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Dizziness and Vertigo describes the basic knowledge and practical skills necessary for managing patients presenting with common symptoms of dizziness and vertigo. It provides practitioners with a comprehensive overview of these conditions, steps for diagnosing patients and various treatment options.This revised and updated edition provides a framework for the accurate diagnosis and management of patients with dizziness and vertigo, covering clinical assessments and case studies. It also includes new methods for treating Ménière's disease and benign paroxysmal positional vertigo (BPPV) and in the field of vestibular rehabilitation.Dizziness and Vertigo is an essential reference for all those who manage patients in the outpatient setting, including general practice trainees, ear/nose/throat (ENT) specialists and physiotherapists.

Human Motor Development: A Lifespan Approach, Eleventh Edition provides an overview of the academic field of study known as human motor development, the examination of lifelong changes in human movement. The book uses a holistic approach and emphasizes the importance of intellectual, social, and physical development and their impact on human motor development at all ages. The unique approach of this book includes the relationships between motor development and critical interactions with cognitive, social, and physical changes across the lifespan.Organized into five parts, the book examines key topics in motor development, including the relationship between cognitive and social development and motor development, factors affecting development, changes across the lifespan, and assessment in motor development, with special attention being applied to adulthood and older adulthood, given the increasing numbers of people in those age groups worldwide. Each chapter includes chapter objectives, a summary, a list of key concepts, questions for reflection, a list of related online resources, and an extensive reference list.Highly illustrated and written for student accessibility by providing access to a fully updated companion website, which includes laboratory exercises, an instructors'manual, a test bank, and lecture slides, Human Motor Development: A Lifespan Approach is essential reading for students of motor control and development, kinesiology, and human performance and for students interested in physical therapy, physical education, and exercise science.

This book evaluates muscle and nerve biopsies. It creates a more analytical view of neuromuscular diseases in the light of clinical findings. Diseases that occur mostly in muscle or nerve tissue may show common clinical findings. Addressing these two issues together will make it easier to understand the diseases. Neuromuscular diseases, normal histology, embryology, and physiopathology of muscles and nerves are discussed with a main focus on differential diagnosis. The book also presents the most cost-effective and easiest-to-follow algorithms for the differential diagnosis of diseases.

The field of muscular dystrophies has expanded significantly with the discovery of the genetic defects and protein products underlying these disorders. New treatments such as antisense oligonucleotides and siRNAs and gene therapies are now in clinical application and in trials. As clinical trials increase, outcome measurement becomes very important, and more validated tools are being developed. This book provides a comprehensive review of these disorders. Clinical features, diagnostic testing including genetic testing of these disorders, the basis and utility of genetic testing, and the basis of genetic therapies are all covered in detail. This book will provide neuromuscular neurologists, general neurologists, and neuromuscular fellows with a much needed update in the field.

As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be theturning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.

For more than 60 years, Merritt's Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today's practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.

Covid-19 and Parkinsonism, Volume 165 in the International Review in Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters that cover a variety of topics, including Parkinsonism associated with viral infections, Covid-19 and nervous system pathology: bench to bedside, Prevalence of Covid-19 in Parkinson's Disease: acute settings and hospital, Covid-19 and Parkinson's Disease: clinical features, long COVID, Smell deficits in Covid-19 and possible links with Parkinson's Disease, Spotlight on non-motor symptoms and Covid-19, and a Summary of treatment paradigms in Parkinson's Disease patients and Covid-19. Additional sections cover Covid-19 and Parkinson's Disease: nursing care, vaccination, telemedicine services, impact on advanced therapies, Covid-19-induced parkinsonism: Real life phenoconversion cases, Loneliness and impact of lockdown on Parkinson's Disease patients during the Covid-19 pandemic, Parkinson's Disease and Covid-19: Impact of ethnicity and palliative care, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Updated release includes the latest information on COVID-19 and Parkinsonism

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

This book, which will hold global appeal, adopts a problem-based approach to childhood disorders of the nervous system with the aim of supporting practicing child neurologists, pediatricians, and residents in training in their management of children with neurological disorders. Throughout, the practical assistance that it offers is based firmly on the best available current scientific evidence. The various pediatric neurologic diseases and organ systems are covered by pediatric neurologists and scientists from leading university hospitals and health centers in both the developed and the developing world. In addition to the full range of more frequent disorders, the book spans the neurological aspects of neglected tropical diseases and neurogenetic diagnostic and management algorithms utilizing the power of emerging DNA technology. A further feature is the inclusion of didactic videos relating to epileptic and movement disorders. As an open access publication with a strong clinical focus, the book will be a handy and valuable reference and resource for all practitioners who deal with childhood neurological disorders.

