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This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud's phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud's is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud's phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch. This fully updated second edition comprehensively discusses various causes of Raynaud's phenomenon including childhood Raynaud's phenomenon, Raynaud's phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud's phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud's phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud's phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors'expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud's phenomenon and the vascular disease of secondary Raynaud's phenomenon. Engaging readers with case vignettes and a plethora of visual aids, Raynaud's Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers.

This completely updated 4th edition now includes two volumes: it retains the easy-to-use handbook format of the previous successful book, while fulfilling the need for a review of the content. Taking into consideration recent advances in systemic and topical treatments, state-of-the-art lasers, and the latest evidence-based recommendations, it now includes biologic agents for psoriasis and their use as off-label treatments in other skin disorders, targeted agents for malignant melanoma and basal cell carcinoma, and new treatment modalities for rosacea, acne, atopic dermatitis, and urticaria, to name but a few. The European Handbook of Dermatological Treatments provides concise, up-to-date overviews of treatment guidelines and clinical pearls for a large number of skin diseases. It is divided into three main sections addressing the many different skin diseases, the drugs available for dermatological treatments, and the various methods applied in dermatology, including fillers, botulinum toxin, lasers, dermoscopy, cryosurgery, and electrosurgery. Written by a recognized expert in the field, each chapter focuses on a particular skin disease, illustrating current treatments while providing a brief synopsis of the etiology and clinical presentation of the disease. Treatment indications and contraindications, modes of action, and dosages are clearly identified and the content is enhanced by a wealth of clinical pictures and tables, making it an engaging tool for professionals, and a valuable learning resource for young practitioners, as well as postgraduate students and residents.

The core of this three-volume book deals with damage-associated molecular patterns abbreviated “DAMPs”, which are unique molecules that save life and fight for survival of all organisms on this planet by triggering robust inflammatory/immune defense responses upon any injury, including those caused by pathogens such as viruses and bacteria. However, these molecules also have a dark side: when produced in excess upon severe insults, they can trigger serious human diseases. The three volumes present current understanding of the importance of DAMP-promoted immune responses in the etiopathogenesis of human diseases and explore how this understanding is impacting diagnosis, prognosis, and future treatment. This third volume addresses the potential of DAMPs in clinical practice, as therapeutic targets and therapeutics, by focusing on a description of antigen-related diseases, which are pathogenetically dominated by DAMPs, that is, infectious and autoimmune disorders and allograftrejection (as an undesired function of these molecules), as well as tumor rejection (as the desired function of these molecules). The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses; Damage-Associated Molecular Patterns in Human Diseases - Vol. 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets.

This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefitfor specialists in the field.

The second edition of Textbook of Systemic Vasculitis expands the scope and strengths of popular first edition of this book. This edition includes some newer topics like deficiency of adenosine deaminase 2 (DADA2),VEXAS syndrome, and other autoinflammatory vasculitides. The histopathology section has a new addition in the form of gastrointestinal (GI) vasculitis. There are invaluable insights into genetics, epidemiology, basic sciences including animal models, pathogenesis, and revised nomenclature systems, imaging modalities such as PET scan, disease activity assessment tools, and promising newer therapies.

