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This reference work aims to be the primary resource in the field of heart disease in children and adult congenital heart disease. It contains nearly 100 chapters covering all aspects of heart disease in three populations: fetus with acquired and congenital heart diseases, children with acquired and congenital heart diseases, and adults with congenital heart diseases. Divided into five main sections, the book provides a comprehensive, up-to-date, and continuously revised overview of what is known in the field as well as resources for practical use such as normal values, medication information, and review of published guidelines. The first section of the book includes historical background on congenital heart disease and the evolution of medical, surgical, and catheter therapeutics. The fetal heart disease section comes next and covers cardiovascular embryogenesis, etiological mechanisms, diagnostic tools, presentation and management, cardiomyopathies, arrhythmias, perinatal management, and emergencies. The bulk of the book lies in the third section on pediatric cardiology, which examines not only basic science, assessment, and therapies but also a wide variety of specific acquired and congenital diseases such as valvular lesions, arterial diseases, cyanotic heart diseases, cardiomyopathies, cardiac tumors, and pulmonary hypertension. This is followed by the section on adult congenital heart diseases, discussing echocardiography, electrophysiology, neurodevelopment, and a variety of unique aspects of congenital heart disease in the adult years. The final section of the book focuses on pharmacology with chapters on inotropes, vasopressors, diuretics, and more. Pediatric Cardiology: Fetal and Pediatric Heart Diseases & Adult Congenital Heart Diseases is an essential reference for physicians, residents, fellows, medical students, nurse-practitioners, and allied health professionals in cardiology, pediatrics, cardiac surgery, and imaging/radiology.

Cardiovascular disease is the major cause of mortality and morbidity around the world. While significant progress has been made in treating a major sub-category of cardiac disease and arrhythmias, significant unmet needs remain. Every day, thousands of patients die due to arrhythmias in the U.S. alone, and atrial fibrillation is the most common arrhythmia that affects millions of Americans at any given time. Therefore, there is an urgent public need to continue to develop new and better therapies for arrhythmias. This book reviews key research methods and protocols in cardiac electrophysiology with a focus on advantages and pitfalls. It will discuss new developments as well as traditional treatments and methods. Chapters will focus on practical implementation and collaborative cross-functional research methods. The book will contain contributions from scientists and clinicians from various academic and industrial research institutions. The inclusion of industrial experts expands the scope and potential audience of this book, and provides important perspective beyond basic science. Contributors will include researchers and clinicians from academic institutions such as the University of Minnesota, Harvard, Washington University, Case Western, Indiana University, and Manchester University. Methods and Models in Cardiac Electrophysiology will be a must-have resource for clinical academic scientists, engineers from industry (Biotech, Pharma, and Medical Device), undergraduate and graduate students, physicians, biomedical engineers, and high school and college teachers interested in studying cardiac electrophysiology and cardiac function. The book may also be of interest to students in the fields of physiology, molecular biology, cellular biology, biomedical engineering, mechanical engineering, electrical engineering, and related areas.

The coronaries are the first branches of the ascending aorta. They arise from their respective sinuses of Valsalva, and gradually branch distally to the myocardium. Abnormalities of the coronary arteries, either congenital or acquired, can be characterized as a lack of origin, abnormal origin, anomalous course, lack of patency, abnormal connections, and/or abnormal drainage of the coronary vessels. Interruptions to or lack of flow can cause significant morbidity and mortality due to ischemia, infarction and fistulous connections, which can lead to cardiac failure, endocarditis and ischemia. Coronary artery anomalies are rare in general populations. Although they can be benign and asymptomatic, they can also be malignant due to their origin and course and can cause sudden cardiac death. As such, an understanding of how to analyze, diagnose and treat them is vital. This book presents the latest advances in congenital anomalies of coronary arteries. It offers a comprehensive overview of the field, including illustrative angiograms and diagrams that demonstrate all possible anomalies and clarify what is abnormal, and also provides practical insights to guide practitioners in their everyday practice.

This book provides a comprehensive overview of the physiology, pathophysiology, diagnosis, medical and surgical management, and future therapies for tricuspid valve disease. It is divided into two sections. The first section covers the basics of the tricuspid valve, including anatomy, epidemiology, and clinical diagnosis with individual chapters focused on hemodynamics, echocardiography, MRI, and CT assessment. The second section examines current treatments for tricuspid valve disease including both surgical and medical management. It discusses special clinical scenarios of tricuspid valve pathology such as tricuspid regurgitation in patients with ICD and pacemaker implants and the role of tricuspid valve disease in patients with heart failure and LVAD therapy. Tricuspid Valve Disease: A Comprehensive Guide to Evaluation and Management is an essential resource for general cardiologists, interventional cardiologists, cardiac surgeons, and innovators in the field of structural heart disease.

This book provides a comprehensive, state-of-the-art overview of cholangiocarcinoma (CCA). The text is structured to effectively present a broad yet concise overview of bile duct cancer, its relevant definitions, classification schemata, clinical management tenets, translational (including molecular and cellular) facets, and future directions. The book features numerous high-yield illustrations and is authored by an eclectic range of renowned experts in various areas of CCA, reflecting the multidisciplinary nature of the field.Filling a critical gap in the field, Diagnosis and Management of Cholangiocarcinoma: A Multidisciplinary Approach is a valuable resource for clinicians and practitioners who treat patients with bile duct cancer.