For more than 45 years, Muscle Biopsy: A Practical Approach has offered, comprehensive, clinically-focused coverage of the acquisition, interpretation, and assessment of muscle biopsies – an area often only lightly covered in pathology texts. Taking an integrated approach that includes clinical, genetic, biochemical, and pathological features, the 5th Edition covers the full range of muscle disease in both adults and children. This highly illustrated, easy-to-use volume helps you navigate this challenging area, bridging the gap between clinical syndromes/disorders and their underlying pathologies. - Fully updated 5th edition of this internationally acclaimed classic in muscle pathology. - Written by internationally recognized world leaders in the field of muscle pathology. - Comprehensive coverage of histology, histochemistry, immunocytochemistry and electron microscopy in parallel with clinical and genetic advances. - Lavishly illustrated with over 600 full colour images. - Fully updated literature review. - Comprehensive update on the rapidly expanding field of neuromuscular disorders. - 4th edition Highly Commended in Pathology category of the prestigious 2014 BMA Medical Book Awards.

'This book fills an important and unique niche in pediatric neurology, and will be a frequently referenced textbook for all clinicians caring for children with epilepsy. It is well-organized and readable, and provides essential and up-to-date clinical data on these individually rare, but collectively more common, disorders.'-Elaine Wirrell, MD, Neurology'Specialists in pediatric neurology, epilepsy, and biochemical genetics will find this volume to be indispensable for their daily practice. The organized approach to an incredibly complex set of disorders will also benefit trainees trying to make sense of the complex field and developing their own clinical approach, as knowledge about metabolic epilepsies continues to grow.'-Carl E. Stafstrom, MD, PhD, Journal of Pediatric Epilepsy The continued explosion of information in neurogenetics and metabolism mandates increasing awareness of current diagnostic and therapeutic strategies in disease settings where prompt identification and intervention is crucial for a positive outcome. This thoroughly revised and greatly expanded new edition of the first book to bridge clinical epilepsy with inherited metabolic diseases brings together leading authorities to present state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies, Second Edition contains 15 new chapters, and all existing chapters have been updated to reflect the latest science and clinical advances in this fast-moving field. New sections on basic and clinical science —covering energetics, metabolomics, pathways, the use of novel investigations like transcranial magnetic stimulation, neuropathology, and genomic technologies—supplement the disease-focused sections. Dedicated chapters focus on recently recognized disorders having novel therapeutic implications, pyridoxal-5-phosphate dependency, Menkes disease, and thiamine transporter deficiency. The book also includes new clinical applications of genomics and advanced generation gene sequencing in the diagnosis of inherited metabolic epilepsies. This readable, well-illustrated reference concludes with an updated clinical algorithm to aid physicians in screening and identifying suspected metabolic disorders and a collection of resources for families. Features Synthesizes cutting-edge diagnostic, clinical, and scientific information on epilepsy and inborn errors of metabolism Completely updated and expanded second edition contains the latest knowledge and 15 entirely new chapters Authored and edited by international experts in neurology, metabolic disorders, and genetics A readable and well-illustrated reference for clinicians Essential coverage of the new generation of genetic tests, which were not widely available or utilized when the first edition was published New chapter on inherited metabolic epilepsies in adult

This updated and expanded new edition of a successful book describes genetic diagnostic entities of neuromuscular disorders. Neuromuscular syndromes are presented clinically either as a case study or as an overview from the literature, accompanied by text presenting molecular defects, and differential diagnosis.This collection of neuromuscular disorders features the differential clinical phenotypes related to each genotype and are representative of the whole spectrum of a genetic muscle disorder, helping the clinician and neuromuscular physician to make a diagnosis. Key points for each genetic disease are identified to suggest treatment, when available, or the main clinical exams useful in follow-up of patients. Genetic Neuromuscular Disorders: A Case-Based Approach is aimed at neuromuscular physicians and neurology residents.

