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Dieses Buch behandelt umfassend grundlegende Aspekte rund um die Therapie mit Neuro-Psychopharmaka. Führende Experten aus dem deutschsprachigen Raum stellen unter bewährter Herausgeberschaft ausführlich den aktuellen State-of-the-art dar. Nach einem historischen Abriss wird zunächst ausführlich auf die neurobiologischen und psychologischen Grundlagen sowie Methodik, Pharmakokinetik, Nomenklatur, Epidemiologie, Interaktionen/UAWs, Arzneimittelkombinationen und Kontrolluntersuchungen eingegangen. Des Weiteren werden verschiedene spezielle Situationen behandelt, z. B. die Psychopharmakotherapie bei Kindern, in Schwangerschaft/Stillzeit und die Anwendung bei geriatrischen Patienten. Vervollständigt wird das Werk durch Kapitel zu den aktuellen formalen Rahmenbedingungen der Psychopharmakotherapie. Hier erhält der Leser einen Überblick über gesundheitsökonomische Bewertungen, z. B. den aktuellen Stellenwert des IQWiG für die Arzneimitteltherapie, sowie über derzeit gültige juristische Aspekte sowie Qualitätsmanagement.

Vertigo and Imbalance: Clinical Neurophysiology of the Vestibular System

Chronic deep brain stimulation (DBS) has been a rapidly evolving area of neurotherapeutics since its initial introduction for the treatment of Parkinson's disease and essential tremor in the 1990s. For these conditions, DBS is now considered accepted therapy for patients failing to adequately respond to m- ical treatment. Since the 1990s, new clinical indications, anatomic targets, and technologies have contributed to an expanding role for DBS in the treatment of other movement disorders such as dystonia and Tourette syndrome as well as for other neurologic disorders such as epilepsy and cluster headache. Early experience has also been reported for psychiatric syndromes, such as obs- sive–compulsive disorder and depression. Experience with DBS in psychiatric disorders is very limited but is reviewed in this volume as neuropsychiatric indications are expected to grow in coming years. Because of the rapidly increasing application of DBS for neurologic and psychiatric indications and the recruitment of increasing numbers of neu- logic, neurosurgical, and psychiatric clinicians to the field, it is appropriate to provide a resource that updates the underlying scientific background, describes methodologies and standards of treatment, and provides information on new technologies essential for clinical success and to advance the field. Deep Brain Stimulation in Neurological and Psychiatric Disorders begins with reviews of the functional anatomy and physiology of motor and nonmotor aspects of the basal ganglia and their connections, which underlie the application of DBS to neurological and psychiatric disorders.

Several antiepileptic drugs (AEDs) now have regulatory indications for treating bipolar disorder. There is growing evidence that AEDs in general have a variety of useful psychotropic effects. Antiepileptic Drugs to Treat Psychiatric Disorders is the first comprehensive, clinically oriented reference on the use of AEDs to treat a variety of psychiat

The prevention, diagnosis and treatment of stress-related disorders are major challenges across medical disciplines. Reasons include a missing covariance between the psychological and physiological stress response and a tremendous intra-individual complexity of disease-related factors, resulting in a broad inter-individual heterogeneity of pathogenetic mechanisms. This book introduces ‘Neuropattern', a new concept that attempts to assess the activity of neuroendocrine interfaces participating in the communication between the brain and the body during stress. This approach allows close examination of the causal mechanisms behind stress-related disturbances and diseases, thus enabling individualized preventive and therapeutic interventions. This publication provides clinicians, researchers and students from the fields of psychiatry, psychology, neurobiology and psychoendocrinology with an excellent overview of how knowledge from basic psychobiological research can be translated for the benefit of their patients.

Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this

about the bookStanding alone as the first definitive and comprehensive book on the subject, this guide describes the most recent studies on the brain-gut connection and psychosocial issues related to patients experiencing visceral pain. Bringing together leading experts from the top-tiers of the science, this source provides 33 engaging ch

Psychische Störungen verstehen! In den letzten Jahrzehnten ist das Wissen um die neurobiologischen Grundlagen psychischer Störungen geradezu explodiert. Neurowissenschaftler, Psychiater und Psychologen sind auf dem Weg, gemeinsam die Geheimnisse rund um das Gehirn zu entschlüsseln. Und nur wer die Grundlagen kennt, kann auch verstehen, wie und warum sich psychische Störungen entwickeln. Die erste Auflage der'Neurobiologie psychischer Störungen'ist ein Meilenstein in der deutschsprachigen Fachliteratur. Das Buch bietet Ihnen Top-Herausgeber und Autoren sowie interdisziplinäre Autorenteams. Jede Störung wird sowohl von der psychiatrisch-neurowissenschaftlichen als auch von der psychologischen Seite beleuchtet. Die neuesten Entwicklungen und Erkenntnisse werden dargestellt. Im ersten Teil werden die Grundlagen der Neuroanatomie, Neurophysiologie und Neuropharmakologie aufgezeigt. Der zweite, störungsspezifische Teil behandelt sämtliche psychischen Störungen von A wie Affektive Störungen bis Z wie Zwangserkrankungen. Die'Neurobiologie psychischer Störungen'ist beides: Eine hervorragende Einführung und DAS Referenzwerk für alle Aspekte der modernen Psychiatrie.

Functional imaging has the capability to reveal changes in the pathophysiology of tissues and organ systems, mapping the progression and severity of disease, uptake of drugs, and the recovery of tissues following trauma, disease episodes or surgery. In this authoritative new work, leading specialists in neurology and neuroimaging present an update

Animal models of neuro- and psychopathological states in humans are an indispensable part of both experimental neurology and biological psychiatry. Written by a team of experts, this book provides an up-to-date detailed overview of the current approaches to the design of viable animal models for eight prominent neuropsychiatric diseases. The book is specifically written with the research-oriented reader in mind — both in academia and the pharmaceutical industry. It contains first-hand information on how to design viable animal models for Alzheimer's disease, epilepsy, Huntington's disease, Parkinson's disease, addiction, depression, fear and anxiety, and schizophrenia. Each chapter also critically discusses the limitations of the animal experimental approach towards an understanding of human neuropsychiatric disorders.The book is an essential source of reference for researchers who seek to successfully continue and elaborate the experimental work that will finally lead to a better understanding of the neurobiological basis of the diseases, as well as to an improvement of both diagnosis and therapy.

Durch bildgebende Verfahren haben in den letzten Jahren einen enormen Zugewinn an Erkenntnissen über die Ursachen und die Pathophysiologie schizophrener Störungen sowie der Wirkungsweise der Medikamente, die zu ihrer Therapie benutzt werden, ermöglicht. Dieses Buch fasst den aktuellen Kenntnisstand zusammen. Dabei werden für alle wichtigen Verfahren (strukturelle Bildgebung, funktionelle Magnetresonanztomographie, Magnetresonanzspektroskopie, Positronen-Emissions-Tomographie) nicht nur die neuesten Forschungsergebnisse diskutiert, sondern auch die methodischen Grundlagen dargestellt. In einem eigenen Kapitel werden die Querverbindungen zu den Fortschritten in der Molekularbiologie schizophrener Störungen aufgezeigt. Erstmals ist in diesem von international ausgewiesenen Experten verfassten Buch das aktuelle Wissen über schizophrene Störungen, wie es mit modernen bildgebenden Verfahren gewonnen wurde, komprimiert verfügbar. Zahlreiche Farbabbildungen und fachkundige Erklärungen machen dieses Buch zu einem Standardwerk für Psychiater und Psychotherapeuten, Ärzte, die sich in diesen Fachrichtungen weiterbilden, Psychologen mit neurobiologischem Interesse und für Menschen, die mit Patienten mit schizophrenen Störungen arbeiten und mehr über die Neurobiologie dieser Störungen wissen möchten.

