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This book covers the intersections between neurointervention and neurology, neurointervention and neurosurgery, and neurointervention and other specialties. It fills the gap in the literature by placing specific emphasis on appropriate patient selection, preparation, and post-procedural management. Concise and comprehensive, this text covers the increasingly important aspects of the neurointerventionalist profession, as it has moved away from a purely technical role to a focus on clinical care. In addition, the most rapidly expanding area of neurointervention, ischemic stroke, is thoroughly examined in this text, where other texts on this subject fail. It is also meant as a reference for non-neurointerventionalists who may desire to learn more about how their patients can benefit from the therapeutic or adjunctive techniques that the neurointerventionalist can provide. Neurointervention in the Medical Specialties, Second Edition is an essential guide written for neurointerventional specialists from all backgrounds, both in practice and in training

An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

Neurointervention in the Medical Specialties is a first-of-its-kind reference that serves as a bridge between the neurointerventionalist and the physicians who most frequently look to these specialists for answers to some of the most intractable problems they face. Providing background on the wide range of diseases treated through neurointervention along with the indications and alternatives to such treatments, this landmark title is grouped into four parts: an introduction to the tools and anatomical structures that are integral to the field; disease processes most often encountered by neurologists, cardiologists, and vascular surgeons; those diseases more frequently treated by neurosurgeons; and finally those diseases first seen by several other specialties including ophthalmologists and head and neck surgeons. Importantly, each chapter includes details of neurointerventional technique and case discussions that are sufficiently detailed to provide a treatment template and guidance to neurointerventionalists in training and practice. At the same time, the descriptions provide referring physicians with insight into how neurointerventional procedures are performed. Finally, there are several concluding, thought-provoking chapters that examine what new opportunities await the field of neurointervention on the horizon. Neurointervention in the Medical Specialties is a major contribution to the literature and invaluable resource for all clinicians and researchers interested in this exciting field.

Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

The first edition of Seizures in Critical Care: A Guide to Diagnosis and Therapeutics, which appeared in 2005, filled an important need in the ar- mentarium of the neurological, neurosurgical, and medical intensivists who deal with seriously ill patients in the ICU setting. Unlike epilepsy, as it u- ally presents in the outpatient department, seizures in ICU patients are nearly always secondary phenomena that signify that something is seriously amiss in very ill patients with primary medical or surgical disease. The job of the int- sivist is to identify the cause of the seizure or seizures, examine the myriad of potential contributing factors, and provide appropriate management and tre- ment that takes all aspects of the patient's illness into consideration. As in the first edition, Dr. Varelas and his associates recognize the extreme importance of prompt recognition, diagnosis, and sophisticated management of seizures in this group of seriously ill patients. Dr. Varelas has now recollected his group of contributors and produced a new and up to date compendium of what one needs to know in order to work effectively in this difficult and demanding area. A welcome addition to the new edition is the chapter by Friedman and Hirsch on the role of continuous monitoring in the ICU which is essential for the diagnosis and treatment of nonconvulsive seizures as these may be the most common form of seizures in this setting but are often missed in the evaluation of patients in stupor or coma.

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette's syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition,'The Dopamine Receptors'serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.

Over the past three decades, carotid artery stenting has evolved to become a promising and viable alternative to carotid endarterectomy, especially for patients deemed to have high surgical risks. In Carotid Artery Stenting: The Basics, Jacqueline Saw and a panel of international experts on carotid artery stenting discuss in depth the details of all contemporary aspects of carotid stenting, while reviewing supporting studies, guidelines, technical perspectives, and peri-procedural management. This textbook serves as a learning resource on the multifaceted management of patients with carotid artery stenosis, with the key focus on extracranial carotid artery stenting. Additional sections detail the specifics of setting up and maintaining a laboratory and discuss the preparation of the carotid artery stenting procedure from both the patient and operator's perspective. Authoritative and highly practical, Carotid Artery Stenting: The Basics is an accessible guide and valuable resource for today's cardiologists, radiologists, and vascular surgeons.