Completely updated and in brilliant full color, Merritt's Neurology, 13th Edition, remains your reference of choice for outstanding guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. Greatly reorganized for ease of use, the 13th Edition features more than 30 new chapters that keep will you up to date with every aspect of your field. Now for the first time, you'll find dozens of video clips online that demonstrate the clinical signs and symptoms of neurologic disorders. Features: Visualize neurologic topics more easily than ever with an all-new, full-color format throughout. Benefit from the fresh perspective of new editors Dr. Elan Louis and Dr. Stephan Mayer, in addition to 180 expert contributors who offer guidance in their areas of expertise. Stay current with today's hottest topics, thanks to new chapters on the global burden of neurological disease; magnetic resonance imaging and other imaging modalities; sleep studies; mild cognitive impairment; concussion; restless legs syndrome; seizures in children; HIV, fetal alcohol syndrome, and drug effects; and many more. Find the information you need more quickly thanks to a reorganized format. In 153 succinct chapters, you'll find the essentials you need on signs and symptoms, diagnostic tests, and neurologic disorders of all etiologies. Watch approximately 40 video clips online to gain a clear understanding of the clinical signs and symptoms of neurologic disorders. Get the up-to-date information you need from the practical, readable resource that's trusted and used by neurologists, primary care physicians, and residents.

This book describes the genetic diagnostic entities of neuromuscular disorders. Each neuromuscular syndrome is presented clinically as a case study, accompanied by text reviewing different molecular defects, DNA research and differential diagnosis. This collection of neuromuscular disorders features the different clinical phenotypes related to each genotype and are representative of the whole spectrum of a genetic muscle disorder, helping the clinician and neuromuscular physician to make a diagnosis. Key points for each genetic disease are identified to suggest treatment, when available, or the main clinical exams useful in follow-up of patients. Genetic Neuromuscular Disorders: A Case-Based Approach is aimed at neuromuscular physicians and neurology residents.

Part of the Oxford Textbooks in Clinical Neurology series, the Oxford Textbook of Neuromuscular Disorders covers the scientific basis, clinical diagnosis, and treatment of neuromuscular disorders with a particular focus on the most clinically relevant disorders. The book is organized into seven sections, starting with the general approach to the patient with neuromuscular disorders and then focusing on specific neuromuscular conditions affecting the peripheral nervous system from its origins at the spinal cord anterior horn on its outward course to their effector muscles and the inbound sensory pathways. Chapters on specific neuromuscular conditions are illustrated with typical case histories and their presenting features, allowing readers to put rarer conditions into their clinical context more easily. The concurrent online version allows access to the full content of the textbook, contains links from the references to primary research journal articles, allows full text searches, and provides access to figures and tables that can be downloaded to PowerPoint®. This textbook will serve as a useful reference for neurologists and specialist trainees in neurology, neuroscientists, neurophysiologists, and other healthcare professionals.

Muscle Biopsy: A Practical Approach gives you all of the unparalleled guidance necessary to effectively interpret and diagnose muscle biopsy specimens for the full range of diseases in both adults and children. Authored by Dr. Victor Dubowitz, an internationally renowned figure in the field of muscle disease, this medical reference book takes an integrated approach to diagnosis and assessment of muscle biopsies that includes clinical, genetic, biochemical, and pathological features. It's the comprehensive, up-to-date coverage you need to evaluate muscle disorders with confidence.Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.Bridge the gap between clinical syndromes/disorders and their underlying pathologies with the guidance of muscle disease expert, Dr. Victor Dubowitz, who skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment.Understand and apply expert techniques for obtaining a muscle biopsy, and familiarize yourself with the histochemical, histological, electron microscopical, and molecular appearance of normal muscle and the pathology of individual muscle disease. Apply all of the latest diagnostic techniques for neurodegenerative and genetic diseases with a brand-new chapter on myopathies associated with systemic disorders and aging, and use advanced techniques such as immunohistochemistry and immunoblotting to produce the most accurate diagnoses possible for a full range of muscle disorders.Stay current in practice with state-of-the-art coverage of genetic markers for individual conditions and antibodies used in immunocytochemical diagnosis.Understand the genetics of muscular dystrophies with absolute clarity through the use of brilliantly simple diagrams and tables, and compare your specimens to a wealth of superb color images capturing the full spectrum of muscle biopsy findings.Take advantage of international insights and fresh perspectives in muscle diseases and disorders from new author Dr. Anders Oldfors, from the Department of Pathology, University of Goteborg, Sweden.

