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Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology.Volume 10 of the series continues to present novel information about new and interesting approaches to treat common neurological disorders, with a focus on neurodegeneration and pain medicine. The volume presents 7 detailed reviews in total.- Neurodegenerative disease: prevention and treatment through plant extracts therapy- Emerging novel approaches and recent advances in Parkinson`s disease treatment and diagnosis- Neurotrophic factors to combat neurodegeneration- Neural bases of executive function in ADHD children as assessed using FNIRS- Modulation of mesenchymal stem cells, glial cells and the immune system by oligodeoxynucleotides as a novel multi-target therapeutic approach against chronic pain- Chronic pain: focus on anticonvulsants- A review of the impact of testosterone on brain and aging-related decline in brain behavioural function

This book highlights the importance of investigating for ADHD in adults with attention difficulties, poor memory and executive function impairments. The authors advocate a neurodevelopmental assessment approach in all phases of life, and explain how to perform such assessments. The identification of ADHD in adults with other psychiatric and neurological disorders will lead to a better response to treatments, and as a result reduce its social, economic and personal burden. ADHD can no longer be considered solely a pediatric condition, as it occurs in a significant proportion of adults worldwide. However, ADHD in adults is often unrecognized and untreated. Diagnosing the disorder in adulthood is a challenge, due not only to the different clinical presentation in this phase of life, but also to the fact that other conditions may mask the symptoms. ADHD constitutes a hidden comorbidity with a detrimental impact of those affected, and a poor response (or even non-response)to several treatments. Intended for psychiatrists, neurologists, specialists in gerontology and neuropsychology, this book is an indispensable resource for all mental health practitioners who want to optimize the treatment of patients affected by psychiatric and neurological disorders who respond poorly to standard treatments.

This is one of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The normative volume focuses on neurology, biology, genetics, and psychology of normative cognitive development. It covers the development of intellectual abilities, visual perception, motor function, language, memory, attention, executive function, social cognition, learning abilities, and affect and behavior. The book identifies when and how these functions develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) - Summarizes research on normative neurocognitive development - Includes intellectual abilities, language, memory, attention, motor function, and more - Discusses genetics and environmental influences on development - Provides interdisciplinary information of use to both researchers and clinicians

Neuropsychological Evaluation of the Child: Domains, Methods, and Case Studies, Second Edition, is an updated and expanded desk reference that retains the first edition's organizational structure, strong practical focus, and lifespan developmental perspective. It is a unique compilation of published and unpublished pediatric neuropsychological test normative data that contains extensive discussion of assessment methods and case formulation. Added for the first time are instructive clinical case vignettes that explicate brain-behavior relationships in youth, from preschool-age through adolescence. These cases illustrate immediate and late effects that result from common and rare medical diseases and psychological disorders, and highlight key issues that arise when examining a child's maturational trajectory and brain-behavioral relationships using convergence profile analysis. Part I, Child Neuropsychology: Current Status, contains four introductory chapters regarding definitions, education and training, and professional roles; reasons for referral; typical and atypical brain development; and clinical practice considerations. In Part II, Clinical Issues, discussion covers the procedural steps of neuropsychological assessment, behavioral assessment techniques, observational data, and oral and written communication of results. These chapters are followed in Part III, Domains and Tests, by extended coverage of topics and tests related to the major neuropsychological domains: intelligence, executive function, attention and processing speed, language, motor and sensory-perceptual function, visuoperceptual, visuospatial and visuoconstructional function, and learning and memory. A final chapter addresses deception in childhood, reasons why a child might reduce effort and invalidate assessment, and the use of performance validity tests, symptom validity tests, and embedded validity indicators to assess noncredible effort. Each of the 16 chapters includes definitions, theoretical concepts, models, and assessment techniques that are essential knowledge for clinical and research pediatric neuropsychologists.

This book presents comprehensive coverage of the RASopathies, one of the largest known recognizable patterns of malformation syndromes, affecting approximately 1 in 1,000 people. These syndromes include neurofibromatosis type 1, Noonan syndrome, Noonan syndrome with multiple lentigines, Costello syndrome, cardio-facio-cutaneous syndrome, Legius syndrome, capillary malformation-arteriovenous malformation syndrome, SYNGAP1 syndrome and central conducting lymphatic anomalies. Noted physician and authority Katherine Rauen and an assembly of the top international experts present detailed discussions of both the science and clinical implications of these fascinating disorders. The major topics covered in this book include the syndromes and genes, the RAS pathway, phenotypic features, animal modeling and treatments. The book will appeal to a wide audience, including clinicians and basic scientists alike such as medical geneticists, genetics counsellors, oncologists, neurologists, cardiologists, dermatologists, behavioralists, orthopedists, ophthalmologists, neuroscientists, RAS biologists, and signal transductionists. This book is also intended for advocate leaders, trainees, and families with RASopathies.

Nesta quarta edição de Condutas em Neurologia Infantil, a colaboração entre duas importantes instituições, Unicamp e UnB, permitiu a atualização de grande parte dos tópicos das edições anteriores. Esta nova edição reforça a importância da semiologia como base, aprofunda diversos temas e inclui conteúdos inéditos, especialmente nas áreas de neurogenética e transtornos do neurodesenvolvimento, refletindo de forma mais precisa a prática clínica atual da especialidade. Organizado em tópicos e com uma abordagem prática, o principal objetivo deste livro é apoiar a conduta clínica diária em Neurologia Infantil, tanto em ambientes hospitalares (pronto-socorro, enfermaria, UTIs) quanto em contextos ambulatoriais. Sem a pretensão de esgotar os temas abordados, sua finalidade é oferecer orientações iniciais e guiar o manejo de casos neurológicos na faixa etária infantojuvenil. Trata-se de um livro de consulta pensado para integrar o dia a dia dos profissionais, como uma ponte entre o que a teoria ensina e o que a prática revela e exige. Destinado principalmente a neurologistas infantis, pediatras, neurologistas e neurocirurgiões, também é de interesse para estudantes de graduação e pós-graduação em Medicina, bem como para profissionais de outras áreas da saúde, que buscam uma fonte de aprendizado nesse campo científico tão vasto quanto desafiador.

