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Since the first edition of this book was published, new knowledge has been gained on Vitiligo. This widely revised and updated second edition, written by worldwide experts in the field, fully reflects this progress. The apparently, simple and poorly symptomatic presentation of the disease has been a strong disadvantage to its study, as compared to other common chronic skin disorders such as psoriasis and atopic dermatitis. A good skin-based angle of attack is also lacking because generalized Vitiligo is clearly epitomizing the view of skin diseases as simple targets of a systemic unknown dysregulation (diathesis). This view has mostly restricted Vitiligo to the manifestation of an auto-immune diathesis and skin events, which are easily detected using skin biopsies in most other situations, have not been precisely recorded, with the argument that a clinical diagnosis was sufficient for the management of the patient with Vitiligo. This richly illustrated second edition reflectsthe constant international effort to share the information gathered about this disorder at the clinical, pathophysiological and therapeutic levels. Its aim still being to bridge current knowledge at the clinical and investigative level, to point to the many unsolved issues, and to delineate future priorities for research.

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

This book discusses typical skin diseases from an immunological point of view, introducing the latest immunological techniques and practices.It begins with a brief overview of the human immune system, including the basic concepts and principles as well as the general symbols used in immunology. Part Two describes the human skin as an integral part of the immune system, explaining the immunological roles of major cellular and molecular composites in the skin. Part Three illustrates typical skin diseases that have immunological involvement (immunodermatological conditions). It describes 40 skin diseases, focusing on immunological causes, pathogenesis, pattern of reaction and treatment choices and responses. The final part discusses advanced immunodiagnostics and immunotherapy in dermatology, providing detailed descriptions of immune techniques for the diagnosis of skin diseases, their principles and background, indications, requirements for sampling, test protocols, interpretation of results and trouble shooting. This work offers insights into both the systemic immune system and the skin immune system, and integrates the information into discussions of clinical diseases, relevant immune techniques and immunological drugs. Presenting the latest advances in clinical immunology, it is an invaluable resource for dermatologists, residents and graduate students in dermatology.

This well-structured and lavishly illustrated book is a comprehensive reference on intraocular inflammation that encompasses all anatomic forms, settings and etiologies. Individual sections are devoted to uveitis associated with systemic disorders, uveitis syndromes restricted to the eye, bacterial uveitis, viral uveitis, fungal uveitis, parasitic uveitis, uveitis caused by other microbes, traumatic uveitis, and masquerade syndromes. Chapters on the different forms of uveitis are in a homogeneous reader-friendly format, with identification of core messages, explanation of etiology and pathogenesis, up-to-date information on diagnostics and differential diagnosis and guidance on the most appropriate forms of treatment and prognosis. Helpful flow charts are included to assist in identification of potential underlying disorders and the reader will also have online access to one hundred informative case reports demonstrating the different courses of intraocular inflammation. The authorsare world experts keen to share their vast experience with the reader. Intraocular Inflammation will be a valuable resource for all physicians who deal with patients with inflammatory eye disease.

免疫学の基本原理を凝縮し、明快に提示した教科書 すべての重要な現象をわかりやすいカラーイラストで説明 名著、アバスの『分子細胞免疫学』(Cellular and Molecular Immunology)の要約版。米国大学で免疫学の指定教科書となっている基礎免疫学テキストの定本。 ◆第4版の主な改訂ポイント 第2章「自然免疫 Innate Immunity」が、より一層、充実した内容に。新規図表が追加され、既存の図表も最新の知見が加わり、アップデート。免疫システムの基本からそれが関与する疾患まで、より理解しやすい構成になりました。 --その他の特徴CD4+T細胞とCD8+T細胞における免疫応答の誘導、遊走、エフェクター機能の特徴をわかりやすく図解。さまざまな細菌とウイルスが細胞性免疫のエフェクター機能に抵抗するさまざまな機構についてわかりやすく図解。アレルギー疾患など免疫システムが関与する疾病に関する記述が豊富。過敏性反応の4つの主な型において、異なる免疫エフェクター機構が、組織損傷と疾病を引き起こす機構についてわかりやすく図解。 ◆訳者序文より（抜粋） 2007 年に刊行された『基礎免疫学：免疫システムの機能とその異常　原著第2 版　2006‒2007 最新版』から7 年の歳月が流れ、今回2014 年に本書が刊行されました。 第2章「自然免疫Innate Immunity」は、原著第4 版では7 ページ増加し、また新たな図表が加わったばかりでなく、既存の図表も最新の知見が加わり、内容が一変しました。本書は以前から自然免疫を基盤に免疫学を記述していましたが、一層自然免疫が充実したことは、現代免疫学の動向を反映しており、現在免疫学を学習している学生ばかりでなく、以前適応免疫を主体として学習してきた研究者などにとっても、最適な教科書となっています。 本書では免疫学を自然免疫から理解するので、適応免疫を含めた免疫システムを容易に理解することが可能です。自然免疫と適応免疫の特異性とレセプターの特徴をわかりやすく図解しています。 免疫学発展の歴史を基盤とし現代ヒト免疫学の集大成された教科書が本書です。◆本書の主な特徴 免疫学の基本原理を凝縮し、明快に提示した教科書。すべての重要な現象をわかりやすいカラーイラストで説明。本書を熟読の上『分子細胞免疫学』を理解すると免疫システムの知識がいっそう深まる。現在免疫学を学習している学生のみならず、以前に適応免疫を主体として学習してきた研究者の方にも、最適な教科書。

