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Migraine is a complex neurological disorder that is characterized by a complex neurobiology, clinical features that may overlap with over 300 causes of headache, and an association with major medical illnesses and comorbid diseases. This books draws upon the authors'vast clinical experience and exhaustive knowledge of the science of migraine and the practice of headache medicine and provides this knowledge in a comprehensive yet digestible format. While migraine is often a subject in other textbooks on headache, it is the sole focus of this volume. The authors provide an up-to-date overview of the evidence base and combine this with their experience and expertise to help practitioners make informed treatment decisions. This book also provides a glimpse into the future describing new treatment modalities, including neurostimulation technologies and biologics that are emerging as potentially valuable treatment options. The authors also deal extensively with the unique and complex management of migraine in women throughout the reproductive life cycle. For those looking for a practical, insightful, and in-depth review on the subject of migraine, there is no other option.

This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.

This book reviews the significant advances in our understanding of glioma biology that have been achieved during the past decade and describes in detail the resultant new approaches to treatment. Improvements in surgical techniques, radiation therapy, and chemotherapy are comprehensively covered, with discussion of their impact in decreasing patient morbidity and increasing survival. In addition, individual chapters are devoted specifically to current treatment for low-grade gliomas, anaplastic gliomas, and glioblastoma multiforme. Other topics addressed include treatment of the elderly patient, investigating emerging therapies from small molecules to immunotherapy and palliative care. This timely book will be a valuable source of up-to-date information for practitioners and will also be of interest to researchers.

The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. - Introduces the scientific foundations for modern movement disorders research - Contributing authors are internationally known experts - Completely revised with 20% new material - Provides a comprehensive discussion of genetics for each type of movement disorder - Covers Parkinson's disease, Huntington's disease, dystonia, tremors, and tics

The book aims to provide a timely update on a group of disorders of growing clinical and research interest. Vertigo and dizziness are far from being rare in total population and approach to them has significantly changed in the last years. Our handbook reports in a practical way what has been recently published on these disorders. As a result, the neurologist will be able to acquire the tools to recognize, diagnose and treat numerous clinical pictures that often border on the expertise of ENT specialists and audiologists. The authoritative interdisciplinary working group that compiled the book intended to provide a practical and integrative view, useful in understanding and solving the problems related to these pathologies (Vestibular Migraine and related disorders) in daily practice. A part on other episodic vertigo have been included in this handbook, as well as a part which deals physiology of the vestibular end organ.

Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord. Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory's applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord. - Chapters authored by international experts in the field of MRI of the spinal cord - Contains'cooking recipes—examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice - Ideal for clinical settings

Klinisch tätige Neurologen setzen täglich elektrophysiologische und sonographische Verfahren ein. Allerdings sind die technischen Grundlagen der eingesetzten Methoden bzw. deren Limitationen bei den einzelnen Fragestellungen bisher häufig nicht bekannt oder verbindlich definiert. Das von der Deutschen Gesellschaft für Klinische Neurophysiologie und funktionelle Bildgebung herausgegebene Buch schließt diese Lücke und fasst erstmals alle gängigen neurophysiologischen Verfahren, wie EEG, EMG, NLG, evozierte Potentiale (sensorisch und motorisch), Polysomnographie, autonome Testung, Hirnstammreflexe, Dopplersonographie und Ultraschall, in einem Buch zusammen. In kurzer und einheitlicher Form werden die verschiedenen Methoden beschrieben sowie die bei den klinischen Fragestellungen zum Einsatz kommenden Ableitungen und die damit verbundenen Probleme vorgestellt. Die Autoren sind international bekannte Fachleute aus Deutschland, Österreich und der Schweiz.

It has been 15 years since the original publication of Neuropsychology of Attention. At the time of its publication, attention was a construct that had long been of theoretical interest in the field of psychology and was receiving increased research by cognitive scientists. Yet, attention was typically viewed as a nuisance variable; a factor that needed to be accounted for when assessing brain function, but of limited importance in its own right. There is a need for a new edition of this book within Neuropsychology to present an updated and integrated review of what is know about attention, the disorders that affect it, and approaches to its clinical assessment and treatment. Such a book will provide perspectives for experimental neuropsychological study of attention and also provide clinicians with insights on how to approach this neuropsychological domain.

Spinal cord imaging has significantly benefited from a variety of new MR imaging methods. Recent decades have also witnessed fundamental progress in understanding of the pathophysiology of spinal cord diseases, treatment options, neurosurgical procedures, and endovascular treatments. This textbook provides an interdisciplinary overview of the new imaging modalities, identifies clues for MR imaging diagnosis and differential diagnosis and describes the anatomical background required to understand spinal cord diseases. Important neurological symptoms are highlighted, and modern treatment options for different diseases are fully explained and discussed. High-quality illustrations, including numerous images, are provided for all important spinal cord diseases, documenting relevant anatomical details, special MR imaging methods, differential diagnoses and possible treatment procedures.