Körperliche Erkrankungen gehen in ihrem Verlauf mit einer hohen psychischen Komorbidität einher. Vor allem eine koexistente Depression und Angst, ein chronischer oder traumatischer Stress üben einen relevanten negativen Einfluss auf das dynamische Krankheitsgeschehen aus. Sie sind nicht nur häufig mit einer erhöhten Morbidität, einer ungünstigeren Lebensqualität und belasteten psychosozialen Integration assoziiert. Sie sind oft auch mit einem erhöhten Mortalitätsrisiko und einem bedenkenswerten Suizidrisiko verbunden. Depression, Angst, chronischer und posttraumatischer Stress können auch die Entwicklung von körperlichen Krankheiten beeinflussen, indem sie allgemeine somatische Krankheitsrisiken vermitteln. Sowohl eine psycho-somatische als auch ein somato-psychische Perspektive ist notwendig, um die komplexen Interaktionen zwischen psychologischer, psychosozialer und biologischer Ebene zu erfassen. Ein allgemeiner Teil nimmt das Thema von psychischer und somatischer Komorbidität in einer bidirektionalen Wirkrichtung auf. Er befasst sich mit theoretischen Konzepten und empirischen Befunden zu möglichen Beziehungen zwischen somatischer Krankheit und medizinischer Behandlungsmodalität einerseits und psychischer Vulnerabilität und Störung andererseits, die traditionellerweise einer „psychosomatischen Perspektive“ in der Medizin zugeordnet werden. In einem speziellen Teil werden diese allgemeinen Aspekte einer biopsychosozialen Betrachtung von Depression, Angst und traumatischem Stress in ihrem potentiellen Einfluss auf definierte internistische Krankheitsrisiken bzw. von koexistenter depressiver, Angst- und posttraumatischer Belastungsstörung bei internistischen Erkrankungen in ihren möglichen Auswirkungen auf Krankheitsdynamik und Krankheitsverlauf jeweils nach traditionellen Organsystemen bzw. nach speziellen medizinischen Behandlungskontexten je gesondert dargestellt. Dieses umfangreiche Werk richtet sich gleichermaßen an die Kolleg•innenaus Psychiatrie und Psychotherapie wie aus den medizinischen Fächern, sowie an alle Leser•innen, die an einer psychosomatischen und somatopsychischen Perspektive auf die komplexen wechselseitigen Beziehungen zwischen psychischen Störungen und körperlichen Krankheiten interessiert sind.

L'Encefalomielite Mialgica / Sindrome da Fatica Cronica (ME/CFS) è una malattia cronica e invalidante che spesso compare dopo un'infezione virale. Il COVID è uno dei numerosi virus che può innescarla, e la scienza ha già visto che un 10-20% dei casi del cosiddetto Long-COVID altro non sono che ME/CFS. Attraverso 150 domande e altrettante risposte si spiega in che cosa consiste questa patologia, a che punto è la ricerca, quali sono i farmaci sperimentati e quali sono i problemi aperti. Un vademecum utile a chi ne soffre o pensa di soffrirne e a chi è semplicemente interessato ad approfondire una delle più grande sfide mediche di questo secolo.

Dieses Referenzwerk bietet dem Allgemeinpädiater, dem angehenden Facharzt und dem (Kinder-)Rheumatologen umfassende Antworten auf alle Fragen der Entstehung, Diagnostik und Therapie von rheumatologischen Erkrankungen bei Kindern und Jugendlichen. Der spezielle Fokus liegt auf der Relevanz und dem Nutzen im Alltag des Pädiaters. Die genauen Angaben zu Therapieempfehlungen und Hinweise zur Evidenz der Therapieverfahren bürgen für einen zuverlässigen und schnellen Behandlungserfolg. Fundierte „State-of-the-Art“-Kinderrheumatologie, praxisbezogen aufbereitet. Ideal zum Nachschlagen für fundiertes Wissen über die Krankheiten, die verwendeten Medikamente und ihre Wirkung im kindlichen Organismus.

Current texts in rheumatology are very detailed and designed specifically for rheumatologists. This clear and concise guide is targeted at the busy clinician who comes into contact with both common and uncommon rheumatologic disorders. Many chapters presents a common clinical scenario and include a definition ofthe disease while outlining incidence and prevalence, common manifestations, treatment and pitfalls. A range of topics are included in the fifteen chapters including osteoarthritis, rheumatoid arthritis, fibromyalgia, metabolic bone disease, gout and scleroderma, among others. Written by experts in the field, Rheumatology for Primary Care Providers is a definitive guide to rheumatology for the primary care physician and non-specialist.

