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This book covers the use of nanomedicine in the delivery of neuroprotective agents, including pharmacological drugs, stem cells, neurotrophic factors, monoclonal antibodies and enzymes to induce greater beneficial effects in neurologic diseases. Thus, the main purpose of the book is to explore the delivery of drugs either alone or in combination with stem cells to enhance neuroprotection in neurological diseases. Brain pathology associated with acute trauma such as head injury and brain blast injury can also be managed using novel treatment strategies. In addition, emphasis is made that standard patterns of brain pathology may be complicated with multiple comorbidity factors where one agent alone is not sufficient to induce brain protection. Enzymes and antibodies may help in combination and enhance the efficacy when administered through nanotechnology. Progress in Nanomedicine in Neurologic Diseases will encourage further research in the field of neuroprotection, brain injury, neurodegenerative diseases, neuropharmacology, neuropathology, and neurology. Students and researchers along with policy makers, teachers and health care professionals may also benefit from the findings of the book for enhanced patients care.

This practical guide presents approaches to working with children and adolescents with neurodevelopmental disabilities who have sleep problems. Divided into four sections, the book begins with the impact of sleep problems in children with disabilities and the evaluation of sleep complaints. The next two sections cover the major categories of sleep disorders as they apply in children with disabilities, and specific neurodevelopmental disabilities with their characteristic sleep manifestations. The last section details options for treatment, which include behavioral and environmental strategies, occupational therapy, exercise, and medications. Chapters feature case studies that introduce and reinforce diagnostic and therapeutic approaches. Those engaged in the care of children with neurodevelopmental disabilities and sleep problems will find this text to be an invaluable guide when assessing and treating sleep disorders.

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

Trainees in subspecialty of geriatric psychiatry and general psychiatry need to master core competencies in geriatric psychiatry in order to practice. This book is designed to provide short-answer question-based learning centering around the core curriculum topics in geriatric psychiatry and is primarily ideal not only for medical students, residents, and fellows, but also for psychiatrists preparing for re-certification. This book features approximately 300 short-answer questions on geriatric psychiatry topics, each comprising the stem of a brief clinical scenario or concise question with expected number of answers. The book also features detailed teaching notes, graphics, and the respective source references. The format is consistently structured from chapter to chapter, practical and concise, and designed to enhance the reader's diagnostic and management ability and clinical understanding. Each answer includes a concise discussion, pertinent illustrations, and source references. This text is a valuable reference and teaching tool that provides an opportunity for learning across a rapidly growing field. The material covered matches the existing postgraduate curricula in geriatric psychiatry and helps prepare candidates for their specialty and subspecialty certification examinations. The cases map well to both the American Geriatric Psychiatry Association and Canadian Academy of Geriatric Psychiatry as well as other international postgraduate curricula. The book covers main topics within geriatric psychiatry, some such as substance use disorders and sexuality and sexual dysfunction in later life. As the Baby Boomers age, this reference will continue to be a valuable staple in geriatric workforce training. Geriatric Psychiatry Study Guide is the ultimate resource for students, residents, fellows, psychiatrists, psychologists, family practitioners, nurses, social workers,and all clinicians rising to the challenges of the mental health segment of the geriatric workforce.

The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson's disease, Alzheimer's disease. Additionally, melatonin's therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin's antioxidant role in Duchenne's muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.

Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body. In addition to its traditional role as a hormone that stimulates red blood cell production, in recent years many laboratories have shown that EPO can act as a neuroprotective compound in a variety of injury paradigms in the nervous system. Past experience with relatively safety profile of this FDA-approved drug makes it an ideal candidate to take it into clinical trials for neuroprotection. We are on the verge of major clinical trials using this drug for neuroprotection in diseases ranging from stroke, to transverse myelitis to chemotherapy-induced peripheral neuropathy. This is the first book of its kind that brings together researchers from many different disciplines of neuroscience to review the current state-of-the-art in EPO and the nervous system. This book will benefit scientists and clinicians interested in neuroprotection in the broadest sense.