- El objetivo principal de esta obra es profundizar en el conocimiento y aplicación de técnicas innovadoras en el ámbito de las neurociencias cognitivas como son la estimulación magnética transcraneal no invasiva y la neuromodulación. - Los autores recogen en esta obra todas aquellas actualizaciones recabadas de los últimos avances producidos y reflejados en estudios clínicos y experimentales realizados sobre dichas técnicas. - Participación de los más reconocidos expertos en la materia, tanto de ámbito nacional como internacional. - Se trata de la primera obra sobre estas terapias que cubre todos los aspectos de una técnica como la EMT y una de las primeras obras de este tipo escrita en español.

Until recently, it was thought that the adult brain is modifiable only during early stages of ontogenesis. However, neurophysiological and neuroimaging studies now indicate that the mature human brain is, under certain conditions, capable of substantial neuroplastic changes. Neuroplasticity reflects the ability of the human brain to alter the pattern of neural activation in response to previous experience, and recent findings indicate that the effects of experience can lead to both structural as well as functional reorganization. It has been shown that pathological neuroplastic changes can be reverted/normalized and that the modulation of the neuroplastic changes can be paralleled by improvement of the patient's status. However, there is a gap between the potential of neuromodulation, technical progress and actual preparedness of medical personnel to provide this type of treatment. A prevalent opinion among medical professionals indicates that training programs and educational materials in neuromodulatory techniques are well needed and appreciated. Neuromodulation will focus on the description and discussion of methods currently available for invasive and non-invasive neuromodulation, their clinical potential, significance and practical applications. In order to facilitate understanding of the topic, the initial part of the textbook will review neurophysiological systems involved in neuromodulation and will provide readers with basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine. Additionally, the clinical use of these techniques will be described with special regard to safety and avoidance of complications.

This book describes the genetic diagnostic entities of neuromuscular disorders. Each neuromuscular syndrome is presented clinically as a case study, accompanied by text reviewing different molecular defects, DNA research and differential diagnosis. This collection of neuromuscular disorders features the different clinical phenotypes related to each genotype and are representative of the whole spectrum of a genetic muscle disorder, helping the clinician and neuromuscular physician to make a diagnosis. Key points for each genetic disease are identified to suggest treatment, when available, or the main clinical exams useful in follow-up of patients. Genetic Neuromuscular Disorders: A Case-Based Approach is aimed at neuromuscular physicians and neurology residents.

The essential guide to monitoring neural function during intricate neurosurgery procedures Intraoperative Neuromonitoring takes you step by step through the proper protocols for measuring and mapping neural function, emphasizing the correct application of intraoperative recordings for improved surgical outcomes. You will learn how to utilize the very latest neuromonitoring tools, and familiarize yourself with the full range of topics pertaining to intraoperative monitoring in neurosurgery. The authors also present both common and lesser-known techniques for neural assessment, resulting in a stand-alone reference that helps you master any type of neuromonitoring for virtually every kind of procedure. FEATURES: The most complete, expert-authored intraoperative neuromonitoring resource available, addressing the most current topics, tools, and techniques to enhance your skills Valuable, learn-as-you-go guidance on measuring and mapping neural structures focuses on the proper evaluation of pertinent patient data and providing the surgeon with accurate updates through the duration of the case Logical five-part organization clearly explains must-know topics such as neuromonitoring during cerebrovascular surgery, mapping cerebral and brainstem function, neuromonitoring in spinal surgery peripheral nerve procedures,and more Numerous illustrations, figures, surgical images, and angiograms Full chapter-ending references provide opportunities for further study and research

Whilst the vast majority of headaches are minor ailments, some patients develop chronic symptoms that have psychiatric dimensions. These symptoms can be immensely challenging to manage and can have a serious impact on the patient's quality of life. The relationship between headache and psychiatric disease is often rationalized as cause and effect; however, the interplay between the two is complex. Management of each of the co-morbid disorders affects the other one in positive and/or negative ways. The Neuropsychiatry of Headache details the current concepts of various headache conditions and the psychiatric syndromes; topics covered include migraine, mood disorders, medication overuse and personality disorders. Headache specialists, neurologists, psychiatrists, neuropsychiatrists and neuropsychologists will find this an invaluable resource for understanding and co-managing these conditions.

Movement disorders affect a growing patient population, but providing comprehensive care is extremely difficult. Several of these conditions are progressive and incurable; the basal ganglia has a complex role in movement control, with many potential malfunctions. This book focuses on rehabilitation approaches that have been developed and utilized internationally in an attempt to minimize impairment and maximize participation amongst these patients. Each chapter is written by movement disorder experts, rehabilitation specialists and health care professionals, giving a broad overview of current interventions and emphasizing the need for interdisciplinary management, focussing on deliverable outcomes. Common conditions such as Parkinson's disease, cerebral palsy, dystonia and Huntington's disease are comprehensively covered. This book gives neurologists, geriatricians and rehabilitation specialists an up-to-date, theoretically-based approach to managing movement disorders related to basal ganglia malfunction. Also valuable for physiotherapists, occupational therapists, speech pathologists, nurses and social workers seeking to develop and plan appropriate interventions.

