitus in 2011, tinnitus research has dramaticallyevolved. In view of the substantial increase in knowledge, most chapters in this second edition are newly written and a few original chapters have had major updates. This edition has nine sections, covering the basics of tinnitus, the neurobiology of tinnitus, pathophysiological models, animal research, diagnosis and assessment, various forms of management and treatment, and finally, a look at the future of tinnitus and tinnitus research. The book will be of great interest to otolaryngologists, neurologists, psychiatrists, neurosurgeons, primary care clinicians, audiologists and psychologists, and students. Because of its organization and its extensive subject index, Textbook of Tinnitus, Second Edition can also serve as a reference for clinicians who do not treat tinnitus patients routinely.

Cannabidiol in Neurology and Psychiatry, Volume 177 in the International Review in Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topic such as Historical perspective on the therapeutic potential of cannabidiol, Cannabidiol: pharmacodynamics pharmacokinetic, Cannabidiol and Alzheimer's disease, Cannabidiol on anxiety disorders, Cannabidiol on psychosis, Cannabidiol on autism spectrum disorders, Cannabidiol in Epilepsy, Cannabidiol in Ischemia/stroke, Cannabidiol in Depression, Cannabidiol and Abuse of drugs, and much more.Additional chapters cover Cannabidiol in fear response and PTSD, Cannabidiol and Pain. and Cannabidiol and Parkinson's disease. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review on Neurobiology series - Updated release includes the latest information on Cannabidiol in Neurology and Psychiatry

Over the past few years, there have been fundamental changes in the diagnosing and treating patients with chronic diseases, significantly affecting management of neurological movement disorders. In addition, the health and fitness sector developed several devices to better classify, track, and potentially treat chronic diseases. Both handling and interpreting these large datasets has been revolutionized, by machine and deep learning approaches, leading to new and more effective therapies, resulting in longer survival rates. Handbook of Digital Technologies in Movement Disorders aims to unite these factors to provide a comprehensive guide to patient focused treatments for movement disorders. This book is divided into five distinct sections, starting with an introduction to digital technologies, concepts, and terminologies. The following section reviews various perspectives on technology in movement disorders, including patient and medical professionals. The third section presents technologies used in detecting, measuring progression, and determining response to treatments. This is followed by reviewing the technology used in various treatments of movement disorders including assistive and robotic technologies. Finally, the last section examines the challenges with technology including privacy and other ethical issues. - Reviews different stakeholders'perspectives on technology in movement disorders - Presents technological advancements for diagnosing, monitoring, and managing Parkinson's disease - Discusses challenges with implementing technology into treatment

Neuropathic Pain, Volume 179 of the latest release in the International Review of Neurobiology serial,, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in International Review on Neurobiology serials - Updated release includes the latest information on Neuropathic Pain

Neuropsychological & Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues, Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as wel as current practices for rehabilitation and targets for essential future interventions in vulnerable populations. This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology. - Discusses the neurocognitive implications of brain and systemic cancer treatments - Examines the foundations of neuropsychological testing and daily life implications, including caregiver support - Covers the psychosocial implications of brain cancer, psychotherapeutic interventions, and cognitive rehabilitation

Drug Addiction Mechanisms in the Brain explores the fascinating world of drug substances and their effects on the brain. This book provides a comprehensive overview of the ten major substances that contribute to drug addiction Information about each substance is presented in a specific chapter, shedding light on their biochemical mechanisms and physiological effects. From the stimulating effects of cocaine to the sedative properties of heroin, and the hallucinogenic experiences induced by LSD, the book takes the reader through the intricate pathways of addiction. Other substances covered in the book include alcohol, nicotine, MDMA, METH, morphine, ketamine, and fentanyl. Readers will gain an understanding about neurochemical alterations in the brain Anyone looking for interesting knowledge about the addictive nature of common drugs and their complex interplay with the brain will find this book informative.