This book focuses on the clinical and preclinical research on traumatic brain injuries where age at time of injury (young versus aged) reveals both parallel and divergent findings at the molecular, cellular, and behavioral levels with insights into alterations in brain structure and function and the implications for recovery. The authors address the hurdles that have been overcome, consider new directions inspired by the most recent research, and the value of data sharing and evidenced based-practice. Traumatic Brain Injuries: Tackling the Unique Terrain of the Injured Young and Aged Brain explores the challenges imposed by an injury that not only causes tissue damage but disrupts brain development and may incite pathological events in the aging brain. With the proliferation of the research literature in traumatic brain injuries, this is the time for a book that surveys the landscape and assesses where the field is headed and what is needed moving forward.

How to Live Well with Dementia: Expert Help for People Living with Dementia and their Family, Friends, and Care Partners provides an array of essential guidance about the different aspects of dementia for all whose lives are touched by dementia, including people living with dementia and their support network.Following an effective Q&A framework, this book offers valuable, easy-to-navigate guidance on the burning questions that those living with a dementia diagnosis and their carer/supporter need to know. Questions addressed include ‘How can I adjust to life with the diagnosis?', ‘How can I plan for the future?', and ‘How can we support our loved ones living with dementia?'. It provides expert explanations about changes in the brain and the various causes and types of dementia, as well as support on how to adjust to living with a diagnosis. It also offers practical information about care planning and advanced directives, maintaining health and social connections, accessing appropriate community care, and supporting medical and hospital care. It concludes with important self-care information for care/support partners.Written jointly by academic experts and experts through lived experience, this book is indispensable for people living with dementia, care partners, and anyone wanting to understand more about the condition, as well as health and social care professionals and students of health and social care.

This book will provide a concise, focused overview of methods of neurological examination, enabling a focused clinical approach for localization in patients with neurological disorders. Chapters provide a systematic approach for clinical examination along with essential aspects of the neuro-anatomy to provide specific information about disease localization. This book assists medical students pursuing DM/DNB- Neurology, MCH -Neurosurgery, MD/DNB- Internal medicine, MBBS students, and Clinicians, including Neurologists, Neurosurgeons, Internal medicine physicians, and other neuro-scientists. It provides a unique opportunity to formulate correct concepts for clinical neurological examination and hence localization but also provides the opportunity to quickly revise the entire book in a short time.

Paediatric Neurology returns for a fourth edition with all the knowledge and guidance you need to investigate, diagnose, and treat common and rare neurological conditions in paediatrics. This unique guide has been fully updated to reflect the latest developments in the field, including a more in-depth look at genetic investigations, new material on neuroinflammation and neuromuscular disorders, extensive updates on epilepsy and other neurology conditions affecting children, and a fully revised pharmacopoeia. Vibrant and informative, the text includes diagrams and tables to enhance understanding and learning, while keeping the book firmly grounded in situations you are likely to encounter in real life. Part of the Oxford Specialist Handbook series that spans the whole of Paediatrics, this unique guide should be at the fingertips of every practising or aspiring paediatric neurologist.

This book provides clinicians with a comprehensive resource on the topic of respiratory complications of neuromuscular disease. It includes chapters by neurologists, pediatric pulmonologists, adult pulmonologists, anesthesiologists, and sleep physicians. The book begins with a review of the pathophysiology and epidemiology of the neuromuscular diseases that affect the respiratory system. It then includes chapters on pediatric concerns and the transition from pediatric providers to adult providers. There is additionally a focus on various therapeutic approaches and the monitoring of noninvasive ventilation. Finally, it includes a chapters on secretion clearance, palliative care and end of life decision making. The book appeals to a broad medical audience including adult pulmonologists, pediatric pulmonologists, respiratory therapists, nurses, sleep medicine providers, and neurologists.

This new book extensively explores a range of topics related to astrocyte-neuron interactions under multiple conditions, in both health and disease. These include the types of interactions that occur during development and the establishment of neuronal circuits that underlie learning and memory formation in various animal models as well as humans. Furthermore, the book addresses topics on how these interactions go awry in disease and injury. In addition, the authors propose inspiring new avenues to explore therapeutic approaches using astrocytes as targets. A cadre of international experts presents a broad range of views on the state-of-the-art of astrocyte-neuron interactions.

This book is focused on how understanding ourselves as humans is incomplete without considering both biological and cultural aspects. Using the neurocultural perspective, the book explores how everything in the world is filtered back and forth through the brain and culture. The thrust of the book, therefore, is to explore the power of art in creating a bridge between cultural and neuroscientific lines of inquiry. Looking at both clinical and non-clinical populations, the text examines historical foundations, distinguishes congenital/developmental conditions from those that are acquired, and emphasizes how the brain constructs our sensory experiences. Several distinctive features separate this research from other publications. First, the book opens with a review of how the historical literature is still etched into the ideas we employ to explain elements across the interdisciplinary fields of art, aesthetics, our sensory experience, psychology, cognition, and well-being. Second, the research adopts a humanistic rather than a philosophical or social science perspective in demonstrating the value of coupling anatomy and physiology with the natural and social environment. In this, artists from all genres are incorporated. Among them are Iris Murdoch, Ludwig van Beethoven, Leonardo da Vinci, Cristoforo de Predis, Rembrandt, Federico Fellini, Chuck Close, and David Hockney. Case studies demonstrate how neuroscientific research meshes with art, individual, and cultural variables in ways that range from health and well-being to physiological decline and biological traumas. These include a case study that examines how Oliver Sacks combined biology and biography in his writings. It also explores art projects in several genres inspired by his studies. Another case study is on the role of film as a useful clinical tool. Here the book also demonstrates that cinematic devices used by filmmakers intersect with perceptual and cognitive neuroscience. A defining feature of the analysis is the integration of research on brain injuries with humanistic responses in film, literature, and the visual arts. This section outlines the lack of consensus regarding the causes and treatment of “shell shock” in World War I before introducing how research and art now work with PTSD/TBI. Finally, the book examines therapeutic cases of professional and non-professional artists, concluding with a discussion of synesthesia and the senses.

