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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

This book provides a comprehensive, state-of-the art review of current and new therapies in treating pancreatic cancer. In addition to discussing the current landscape for treating various stages of pancreatic cancer, the text highlights several standard and emerging approaches, with a particular emphasis on novel endoscopic, surgical, chemotherapeutic, radiotherapeutic, targeted, and immunotherapeutic strategies. The volume also features concepts on the potential economic effects associated with the development and implementation of new treatments in pancreatic cancer. Written by experts from a variety of integrative disciplines, Current and Emerging Therapies in Pancreatic Cancer is a valuable resource for oncologists, gastroenterologists, surgeons, and other professionals who treat and manage patients with pancreatic cancer.

This is a follow-up to the 2007 review of the literature on online/offline interventions done by Marks, Cavanagh, & Gega (Psychology Press). Consequently, this review includes summaries of research published since 2006 to date. Since publication of that original work, the number of references about online/offline interventions has mushroomed greatly, to the point that many more chapters were added to cover as many references as possible. None are included in the previous literature review. This book covers research summaries with separate chapters ranging from internalizations (anxiety, depression) to addictions, externalizations, and children and their families, physical illnesses, severe mental illnesses, including obsessive compulsive disorders, with one entire chapter dedicated to where most of the research has occurred in the last decade, and that is - Post-traumatic Stress Disorders. A whole section is dedicated to separate chapters on Counseling, Psychotherapy, and Training. A final chapter covers many controversial issues in online/offline interventions, including cost-effectiveness, extra-channel non-verbal behavior, the place of theory in online/offline interventions, and the now-predictably positive future of online interventions as the major approach to deal with most mental illnesses in the 21st century.

This volume focuses on critical issues surrounding the intersection of genetics, health, and society. It provides a critical examination of sociological and biomedical approaches to genomics, including strengths and limitations of each perspective.

Concurrent Treatment of PTSD and Substance Use Disorders Using Prolonged Exposure (COPE) is a cognitive-behavioral psychotherapy program designed for patients who have posttraumatic stress disorder (PTSD) and a co-occurring alcohol or drug use disorder. COPE represents an integration of two evidence-based treatments: Prolonged Exposure (PE) therapy for PTSD and Relapse Prevention for substance use disorders. COPE is an integrated treatment, meaning that both the PTSD and substance use disorder are addressed concurrently in therapy by the same clinician, and patients can experience substantial reductions in both PTSD symptoms and substance use severity. Patients use the COPE Patient Workbook while their clinician uses the Therapist Guide to deliver treatment. The program is comprised of 12 individual, 60 to 90 minute therapy sessions. The program includes several components: information about how PTSD symptoms and substance use interact with one another; information about the most common reactions to trauma; techniques to help the patient manage cravings and thoughts about using alcohol or drugs; coping skills to help the patient prevent relapse to substances; a breathing retraining relaxation exercise; and in vivo (real life) and imaginal exposures to target the patient's PTSD symptoms.

This text book has been received enthusiastically by the medical profession since its first publication in the year 2002.The book is primarily targeted to diabetologists, endocrinologists and physicians involved in diabetes care. The third edition of the book is a fully revised edition, incorporating all newer advances on the subject. The book contains 94 chapters covering basic physiology, ethiopathology, epidemiology, genetics and immunology of diabetes. The clinical sections include clinical profile, management of diabetes and its complications. The last sections cover diabetes at different phases of life, living with diabetes and diabetes healthcare delivery. The last chapter gives an extensive insight into the shape of things to come in the near future. Above contents include comprehensive accounts of each subject and are written with great accuracy and lucidity. Although the previous editions focused on the diabetes in the developing world, the present edition has shifted its focus to whole world, thus enhancing the utility of the book to the readers anywhere. This book is expected to fulfill a vital role in promoting the understanding of diabetes.