Many patients referred for an epilepsy evaluation actually suffer from one of many conditions that can imitate it. Imitators of epilepsy are a diverse group that involve consideration of many areas of internal medicine, neurology, and psychiatry. The most important imitators of epileptic seizures are dizziness, vertigo, syncope, complicated migraine; and somewhat less frequently sleep disorders, transient cerebral ischemia, paroxysmal movement disorders, endocrine or metabolic dysfunction, delirium, psychiatric conditions or transient global amnesia. Clearly under-recognized are hyperventilation episodes, panic attacks, and other psychogenic and psychiatric paroxysmal disorders that may simulate epileptic seizures. This volume provides a comprehensive review of the differential diagnosis of seizures: how do the imitators of epilepsy present clinically, what are their particular distinguishing historical features, and what tests are helpful with diagnosis?Expanding beyond the first edition, this second edition is divided into four sections. The first deals with an introduction and approach diagnosing spells, the electroencephalography of epilepsy and its imitators, and specialized tests of diagnosis such as measurement of serum prolactin. There are chapters on epileptic seizures that do not look like typical epileptic seizures, and conversely, apparent epileptic seizures that are not. A second section approaches imitators of epileptic seizures along age-based lines; i.e., what sorts of spells are likely to beset infants, children, or the elderly? A third section addresses individual imitators of epilepsy, ranging from the common to the rare, from dizziness and faintness to startle disease, arranged according to whether they might simulate partial, generalized, or both types of epileptic seizures. The volume finishes off with hyperventilation syndrome, psychogenic seizures (with or without epilepsy), and panic disorders. Most chapters review the basic definitions and physiology of the respective imitator, followed by the clinical characteristics. Emphasis is given to those features that may differentiate it from an epileptic event, but also mark it for what it is, and give possible criteria for an alternate diagnosis. Case vignettes are used to illustrate particular aspects, along with tables that compare and contrast phenotypically similar conditions. Based on their extensive clinical experience, the authors provide a personal perspective on diagnosis and treatment.

Das Frontalhirn – wesentliches anatomisches Korrelat menschlichen Geistes und seiner Erkrankungen Höhere kognitive Leistungen sind ohne Frontalhirn nicht denkbar, psychische Störungen ebensowenig. Die aktualisierte und erweiterte Neuauflage vereint die neuesten Erkenntnisse über die Funktionen des Frontalhirns und seine fundamentale Bedeutung für neuro-psychiatrische Erkrankungen. Neu aufgenommen in die 2. Auflage:'Theory of Mind'Psychosomatische Aspekte: Alexithymie, chronische Schmerzen Motion und Emotion: Morbus Parkinson, Depression Zwangsstörungen Alle Beiträge wurden gründlich überarbeitet, aktualisiert und spiegeln den neuesten Forschungsstand wider. State-of-the-art für alle, die es genauer wissen wollen!

This reference text provides an insightful and unified synthesis of cognitive neuroscience and behavioral neurology. The strong clinical emphasis and outstanding illustrations will provide neurologists, psychiatrists, neuropsychologists, and psychologists with a solid foundation to the major neurobehavioral syndromes. With backgrounds in behavioral neurology, functional imaging and cognitive neuroscience, the two authors are in an ideal position to cover the anatomy, genetics, physiology, and cognitive neuroscience underlying these disorders. Their emphasis on therapy makes the book a'must read'for anyone who cares for patients with cognitive and behavioral disorders.

Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.