Designed to be a practical reference guide, chapters succinctly provide a current overview of the relevant area while concise enough to be read in a single sitting. All of the major co-morbidities of epilepsy are reviewed, as well as the impact of anti-epileptic medications and other therapies. In addition, a specific chapter about older patients with epilepsy is also included. This book supplies the reader with a deeper understanding of the relevant co-morbidities in epilepsy as well as providing insights into strategies to help in the holistic treatment of patients. While primarily UK-focused it will also be of interest to medical/nursing practitioners around the globe, including in the developing world, and to epilepsy charities and interested lay- readers/patients.

This innovative book offers a multidimensional exploration of the epistemological foundations of psychiatry and its major disorders. By emphasizing the importance of phenomenology in unravelling the intricate interplay between basic categories of human experience and neurobiological processes, it advocates for a shift in both psychiatric research and clinical practice. Phenomenological Neuropsychiatry presents psychiatry as a hybrid discipline that synthesizes subjective mental experiences with objective neuroscientific findings and forms an integrative and interdisciplinary structure that provides a dialectical bridge between understanding, compassion, and explanation. The first section of the book presents the lived experience of psychosis and argues for a more inclusive approach to mental health issues. The second section examines the ways in which psychiatric knowledge is constructed and the unique challenges posed by combining understanding and explanation of mental disorders. Section three sheds light on how disruptions in bodily experiences, memory processes, and self-perception can contribute to the development and manifestation of psychiatric issues. The following section discusses disorders of mood and anxiety, including the phenomena of depression, obsessions, and depersonalization. The fifth and final section provides an in-depth examination of psychotic disorders. It covers a range of topics, such as timing, intentionality, self-monitoring of action in schizophrenia, and the neurobiology of prodromal psychosis. As a singular work dedicated to revitalizing and advancing cross-fertilization between psychiatry and phenomenology, this groundbreaking book clears the foggy operationalized clusters of mental symptoms that may obscure diagnosis and treatment and argues for systematic integration of patient subjectivity and collaboration in clinical research. It features an authorship of the leading clinicians and thinkers from throughout the world in psychiatry, psychology, neuroscience, social sciences, and philosophy. Phenomenological Neuropsychiatry: How Patient Experience Bridges the Clinic with Clinical Neuroscience is a major contribution to the clinical literature and a must-read for psychiatrists, neurologists, psychologists, and professionals and students from other disciplines concerned with absorbing a deeper understanding of psychiatric disorders.

Unveil the next frontier in neurodegenerative disorder research with Integrating Neuroimaging, Computational Neuroscience, and Artificial Intelligence. This groundbreaking book goes beyond traditional approaches, utilizing the power of interdisciplinary integration to illuminate new pathways in diagnosis and treatment. From AI-driven diagnostics to computational neuroscience models, this book showcases the forefront of innovation. Join us in exploring the future of neurodegenerative care, where collaboration and cutting-edge technology converge to redefine possibilities.Key Features: Integrates diverse fields of research, from neuroimaging to computational neuroscience and Artificial Intelligence. Emphasizes the translation of research findings into practical applications, ultimately benefitting patients and clinical practice. Reviews the implementation of Artificial Intelligence and computational models in diagnostic settings. Elucidates the current state of translational neuroscience exploring potential areas for further research and collaboration, including personalized treatments and drug development. Contributions from an international team of experts from diverse disciplines.

Advances in Alcohol Use Disorder Treatment, Volume 178 in the International Review in Neurobiology series, presents a comprehensive exploration of emerging therapies and approaches in the field. Topics in this new release include Introduction: Current Treatments, Oxytocin and Vasopressin, Neuroactive steroids, Pharmacological activators of ALDH2, Anti inflammatories and mesenchymal stem cells, Sodium oxybate, Psychedelic compounds, Cannabinoids, Environmental Enrichment, Animal models and translational challenges, GABAergic compounds, and Ghrelin system and GLP-1. - Explores neurobiological, pharmacological, and unconventional modalities for treating AUD - Integrates insights from leading experts, bridging pre-clinical and clinical viewpoints - Investigates new compounds and cutting-edge research in AUD treatment

This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read at Oxford Academic and offered as a free PDF download from OUP and selected open access locations. Jasper's Basic Mechanisms of the Epilepsies has served as the definitive reference in the field of basic research in the epilepsies for five decades through four well-regarded editions. Since its inception, the book has been an indispensable must-read and belongs in the hands of every experimental epilepsy investigator, practicing epileptologist, clinical neuroscientist, and student for both clinical and basic science reference, doctoral and board exam preparation. This fifth edition is the most ambitious yet and remains the definitive reference in the field, providing encyclopedic and updated coverage of the current understanding of basic research in the epilepsies, while also mapping new research directions for the next decade, and reviewing how molecular laboratory evidence is now being translated into new therapeutics. In 79 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility and, ultimately, their contributions to epileptogenesis. It provides a framework for expanding the monogenic epilepsy genome and understanding the complex heredity responsible for common epilepsies. It explores the molecular and cellular disease mechanisms of ion channelopathies, developmental epilepsy genes, and progressive myoclonic epilepsies. It considers newly emerging mechanisms of epilepsy comorbidities. And, for the first time, it describes current efforts to identify biomarkers of disease progression and translate discoveries of epilepsy disease mechanisms into new therapeutic strategies at the frontier of molecular medicine.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in neurology and allied disciplines.The twelfth volume of this series features these reviews:Chapter 1: Recent Drugs Tested in Clinical Trials for Alzheimer's and Parkinson's Diseases Treatment: Current Approaches in Tracking New DrugsChapter 2: Neurobiology of Placebo: Interpreting Its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in TherapeuticsChapter 3: Role of Gut Microbiota in Neuroinflammation and Neurological DisordersChapter 4: The Role of Age in Pediatric Tumors of the Central Nervous SystemChapter 5: Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related ComorbiditiesChapter 6: Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning.