The explosion of information in neurogenetics and metabolism mandates increasing awareness of appropriate diagnostic and therapeutic strategies in the setting of certain epilepsies, especially those of very early onset. There are over 200 inherited disorders that are associated with seizures and prompt identification and intervention is crucial for a positive outcome. This text brings together leading authorities presenting state-of-the-art clinical reviews covering the science, recognition, and treatment of the inherited metabolic epilepsies and related disorders. Inherited Metabolic Epilepsies opens with a section on general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, neuroimaging, seizure patterns and EEG findings, new technologies, and the ketogenic diet in metabolic epilepsies. The next two sections are devoted to the cohort of specific small molecule disorders (aminoacidopathies, organic acidopathies, mitochondrial disorders, urea cycle disorders, neurotransmitter disorders, and glucose-related disorders) and large molecule disorders (lysomal storage disorders, peroxisomal diseases, glycosylation defects, and leukodystrophies) that are treatable yet can be so vexing to clinicians and investigators. The book concludes with a clinical algorithm designed to be a resource for the physician in search of direction when considering an inherited metabolic disorder as the explanation for a patient with epilepsy.Inherited Metabolic Epilepsies Key Features: Presents the latest scientific thinking and clinical wisdom for a poorly understood group of disorders that have devastating consequences if unrecognized or not promptly treated Expert authorship from both the genetic-metabolic and epilepsy communities provides state-of-the-art guidance for understanding and managing these disorders A readable text for clinicians highlighting the relation between metabolic errors and epilepsy Concludes with a practical algorithm for evaluating a patient with a possible metabolic epilepsy

Die Neuropathologie umfasst die Krankheiten des zentralen und peripheren Nervensystems mit seinen Hüllen sowie der Skelettmuskulatur. Die vorliegende Auflage folgt in ihrer Didaktik und Gestaltung der erfolgreichen vorigen Auflage. Berücksichtigt werden zahlreiche neue Krankheiten und Entitäten, die seither durch die Genetik oder neue Techniken der Immunhistochemie und Molekularbiologie entdeckt oder abgegrenzt worden sind. Viele neue, größtenteils farbige, repräsentative Abbildungen und Tabellen dokumentieren den Fortschritt, ohne den übersichtlichen Charakter des Werkes und damit seine Zielrichtung als Hilfe in der praktisch-neuropathologischen/pathologischen und klinisch-neurologischen/neurochirurgischen Diagnostik zu mindern. Im Vordergrund steht die Morphologie, Pathogenese, Ätiologie und Diagnostik der Erkrankungen, wobei auch klinische Aspekte berücksichtigt werden. Nach wie vor ist die Kenntnis der Morphologie die Basis und Voraussetzung für das Verständnis der Krankheiten in Klinik und Praxis.

The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications. Starting with an overview of muscular dystrophies, the book's 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery–Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies. This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders. - Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management - A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies - An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders

La pathologie neurologique infantile occupe une place majeure dans la pathologie pédiatrique, en raison de sa fréquence et de la gravité de ses conséquences sur le développement psychomoteur des enfants. La 3e édition de Neurologie pédiatrique, qui paraît 12 ans après l'édition précédente, a été entièrement réécrite afin d'intégrer les progrès extrêmement rapides effectués dans divers domaines tels que la génétique moléculaire, les connaissances des mécanismes physiopathologiques, les méthodes d'investigation, les avancées thérapeutiques. Cette nouvelle édition rend compte de cette fascinante évolution. Ainsi les chapitres consacrés à l'imagerie structurale et fonctionnelle, le développement du système nerveux, les malformations, les maladies neurométaboliques, neurodégénératives, neuromusculaires, les pathologies circulatoires, tumorales, infectieuses, etc., sont entièrement mis à jour. Un nouveau chapitre très complet porte sur le diagnostic anténatal des pathologies neurologiques, qui occupe maintenant une place fondamentale dans la pathologie pédiatrique. Le chapitre consacré à l'épilepsie, pathologie la plus fréquemment rencontrée en neuropédiatrie, a bénéficié d'une refonte complète prenant en compte les nouveaux moyens d'investigation diagnostique et les nouveaux traitements médicaux et chirurgicaux. Les déficiences et handicaps neurologiques sont analysés du point de vue de leurs conséquences médicales, mais également éducatives à la lumière de la loi du 11 février 2005 sur le droit des personnes handicapées. Les fonctions cérébrales supérieures de l'enfant et leurs dérèglements sont étudiés et enrichis des apports sur la connaissance du rôle du cervelet dans la cognition. La place de la pédopsychiatrie dans les maladies neurologiques a été considérablement développée, notamment à travers le problème complexe des pathologies de conversion chez l'enfant. Cette 3e édition de Neurologie pédiatrique constitue actuellement le traité le plus complet et le plus à jour dans le domaine de la neurologie infantile, aussi bien dans la littérature française qu'étrangère.