Having been a fairly dormant specialty for many decades, in recent years there has been a remarkable increase in activity in Neuro-oncology from basic science through to the clinics. Reflecting this there have been considerable advancements in the understanding of the biology of CNS malignancies which have infirmed the development of many novel and successful therapies. This work aims to bring together the scattered literature on the new concepts in neuro-oncology for the benefit of those in the field. The book moves from concepts in the scientific basis of neuro-oncology, through to modelling techniques and finishing on the translation into clinical practice.

The first edition of Parkinson's Disease and Nonmotor Dysfunction was published in 2005 to provide a source of detailed information that could be readily accessed by the practicing physician. The widely praised first edition described and explained these nonmotor features that had at that point received insufficient attention both in the medical and in the lay literature. Since the publication of the first edition, awareness and knowledge of the nonmotor features of PD has dramatically expanded, calling for a new edition of this important title. Timely, fully updated and expanded, Parkinson's Disease and Nonmotor Dysfunction, Second Edition, offers a state-of-the-art overview of the topic from the same talented group of experienced researchers and clinicians who were the driving force behind the first edition. Importantly, a range of additional aspects of nonmotor dysfunction in PD -- such as dermatological, vestibular, and dental dysfunction -- have been included in this second edition, which remains subdivided into five diverse domains: Behavioral abnormalities, autonomic dysfunction, sleep-related dysfunction, sensory dysfunction, and other aspects of PD such as oculomotor dysfunction, fatigue, and maxillofacial issues. An invaluable contribution to the literature in movement disorders, this revised and expanded collection of contributions by an even larger contingent of superbly knowledgeable authors will further increase awareness of the manifold contributions that nonmotor features may make to the collective clinical picture experienced by the patient with PD.

Der Weg vom Symptom zur Diagnose ist in der Schmerztherapie eine entscheidende Phase in der Behandlung des Patienten. Alle Ärzte, die Patienten mit chronischen Schmerzen behandeln müssen, finden in der 3. Auflage des Buches klare Empfehlungen zu deren Versorgung:Grundlagen der Schmerztherapie: Konzepte, Entstehung der Chronifizierung u.a.Symptomerkennung und Diagnostik Medikamentöse und nichtmedikamentöse Verfahren in der SchmerztherapieBeschreibung der häufigsten Schmerzsyndrome Plus: Therapie besonderer Patienten, z.B. Schwangere, alte Menschen, Abhängige; Begutachtung von Schmerzpatienten; Palliativmedizin, Versorgungskonzepte und CodierungEin Buch für schmerztherapeutisch tätige Ärzte und Psychotherapeuten in allen Fachgebieten: Allgemeinmedizin, Anästhesie, Orthopädie, Neurologie, Innere Medizin.

There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early

- A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. - International list of contributors including the leading workers in the field. - Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care. - A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. - International list of contributors including the leading workers in the field. - Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment. Mirroring the first book, this two-volume edition is divided into two parts. Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders. Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes. Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners. General neurologists as well as specialists in neuromuscular medicine andtrainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused. Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.

In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenes

Die 3. Auflage enthält eine aktualisierte Darstellung aller klinisch relevanten Modalitäten (SEP, VEP, AEP, Magnetstimulation, ereigniskorrelierte Potentiale und Schmerz-evozierte Potentiale). Die bewährten, detaillierten Angaben zur Durchführung der einzelnen Verfahren sowie zur Auswertung und Befundung der Untersuchungsergebnisse werden ergänzt durch eine große Zahl illustrativer Abbildungsbeispiele und Normwerttabellen.

'I am pleased to include this text in my library, and I am confident that it will serve as an excellent resource for years to come.'--PsycCRITIQUESThis book serves as an A-Z reference that addresses the neuropsychological aspects of 300 neurological, neuropsychiatric, and neuromedical disorders. Each entry follows a 5 section structure that will cover (1) essential features of the disorder (2) physiological basis of the disorder (3) neuropsychological and other clinical presentation (4) assessment and diagnostic practices (5) evidence-based treatments and interventions. This book is written for clinical professionals and students in training to aid in clinical awareness, diagnostic accuracy, and intervention successfulness.The text goes beyond the emotional and behavioral aspects of each disorder and views the broader impacts of the symptoms. This approach emphasizes the importance of looking at the other functional impacts of these manifestations (e.g. cognitive deficits secondary to depression, orthodopaedic ambulation issues). The emphasis on neuropsychological sequelae, physiological basis, and means of diagnosing and treating of 300 conditions across the lifespan make this the most comprehensive resource available to professionals in and around neuropsychology, neuropsychiatry and the behavioral neurosciences. Key Features:Presents 300 highly-structured entries providing disorder features, pathology and physiology, clinical representation, assessment and diagnosis, and evidence-based treatments and interventions Covers neurological, neuropsychiatric, and neuromedical disorders across the lifespan (pediatric, adult, and geriatric populations)Includes interventions and methods of treatment for the outcomes patients may experience