Migraine Management, Volume 196 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable, are also critically reviewed. Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness is also explored. - Summarizes evidence-based best treatment for migraines - Differentiates treatment based on patient population, migraine type, and clinical setting - Includes pharmacological, biobehavioral, and physical treatments - Provides specialized treatments for children, the elderly, and pregnant patients

Over the past few years, there have been fundamental changes in the diagnosing and treating patients with chronic diseases, significantly affecting management of neurological movement disorders. In addition, the health and fitness sector developed several devices to better classify, track, and potentially treat chronic diseases. Both handling and interpreting these large datasets has been revolutionized, by machine and deep learning approaches, leading to new and more effective therapies, resulting in longer survival rates. Handbook of Digital Technologies in Movement Disorders aims to unite these factors to provide a comprehensive guide to patient focused treatments for movement disorders. This book is divided into five distinct sections, starting with an introduction to digital technologies, concepts, and terminologies. The following section reviews various perspectives on technology in movement disorders, including patient and medical professionals. The third section presents technologies used in detecting, measuring progression, and determining response to treatments. This is followed by reviewing the technology used in various treatments of movement disorders including assistive and robotic technologies. Finally, the last section examines the challenges with technology including privacy and other ethical issues. - Reviews different stakeholders'perspectives on technology in movement disorders - Presents technological advancements for diagnosing, monitoring, and managing Parkinson's disease - Discusses challenges with implementing technology into treatment

In the complex realm of our physiology, the vagus nerve stands as a silent orchestrator, influencing health and disease in ways that have long been underestimated. Vagus Nerve Stimulation delves into the profound significance of this 10th cranial nerve, tracing its course through the body and illuminating its role as a vital component of the parasympathetic nervous system. This comprehensive reference, contributed by leading experts at the forefront of medical science, unveils the groundbreaking field of vagus nerve stimulation—a non-invasive approach to harness the body's innate potential for health optimization, inflammation control, and disease modification. Contributed by leading experts in the field, this comprehensive volume serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. This book starts with the foundational insights in Basic Science and Technical Considerations. From there, it continues to Neurologic Conditions, where chapters explore applications for epilepsy, cluster headaches, and concussions. Evolving Therapy for Neurologic Conditions introduces cutting-edge treatments for acute ischemic stroke, synaptic plasticity, and neurodegenerative disorders. The book extends into Psychiatric and Somatic Conditions, providing insights into anxiety, depression, addiction disorders, and more. Conventional Inflammatory Conditions shed light on vagus nerve stimulation's role in combatting sepsis, immune-mediated inflammatory diseases, and metabolic syndrome, among others. Concluding with a foray into Oncology, the book highlights the potential of vagus nerve stimulation in addressing the lingering effects of long covid and migraine. With an authoritative blend of scientific rigor and practical application, this reference serves as an indispensable guide to the vast landscape of vagus nerve stimulation, transforming our understanding of health and wellness. - Translates the basic science of vagus nerve stimulation into real-world clinical applications - Explains VNS anatomy and signaling through central and autonomic nervous system - Reviews VNS treatment of neurological, psychiatric, and inflammatory disorders - Extends clinical utility to cardiac, renal, and metabolic disorders. - Provides new insights to the disorder of vagus insufficiency syndrome - Explores VNS treatment for headaches, TBI, stroke, seizures, and pain.

This Open Access book on Complications in Neurosurgery contains the proceedings of the 2nd ICCN conference held in Mumbai in 2019. The work illustrates and discusses key point of intra- and postoperative complications encountered in brain, spine and peripheral nerve surgery. In addition, this compilation addresses topics in ethics, with further contributions covering medico legal and didactic aspects. It draws from the experience of an international team of experts from all subspecialties in neurosurgery, including oncology, vascular, spine, pediatrics and others. The articles were written by renown specialists in the field who are stepping forward to share their valuable professional experience with colleagues following their joint mission to improve future patient care.

​The second edition of this book explores different aspects of the relationship between hypertension and brain damage, providing readers with up-to-date information that will be of interest to clinicians and researchers alike. In recent years, numerous studies have been published that have added new evidence on different aspects of the disease. New recommendations and the latest hypertension guidelines on stroke and dementia will be described in this edition, which will include not only updated content but also new chapters on aspects that have recently emerged in relation to hypertension and brain damage. After an introductory chapter on the epidemiology and burden of neurological disease induced by hypertension, the significance of various comorbidities that represent risk factors for brain damage in the context of hypertension is discussed. The effects of hypertension on small and large cerebral arteries and the consequences on brain damage are then examined in detail. Similarly, the association between hypertension and ischaemic stroke, transient ischaemic attack and haemorrhagic stroke is explored in depth, and the evidence and guidelines for reducing hypertension during the acute phase of each form of stroke are summarised. Both primary and secondary prevention of stroke are addressed, with the results of major studies presented. The reader will also find interesting new perspectives on the role of different imaging techniques, including CT and functional MRI, in detecting and diagnosing brain damage in patients with hypertension. The concluding chapters examine the relationship between hypertension and cognitive decline and dementia associated with hypertension, its pathophysiology, the detection of cognitive impairment in daily practice, and its prevention and treatment.

Hone your clinical reasoning and diagnostic skills with a new series of case-based topic-specific studies. This compilation of twenty neurology-related cases includes presenting clinical manifestations and a discussion of the broad range of possible diagnoses, with a reveal of the actual diagnosis at the end. Does this child have a classic presentation of a rare condition or an atypical presentation of a common diagnosis? Does the patient have a primary neurological condition or a neurological manifestation of a systemic disease? Several patients in this collection presented with ataxia, but their final diagnoses range from the unsurprising cerebellar tumor to uncommon conditions like heavy metal poisoning and rare genetic disorders. Does the child with diffuse weakness have a classic condition such as Guillain-Barré syndrome, a vitamin deficiency, one of the periodic paralyses, or an autoimmune disorder such as myasthenia gravis? Cases also include relatively new conditions such as autoimmune encephalitis or genetic disorders but remind us not to overlook well-known but now uncommon conditions like vitamin deficiencies or remote neurological dysfunction due to cancer in another organ.