This book provides a comprehensive, up-to-date review of the state of knowledge on the role of microbes in inducing autoimmune diseases. The initial chapters address the basic concept and clinical implications of immunology, while the following section discusses the role of genetics, epigenetics, hormones, stochastic and environmental factors in the pathogenesis of autoimmunity. The third section introduces readers to various autoimmune disorders and presents the cellular and molecular mechanisms of autoimmune diseases. In closing, the book examines the role of intestinal flora in the development of autoimmune diseases, delineates the underlying mechanism responsible for autoimmunity onset, and examines the potential of microbial therapeutics in the prevention and treatment of autoimmune diseases. Given its scope, the book offers a valuable asset for all scientists and clinicians working in immunology, rheumatology and autoimmune diseases.

The emphasis in this book is on providing evidence-based basic understanding of the subject. The pathophysiology of diseases has been simplified. Modes of presentation and approach to investigations are given in a clinically applicable manner. Therapeutic plan, as given in guidelines, is summarized and presented in a way it has to be used in practice. Each chapter has been written by an expert in the field. Language is simple to comprehend. Enriched with graphs and tables for easy understanding. Effects of COVID-19 on various systems have been included. Provides an Indian perspective of the diseases in each chapter. Includes MCQs in the chapters for revision. Selected readings can be used for more information on the topic.

This textbook details the latest diagnostic and management options available when treating patients with diseases affecting the oral mucosa. It comprehensively covers the content required to successfully pass dermatology and stomatology board examinations, while being a valuable resource for dentistry trainees. Chapters cover aspects of mucosal immunity and clinical scores along with a range of diseases. Didactic features including learning objectives enable the reader to better extrapolate the key concepts covered in each chapter.Diseases of the Oral Mucosa: Study Guide and Review presents an in depth overview of the latest diagnostic tools and management options available for diseases of the oral mucosa and is an ideal resource for trainee and practising dentists, dermatologists and stomatologists preparing to sit board examinations.

Sjögren-Syndrom, Lupus erythematodes (SLE), Sklerodermie – dies sind nur einige der verschiedenen Formen der Kollagenose. Diese Autoimmunerkrankungen sind äußerst komplex und gehören sehr oft zu den Differentialdiagnosen entzündlicher Erkrankungen. In diesem Buch stellen Experten die einzelnen Kollagenosen vor. Die Thematik des Buchs erstreckt sich von der Epidemiologie bis hin zu Pathogenese, Autoantikörpern/Biomarkern, Krankheitsmanifestationen und Therapie der verschiedenen Organmanifestationen. Verständlich für den Hausarzt und Internisten erläutert sind die klinischen Bilder, die Diagnostik und die Therapie, für den Rheumatologen werden interessante Neuerungen in Diagnostik und Therapie vorgestellt.

3624 Einträge und über 8800 Suchbegriffe zu allen Haupt- und Nebengebieten der Laboratoriumsmedizin:· Kenngrößen mit Präanalytik, Analytik und Interpretation· Analysemethoden gut verständlich beschrieben· Statistik und Qualitätsmanagement, Labororganisation und EDVDer schnelle Zugang zur gesuchten Information wird erleichtert durch den lexikalischen Aufbau von A bis Z und einheitlich strukturierte Beiträge mit Literaturverweisen; über 730 Abbildungen (davon über 400 in Farbe) und über 380 Tabellen tragen zur Anschaulichkeit bei.Neu in der 3. Auflage· Ein Großteil der Beiträge wurde aktualisiert und zahlreiche neue Einträge und Suchbegriffe aufgenommen· Parallel zur gedruckten und eBook-Ausgabe erscheint eine online-Version, die als Live Reference-Ausgabe kontinuierlich aktualisiert wirdFür Ärzte aller Fachgebiete, Biochemiker, Chemiker, Fachberufe im Gesundheitswesen, Pharmazeuten, Toxikologen und Verwaltungsmitarbeiter im Gesundheitswesen sowie Lernende in den entsprechenden Studien- und Ausbildungswegen.dsf