Die Behandlung von neuropathischen Schmerzen stellt in der klinischen Praxis noch immer eine große Herausforderung dar. In den letzten Jahren haben sich deutliche Fortschritte in unserem Wissen zur Pathophysiologie neuropathischer Schmerzen ergeben, und es haben sich neue therapeutische Optionen eröffnet. Mit der Behandlung von Patienten, die an neuropathischen Schmerzen leiden, sind Klinikärzte der verschiedensten Disziplinen, Hausärzte, niedergelassene Neurologen, Internisten und Anästhesisten betraut. Dieses Buch soll für alle, die solche Patienten behandeln, eine praktische Orientierungshilfe und ein Nachschlagewerk bei speziellen Fragestellungen darstellen.

Handbook of Pain and Palliative Care:Biobehavioral Approaches for the Life Course Rhonda J. Moore, editor This book takes both a biobehavioral and a lifespan approach to understanding long-term and chronic pain, and intervening to optimize patients'functioning. Rich in clinical diversity, chapters explore emerging areas of interest (computer-based interventions, fibromyalgia, stress), ongoing concerns (cancer pain, low back pain), and special populations (pediatric, elderly, military). This coverage provides readers with a knowledge base in assessment, treatment, and management that is up to date, practice strengthening, and forward looking. Subject areas featured in the Handbook include: ▪ Patient-practitioner communication▪ Assessment tools and strategies▪ Common pain conditions across the lifespan▪ Biobehavioral mechanisms of chronic pain▪ Pharmaceutical, neurological, and rehabilitative interventions▪ Psychosocial, complementary/alternative, narrative, and spiritual approaches▪ Ethical issue and future directions With the rise of integrative perspective and the emphasis on overall quality of life rather than discrete symptoms, pain management is gaining importance across medical disciplines. Handbook of Pain and Palliative Care stands out as a one-stop reference for a range of professionals, including health practitioners specializing in pain management or palliative care, clinical and health psychologists, public health professionals, and clinicians and administrators in long-term care and hospice.

Dedicated to Camillo Golgi, a neuroscience pioneer, the volume deals with the process of diagnosis and the strategies of treatment of pain. The most recent data on the biochemical basis of neurotransmission are reported, and the results of updated researches in pain processing, either concerning the brainstem, the thalamus and the limbic system are analysed. The importance of the ethical aspect in decision-making during the treatment of terminally ill patients is underlined.

Ataxia is a neurological sign and symptom characterized by lack of coordination of muscle movement that is due to dysfunction of the parts of the nervous system, such as motor control of the cerebellum. Although the cause of the dysfunction varies from mutations in channels for potassium and/or calcium to progressive degeneration of cerebellar tissue-specific neurons, the neurological signs and symptoms of ataxia are similar. The treatment of ataxia and its effectiveness depend on the underlying cause, and it could be managed by pharmacological treatments and through physical therapy and occupational therapy. The treatment may ameliorate the signs of ataxia, but it is not likely to eliminate them entirely. In this book, the authors present current research in the study of the causes, symptoms and treatments on ataxia.

Appropriately select, implement, and interpret electrodiagnostic tests to identify a full range of central and peripheral nervous system disorders with Aminoff's Electrodiagnosis in Clinical Neurology! Covering everything from basic principles to the latest advances in electrodiagnosis, this medical reference book helps you make optimal use of this powerful but complex diagnostic modality in compliance with regulatory and professional standards, so you can diagnose patients accurately and initiate effective treatment and management strategies.Deepen your understanding of the principles, scope, limitations, diagnostic importance, prognostic relevance, and complications for each technique. Visually grasp the technical and practical aspects of electrodiagnostic tests with almost 800 charts, figures, and tables. Rely on the knowledge, experience, and perspective of renowned expert Dr. Michael J. Aminoff and an international team of contributors comprised of a virtual'who's who'of clinical neurophysiology. Keep up with developments in the field through significant updates, including new chapters on Artifacts and Normal Variants in the Electroencephalogram; Microneurography; Clinical Applications of Nerve Excitability Testing; Ultrasound of Muscle and Nerve; The Blink Reflex and Other Brainstem Reflexes; Visual Evoked Potentials, Electroretinography and Other Diagnostic Approaches to the Visual System; and Magnetic Stimulation in Clinical Practice and Research. Meet regulatory and professional standards and apply best practices with state-of-the-art guidance (for both non-specialists and specialists) emphasizing the clinical applications of each electrodiagnostic technique. Get easily actionable information and avoid mistakes with electrophysiologic findings integrated into the clinical context in which they are obtained.