Published in 1997 as the first single-authored book on critical care neurology, The Practice of Emergency and Critical Care Neurology serves as a comprehensive guide to managing all aspects of critically ill neurologic patients. Following patients from the moment they enter the emergency department, this textbook demonstrates how specialists in the neurosciences assume full responsibility for patient care. Edited succinctly for relevance, this book differs from conventional textbooks by following the time course of clinical complexities as they emerge and change, instead of focusing on just the theoretical aspects of the field. Great emphasis is placed on the management of unstable and deteriorating patients. As any patient presents a unique, complex problem, the book pays special care in describing the considerations behind the rapid-fire decisions that comprise the work environment of the neurointensivist. In this new third edition, all chapters have been revised with added information and, in some, new concepts and ideas. Key features of this new edition include: 1. Additional chapters on the basics of neuroimaging and its interpretation; basic pharmacology issues in the intensive care setting (e.g., drug interactions and side effects); intoxications; the principles of critical care ultrasound and its relevance in the NeuroICU and the principles of neuro palliation including neuroethics 2. Rich illustrations using color photos of patients and drawings of important basic concepts of mechanisms in diseases of neurocritical care 3. Fully updated and comprehensive reference list 4. Narrated instruction video of the coma FOUR score

Das Praxisbuch der Neurorehabilitation…… komplett aktualisiert und überarbeitet: Das große Praxisbuch bietet Grundlagen- und Praxiswissen, detailliert, kritisch, verständlich und an den Bedürfnissen der Patienten orientiert – ein rundum alltagstaugliches Arbeitsbuch für Teams, ein Lehrbuch für die Aus- und Weiterbildung. Mit neuen Kapiteln u.a. zu Telerehabilitation und der Umsetzung spezieller Therapieformen wie Virtual Reality, musikgestützte Therapie, Natur und Tiere.Umfassend: Mit ausführlicher Darstellung der Grundlagen und der Tätigkeitsfelder, beginnend von der Behandlung auf der Stroke Unit bis hin zur Rückkehr in Familie und Beruf.Interdisziplinär: Die gemeinsame Ausbildungs ​​– und Arbeitsgrundlage für alle Berufsgruppen, die in interdisziplinären Teams zusammenarbeiten: Ärzte, Pflegekräfte, Physiotherapeuten, Ergotherapeuten, Logopäden, Neuropsychologen, Sozialpädagogen, Musiktherapeuten u.a.Aktuell: Wissenschaftlich, evidenzbasiert, durchgängig mit bio-psycho-sozialer Orientierung und von den Prinzipien der ICF (Internationale Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit) geleitet.Kompetent: Fundiertes Fachwissen aus langjähriger Erfahrung, vermittelt von über 50 renommierten internationalen Autoren (aus Deutschland, Schweiz, Großbritannien, Finnland, USA).Informativ: Auch mit Reflexionen über Themen wie „Kontextsensitive Neurorehabilitation“ „Teamarbeit und Zielsetzung“, „Sexualität“, „ Identität und Biografie“, „Holistische neuropsychologische Rehabilitation“.Leserfreundlich: Leicht zugänglich mitEinheitlicher Aufbau der Kapiteloptischer Textstrukturierung: mit Trailers, Praxistipps, Übersichtsboxen, Exkursen („Näher betrachtet“) und mehr…

This thoroughly revised second edition features a collection of case studies of cerebrovascular disease. The cases are carefully selected to provide an insight into the different kinds of stroke syndromes from the common through to more rare presentations of cerebrovascular pathology. New topics covered include mechanical thrombectomy and advanced imaging techniques which have been developed and brought into clinical practice over the past five years. A range of diagnostically challenging cases are also discussed. Each case is worked through with a discussion on presentation, clinical features, examination, radiological findings and management. Key clinical and radiological learning points are highlighted assisting the reader to quickly extrapolate the most important information covered in each chapter. Stroke Medicine: Case Studies from Queen Square is a detailed case-based resource based-upon the experiences of leading figures in the field. Therefore, itis ideal for use by both medical students and physicians in all stages of training from foundation years through to consultancy who wish to learn more about this subject.

Dieses Buch beleuchtet die Wirkungen von Musik auf Gesundheit, Wohlbefinden und Lebensqualität aus der Sicht interdisziplinärer, musikwissenschaftlicher und medizinischer Forschung. Hochrangige Expert•innen aus vielfältigen Fachgebieten stellen die wissenschaftlichen Grundlagen für medizinische, therapeutische, pädagogische und andere Anwendung vor. Inhaltlich spannt es den Bogen von den psychophysiologischen Grundlagen emotionaler Wirkungen des Musikhörens bis hin zu musikmedizinischen und -therapeutischen Interventionen. Musik erweist sich vielfach als äußerst wirksame, nahezu nebenwirkungsfreie und vergleichsweise kostengünstige unterstützende Strategie für Prävention, Therapie und Rehabilitation in vielen medizinischen Fachbereichen.Ein breites Spektrum musikalischer Aktivitäten einschließlich Musikhören, Laienmusizieren, Chorsingen, Tanzen und verschiedene Formen musiktherapeutischer Strategien steht den Erfordernissen unterschiedlicher Zielgruppen, individuellen Unterschieden, Vorlieben und kulturellen Hintergründen gegenüber. Die Neuauflage wurde aktualisiert und mit Inhalten zu COVID 19 und einer neuen Sektion zu gesundheitlichen Belastungen durch Musik erweitert.Ärzt•innen und medizinisches Personal in Sozial- und Pflegeberufen erhalten profunde Informationen über Chancen und Grenzen musikbezogener Angebote. Die Kapitel eignen sich ebenso als Einstiege für Wissenschaftler•innen zahlreicher Fachrichtungen aus Sozial-, Natur- und Geisteswissenschaft.