This second edition updates established evidence for contemporary management of ischemic stroke. Therapeutics for acute management, secondary prevention, recovery, rehabilitation, asymptomatic cerebral ischemia, special populations, and implementation of stroke systems of care are all discussed. Chapters are authored by leading academicians from around the world with real-world clinical practice experience, and comprise the scientific rationale and expert consensus recommendations, which underlie prevailing (and possibly future) therapeutic strategies for managing ischemic cerebrovascular disease. New chapter topics include neuroprotectants, treatment of the oldest old, brain-computer interfaces, disparities, and the global burden. The specialist or general practitioner will gain critical knowledge in stroke management, current clinical challenges and promising new therapies under investigation.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in neurology and allied disciplines.The twelfth volume of this series features these reviews:Chapter 1: Recent Drugs Tested in Clinical Trials for Alzheimer's and Parkinson's Diseases Treatment: Current Approaches in Tracking New DrugsChapter 2: Neurobiology of Placebo: Interpreting Its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in TherapeuticsChapter 3: Role of Gut Microbiota in Neuroinflammation and Neurological DisordersChapter 4: The Role of Age in Pediatric Tumors of the Central Nervous SystemChapter 5: Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related ComorbiditiesChapter 6: Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning.

This book is a comprehensive reference of the neuraxial route for the delivery of therapeutics. It reviews the historical evolution of this approach from its inception in the later 1800's to present day. This amply referenced text covers basic discussions of spinal anatomy, embryogenesis, neuraxial vascularity, cerebrospinal fluid flow dynamics and parenchymal molecule movement. The pharmacokinetic and pharmacodynamic properties of different intrathecal agents are explored in detail with particular reference to clinical correlates in pain and spasticity. Particular attention is paid to the issues relevant to preclinical models of intrathecal delivery and the assessment of spinal pathologies arising from acute and chronic intrathecal drug delivery. Chapters provide essential discussions of clinical aspects of patient care, including patient evaluation and screening, trialing and device management, troubleshooting problems and addressing complications, best practices, cost-effectiveness and future of the therapy. Clinicians and researchers who practice intrathecal therapy and study neuraxial mechanisms will find Neuraxial Therapeutics, to be an invaluable guide to this treatment modality.

This book provides a physician's pathfinder for COVID specific headache disorders as well as general headache practice in a pandemic era. Practical solutions to headache management at every level are highlighted, along with the changing nature of previous headache disorders under lockdown conditions. Headache Disorders in Pandemic Conditions examines the specific nature of headache symptoms during COVID-19 infection, the secondary causes of COVID-specific headache disorders and practical issues of previous known headache disorders during a pandemic. The book also explores the effect of lockdown on headache management and changes in headache education, practice, risks and guidelines. Neurologists, headache specialists, general practitioners, medical students and residents will find this book to be a practical and clear guide to Covid-19 specific headache disorders in clinical practice.

This handbook systematically presents biomarkers for traumatic injuries. The book covers topics such as traumatic brain injury, liver injury, burn severity, muscle heart damage, and acute inflammation in polytrauma and their detection by biomarkers.Biomarkers and methods used in critical care and critically ill patients are discussed, as well as biomarkers in trauma and special conditions. Specific biomarker components are explained and models for modeling trauma in research are presented.This systematic handbook is an excellent resource for researchers and specialists in trauma research and treatment, as well as clinicians and physicians who want a thorough overview of various injuries, trauma, and their detection methods.

Fatigue is a major symptom in patients with multiple sclerosis (pwMS) and is mainly responsible for unemployment, early retirement but also social withdrawal. This book combines reporting of actually existing scientific knowledge with guidance for clinical practice. As such the book helps health care professionals in all countries to better understand fatigue symptoms but also to help patients to better cope with them.