This is the long-awaited successor to Jeffrey Cummings'classic work, Clinical Neuropsychiatry, published in 1985. That book represented an integration of behavioral neurology and biological psychiatry into a single volume devoted to explicating brain-behavior relationships. It was clinically oriented and intended for practitioners caring for patients with neuropsychiatric disorders. The new title reflects the authors'effort to link the recent explosion of new information from neurochemistry, neuroanatomy, genetics, neuropharmacology, neuropathology, and neuroimaging to the clinical descriptions. Yet the clinical emphasis of its predecessor has been maintained. Each chapter has a consistent approach and the book as whole provides a practical, easy-to-use synthesis of clinical advice and basic science. The volume is enhanced by 4-color images throughout. It is intended for students, residents, fellows, and practitioners of neurology, psychiatry, neuropsychology, and cognitive neuroscience. It will also be of interest to individuals in neuroimaging.

An A-to-Z look at these crippling disorders!Compiled by one of the foremost researchers in the field of immunology, The Concise Encyclopedia of Fibromyalgia and Myofascial Pain is an A-to-Z summary of current knowledge that updates patients and health care professionals on these disabling clinical disorders. This vital information has been organized in an easy-to-use format that lets you become familiar with highlights of the most relevant topics.The Concise Encyclopedia of Fibromyalgia and Myofascial Pain gives you immediate access to the latest advances in rheumatology, cardiovascular medicine, endocrinology, epidemiology, immunology, infectious diseases, neurology, psychiatry, and psychology that form the basis for new lines of research and therapeutic intervention. This comprehensive reference summarizes information published mainly in the last decade, providing a thoughtful and balanced resource that will educate and increase awareness of these often-misdiagnosed disorders.The Concise Encyclopedia of Fibromyalgia and Myofascial Pain allows easy access to: relevant case study findings, summarized to provide the answers you need evidence-based alternative medicine approaches pertinent findings on related disorders an extensive bibliography Comprehensive and thorough, The Concise Encyclopedia of Fibromyalgia and Myofascial Pain gives you the information you've been looking for on these painful disorders that affect more than six million Americans. This important book gives health care professionals a greater understanding and awareness of fibromyalgia and myofascial pain and gives patients help at their fingertips.

The authors of this book developed the only clinical neurochemistry laboratory equipped routinely to assay all circulating neurotransmitters. These parameters have been measured in more than 20,000 normal, severely diseased, depressed, stressed and psychosomatic patients. The results obtained have been published in more than 100 scientific papers. The authors postulated the existence of at least three well-defined types of pathophysiologic profiles: (1) endogenous depression, (2) dysthymic depression, and (3) uncoping (maladapted) to stress. Being aware of them, clinicians can prescribe distinct neuropharmacological therapies. The first and third profiles are also registered in Th1 and Th2 autoimmune diseased patients, respectively. The first part of the book is devoted to the outline of these central neurocircuitry functions during the wake-sleep cycle in normal subjects as well as depressive states, uncoping stress, psychotics, bipolar disorders and panic attacks. Due to these neuroautonomic and neuroimmune interactions being noticed, various neuropharmacological therapeutic approaches can be referred to. In a second part the authors present treatments able to cure or help improve diseases presenting with a Th1 autoimmune profile as well as a Th2 autoimmune profile. (A Karger''Publishing Highlights 1890–2015''title.)

Our scientific approach to depression depends on the theoretical framework available for depression and its etiology, and on the tools we have to investigate brain function. The implication of this means that models of depression will change with time. This book brings together recent updates on the main themes of depression research, presented by active researchers. One major advance has been in brain imaging. Consequently five of the chapters deal with this method, either by examining brain structure, brain function, or functional neurochemistry. A second topic is the renaissance of psychological approaches, both in terms of the neuropsychology of depression and the use of effective psychotherapy as an important adjunct to pharmacology. Recent years have seen a change from one-neurotransmitter explanations to delineating complex relationships and interaction. One such interaction, that between stressm hormones and serotonin, is explored in this volume. Finally, the role of behavioral animal models is discussed. This book will be of immense value to researchers working in the field, as well as clinicians and trainees in understanding the rationale of new diagnostic and treatment approaches. Biologists, pharmacologists and physicians will also benefit from the data on current depression research.