In spite of great improvements in prehospital, critical care, and surgical management, traumatic brain injury is still a leading cause of death and disability resulting in great socioeconomic burden. This book provides a comprehensive and practical perspective of the management of traumatic brain injury, from prehospital setting to discharge. Even more, the book highlights the importance of pathways (Trauma Center and Neurocritical Care Unit) and the central role of the specialized neurocritical care team and neurological critical care units in the practice of neurocritical care. Encouraging a practical, protocol-driven, multidisciplinary approach for both adult and pediatric patients, the authors provide a methodological description of the diagnostic and therapeutic management of patients with traumatic brain injury throughout the patient journey. Neuromonitoring assumes predominant importance, with an increasing role of noninvasive monitoring (near-infrared spectroscopy, Pupillometry, transcranial color Doppler-TCD, transcranial color duplex-TCCD, and optic nerve ultrasound) and neurophysiology (electroencephalography and evoked potentials) for early recognition of complications and rapid assessment of the effectiveness of medical treatment. However, the increasing amount of data increases the complexity of interpreting the collected information. The basic principles of multimodal monitoring and the computer-assisted method are presented to provide an overview of the future direction regarding the integration and interpretation of different data obtained from various techniques.Paying particular attention to prognosis and treatment-limiting decisions, the authors reviewed the critical role of neurorehabilitation and the clinical and bioethical perspective on brain death, organ donation, and communication with the family.

This collection of epilepsy surgical cases illustrates patients with straightforward and challenging pharmacoresistant epilepsy. These cases convey the advancements, investigative strategies, past and modern surgical tools, and sophisticated state-of-the-art of epilepsy surgery and its disciplines. This textbook is organized into four major sections that parallel the contemporary FDA-approved and clinically applicable approaches: resective surgery, disconnection procedures, laser therapy, and neuromodulation. The chapters provide a case-based, interactive, and multidisciplinary integrative approach to pre-operative evaluation, data analysis, and surgical decision-making. In addition, we present alternative approaches to certain diagnostic tools, decision-making strategies, and surgical interventions.This textbook will provide trainees and clinicians with an exhaustive understanding of epilepsy surgery. Moreover, it will be an invaluable resource for preparation for the epilepsy board examination

This book is a comprehensive resource on acute neurorehabilitation consultations. When a patient first undergoes a traumatic brain or acquired spinal cord injury, an immediate consultation is needed with a rehabilitation specialist. In-depth literature reviews, practice guidelines, and case studies offer in-depth, practical coverage of the complete neurorehabilitation consultation with information on specific testing tools and metrics. The acute care consultant works in concert with other physicians and medical professionals, so throughout the text considerations on how to best organize the team to maximize care is carefully considered. Chapters also explore acute neurological sequelae, including arousal and stimulation, sleep, agitation, spasticity, and seizure prevention, for which an acute care consultant could provide important insight, treatment, and future management recommendations. The book concludes with advice on how to best transition patients from acute to long-term care, including patient prognostication and family education. This is an ideal guide for physiatrists and neurologists aiming to maximize recovery outcomes for their patients.

This revised, expanded third edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. Each chapter now contains teaching/training MCQs to help with retention of information learnt from each chapter and this will be of considerable use to those training or about to the examined inthe field of inherited stroke.Additional questions via app: Download the Springer Nature Flashcards app for free and use exclusive additional material to test your knowledge.

This book primarily aims to assists doctors from non-neuroscience background to acquire knowledge about common neurological disorders encountered in a resource-constrained setup in a case-based and practical approach. The book elucidates the value of proper and systematic approach to the patient, how proper history taking and clinical evaluation, followed by appropriate investigations can narrow down the differential diagnoses and help proper and timely management of the patients.The book covers most of the common neurological disorders and scenarios encountered in clinical practice and will benefit clinicians facing difficult cases, particularly those involving fundamental research and diagnostic methods. This book is useful for physicians working in internal medicine, physicians handling neurology cases in resource-constrained facilities, and fellows in neurology. The contents of this book support and practically enhance the knowledge acquiredfrom other text books.

Machine learning (ML) and deep learning (DL) have become essential tools in healthcare. They are capable of processing enormous amounts of data to find patterns and are also adopted into methods that manage and make sense of healthcare data, either electronic healthcare records or medical imagery. This book explores how ML/DL can assist neurologists in identifying, classifying or predicting neurological problems that require neuroimaging. With the ability to model high-dimensional datasets, supervised learning algorithms can help in relating brain images to behavioral or clinical observations and unsupervised learning can uncover hidden structures/patterns in images. Bringing together artificial intelligence (AI) experts as well as medical practitioners, these chapters cover the majority of neuro problems that use neuroimaging for diagnosis, along with case studies and directions for future research.

In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies.Ion channels are critical membrane bound proteins that underpin many fundamental processes in the central and peripheral nervous system including action potential generation and propagation and the control of neurotransmitter release at all CNS synapses as well as at the neuromuscular junction. Ion channels are consequently essential for all motor actions, cognitive functions and sensory perceptions. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given the fundamental processes that are dependent on ion channel function, it is perhaps unsurprising that genetic or immunologically mediated ion channel dysfunction can result in almost any neurological symptom; patients may present to virtually any subspecialty within both adult and child neurology. The advances that have been made here have not only increased knowledge about the fundamental molecular mechanisms at play, but have also improved our ability to both diagnose and treat many of these disorders in clinical practice. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the Neurological Channelopathies.The book will begin with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations but with potential for common treatment approaches. This initial chapter considers the classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter will consider•Pathophysiological underpinnings - genetic or immunological•Clinical presentations•Diagnostic approach•Treatment and management - Identifies importance of ion channels to CNS & PNS function - Considers the classification, genetics, and physiology of ion channels - Presents all major immunological and genetic channelopathies - Provides clinical presentation, diagnosis, and treatment of channelopathies

This fourth edition offers a practical guide to endovascular treatment of cerebrovascular disease and provides a comprehensive reference for the related neurovascular anatomy and the various disorders that affect the vascular system. Chapters cover fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriateBuilding on the previous edition, the text is presented similarly in style and scope to emphasize accessibility and ease of reading. All chapters are fully updated to include more recent data, and obsolete products and techniques are replaced with the most current technology. Some key updates include:A greater emphasis on the use of radial artery access for the discussed endovascular techniques.The associations of COVID-19 with ischemic stroke and the implicationsof providing care for cerebrovascular patients during a pandemic.An extensive update to the acute ischemic stroke chapter with new references and format to more closely follow the format of other chapters in that section.Expansion of the pediatric sections of disease chapters, including discussions of genetic associations with disease. This is an ideal guide for clinicians and trainees in neurology, neurosurgery and neuroradiology, as well as practicing clinicians in related fields caring for patients with cerebrovascular disease.

