Search

Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the'cause and the'cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.

Clinical Neurophysiology is aimed at bedside clinical application of neurophysiological tests, with emphasis on clinical problem solving. Highly illustrated format including line diagrams, clinical photographs, CT scan and MRI pictures with corresponding neurophysiological findings is a special feature of this book. Clinical Neurophysiology is written by clinicians for fellow clinicians. This book will be useful to all those ordering, conducting or interpreting electrodiagnostic tests, especially students and clinicians in the areas of neurology, neurosurgery, and pediatrics. The exposition is systematically organized into the following three parts: Nerve Conduction: It discusses the basis of electrodiagnostic signals and their measurements. The techniques of performing nerve conduction tests of various nerves have been illustrated with a series of simple line diagrams. Electromyography: It deals with the basis of EMG signals, their recording and interpretation. The application of myography in various myopathies and neurogenic disorders has been discussed in detail. A review of single fiber electromyography is included. Evoked Potentials: This covers visual, brainstem, somatosensory and motor evoked potentials. New to this Edition - Three chapters: Electrodiagnosis in Pediatric Practice, Cognitive Evoked Potential, and Role of Clinical Neurophysiology in Prognosis of Neuromuscular Disorders. - Updation of all chapters in the light of recent advances in genetics, immunology, molecular diagnosis, and neurophysiology. - Extensive revision of Electromyography, Clinical Application of Electromyography and Nerve Conduction, and Repetitive Nerve Stimulation. - Many additional illustrations highlighting the clinical applications of various tests.

This volume provides a comprehensive accounting of pain and its relation to neurology. It is dedicated entirely to the mechanisms and clinical aspects of the subject, and provides a wealth of information on the latest neurobiological and clinical data surrounding the topic. From discussions of the physiology and pathology of the pain pathways from signaling, via spinal cord and supraspinal processing to endogenous pain modulation, users will gain an invaluable reference that provides a new understanding of pain related topics, including cytokines, sex differences, and the autonomic nervous system. Practicing clinicians, internists, surgeons, and those in the fields of psychiatry and gerontology will gain a greater understanding of this challenging topic with chapters that deal extensively with peripheral and central pain conditions, including specific disorders such as fibromyalgia, whiplash, psychiatric diseases, dementia, and even cancer. In addition, treatments for neuropathic pain are also thoroughly presented and discussed. • A comprehensive guide to the topic of pain and its relation to neurology• Invaluable information on specific topics of interest, including discussions of pain and its implications for related diseases and conditions such as fibromyalgia, whiplash, and even psychiatric disorders• Treatment protocols for neuropathic pain and patient care

Spanning a wide array of topics relating to the diagnosis and treatment of cerebrovascular disease, this reference collects the latest studies and recommendations from a team of 75 leading authorities on the subject-including the management of subarachnoid hemorrhage, the treatment of acute ischemic stroke and aneurysms, and surgical interventions

Das EP-Standardwerk in aktualisierter Neuauflage! Evozierte Potentiale bietet mit über 700 Seiten sämtliche relevanten Aspekte zum Thema. Ärzte in Weiterbildung und Fachärzte in Klinik und Praxis werden auf alle Fragen eine Antwort finden. In der Neuauflage wurden sämtliche Kapitel aktualisiert und überarbeitet. Neu: - Leserfreundliches, zweifarbiges Layout - Viele neue Abbildungen - Didaktische Elemente erleichtern das Lesen und Lernen Ein schwieriges Thema wird hier verständlich, gründlich und komplett abgehandelt. Es eignet sich für Einsteiger und Fortgeschrittene - zum Lesen, Lernen und Nachschlagen. Das Buch mit Potential!

Filling a gap in the literature, this reference offers 25 authoritative chapters on the epidemiology, clinical characteristics, and medical and surgical treatment of essential tremor and various tremor disorders, including chapters on Parkinsonian, cerebellar, neuropathic, post-traumatic, psychogenic, and drug-induced tremor. Reporting on the lates

Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical abnormalities, and provided us with essential and unpublished f- and cellular processes underlying myelin disorders. ures: our friends Susan Blaser,from the Hospital for This immense progress has prompted us to embark Sick Children in Toronto,and Zoltán Patay,from the upon the enormous task of rewriting the previous King Faisal Hospital in Riyadh. edition and adding 40 chapters. In doing so we have Many people at the VU University Medical Center tried to cover most white matter disorders,hereditary have been of great technical help to us in producing and acquired,and to present a collection of images to high quality images and in providing secretarial illustrate the field to the fullest possible extent. This assistance. The contributions of these people are edition will therefore be more complete than the pre- mentioned separately in the acknowledgements.