In providing care to diabetic patients, education to patient and family members is one of the most important aspects of management. The informed decisions about self-monitoring of blood glucose (SMBG), nutrition, exercise, weight control, eye and foot care, use of oral medications and insulin, prevention of micro- and macrovascular complications cannot be effectively managed without knowledge of diabetes. Also, the factors such as desire to learn, cognitive abilities, attitudes, depression, family support, barrios to care and cultural and ethnic back ground influence the learning process. Obviously, physicians and other health care professionals play a pivotal role in providing education and care to patients with this chronic devastating disease. Most of the care of diabetes and steps to prevent its complications occurs in the institutional or private clinics. There is vast amount of literature, often confusing and contradictory, is available on multitude of topics concerning diabetes and its complications. This book has made a sincere effort to provide new and futuristic information in diabetes management, which is not overwhelming. Chapters are written as easy to understand clear information and practical guidelines by expert international clinicians and scientists. Also, the chapters in this book have made an attempt to provide unbiased and evidence-based information in a comprehensive yet concise manner to be a useful guide for practicing primary care physicians, endocrinologists and other health care providers in their quest of providing excellent care to their diabetic patients. The authors have taken meticulous efforts to provide current practice recommendation. In many chapters the tables and figures stipulate clear and concise guidance which can be used as ready reference material by busy practitioners. Unique chapter on Diabetes Registry discuss and provide guidelines how diabetes registry can help institutions, private practice clinics and individual clinicians to manage the patients with this chronic disease and its complications. The chapter on epidemiology enhances the understanding of multifaceted nature of pathophysiology and risk factors of diabetes and importance of this understanding in overall management of diabetes. The chapter on self-monitoring of blood glucose (SMBG) explores controversies and provides guidance on how parsimonious and structured use of SMBG can lead to improved glycemic control and health outcomes in diabetic patients. Easy to understand and clear guidelines on the management of pregnant diabetic patient from pre-partum to post-partum and treatment of congestive cardiac failure and hypertension in diabetic patient are outlined in specific chapters. A new concept in health care delivery ‘Medical Home'for diabetes which leverages resources and improves outcomes while holding down cost is discussed in clear and concise manner in the chapter ‘management of diabetes in primary care'. The book also describes state-of-art and evidence based information for management of diabetic neuropathy, erectile dysfunction, and diabetic foot and eye disorders. Utility of food frequency questionnaire and motivational interview, the key aspects of nutritional management are discussed in specific chapters. A clear understanding of pathophysiology and treatment of type 2 diabetes in youth as well as guidelines for management of diabetic patients during religious fasting, international travelling and shift work are described in dedicated chapters.

The MassGeneral Hospital for Children Handbook of Pediatric Global Health is a concise resource for the ever-increasing number of health professionals involved in global health, many of whom spend a few weeks to months or even years providing medical care in resource-poor countries. This Handbook provides practical, evidence-based, hands-on guidance for managing and preventing childhood illnesses when resources are limited in low- and middle-income countries. It also offers a setting-specific understanding and management approaches to the major causes of childhood mortality, including pneumonia, diarrhea, birth asphyxia, complications of preterm birth, and neonatal sepsis. The Handbook provides an overview of childhood mortality, health systems, and the various stakeholders that play a role in the global health arena, and also contains chapters focusing on adolescents who are increasingly recognized as a unique population in whom interventions can go a long way in bothconsolidating the gains made in childhood and preventing adult disease. Finally, key topics in non-communicable diseases are covered, including trauma and injuries, pediatric mental health, child and adolescent rights, and oral health. Not meant solely for pediatricians, the Handbook is designed for generalists, specialists, doctors, nurses, other health care workers, and those in training. An indispensable reference for health professionals overseas, the Handbook will also be a useful addition and resource for academic centers and universities in industrialized nations that are creating courses for trainees who will do clinical electives abroad during their training.

This text examines how the ever-changing demographics in the United States require sensitivity and competency in clinicians treating individuals from diverse backgrounds, and also how those demographics relate to health disparities. It addresses the three key disorders that affect adults: language/cognitive disorders associated with dementia, language/cognitive disorders associated with traumatic brain injury, and aphasia and right-hemisphere disorders.

Meet the growing challenges of diabetes and obesity management with Endocrinology: Adult and Pediatric: Diabetes Mellitus and Obesity - a new diabetes and obesity eBook from the same expert endocrinologists responsible for the highly acclaimed two-volume Endocrinology clinical reference. With all of the latest advances loaded on your favorite eReader, you'll be able to put today's best practices to work for your patients. - Stay abreast of the newest knowledge and advances in diabetes mellitus and obesity, including today's increased focus on controlling autoimmunity and preserving or replenishing beta-cell mass in the management of type 1 diabetes; complications of diabetes and their pathogenesis, morbidity, and treatment; new findings and treatments for obesity; and much more. - Count on all the authority that has made Endocrinology, 6th Edition, edited by Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.