••Selected for Doody's Core Titles® 2024 in Psychiatry••Anatomy of Neuropsychiatry: The New Anatomy of the Basal Forebrain and Its Implications for Neuropsychiatric Illness, Second Edition, builds upon reprised classic chapters by Lennart Heimer and Gary Van Hoesen describing the cortical and subcortical structure and functional involvements of several functional–anatomical macrosystems in the human forebrain, the existence of which obviates the vaunted heuristic value of the'limbic system'concept in the study of motivation and emotion. New narrative brings in important historical, philosophical, and histotechnical contexts, integration with novel technologies (e.g., optogenetics) and structures (e.g., rostromedial tegmental nucleus), a deeper dive into the interactions of forebrain and prospective cerebellar macrosystems with the reticular core of the brain, and current viewpoints on the essential role of macrosystems in motion, motivation, emotion, cognition, and neuropsychiatric well-being. - Presents discredited concept of the limbic system - Reviews the neuroanatomy of the basal forebrain, greater limbic lobe, and reticular core - Includes Clinical and Basic Science Boxes highlighting specific concepts, structures, and neuronal circuits from functional and clinical perspectives - Features 10 videos of dissections of human brain done by the late Lennart Heimer

This new edition elucidates the radiation therapy protocols and procedures for the management of adult patients presenting with primary benign and malignant central nervous system tumors. With the development of new treatment strategies and rapid advancement of radiation technology, it is crucial for radiation oncologists to maintain and refine their knowledge and skills. Dedicated exclusively to adult CNS radiation oncology, this textbook explores CNS tumors ranging from the common to the esoteric as well as secondary cancers of metastatic origin. The first half of the book is organized anatomically: tumors of the brain, spinal cord, leptomeninges, optic pathway, ocular choroid, and skull base. The second half covers primary CNS lymphoma, rare CNS tumors, metastatic brain disease, vascular conditions of the CNS, radiation-associated complications, and radiation modalities. This new edition is updated throughout and includes several new chapters, including: palliative radiation therapy for leptomeningeal disease, preoperative treatment for brain metastases, advanced neuroimaging for brain tumors, and MR-LINAC for brain tumors. Each chapter provides guidance on treatment field design, target delineation, and normal critical structure tolerance constraints in the context of the disease being treated. Learning objectives, case studies, and Maintenance of Certification Self-Assessment Continuing Medical Education-style questions and answers are incorporated throughout the book. This is an ideal guide for radiation oncologists, residents, and fellows, but medical students may also find value in the text.

This encyclopedic reference takes into account the status of interventional neuroradiology in the treatment of acute ischemic stroke. It explains and discusses the various options to recanalize occluded extra-and intracranial vessels. The book provides an in-depth description of the different endovascular treatment strategies, including thrombectomy for large vessel inclusion, balloon angioplasty and intracranial atherosclerotic stenosis, and stenting of extra- and intracranial arterial dissections and their conservative treatment, and bypass surgery for subacute and chronic cerebral hypoperfusion. The book also offers tips and tricks for each procedure to enable readers to understand better the benefits and limitations of the endovascular management of ischemic stroke patients. Similarly, it explains the technical aspects of the procedures with their respective pros and cons. Written by respected experts in the field, the book will be a valuable resource for interventional neuroradiologists and neurologists, vascular and endovascular neurosurgeons, stroke neurologists, and other practitioners at all levels of experience.

This Springer Major Reference Work provides a detailed translational overview of neuroimmune diseases for neuroscientists and clinicians, clarifying the pathological mechanisms underlying neuroimmune diseases and building a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The new edition features updated chapters throughout, including coverage of new findings, new diagnostic criteria, and therapeutic algorithms. Neuroimmune Diseases, 2nd edition, also includes new chapters with a translational approach. The book will be invaluable for use in clinical practice of neuroimmune diseases.

The recent high-profile murders of George Floyd, and other African American individuals, along with the prevailing coronavirus disease (COVID-19) pandemic have reinforced the notion that certain marginalized populations have worse health outcomes than other populations, likely due to unequal and unjust policies and practices. Neurological processes and prognoses frequently vary by sex/gender, race/ethnicity, socioeconomic status, and geographic location. In particular, individuals of lower socioeconomic status and from minority racial and ethnic backgrounds have worse neurological health and often receive a lower standard of neurological care. These inequities in neurological outcomes are attributed to wider societal social influences, which impact how people live and how neurology is practiced. Published evidence suggests that healthcare providers and the healthcare system contribute to inequities in neurological care for vulnerable and underserved populations. However, educating neurology care providers about these issues and training them to provide equitable care for these patients can potentially improve neurology care access, delivery, and outcomes. In this book we provide the theoretical background, scientific evidence, and experiential knowledge warranted to properly care for vulnerable, underserved patients with neurological diseases at the levels of the provider and system. This book examines the root causes of neurological health inequities across a broad range of topics and offers possible solutions for achieving neurological health equity. Initial chapters help to frame the overall issue of neurological health equity. Subsequent chapters evaluate neurological health equity from the clinical practice standpoint, with a focus on select populations and subspecialty care delivery settings. Lastly, we discuss the bigger picture with regard to the pipeline of practitioners and purview of policy makers. This text is relevant for neurology residents and fellows, multidisciplinary neurological care practitioners (neurologists, neurosurgeons, advanced practice providers, hospitalists, emergency physicians, critical care physicians, pharmacists, and allied health personnel), and public health researchers and health policy makers. The book is divided into three sections: Principles, Neurological Conditions, and Priorities. The first section establishes the framework and explains various key terminologies and concepts, which undergird the care of vulnerable and undeserved patient populations. The second section, Neurological Conditions, covers key neurological diseases by sub-specialty describing published evidence of care and outcome disparities, gaps in knowledge, practical techniques for bridging these disparities on provider and system levels. The third section, Priorities, identifies important areas of focus and improvement targeting trainees, researchers, community partners, stakeholder organizations and policy makers, which would be crucial for implementing sustained societal-level enhancements in the neurological health of these vulnerable populations.