The topography of the brainstem is complex, and even experienced neurologists find it challenging to localize brainstem lesions and diagnose brainstem disorders. This richly illustrated book provides a comprehensive review of brainstem disorders and presents the clinical knowledge necessary for diagnosis. The opening sections document the brainstem neuroanatomy and discuss current diagnostic methods. The entire spectrum of clinical findings in brainstem disorders is then described, and topodiagnostic aspects of the neurological findings are explained in detail. The descriptions of brain stem disorders are consistently structured and are supported by many MR images and short case reports. In addition to primary brainstem lesions, such as vascular brainstem syndromes, other disorders are considered that do not exclusively show brainstem symptoms or signs, e.g., multiple sclerosis. This book will serve as an invaluable reference work for neurologists in clinical practice or further education.

The new third edition of Pediatric Stroke and Cerebrovascular Disorders provides a modern clinical approach to managing stroke and other cerebrovascular problems in infants, children, and adolescents. Incorporating data from important clinical trials and case series, recommendations from the American Heart Association evidence-based paper on the management of pediatric stroke, and the latest information on new diagnostic techniques, the book offers a comprehensive analysis of the current thinking and practice by three physicians who have vast clinical experience in this challenging field. The third edition of this classic work has been completely updated and rewritten to reflect current science and practice. Covering occurrence, etiology, diagnosis, and treatment, this integrated state-of-the-art text is essential reading for anyone involved in the care of children with suspected stroke or other cerebrovascular abnormalities. The third edition of this classic work has been completely updated and rewritten to reflect current science and practice. An extensive, entirely new chapter on treatment provides specific guidance on when to use antiplatelet agents, anticoagulants, and thrombolytic agents in children and also includes a section on neurorehabilitation after stroke. An expanded and thoroughly updated diagnostic approach chapter covers the latest applications in stroke imaging such as computed tomography angiography, diffusion weighted MRI, and perfusion CT. The first chapter stresses the etiology and pathophysiology of childhood stroke as the basis for evaluations and treatment. Features of Pediatric Stroke and Cerebrovascular Disorders, Third Edition Include: Comprehensive in scope: detailed analysis of the pathogenesis, diagnosis, and treatment of cerebrovascular disorders in children with many evidence-based management guidelines The third edition has been updated to include recommendations from the AHA consensus guidelines All chapters in the third edition have been revised and updated An extensive, entirely new chapter on treatment provides specific guidance on when to use antiplatelet agents, anticoagulants, and thrombolytic agents in children Stresses the etiology and pathophysiology of childhood stroke as the basis for evaluation and treatment Maintains the practical, clinical flavor established in previous editions, with numerous illustrations and useful suggestions for patient care Written by internationally known stroke experts: Dr. Roach chaired the AHA panel that produced the consensus guidelines on childhood stroke and Drs. Lo and Heyer have published extensively on stroke and related topics

Questa terza edizione, interamente rivista, aggiornata e ampliata, tratta in modo completo ed esauriente i disturbi del comportamento secondari a lesioni e disfunzioni cerebrali acquisite, che occupano un vasto territorio intermedio tra la neurologia, la psichiatria e la psicologia. L'elevata e aggiornata qualità delle informazioni contenute fa di questo volume un punto di riferimento indispensabile per neurologi, psichiatri, psicogeriatri, neuropsicologi e psicologi, per gli studenti in formazione nelle discipline neuropsichiatriche e psicologiche, per gli esperti in neuroriabilitazione e per tutti coloro che sono interessati ad approfondire le attuali conoscenze sulle basi neurobiologiche del comportamento umano, sui rapporti fra mente, cervello e ambiente e sui disturbi che si possono manifestare quando lesioni o disfunzioni cerebrali alterano tali rapporti.

Synthesizing coverage of sensation and reward into a comprehensive systems overview, Neurobiology of Sensation and Reward presents a cutting-edge and multidisciplinary approach to the interplay of sensory and reward processing in the brain. While over the past 70 years these areas have drifted apart, this book makes a case for reuniting sensation a

Der Patient mit chronischem Muskelschmerz stellt für Ärzte verschiedener Fachrichtungen immer noch ein Problem dar. Beiträge national und international ausgewiesener Experten informieren über den neuesten Erkenntnisstand.

The leading reference on electroencephalography since 1982, Niedermeyer's Electroencephalography is now in its thoroughly updated Sixth Edition. An international group of experts provides comprehensive coverage of the neurophysiologic and technical aspects of EEG, evoked potentials, and magnetoencephalography, as well as the clinical applications of these studies in neonates, infants, children, adults, and older adults. This edition's new lead editor, Donald Schomer, MD, has updated the technical information and added a major new chapter on artifacts. Other highlights include complete coverage of EEG in the intensive care unit and new chapters on integrating other recording devices with EEG; transcranial electrical and magnetic stimulation; EEG/TMS in evaluation of cognitive and mood disorders; and sleep in premature infants, children and adolescents, and the elderly. A companion website includes fully searchable text and image bank.