Comprendre tous les concepts essentiels de l'immunologie! Concis et accessible, ce manuel représente une parfaite introduction à l'immunologie moderne pour les élèves de tout niveau. Cette 4e édition s'enrichit des résultats des recherches les plus récentes pour offrir la meilleure compréhension possible du système immunitaire et des pathologies causant ses dérégulations. Cet ouvrage propose : - 250 illustrations et tableaux en couleur ; - Un programme entièrement mis à jour ; - Un accès rapide et clair à l'information grâce à une organisation par mécanismes ; - Des points récapitulatifs ; - Une validation immédiate des connaissances acquises par des cas cliniques réels. Un glossaire, disponible en annexe et en livret détachable, rassemble l'ensemble des termes indispensables en anglais et en français. Ce livre se révèle incontournable pour les étudiants en médecine, biologie, biochimie et pharmacie.

Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.

Over the past ten years, a number of cytokines and growth factors have proven to be as effective therapeutics. While these products have certainly established recombinant biologics as a major pharmaceutical growth sector, the continued interest in this class of drugs arises from the fact that today we have a far better understanding of the human immune response, both at a cellular and molecular level. This has resulted in a more methodical characterisation of these factors which has given clinical researchers an opportunity to plan Phase 1 clinical trials that can provide substantial information on the activity of the cytokine in humans. Currently, a great deal of effort is also being channelled into identifying cytokines from the various DNA databases. Our major objective for this book is to profile cytokines that have been recently identified. The therapeutic potential of these cytokines based on their known properties will be discussed by the authors. The main aim of this book is to provide...

Examines the mechanisms of both the innate and adaptive immune systems as they relate to infection and disease.

This continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. This compilation focuses on the symptoms, diagnosis and treatment of Pompe disease; insulin resistance and its relation to intra-uterine growth retardation; evidence-based medicine research; the therapeutic values of Vitamin E supplements; megalin-mediated endocytosis in renal proximal tubule cells; and biofilm development kinetics.

Autoimmune Diseases in Endocrinology is a comprehensive and novel text that examines key features that predispose individuals to autoimmune diseases. The text begins with three introductory chapters which provide sufficient information so that anyone, including those without a background in recent immunology, will be able to understand the developments in the field. The next and largest section of the book concerns autoimmune thyroid disease, and authors of these chapters take the reader through the basic epidemiology, genetic and environmental risk factors, immunopathogenesis, and the diagnostic and management aspect of the disease. The next section discusses Type 1 diabetes mellitus. In the final section, authors explain other autoimmune endocrinopathies, including Addison's disease, premature ovarian failure, autoimmune hypophysitis, and autoimmune polyglandular syndrome types 1 and 2. Comprehensive and timely, Autoimmune Diseases in Endocrinology will become an essential reference for all endocrinologists and internal medicine practitioners working in this field.

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The'50th International Workshop of the Ernst Schering Research Foundation'focussed on'Animal Models of T Cell-Mediated Skin Diseases'. Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Regulatory T-cells are essential components of the immune system, and several different subsets of regulatory T-cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Recent developments and viewpoints in the field of CD4+CD25+ regulatory T-cells as well as the potential use of regulatory T-cells in immunotherapy of inflammatory diseases are discussed in this volume. By linking data from experimental models with recent findings from the clinic, this book will be of interest to immunologists and other biomedical researchers as well as clinicians interested in the regulation and manipulation of the immune response during inflammatory disease.