Viele Fragen…Intensivmedizinische Therapie der schweren akuten Pankreatitis: welche Standards heute?Evidenz zur interventionellen Therapie von Pseudozysten?Ergebnisse randomisierter Studien zur interventionellen und operativen Therapie der chronischen Pankreatitis?Bedeutung der bisher verkannten Autoimmunpankreatitis in der Differenzialdiagnose entzündlicher Pankreaserkrankungen?Gutartige zystische Neoplasien: wann systematische Überwachung, wann operieren?Endokrine Tumoren des Pankreas: Standards der Diagnostik, Überwachung und operativen Therapie.Adjuvante bzw. neoadjuvante Chemotherapie beim Pankreaskarzinom: wann und wie?Onkologische Resektion beim Pankreaskarzinom, welcher Nutzen? Effizienz der palliativen Chemotherapie?Neue therapeutische Konzepte und bessere Heilungschancen bei periampullären Karzinomen? … die präzisen Antworten der Experten finden Sie hier.

Food and nutrients are the original medicine and the shoulders on which modern medicine stands. But in recent decades, food and medicine have taken divergent paths and the natural healing properties of food have been diminished in the wake of modern technical progress. With contributions from highly regarded experts who work on the frontlines of disease management, the bestselling first edition of Advancing Medicine with Food and Nutrients, Food and Nutrients in Disease Management effectively brought food back into the clinical arena, helping physicians put food and nutrients back on the prescription pad.Board-certified in General Preventive Medicine, Ingrid Kohlstadt, MD, MPH has been elected a Fellow of the American College of Nutrition and a Fellow of the American College of Preventive Medicine. Guided by Dr. Kohlstadt, this authoritative reference equips clinicians with the information they need to fully utilize nutritional medicine in their practice. New in the Second Edition Toxic exposures such as molds, microbial infections, xenoestrogens, heavy metals, and inert nanoparticles Food safety issues: precautions for patients with preexisting medical conditions, adequate labeling of food allergens such as gluten, potential adverse effects of artificial sweeteners, consequences of applying ionizing radiation to food, food-borne mycotoxins, critical food restrictions following bariatric surgery, precautions for preparing food in the home Consumer advocacy issues on navigating claims of medical foods and dietary supplements Physical forces on nutritional needs, such as ultraviolet light initiating vitamin D synthesis, non-ionizing radiation's effects on brain glucose metabolism and excess body fat's effects on inflammation and hydration Preventive medicine and how to preserve resiliency at the individual and public health levels Written by doctors for doctors, Advancing Medicine with Food and Nutrients, Second Edition reunites food and medicine. Buttressed with new evidence, leading physicians on the frontlines of disease management apply the latest scientific advances to the clinical practice of medicine. Each chapter offers adjuncts to standard care, fewer side effects, improved risk reduction, or added quality of life.An article by Ingrid Kohlstadt on education and nutrition appeared in TIME Magazine online on November 12, 2014.

The Indian subcontinent is a vast land mass inhabited by over one billion people. Its rich and varied history is reflected by its numerous racial and ethnic groups and its distinct religious, cultural and social characteristics. Like many developing countries in Asia, it is passing through both demographic and epidemiological transitions whereby, at least in some parts, the diseases of severe poverty are being replaced by those of Westemisation; obesity, diabetes, and heart disease, for example. Indeed, as we move into the new millennium India has become a land of opposites; on the one hand there is still extensive poverty yet, on the other hand, some of the most remarkable developments in commerce and technology in Asia are taking place, notably in the fields of information technology and biotechnology. India has always fascinated human geneticists and a considerable amount of work has been done towards tracing the origins of its different ethnic groups. In the current excitement generated by the human genome project and the molecular and genetic approach to the study of human disease, there is little doubt that this field will develop and flourish in India in the future. Although so far there are limited data about genetic diseases in India, enough is known already to suggest that this will be an extremely fruitful area of research.

The RSSDI Textbook on Diabetes Mellitus provides information about the prevalence of Diabetes Mellitus in India and discusses various aspects of the disease. This publication has been planned keeping in view several objectives. One of these objectives is that a large number of primary care physicians as well as an increasing number of specialists are in need of comprehensive knowledge on basic and applied aspects of the disease. The authors and compilers of the book feel that India needs a book of her own to cater to the needs of the burgeoning number of medical practitioners dealing with diabetes in this country as well as to those of its neighbors in South, Mid and South East Asia. The scope of the textbook has been proposed to be wide so as to be of service to general practitioners as well as to broaden their academic outlook. It has been designed to target the requirements of family physicians, academicians, clinical researchers and diabetes oriented health professionals at large. Each chapter is comprehensive and reasonably elaborate and lists of references are adequate and appropriate. Contributions provided by experienced professors as well as senior and young clinical researchers from all parts of the country and some from abroad, have enriched the contents to the best possible extent.

