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The latest edition of this practical handbook provides a concise yet comprehensive overview of common and rare problems with hemostasis and thrombosis. Through thoroughly updated and revised chapters, the text features practical information on diagnosing and managing troublesome hematologic conditions often found in clinical practice. The handbook also spotlights advances in the field since the publication of the last edition, including multiple novel coagulation factors for hemophilia, the increasing use of novel anticoagulants and their reversal agents, and the increasing use of genetics for diagnosis. Written by experts in the field, Hemostasis and Thrombosis, Fourth Edition is an invaluable resource for healthcare professionals who treat patients afflicted with these conditions.

First published in 2006, the bestselling Wintrobe's Atlas of Clinical Hematologyhas now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.

Dieses Buch stellt praxisrelevante Aspekte des Spezialgebietes'Gerinnung'einschließlich Diagnostik und Therapie von Gerinnungsstörungen für Chirurgen dar. Im Fokus stehen wichtiges Wissen zu Blutungsneigung und Thromboseneigung im Rahmen operativer Eingriffe.

In this second edition of Disorders of Thrombosis and Hemostasis in Pregnancy - A Guide to Management the content has been thoroughly updated, with a particular focus on strengthening the management sections to ensure that advice on management represents state of the art.

Coagulopathy (also called clotting disorder and bleeding disorder) is a condition in which the blood's ability to clot (coagulate) is impaired. Acquired hemophilia is a rare disorder characterized by spontaneous bleeding in a patient with no previous personal or family hemorrhagic history. The first chapter explores the challenges associated with this disease, its unfamiliarity often causing a delay in diagnosis and therapeutic approaches. The second chapter focuses on lower gastrointestinal bleeding (LGIB) in children, describing the epidemiology, etiology and clinical management. The third chapter reviews the pathogenesis, risk factors and treatment strategies of coagulopathy in patients with craniocerebral injury. The next article examines Vitamin B12 with its four cobalamin vitamers, which often play a role in coagulation. The next chapter starts with a description of the methodology of viscoelastic hemostatic assay, followed by a review of literature on the utilization of thrombelastography (TEG) or rotational thromboelastometry (ROTEM). Finally, the role of TEG and ROTEM to monitor or guide prophylaxis/treatment of thromboembolic events and the limitations of using them to detect hypercoagulability and identify patients with increased risks for thromboembolic complications are discussed. The final chapter of this book focuses on the use of fresh frozen plasma (FFP) in patients who are not actively bleeding, critically questions these assumptions in the context of pre-procedural administration of FFP, and also examines why carrying out high quality trails in this area has been so problematic.

Since the second edition of Hemostasis and Thrombosis published over a decade ago, advances on assessing, treating and preventing common and rare hemostatic problems have emerged. This latest edition features these new developments while providing practical information on diagnosing and managing these troublesome conditions often found in clinical practice. Concise and convenient, healthcare professionals will find this text to be an invaluable resource.

Gibt es in den Zeiten der durch das Internet schnellen Verfügbarkeit von Fachartikeln, Review- Artikeln, Guidelines und anderen Informationen eine Notwendigkeit ein Buch zur Hämostas- logie herauszugeben? Auf den ersten Blick nicht, zumal ein Buch, das aufgrund der Komplexität des Querschnittfachs Hämostaseologie ein Vielautorenbuch sein müsste und das damit fast zwangsläufig den Nachteil einer eingeschränkten Aktualität durch die relativ lange Zeitspanne zwischen der Konzeption und der Auslieferung haben würde. Nach intensiven Diskussionen haben wir uns für eine Neuauflage entschlossen. Wir glauben, dass kein Review ein derartiges Buch adäquat ersetzen kann. Erleichtert wurde unser Entschluss aber vor allem dadurch, dass es gelang das Herausgeberteam zu erweitern. So konnten wir uns nicht nur fachlich verstärken, sondern die Betreuung der einzelnen Autoren und Themenfelder wese- lich verbessern. Herr Professor Gawaz hat zusammen mit Herrn Privatdozent Langer die Betr- ung der thrombozytären und kardiovaskulären Themenfelder übernommen. Ihre Expertise in der plasmatischen Gerinnung und der Fibrinolyse haben unsere Wiener Kolleginnen Frau Professor Mannhalter und Frau Professor Geiger eingebracht und dadurch diese Abschnitte des Buches entscheidend geprägt. Ohne das Engagement des neuen Teams hätten wichtige Fragestellungen im Buch nicht angesprochen werden können. Dank der Disziplin der Autoren ist es gelungen, den Zeitraum der kompletten Manuskri- erstellung in einem noch vertretbaren Rahmen von etwas mehr als zwei Jahren zu halten. Dafür und für die hohe Qualität der einzelnen Beiträge möchten wir uns bei allen Autoren bedanken.

Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.

La enfermedad tromboembolica venosa se caracteriza por la obstruccion del flujo sanguineo en los vasos sanguineos venosos afecta multiples mecanismos de la hemostasia, tanto hereditarios como adquiridos. El conocimiento de estos mecanismos permite realizar las medidas necesarias para efectuar profilaxis primaria y secundaria. Actualmente ha surgido un numero cada vez mayor de alternatives terapeuticas que pueden mejorar la morbimortalidad de los enfermos.