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. - Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors - Preclinical models in COMT inhibitor devlopment - Transgenic COMT mice – latest information summarized - Chemistry of COMT inhibitors and their design with molecular modelling - COMT gene and its regulation and relation to dopamine related diseases - Role of cofactor SAM regulation in relation to homocysteine - Nonclinical and clinical safety of COMT inhibitors summarized - Future prospects of COMT inhibitors in Parkinson's disease

Movement Disorders 4, the newest volume in the Blue Books in Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and pharmacologic treatment on the full range of movement disorders.Emphasizes the vast array of pharmacologic therapeutics, backed by clinical trials of the past 15 years to help you determine the best and most up-to-date drug therapy. Provides the latest on hot topics such as frontotemporal dementia and Tourette's and related disorders, keeping you up to date on today's issues. Presents the surgical management of Parkinson's Disease to help you determine when to recommend surgery and for which patients. Includes extensive comprehensive information on Parkinson's so you can better diagnose and treat PD patients. Offers more clinical details on tremors, differentiating between PD and other movement disorders and the genetics of movement disorders so you can determine which movement disorder is present.

This edition of the companion volumes Muscle Pain: Understanding the Mech- isms and Muscle Pain: Diagnosis and Treatment is essential reading for those interested in clinical approaches to acute and chronic pain conditions involving muscle tissues and in the mechanisms underlying these conditions. The volumes cover a very important topic in pain medicine, since muscle pain is very common and can often be dif?cult to diagnose and treat effectively. Furthermore, chronic pain involving muscle and other components of the musculoskeletal system increases with age, such that it is a common complaint of those of us who are middle-aged or older. Indeed, as changing population demographics in “west- nized” countries result in higher proportions of the population living longer and being middle-aged and elderly, chronic muscle pain will likely become even more of a health problem. In the case of acute muscle pain, this can often be very intense, and in the short term can limit or modify the use of components of the musculoskeletal system associated with the sensitive muscle. Chronic muscle pain can also be intense, as well as unpleasant and disabling, and it is in many cases the over-riding symptom of most musculoskeletal disorders that are associated with long-term deleterious changes in musculoskeletal function.

'Due to the generous representation of the afferent visual system within the brain, neurological disease may disrupt vision as a presenting symptom or as a secondary effect of the disease. Conversely, early developmental disturbances of vision often disrupt ocular motor control systems, giving rise to complex disorders such as nystagmus, strabismus, and torticollis. The signs and symptoms of neurological disease are elusive by their very nature, presenting a confounding diagnostic challenge. Neurological medications and neurosurgical treatments can produce neuro-ophthalmological dysfunction that can be difficult to distinguish from disease progression. Affected patients may experience substantial delays in diagnosis, and are often subjected to extensive (and expensive) diagnostic testing. Scientific articles pertaining to specific disorders are scattered throughout medical subspecialty journals. These children continue to'fall through the cracks'of our medical education system. The increasing recognition that pediatric neuro-ophthalmology comprises a distinct set of diseases from those seen in adults has led to its emergence as a dedicated field of study.'Since the original publication of Pediatric Neuro-Ophthalmology nearly fourteen years ago, interest in the field has burgeoned. Pediatric ophthalmology and pediatric neurology subspecialty conferences often include symposia dedicated to recent advances in pediatric neuro-ophthalmology. Technical advances in neuroimaging have given rise to a more integrated mechanistic classification of neuro-ophthalmological disease in children. Our understanding of neurodevelopmental disorders of the visual system has expanded, longstanding monoliths have been dissembled into component parts, basic molecular mechanisms have taken center stage, and genetic underpinnings have become definitional. Evolutionary alterations can now be observed at the level of the gene, adding a new dimension to our understanding of diseasepathogenesis. New classifications now encompass clinically disparate conditions. Descriptive definitions have been supplanted by mechanistic ones, and clinical definitions superseded by genetic ones. Our concept of disease pathogenesis has been revised and in some cases overturned. Bearing witness to these remarkable advancements has compelled me to enhance and expand the first edition of Pediatric Neuro-Ophthalmology into this new and revised one.'In the first edition of this book, our goal was to present the clinical characteristics, diagnostic evaluation, and therapeutic options for the common neuro-ophthalmologic disorders of childhood. In so doing, we designed the book to be provide a narrative journey through the thought processes involved in the clinical management of these disorders. In this edition, I have retained the basic narrative format of original book, while expanding the exploration of these complex visual disorders in the context of the many new scientific advancements and discoveries that have come to light. These conditions are fun to diagnose, fascinating to understand, and gratifying to manage.'--from the Preface to the 2nd Edition.