Thanks to the omnipresent computer, current statistics can include data files of many thousands of values, and can perform any exploratory analysis in less than seconds. This development, however fascinating, generally does not lead to simple results. We should not forget that clinical studies are, mostly, for confirming prior hypotheses based on sound arguments, and the simplest tests provide the best power and are adequate for such studies. In the past few years the authors of this 5th edition, as teachers and research supervisors in academic and top-clinical facilities, have been able to closely observe the latest developments in the field of clinical data analysis, and they have been able to assess their performance. In this 5th edition the 47 chapters of the previous edition have been maintained and upgraded according to the current state of the art, and 20 novel chapters have been added after strict selection of the most valuable and promising novel methods. The novel methods are explained using practical examples and step-by-step analyses readily accessible for non-mathematicians. All of the novel chapters have been internationally published by the authors in peer-reviewed journal, including the American Journal of Therapeutics, the European Journal of Clinical Investigation, The International journal of Clinical Pharmacology and therapeutics, and other journals, and permission is granted by all of them to use this material in the current book. We should add that the authors are well-qualified in their fields of knowledge. Professor Zwinderman is president-elect of the International Society of Biostatistics, and Professor Cleophas is past-president of the American College of Angiology. From their expertise they should be able to make adequate selections of modern methods for clinical data analysis for the benefit of physicians, students, and investigators. The authors, although from a different discipline, one clinician and one statistician, have been working and publishing together for over 10 years, and their research of statistical methodology can be characterized as a continued effort to demonstrate that statistics is not mathematics but rather a discipline at the interface of biology and mathematics. They firmly believe that any reader can benefit from this clinical approach to statistical data analysis.

Genetics of Diabetes Mellitus is intended to be a resource for both researchers in the field as well as endocrinologists, diabetologists, and geneticists who seek to learn more about this rapidly changing and important field. The text contains chapters from experts in the area who review aspects of the genetics of both type 1 and 2 diabetes mellitus as well as various syndromic forms of diabetes. The chapters are approachable for those who are not experts in the field of genetics but also comprehensive, so as to serve as an important resource for researchers interested in the genetics of diabetes mellitus. A description of basic concepts of the genetics of complex diseases like type 1 and type 2 diabetes is provided as background. Type 1 diabetes is addressed in chapters exploring genetic determinants that affect the autoimmune process characteristic of type 1 diabetes, the role of the insulin gene in the pathogenesis of type 1 diabetes and additional genes that may impact upon the risk of type 1 diabetes. The impact of genetic determinants on the pathophysiology of type 2 diabetes is covered, as are chapters that address specific genes that are important for the development of type 2 diabetes. Finally, syndromic forms of diabetes, including Maturity Onset Diabetes of the Young and mitochondrial diabetes, and the insight that these disorders provide into more common forms of diabetes are reviewed. Thus, this comprehensive and up-to-date text will serve as an important resource for those actively engaged in research in this area and clinicians treating these patients to provide an up-to-date entrée for those seeking to become more knowledgeable in the area.

What is unique about the process in the discussion of healthcare and interventions to use when working with families? What assessment tools provide guidance for healthcare providers as they determine interventions for families in their care? What are the changing dimensions of contemporary family life, and what impact do those dimensions have on health promotion for families? How is family healthcare changing in terms of practices, delivery systems, costs and insurance coverage?Students are able to explore these questions and more in the Encyclopedia of Family Health. Approximately 350 signed articles written by experts from such varied fields as health and nursing, social and behavioral sciences, and policy provide authoritative, cross-disciplinary coverage. Entries examine theory, research and policy as they relate to family practice in a manner that is accessible and jargon-free. From ′Adolescent Suicide′ and ′Alternative Therapies′ to ′Visitation during Hospitalization′ and ′Weight Problems and Genetics′, this work provides coverage of a variety of issues within a family context. The Encyclopedia of Family Health provides a comprehensive summary of theory, research, practice, and policy on family health and wellness promotion for students and researchers.

The devastating psychological, physical, and spiritual damage wrought by the misuse of drugs is indisputable. However, there is a recurring debate over the causes of substance abuse that typically divides along two common assumptions: people either abuse drugs and alcohol out of sheer pleasure-seeking drives that run amok, or to escape or assuage aversive states of comorbid anxiety or depression. Substance Abuse and Emotion goes beyond this dichotomy in its exploration of recent, significant field observations, theory construction and rigorous testing, and laboratory research to advance working models for a new research paradigm on substance abuse and comorbidity.