Title from e-book title screen (viewed on March 20, 2005)

Title from e-book title screen (viewed on Nov. 15, 2004)

Title from ebook title screen (viewed August 30, 2004).

Despite major advances in the understanding of stroke mechanisms that have occurred over the past quarter century, stroke continues to rank among the leading causes of death and disability worldwide. Although currently it may be difficult to believe, early doubts were expressed as to whether inter­ ventions in risk factors for either coronary disease or stroke would actually lead to a reduction in the incidence of these disorders. However, large clini­ cal trials in hypertension, carotid disease, atrial fibrillation, and antithrombotic and antiplatelet therapies have effectively demonstrated the efficacy of these targeted interventions in reducing stroke incidence. More recently, after earlier uncertainty regarding the role of elevated lipids as a risk factor for stroke, clinical trials of the statins have also demonstrated a significant reduction in the incidence of ischemic stroke. However, as em­ phasized in Handbook of Stroke Prevention in Clinical Practice, despite these gains and the initial decline in stroke incidence that did occur in the 1960s and 1970s, the incidence of stroke disappointingly has failed to show a fur­ ther significant decline since that time. The editors of Handbook of Stroke Prevention in Clinical Practice raise the very important question of whether recognized strategies for stroke preven­ tion have been widely or effectively implemented. They correctly empha­ size the critical importance of identifying the mechanism of stroke in each patient so as to properly direct prevention and treatment. As Dr.

Although some decades have passed, there are still worldwide controversies about a concept of human death on neurological grounds. There are also disagreements on the diagnostic criteria for brain death, whether clinical alone or clinical plus ancillary tests. Moreover, some scholars who were strong defenders of a brain-based standard of death are now favoring a circulatory-respiratory standard. The study of coma is extremely important because lesions of the brain are responsible for quality of life in patients or cause of death. The main goal of Brain Death and Disorders of Consciousness is to provide a suitable scientific platform to discuss all topics related to human death and coma.

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

This text is a fully integrated summary of all aspects of clinical neurophysiology. It is written by nationally recognized experts who work together at Mayo Clinic. All the authors are heavily involved in the teaching of clinical neurophysiology to residents in neurology, neurosurgery and physical medicine, and to post-residency fellows in EEG, EMG, autonomic disorder, sleep disorders, peripheral nerve diseases, and muscle diseases. The first section is a review of the basics of clinical neurophysiology. The second considers the assessment of disease by anatomical system. The third explains how clinical neurophysiologic techniques are used in the clinical assessment of diseases of the nervous system. This thoroughly revised Second Edition includes new approaches and a new chapter on the clinical neurophysiology of pain. The clinical problems in which each of the clinical neurophysiologic approaches can add to the diagnosis and management of neurologic disease are detailed, especially the assessment of clinical symptom complexes with electroencephalography (EEG). The discussions of pediatric EEG disorders, ambulatory EEG, new equipment and digital analyses, magneto-EEG, electromyographic (EMG) techniques, motor unit number estimates, myoclonus on surface EMG, segmental sympathetic reflex, and postural normotension have been expanded. Chapters on EMG quantified and single fiber EMG have been reorganized, and major revisions have been made in the discussion of sensory potentials, somatosensory evoked potentials, acoustic reflex testing, cardiovagal function, physiologic testing of sleep, and assessment of sleep disorders. New approaches are discussed in each of the four chapters on monitoring neural function during surgery, particularly with motor evoked potentials.

Building on the author's personal experience in working with fellows and residents in the electromyography laboratory, this volume is the definitive reference in the field. It is intended for clinicians who perform electrodiagnostic procedures as an extension of their clinical examination, and will be of value to neurologists and physiatrists who are interested in neuromuscular disorders and noninvasive electrodiagnostic methods, particularly those practicing electromyography (EMG). The book provides a comprehensive review of most peripheral nerve and muscle diseases, including specific techniques and locations for performing each test. Divided into two major sections, the first addresses the basics of electrodiagnosis, including information on anatomy and physiology, techniques for nerve conduction studies, and discussions of the blink reflex and H-reflex, etc. The second section presents each neuromuscular disorder, covering clinical aspects and extensive information on the distinctive electrophysiological findings typical of the disease. New for this edition: thorough updating of all chapters with extensive new references; entirely new sections on magnetic stimulation, human reflexes, late responses, quantitative EMG, motor unit number estimate, threshold electrotonus, and pediatric electrodiagnosis; consolidated yet comprehensive coverage of periperhal, as well as CNS studies, offering a practical approach for problem-solving; ample space allotted for clinical discussion.