Evidence-based, peer reviewed, best practice management guidelines for neurologists Diagnosis is only part of the puzzle. Effective treatment is what your patients really want. The European Federation of Neurological Societies has been publishing management guidelines in the European Journal of Neurology for many years. Developed by a consensus approach, using graded evidence, and then fully peer reviewed, these guidelines provide gold-standard, best-practice guidance to the treatment of neurological disorders. They help bridge the gap between what is done and what should be done for patients with neurological disorders. The basic guidelines have been expanded with ‘Recommendations'based on strong evidence and ‘Good Practice Points'where only weaker evidence is available. The Guidelines in this volume cover: Investigation Major neurological diseases Neuromuscular diseases Infections Neurological problems Sleep disorders Rehabilitation The European Handbook of Neurological Management provides a thoroughly rounded and grounded approach to best-practice neurological management using evidence-based principles.

'There is a need for a paradigm shift in our thinking about the pathogenesis of multiple sclerosis.'Challenging Charcot's hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS. Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement. As internationally recognized specialists in a wide range of MS disciplines, the authors explore genetic tools for identifying patients who are most likely to experience spontaneous remyelination. Epidemiology studies offer additional avenues of treatment. Examples include uric acid, statin drugs, estrogen and progesterone. MS affects nearly 400,000 people in the United States, many of whom are between18 and 40 years of age. With their novel, multifaceted approach to basic science—and their applications in understanding cause and treatment—the authors offer help to clinicians and hope to patients.

This volume deals with brain development malformations of the central nervous system, showcasing a unique approach that furthers research through systematic integration of exciting new developments from fields including molecular genetics, neuroimaging, and neuropathology. By integrating data and research from these disciplines, better conceptualization of the mechanisms of the developmental processes is achieved. Clinicians will find invaluable insights into complex issues, including midline hypoplasias, disorders of segmentation of the neural tube, and hamartomatous disorders of cellular lineage, amongst others. The clinical manifestations of central nervous system malformations are also discussed, along with new advancements in MRI techniques and analysis, including volumetric morphology, spectroscopy, and functional neuroimaging. Sections dedicated to management and treatment are also included in an effort to aid clinicians in their goal of providing better care for individuals affected by these types of malformations. • A single source that encompasses the various aspects of cerebral malformations • A unique approach that furthers research through systematic integration of exciting new developments from fields including molecular genetics, neuroimaging, and neuropathology• New diagnostic tools, management protocols, and treatments for patient care

This brand-new text provides you with an easy-to-use, comprehensive reference that features a clinical perspective balanced with relevant basic science. Inside, you'll find discussions of the latest research and how it has led to a greater understanding of the cause of disease, as well as burgeoning tests and the latest therapeutic agents available. From Alzheimer's disease to vestibular system disorders, you'll find the practical guidance you need to diagnose effectively and provide an appropriate therapeutic approach for each individual case. Plus, a templated, four-color design offers you easy access to pertinent informationIntegrates basic science with clinical neurology to help you better understand neurologic diseases and provide the most accurate diagnosis and best treatment plan for each patient.Discusses the latest research results and offers new information on treatment options.Features the expertise of international authorities, providing a worldwide perspective.Uses a templated, four-color format that makes information accessible and easy to understand-particularly the basic science concepts.

The European Handbook of Neurological Management, published in collaboration with the European Federation of Neurological Societies (EFNS), is a unique book that brings together peer-reviewed guidelines for the treatment and management of neurological disease. For the first time, neurologists can find advice on management aspects of most neurological disorders that is either evidence-based or, where the evidence is inadequate, the consensus guidance of an international European panel of experts. The guidelines fall naturally into sections that cover: Investigation: cerebrospinal fluid analysis, imaging, diagnostic antibodies and skin biopsy Major neurological diseases: stroke, migraine, Parkinson's disease, dystonia, mild traumatic brain injury, multiple sclerosis and Alzheimer's disease Neuromuscular diseases: motor neuron disease, inflammatory neuropathy, muscular dystrophy and myasthenia gravis Infections: HIV infection and encephalitis Neurological problems: treatment of neuropathic pain, acute relapses of multiple sclerosis and status epilepticus, to name but a few Sleep disorders: Narcolepsy, other sleep disorders and restless legs syndrome Cognitive rehabilitation. The European Handbook of Neurological Management is a book that any neurologist, without regard to national boundaries, will find a useful aid in the day-to-day management of neurological disease.

Examining infant through geriatric patients, this guide compiles expert recommendations and research on the wide array of conditions that can secondarily impair cognition or behavior. Supplying key clinical, diagnostic, and therapeutic information, this reference analyzes topics including cerebrovascular disease, infectious processes, multiple scle