Febrile seizures are the most common seizures in infants and children worldwide, This fact provides strong impetus to study and understand them and their consequences, and consider their treatment. These topics were the focus of the first edition of this book. The 20 years since the publication of this first edition have witnessed an explosion of new information about febrile seizures, meriting this new edition. Key advances have been made in the genetics and neurobiological underpinnings of febrile seizures and especially the very long fever-related seizures called febrile status epilepticus. The role of neuroinflammatory factors in the emergence of these seizures and their consequences, the demonstration of unique clinical and neuroradiological aspects of febrile status epilepticus, and the prospect of predictive (bio)markers to identify and characterize cognitive and epilepsy outcomes are exciting and important. In this edition, the authors and editors tackle these developments in chapters addressing the questions of parents, physicians, allied health care professionals and basic and translational scientists. - Reviews all aspects of febrile seizures, including epidemiology, neurobiology and treatment - Discusses novel and newly discovered information based on up-to the minute methods - Provides an engaging style that is accessible to clinicians, researchers and educated parents

Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors, Volume 171 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on Neurodegenerative diseases, Stress induced exacerbation of Alzheimer's disease brain pathology is thwarted by co-administration of nanowired cerebrolysin and amyloid beta peptide antibodies with serotonin 5-HT6 receptor antagonist SB-39988, Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress, Efficacy of invasive and non-invasive methods for the treatment of Parkinson´s disease: nanodelivery and enriched environment, and much more. Other sections cover Sleep deprivation induced exacerbation of Parkinson's disease pathophysiology is attenuated by co-administration of nanowired cerebrolysin and serotonin-3 receptor antagonist ondansetron, Co-administration of DL-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with brain injury, Stress and brain diseases, Pathophysiology of sleep deprivation enhances amyloid beta peptide and p-tau in the CSF and brain, Neuroprotective effects of nanowired delivery of multimodal drug cerebrolysin and monoclonal 5-HT antibodies, Prior heat exposure exacerbates brain blast injury, Neuroprotection by nanodelivery of cerebrolysin with serotonin 6 receptor antagonist SB-399885, the Effects of curcumin nanodelivery on several brain pathologies, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Internation Review on Neurobiology series Updated release includes the latest information on Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors

Understanding the Behavioral and Medical Impact of Long COVID serves to expand the research around the illness in order to enable health care researchers and practitioners to address the questions that are imperative to individuals suffering from this condition. Through its multi-faceted approach, the book puts forth a maturation of research and interventions that are theoretically sound, empirically valid, innovative, and creative in the Long COVID area.As a scholarly and scientific compilation of Long COVID symptoms and related disorders, this book offers unparalleled insight into the critical developments across medical areas treating this illness. It helps to fill the space that the pandemic had created for knowledge of the condition, and contributes to the emerging emphasis on translational research blending the social sciences and biological fields. By putting forth the most optimal medical care practices in the treatment of complex Long COVID symptoms, this practical anthology will serve as a guide for practicing clinicians in assessment as well as treatment. It will also benefit researchers aiming to gain more understanding of Long COVID through its discussion around the critical developments in other medical areas treating the condition, and paves the way for the collaboration and future research needed to best support the global effort to mitigate the effects of this illness.This book will be essential reading for academics, practitioners, and researchers. It will appeal to individuals engaging with the fields of medicine, public policy, psychology, and for researchers looking to gain clarity about our current understanding of Long COVID. It will further be of interest to public/government agencies, nonprofit organizations, and the general public wanting to gain more information about these ambiguous and evasive symptoms.

Adenosine A2A Receptor Antagonists, Volume 170 in the International Review of Neurobiology series highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including A2A Adenosine Receptor Agonists, Antagonists, Inverse Agonists and Partial Agonist, Chemistry – agonists, antagonists, partial agonists, inverse agonists, Functional roles of adenosine receptors – biochemistry and neuronal plasticity, A2A and Depression, A2AR and glial function, The adenosine A2A receptor in the basal ganglia: expression in health and disease, heteromerization, functional selectivity and signaling, How and why A2a receptor become to be a therapeutic target in Parkinson's disease therapy, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology - Updated release includes the latest information on Adenosine A2A Receptor Antagonists