Empirical evidence shows that treatment failure is a significant problem and one that practitioners routinely overlook. A substantial minority of patients either fail to gain a benefit from the treatments offered to them, or they outright worsen by the time they leave treatment. Intervening in a timely fashion with such individuals cannot occur if practitioners are unaware of which cases are likely to have this outcome. Prevention of Treatment Failure describes procedures and techniques that can be used by clinical practitioners and administrators to identify patients who are at risk for treatment failure. The book summarizes evidence that convincingly shows that a shift in routine care is needed, and that such a shift can be accomplished easily through integrating specific methods of monitoring patient treatment response on a frequent basis in routine care. Treatment response is placed in the context of historical views of healthy functioning and operationalized through the use of brief self-report scales. Providing alert-signals to therapists, along with problem-solving tools, is suggested as an evidence-based practice that substantially reduces patient deterioration and increases the chances of the return to normal functioning. The book also provides illustrations on how accumulated data resulting from monitoring patient treatment response can be used to improve systems of care.

Growing numbers of young people—some 10% to 20% of school-age populations—have mental health problems requiring intervention, and current policy initiatives identify evidence-based therapies as the most effective and relevant forms of treatment. By reviewing evidence-based treatments (EBTs) across a wide spectrum of conditions, the Handbook of Evidence-Based Therapies for Children and Adolescents: Bridging Science and Practice closes the gaps between children's needs and services as well as those between research, training, and practice, Several EBT options, both proved and promising, are offered for each covered disorder and are bolstered by case examples, tables, and reference lists. Features include chapters on implementation issues such as diversity, family treatment, assessment strategies, and community settings, and step-by-step guidance for the researcher looking to gather empirical support for therapies. With comprehensive coverage provided by numerous leading experts in the field, this volume covers the broadest range of disorders over the widest pediatric-adolescent age range, including: Behavioral disorders, ADHD, aggression, bullying. Phobias, panic disorders, school refusal, and anxiety. Autism and pervasive developmental disorders. Depression, mood disorders, and suicidal behavior. Alcohol and drug abuse. Eating disorders and obesity. PTSD. With its emphasis on flexibility and attention to emerging issues, the Handbook of Evidence-Based Therapies for Children and Adolescents is essential reading for anyone who works to address the mental health needs of children, including clinical child, school, and counseling psychologists; clinical social workers; and child psychiatrists as well as advanced-graduate level studentsin these and other related fields.

Psychosomatic illness can generally be considered as physical illnesses that are believed to be psychologically based; hence they are often referred to as'psychophysiological'disorders. Focusing on the emerging challenges in the fields of both sleep and psychosomatic medicine, Sleep and Psychosomatic Medicine interphases between psychiatry, sleep

- El síndrome metabólico es uno de los retos más intrigantes y fascinantes de la medicina contemporánea. Se trata de una patología en la que confluyen problemas de distintas áreas de la medicina: diferentes grados de hipertensión, acumulación de grasa, insulinoresistencia, estados protrombótico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que lo que la suma de los factores individuales supondría. - Se trata de una'enfermedad'nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya rápida extensión se debe fundamentalmente a la adopción del estilo de vida occidental: fundamentalmente, muy poca actividad física e ingesta excesiva de alimentos. - Esta obra trata el concepto del Síndrome metabólico en su más amplio sentido y da respuesta a la multitud de incógnitas que todavía presenta esta patología. Con un enfoque multidisciplinar y un equipo de colaboradores internacionales (España, Italia, Japón, Alemania, Estados Unidos, Reino Unido, Finlandia, Australia, etc.) de primer nivel en las distintas áreas, escrita íntegramente en inglés, revisa todos los aspectos relacionados con el Síndrome metabólico, desde el punto de vista de la fisiopatología molecular y la epidemiología genética: obesidad, insulinoresistencia, dislipidemias, hipertensión, enfermedad cardiovascular y otros nuevos como inflamación molecular, estado protrombótico, disfunción endotelial... - Todos los capítulos presentan un abstract, en inglés y castellano, al inicio de cada capítulo con los puntos fundamentales que se van a desarrollar en ese capítulo. - Esta obra trata el concepto del síndrome metabólico en su más amplio sentido y da respuesta a la multitud de incógnitas que todavía presenta esta patología. - Se trata de una'enfermedad'nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya rápida extensión se debe fundamentalmente a la adopción del estilo de vida occidental. - Todos los capítulos presentan un abstract, en inglés y castellano, al inicio de cada capítulo, con los puntos fundamentales que se van a desarrollar en ese capítulo.