Diabetes, particularly type 2, has become increasingly more common around the world. Consequently, the effect of diabetes on the brain has achieved enormous public health importance. A surge in pre-clinical and clinical research on topics ranging from management of hyperglycemia in acute stroke to disturbances in insulin signaling in Alzheimer's disease has led to substantial progress in the field. Written by a panel of international experts, Diabetes and the Brain provides in depth reviews on the cerebral complications of diabetes, and offers introductory chapters on current insights on the pathophysiology and clinical management of diabetes, as well as neuropsychological assessment and dementia. This relevant and easily accessible book explains the cerebral complications of diabetes, with an update on diabetes for neurologists, psychiatrists, and mental health providers and researchers in general,and on stroke and dementia for those involved in research and clinical practice in diabetes.

This book is written for those who evaluate the many quirks and behaviors encountered in the lives of developing children. The number of important pathologic conditions that befall this age group is staggering. However, equally staggering is the number of episodic and often benign or developmentally programmed paroxysmal events encountered in this population. The nature of these episodic events in many circumstances leads to their erroneous identification as epileptic in nature. This book serves as a compendium of those episodically manifest entities often uniquely observed in childhood. The book is organized with some foundations in terminology and an in depth analysis of epidemiology of many of these disorders. As best possible, epidemiologic data are compiled with incidence and prevalence figures provided for comparisons. Discussion on the deductive approach to their clinical assessment is provided along with emphasis on the diagnostic clues contained within the descriptive and observational information provided during clinical evaluation. A categorization of the differential features and ages of presentation are provided as a means to help direct logical diagnostic considerations. Subsequent chapters are organized by major topic (i.e.) Syncopes, Sleep Phenomena, Somatization, Factitious Illness, Movement Disorders, and Migraine Syndromes. Each chapter provides discourse on the general principles of underlying pathophysiologic mechanisms and current knowledge about the chapter topic under discussion. Specific clinical entities encompassed within the general topic are then discussed individually with particular attention to their clinical descriptions and presentations, natural history, particular pathophysiology, genetics, pertinent laboratory, and treatments. The text is amplified by pertinent tables highlighting diagnostic criteria where this applies and reference information where needed. The text is generously referenced to encompass the most relevant information available.

Epilepsy and migraine are two frequent chronic neurological disorders which have complex links. Their comorbidity is well established by epidemiological data. Both are characterized by recurrent epileptic or migrainous attacks, sometimes intermingled. Their clinical symptoms may overlap. Moreover, some drug therapies can be used for both disorders. What is this so particular link? This is exactly what this book aims to show! This book reports the most recent progresses observed in all the fields covered by-epilepsy and migraine. Epileptologists, who sometimes are not familiar with those fields, will find information on physiopathology, genetics and clinical classifications of migraine. Edited by famous international specialists of migraine and/or epilepsy, this book will be essential to physicians in charge of this double therapeutic approach.

Clinical Neurophysiology, Third Edition will continue the tradition of the previous two volumes by providing a didactic, yet accessible, presentation of electrophysiology in three sections that is of use to both the clinician and the researcher. The first section describes the analysis of electrophysiological waveforms. Section two describes the various methods and techniques of electrophysiological testing. The third section, although short in appearance, has recommendations of symptom complexes and disease entities using electroencephalography, evoked potentials, and nerve conduction studies.

Functional magnetic resonance imaging (fMRI) and Electronecephalography (EEG) are very important and complementary modalities since fMRI offers high spatial resolution and EEG is a direct measurement of neuronal activity with high temporal resolution. Interest in the integration of both types of data is growing rapidly as it promises to provide important new insights into human brain activity as it has already done so in the field of epilepsy. The availability of good quality instrumentation capable of providing interference-free data in both modalities means that electrophysiological and haemodynamic characteristics of individual brain events can be captured for the first time. Consequently, it seems certain that the integration of fMRI and EEG will play an increasing role in neuroscience and of the clinical study of brain disorders such as epilepsy. The proposed book will discuss in detail the physiological principles, practical aspects of measurement, artefact reduction and analysis and also applications of the integration of fMRI and EEG. All applications, which are mainly in the fields of sleep research, cognitive neuroscience and clinical use in neurology and psychiatry will be reviewed.

Increasing interest in the study of coordinated activity of brain cell ensembles reflects the current conceptualization of brain information processing and cognition. It is thought that cognitive processes involve not only serial stages of sensory signal processing, but also massive parallel information processing circuitries, and therefore it is the coordinated activity of neuronal networks of brains that give rise to cognition and consciousness in general. While the concepts and techniques to measure synchronization are relatively well characterized and developed in the mathematics and physics community, the measurement of coordinated activity derived from brain signals is not a trivial task, and is currently a subject of debate. Coordinated Activity in the Brain: Measurements and Relevance to Brain Function and Behavior addresses conceptual and methodological limitations, as well as advantages, in the assessment of cellular coordinated activity from neurophysiological recordings. The book offers a broad overview of the field for investigators working in a variety of disciplines (neuroscience, biophysics, mathematics, physics, neurology, neurosurgery, psychology, biomedical engineering, computer science/computational biology), and introduces future trends for understanding brain activity and its relation to cognition and pathologies. This work will be valuable to professional investigators and clinicians, graduate and post-graduate students in related fields of neuroscience and biophysics, and to anyone interested in signal analysis techniques for studying brain function.