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP). It links common clinical problems in developmental pediatrics and pediatric neurology to current concepts and translational research advances in developmental neurosciences, medical genetics, and related disciplines. The first section of the book provides a comprehensive and up-to-date overview of development of the brain, including topics such as neuronal stem cells, epigenetics, and the influence of the prenatal environment. The next three sections analyze the epidemiology, diagnosis, interventions, and controversies and research directions associated with each of the three neurodevelopmental disorders. It also examines co-morbidities common to all three disorders, such as disturbed sleep, seizures, behavioral disorders, and pain. It concludes by highlighting the impact of ASD, FASD, and CP on family dynamics and provides tools and resources based on foundational concepts such as neuroethics, bioinformatics, community engagement, and advocacy. Learning objectives, key points, clinical vignettes, and multiple choice questions are incorporated throughout the book. With its comprehensive treatment of disease mechanisms, genetics, and pathophysiology associated with these disorders and its discussion of potential therapies and novel treatments, Neurodevelopmental Pediatrics: Genetic and Environmental Influences is an essential resource for developmental pediatricians, child neurologists, fellows, residents and graduate students.

This book provides a detailed practically focused guide on the latest diagnostic and treatment techniques available for normal pressure hydrocephalus (NPH). Chapters in this work cover the latest developments related to this condition. It introduces how to use a range of diagnostic modalities including magnetic resonance scanning along with how artificial intelligence and machine learning methodologies can be applied. Cases are presented to reinforce how the methods covered can be appropriately applied and guiding principles are also given to assist the reader in developing a thorough understanding of the topic. Potential complications and means of mitigating these are also described. Normal Pressure Hydrocephalus is a detailed practically applicable resource on NPH with insightful contributions covering relevant aspects of pathophysiology, diagnostic modalities and treatment strategies, making it an ideal resource for all medical practitioners whoencounter these patients.

As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be theturning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.

The book provides a comprehensive overview of the medical implications, pathophysiology, and treatment of Obstructive Sleep Apnea (OSA), a disease that creates increased health risks, most notably those related to the cardiovascular and cerebrovascular systems.The opening chapters are dedicated to the definition of OSA, its diagnosis, and the treatment options. The following chapters address primary forms of disease presentation in each medical field, with the latest evidence.Given its characteristics, the book will enable the reader to adopt a broad strategy for evaluating and managing OSA patients. In addition, it will be a valuable resource for all the clinicians who treat sleep-disordered breathing, including otolaryngologists, pulmonologists, cardiologists, neurologists, etc.

The fascinating story of glutamate, the neurotransmitter that controls the structure and function of the brain in health and neurological disorders.Sculptor and Destroyer tells the story of a simple, little-known molecule that became a master architect and commander of the human brain: glutamate. Upward of 90 percent of the neurons in the human brain deploy glutamate as their neurotransmitter. Other neurotransmitters can only exert their effects on brain function by subtly modifying the ongoing activity of glutamatergic neurons, but during brain development glutamate controls the growth of dendrites and the formation of synapses. In this eye-opening book, Mark Mattson explains how the neurotransmitter glutamate controls the structure and function of neuronal networks in the brain, thereby mediating the brain's capabilities, including learning and memory, creativity, and imagination. Mattson also delves deeply into the dark side of glutamate, which he calls the “destroyer” side. He shows how relatively subtle aberrancies in the activity of neurons that deploy glutamate may result in behavioral disorders ranging from autism and schizophrenia to chronic anxiety and depression. More dramatically, he describes how glutamate can excite neurons to death, a process that occurs in epilepsy and stroke and, perhaps even more insidiously, in Alzheimer's disease, Parkinson's disease, ALS, and Huntington's disease. Sculptor and Destroyer concludes with a perspective on how knowledge of glutamate's roles in neuroplasticity might be applied to the optimization of brain health throughout our lives. Written inengaging, approachable prose, Sculptor and Destroyer will be of interest to anyone in the fields of neuroscience, neurology, psychiatry, and psychology, as well as to anyone with a curiosity about the human brain.

Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.