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The sixth volume of this series features reviews on roles of mesenchymal stem cells in cartilage regeneration and bone regeneration, liver regeneration, cardiogenesis, cardiomyocyte differentiation, and regenerative therapy for neurodegenerative disorders.

In 1858, Drs. Henry Gray and Henry Vandyke Carter created a book for their surgical colleagues that established an enduring standard among anatomical texts. After more than 150 years of continuous publication, Gray's Anatomy remains the definitive, comprehensive reference on the subject, offering ready access to the information you need to ensure safe, effective practice. This 41st edition has been meticulously revised and updated throughout, reflecting the very latest understanding of clinical anatomy from field leaders around the world. The book's traditional lavish art programme and clear text have been further honed and enhanced, while major advances in imaging techniques and the new insights they bring are fully captured in new state-of-the-art X-ray, CT, MR, and ultrasonic images. Presents the most detailed and dependable coverage of anatomy available anywhere. Regional organization collects all relevant material on each body area together in one place, making access to core information easier for clinical readers. Anatomical information is matched with key clinical information where relevant. Numerous clinical discussions emphasize considerations that may affect medical care. Each chapter has been edited by experts in their field, ensuring access to the very latest evidence-based information on that topic. More than 1,000 completely new photographs, including an extensive electronic collection of the latest X-ray, CT, MR, and histological images. The downloadable Expert Consult eBook version included with your purchase allows you to search all of the text, figures, references and videos from the book on a variety of devices. Carefully selected electronic enhancements include additional text, tables, illustrations, labelled imaging and videos – as well as 24 specially invited ‘Commentaries'on new and emerging topics related to anatomy.

The third edition of Human Malformations and Related Anomalies is a comprehensive reference and clinical guide to significant human malformations. Authored by 40 authorities in genetics and dysmorphology, this streamlined new edition offers an authoritative and richly illustrated guide to clinical presentation, associated anomalies, treatment, and prognosis.

Congenital Heart Diseases are of the utmost importance in modern cardiology. This is a book that deals with essential matters which are developed by experienced researchers in their respective fields. An updated approach to these issues was largely sought after. The authors share their own papers and experience with the enthusiastic professionals reading their work all throughout the chapters in an easy-to-read format. Modern medical practice demands continuous research on specific topics. Thereafter, this book is devoted to the development of the coronary arteries facing the fact that coronary artery disease is the most common cause of mortality in the developed world. The the role of the estrogen receptor and transforming growth factors in coronary intimal hyperplasia and thorough descriptions of new diagnostic techniques in congenital heart diseases are also displayed (severe congenital heart defects are generally diagnosed during pregnancy or soon after birth while less severe defects often are not diagnosed until children are older). Accordingly, complex malformations of the heart, fetal arrhythmias and pulmonary hypertension are also included. In as much as other specific subjects are relevant as well, topics like an etiological overview of intrauterine ductus arteriosus constriction, restrictive cardiomyopathy in children or hybrid procedures for congenital heart disease, namely palliation of hypoplastic left heart syndrome, closure of muscular ventricular septal defect and stenting of branch pulmonary arteries are developed as well. Last but not least, the long-term outcomes of congenital heart diseases, including medical, interventional and emergency treatments, are examined.

The Update compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

The present book Cardiac Functioning, Disorders, Challenges and Therapies is aimed to create a combined collection of study material for medical professionals, researchers and students to understand outcome of recent cardiac researchers at a glance. The chapters have been written by the renowned and internationally established cardiologists. The book covers many topics of current interest to cardiologists and physiologists ranging from cardiac conducting system to recent therapeutic approaches and researches made in the area of heart treatment therapies.

The book will be written by the experts in the disease including imaging, interventional cardiology and surgical valve expertise. The book has five main sections: Aortic Valve Disease Mitral Valve Disease Tricuspid Valve Disease Pulmonic Valve Disease Multimodality Imaging The main objectives of the book are: 1- to provide the main guidelines to clinicians on how to identify and diagnose valvular heart disease 2- to provide an overview of what the near future will bring in the diagnosis, prevention and risk stratification of patients to catheter versus surgical approaches 3- to outline the possible implications for medical therapies in slowing progression of calcific aortic valve disease and myxomatous mitral valve disease

Stress in Health and Disease presents the principal pathways mediating the response to a stressor. It discusses the clinical background of cross-resistance and treatment with stress-hormones. It addresses the diseases of adaptation or stress diseases, diagnostic indicators, and functional changes. Some of the topics covered in the book are the concept of heterostasis; stressors and conditioning agents; morphology of frostbite; characteristics manifestations of stress; catecholamines and their derivatives; various hormones and hormone-like substances; FFA, triglycerides and lipoproteins; morphologic changes; and hypothalamo-hypophyseal system. The gastrointestinal diseases of adaptation are covered. The schizophrenia and related psychoses is discussed. The text describes the manic-depressive disease and senile psychosis. A study of the experimental cardiovascular diseases and neuropsychiatric diseases is presented. A chapter is devoted to the diseases of adaptation in animals. Another section focuses on the shift in adenohypophyseal activity and catatoxic hormones. The book can provide useful information to scientists, doctors, students, and researchers.