In this unique book, Dr. Bertorini guides you through more than 100 cases that demonstrate the diagnosis and management of a wide range of common and rare neuromuscular disorders. No other reference boasts such a large array of clinical studies devoted to all areas of this broad topic! Each case study reviews the etiologies, pathogenesis, differential diagnosis, and management of a particular disorder, helping you not only recognize its presentation, but also determine a diagnosis and the best treatment plans for your patients. You'll also find expert guidance on the basic mechanisms of neuromuscular disorders, clinical examination, and diagnostic tests-including EMG, muscle biopsy, genetic testing, and more.More than 100 detailed case studies explore both common and rare neuromuscular disorders and the treatment protocols for each, equipping you with the knowledge you need to confidently manage any challenge. Each case includes a summary of important points or highlights of the study.Case studies are arranged either by complaint or by diagnosis so that you can successfully manage your patients with or without an initial diagnosis. Comprehensive coverage of EMGs and nerve conduction studies and other diagnostic tests, including muscle and nerve biopsies and genetic testing, helps you accurately diagnose nerve, muscle, and neuromuscular transmission disorders. Detailed discussions of treatment plans and commonly used drugs enhance your management of autoimmune disorders, painful neuropathy, dysautonomia, and other neuromuscular disorders.A reader-friendly format takes you step by step through the diagnosis and treatment of neuromuscular disorders, from the basic anatomy and physiology of the nerve and muscle through to clinical evaluation, diagnostic testing, and therapy. More than 350 high-quality illustrations, including full-color patient photographs, biopsies, and EMG tracings, make complex concepts easier to understand and apply.

Textbook of Epilepsy Surgery covers all of the latest advances in the surgical management of epilepsy. The book provides a better understanding of epileptogenic mechanisms in etiologically different types of epilepsy and explains neuronavigation systems. It discusses new neuroimaging techniques, new surgical strategies, and more aggressive surgical approaches in cases with catastrophic epilepsies. The contributors also analyze the improved statistics of surgical outcome in different epilepsy types. This definitive textbook is an invaluable reference for neurologists, neurosurgeons, epilepsy specialists, and those interested in epilepsy and its surgical treatment.

International experts present in this volume advances in reconstructive neurosurgery focusing on the fields of neurotrauma and neurodegenerative disorders. The highlights include building an international strategy for risk reduction, documentating an multidisciplinary approach towards restoration of function in paraplegic spinal cord-injured patients, describing a new approach for statistical analysis in traumatic brain injury trials, describing blood flow changes in diffuse brain injury, discussing rehabilitation programs in Germany following acute brain injury, describing research data form Taiwan on neurotrauma, showing the neuropsychiatric effects from deep brain stimuation fro ovement disorders, difining the role played by imanging for deep brain stimulation targeting in mental illness, using radiosurgery in decompresssion in the treatment of trigeminal neuralgia, describing the development of radiosurgery from brain to the spine, listing new transgenic animal models of Parkinson's disease, discussing gene therapy for neuropathic pain and Parkinson's disease, and finally, discussing constrained-induced movement therapy fro stroke patients, and endovascular therapy for cerebrovenous disorders.

Movement disorders in children: a clinical update with video recordings covers a wide range of disease conditions that are characterized by involuntary movements possibly associated with signs of more diffuse dysfunction of the nervous system.These include both genetically determined and acquired conditions, running a clinical course that may be progressive, static, or paroxysmal. Recent years have witnessed growing interest in the movement disorders of children. There has been an increase in our understanding of the pathogenesis of these disorders, and new perspectives for their diagnosis and treatment have emerged. This book aims to provide neurologists, paediatricians, and specialists in developmental medicine with a comprehensive update on these issues. The more recent advances on dystonias, neurotransmitter disorders, chorea and PANDAS, tics and Tourette syndrome, paroxysmal dyskinesias, psychogenetic movement disorders and other specific syndromes and diseases - such as opsoclonus-myoclonus, rapid onset dystonia-parkinsonism, pan-tothenate kinase-associated neurodegeneration and Rett syndromes - are illustrated, and current topics on genetics, biochemistry, brain imaging, physiological investigations, quantitative assessment, and the pharmacological and surgical treatment of childhood movement disorders are covered. The book also includes significant video documentation which we trust may be a helpful and crucial contribution for all professionals involved in the field of movement disorders, where the correct semiologic definition of the different conditions is one of the most important but problematic steps in the diagnostic work-up.