This extensively updated edition provides a comprehensive review of intensive care for neurologically injured patients from the emergency room and ICU through the operating room and post-surgical period in two comprehensive volumes. The Editors of this second volume present a comprehensive textbook that incorporates best practice/evidence-based medicine and performance improvement, while it champions the three characteristics needed in our neuro–ICUs: patient and family centered high-quality care, education, and discovery. This volume concentrates on perioperative management, monitoring and pharmacotherapy, examining the neurological problems most frequently seen in intensive care, and describes the various types of neurosurgery and critical features of the management of patients. General issues are discussed across the textbook, such as cardiac care, fluids and electrolytes, nutrition, and monitoring as well as more specific conditions and complications including elevated intracranial pressure, seizures, and altered mental states. Listening to an injured brain is not easy. It takes knowledge, dedication, and understanding of the critically ill patient and their family. Textbook of Neurointensive Care Volume 2: Perioperative Management, Monitoring, Pharmacotherapy provides the reader with a detailed resource for studying this most complex area of medicine. It is thus essential reading for all trainees and professionals in critical care, neurosurgery, anesthesia and neurology.

This book provides a comprehensive overview of the current state of knowledge on autism in females, in order to help understand and clarify gender implications in the autistic female phenotype. Despite the reported higher risk of developing autism in males than in females, few studies have investigated the gender differences at the clinical and neurobiological level. Possible genetic protective factors, as well as differing neurobiological brain trajectories, could be responsible for the male/female discrepancy in prevalence rates (4:1). Moreover, a different clinical phenotype regarding the onset of symptoms, behavioral features and social motivation often skews diagnosis in women. Specifically, the phenomenon of camouflaging or hiding symptoms in high functioning females, due to behavioral coping strategies, contributes to incorrect or delayed diagnosis. In addition to addressing an important gap in the literature, this book provides concrete and specific diagnostic recommendations and intervention strategies. In addition, a dedicated chapter presents clinical case reports and shares the personal experiences of autistic women. Given its scope, the book will appeal to clinicians and practitioners, as well as researchers and students in the fields of child and adult psychiatry, psychology and neuropsychiatry.

The Oxford Textbook of Neurohaematology is a single source of knowledge on the diverse neurological conditions associated with malignant and classical haematological diseases. The book covers the full range of haematological diseases, both malignant and classical, that impact the central, peripheral, and autonomic nervous systems. The book is divided into three sections. In the first section, neurological conditions associated with malignant haematological diseases are presented. This section begins with chapters on primary haematological malignancies of the nervous system including primary central nervous system lymphomas, vitreoretinal lymphoma, and other rare primary malignancies such as Hodgkin disease and lymphoproliferative disorders. Next, a chapter on histiocytic tumours of the central nervous system presents the neurological conditions associated with the Langerhans and non-Langerhans histiocytoses. This is followed by chapters covering the neurological complications of systemic myeloid and lymphoid malignancies. The second section of the book covers neurological complications of the treatments used in the management of haematological malignancies such as chemotherapy, radiation, and immunotherapy including chimeric antigen receptor T cells. The third and final section of the book features chapters on the neurological complications associated with classical haematological diseases including disorders of red blood cells (e.g., sickle cell anaemia), disorders of platelets and coagulation (e.g., immune thrombocytopenia), and disorders of white blood cells (e.g., hyperviscosity syndrome). Edited by leading authorities in the field, this book will serve as a useful resource for neurologists, haematologists, and oncologists, as well as for subspecialists and allied health professionals involved in the management of haematological diseases and their neurological manifestations.

This book represents a significant advance in the field of evidence-based acupuncture, specifically in regard to neurological disorders. It is a testament to the promising future of acupuncture, integrating the complexities of the human brain with the healing art of acupuncture. Each chapter leads readers to an expanded perspective where past and future, tradition and technology, converge in the pursuit of healing and well-being. In recent decades, technologies like functional magnetic resonance imaging (fMRI) have revolutionized our understanding of the human brain, enabling scientists to observe the brain's response to acupuncture in real-time. Tracing the pathways from acupoint to brain structure reveals fresh insights on the therapeutic function of acupoints and meridians. Participate in this journey to understand how acupuncture influences the brain, exploring new frontiers in the treatment and understanding of brain-related conditions. This book offers a rich blend of traditional healing wisdom and contemporary scientific insight.

This book was written by Kenneth M. Heilman, a neurologist with a long and productive clinical and academic career, including being a researcher and teacher. Based on his experiences and achievements, as well as his frustrations and failures, he examines the challenges of healthcare, including what problems exist and how these problems may be improved. Each chapter in this book focuses on integral areas of medicine, including research, creativity, career development, patient-physician relationship, wellness, medications, social considerations such as race, and medicine's future. Changes in Medicine offers a unique view to the rapidly evolving field of neurology and practicing medicine.

This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer's disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer's disease.Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer's agents Explains the role of phytomolecules and natural products in Alzheimer's therapy Reviews preclinical ways to assess drugs focusing on Alzheimer's disease Covers biomarker analysis for Alzheimer's disease Discusses the onset and progression of Alzheimer's disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.

Las claves para una buena salud cerebral El cerebro tiene la capacidad de reorganizarse y crear nuevas conexiones neuronales a lo largo de la vida. Esta facultad, conocida como'neuro plasticidad', le permite adaptarse a nuevas experiencias y aprender otras habilidades. A medida que envejecemos, se producen ciertos cambios que pueden afectar a la función cognitiva, pero que no representan necesariamente un deterioro intelectual. El cerebro de mediana edad puede no ser tan rápido o eficiente en ciertas áreas (velocidad de procesamiento, atención o memoria de trabajo) como los más jóvenes, pero tiene su propio conjunto de fortalezas y habilidades que se pueden aprovechar y desarrollar para ayudar a las personas a continuar creciendo y aprendiendo a lo largo de sus vidas. «En este libro la idea general es, por una parte, explorar las funciones cognitivas para saber de qué estamos hablando, y por otra, conocer más a fondo lo que ocurre en la mediana edad, qué cambios vamos a observar, cómo los podemos abordar y en qué medida es posible compensarlos, sustituirlos o estimularlos».