The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet's disease, Sjogren's syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

This book examines in detail the clinical implications of those diseases that either are primarily triggered by air pollution or represent direct consequences of air pollutants. The aim is to provide medical practitioners with practical solutions to issues in diagnosis and treatment while simultaneously furnishing other interested parties with crucial information on the field. The book introduces the concept that air pollution-related diseases constitute a new class of pathologies. A wide range of conditions mainly attributable to air pollution are discussed, covering different body systems and pollution impacts in subsets of the population. In addition to presenting state of the art overviews of clinical aspects, the book carefully examines the implications of current knowledge for social and public health strategies aimed at disease prevention and prophylaxis. The Clinical Handbook of Air Pollution-Related Diseases will greatly assist doctors and healthcare workers when dealing with the consequences of air pollution in their everyday practice and will provide researchers, industry, and policymakers with valuable facts and insights.

Point-of care ultrasound, or ultrasound performed and interpreted by the clinical in the clinic/office or at the bedside, has been rapidly expanding in use among multiple medical specialties. Musculoskeletal ultrasound has added value to clinical care to expedite diagnoses by visualizing mechanical versus inflammatory features and correlating these findings with patient's symptoms. The use of power Doppler to assess for subclinical inflammation or active hyperemia has been a distinguishing use of ultrasound for rheumatologists. Accurate needle guidance with ultrasound for joint and tendon procedures has allowed expansion of procedures in the clinic and has been associated with less pain and precise targeting of affected structures. Musculoskeletal ultrasound education is now offered in nearly all rheumatology fellowship training programs in the United States and is also included in residency training in other specialties (e.g. physical medicine and rehabilitation, orthopedics, podiatry, emergency medicine, and family medicine). Since the publication of the first edition of Musculoskeletal Ultrasound in Rheumatology Review, there has been tremendous growth of musculoskeletal ultrasound in the field of rheumatology as well as other musculoskeletal specialties.The expanded second edition of this practical guide provides an updated clinical review of diagnostic and interventional applications of musculoskeletal ultrasound in rheumatology. New and revised chapters focus on the use of ultrasound in the diagnosis of specific rheumatic diseases such as osteoarthritis, scleroderma, psoriatic arthritis, gout, and lupus. Each chapter covers a standardized protocol of joint images with probe placement and includes numerous examples of common ultrasound pathologies. Study tools such as key-concept overviews, lists of important studies in the field, and extensive questions for self-assessment are included throughout.Written by current experts and thought leaders in the rapidly advancing field of rheumatology ultrasound, the second edition of Musculoskeletal Ultrasound in Rheumatology Review is an essential reference for physicians and related professionals, residents, fellows, graduate students and nurses in rheumatology, imaging and radiology, sports medicine, internal medicine, and physiotherapy.

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.

Significant progress has been acquired in the treatment of rheumatic conditions with the introduction of biologic therapies, which has enabled better control of disease activity and improved patients'long-term outcome. Apart from several biologic treatments already licensed for use in autoimmune rheumatic conditions, numerous other agents are currently under investigation. This rapid expansion of the therapeutic armamentarium requires a critical analysis of individual biologic options and their clinical indications, in order to facilitate the optimal use of these new therapies. The authors felt that a comprehensive book revisiting all the evidence available regarding the efficacy, cost-effectiveness and health implications of the use of biologics in rheumatology was needed in order to integrate the clinical, ethical and socio-economic aspects related to their use. This book is aimed at specialist doctors, trainees, nurses and health professionals working in the field of rheumatology. It critically appraises the level of evidence behind the use of biologic agents in diverse autoimmune diseases, comprising separate chapters which focus on rheumatoid arthritis, systemic lupus erythematosus, myositis, systemic sclerosis, Sjogren's syndrome, seronegative spondyloarthropathies, psoriatic arthritis and psoriasis, small, medium and large vessel vasculitis, osteoporosis, and interstitial lung disease associated with rheumatic conditions. In addition, the book explores aspects related to the use of biologic agents, such as ethical considerations of consenting patients to take part in clinical trials with biologics, and adolescent and adult rheumatology nurse perspectives related to patients'benefits of biologic therapies. Particular interest is given to the use of biologics during pregnancy and assessment of their infectious risks. A separate chapter explores the off-target benefits associated with the use of anti-TNF therapies. Several chapters include data about cost-effectiveness, and national and international guidelines for the use of biologic agents in different rheumatic conditions.

Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment.This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society.Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.

A Visual Guide to Scleroderma and Approach to Treatment offers a focused analysis of the diagnosis and management of scleroderma. Specifically designed to enlighten and update students and trainees, practicing rheumatologists and general practitioners on the various forms of systemic sclerosis, the book is designed to be an easily accessible tool that also covers potential complications and the latest treatment developments. A Visual Guide to Scleroderma and Approach to Treatment emphasizes recognition of common clinical features by focusing on and illustrating severe and less severe forms of the disease that can involve internal organs such as the gastrointestinal tract, heart, lungs and kidneys. Photos and radiographs introduce each chapter and are accompanied by a guide to workup and treatment. A comprehensive and invaluable addition to the literature, this text is not only a necessary resource for students, trainees and primary care physicians; it will also be of significant interest to specialists in the fields of rheumatology, dermatology, pulmonology, cardiology, gastroenterology and nephrology.

Raynaud's Phenomenon: A Guide to Pathogenesis and Treatment comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists alike. In the last decade, there have been important advances not only in understanding the pathophysiology of Raynaud's Phenomenon (RP), but also in developing diagnostic methods and effective drug and non-drug therapies. Thoroughly discussing the various manifestations of RP, including childhood RP, RP secondary to connective tissue disease, and a variety of other associated disorders that include vascular perturbation that mimics RP, this title provides a wealth of new information available on normal and abnormal thermoregulation and helps physicians identify the best therapeutic approaches to treating RP. The work offers differential diagnosis options, reviews potential causes such as autoimmune disease, industrial trauma, drugs, and metabolic causes and provides clear recommendations for therapy. Engaging readers with case vignettes and a plethora of visual aids, Raynaud's Phenomenon: A Guide to Pathogenesis and Treatment is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to physicians, patients, and individuals dealing with these disease processes.

The spectrum of systemic rheumatologic disease (often termed connective tissue disease) is characterized by autoimmune-mediated organ dysfunction, and the lungs are a frequent target. There are numerous pulmonary manifestations associated with connective tissue diseases, and all patients with rheumatologic disease are at risk of developing associated lung disease. Pulmonary Manifestations of Rheumatic Disease covers the comprehensive management of rheumatologic lung disease, which requires a multi-disciplinary approach and is optimized by active engagement by rheumatologists working closely with pulmonologists and other specialists. The book offers a practical reference using a case-based approach for practicing clinicians in the ongoing assessment and understanding of rheumatologic lung disease, and presents the science and pathophysiology underlying rheumatologic lung diseases. The first text of its kind specifically dedicated to describe diverse, commonplace, and challenging aspects of rheumatologic lung diseases, Pulmonary Manifestations of Rheumatic Disease serves as an invaluable tool for the practicing clinician.

This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.

Current methods of diagnosis and treatment in the specialty of angiologyVascular Medicine, Second Edition presents the current methods of diagnosis and treatment across the entire specialty of angiology, providing clear guidance on vascular medicine from well-known specialists. Updates include coverage of recent advances in endovascular therapy, an introductory anatomy section in each chapter, and a detailed duplex ultrasonography section for every vascular region. This new edition also contains chapters on the increasingly important areas of acute stroke treatment and renal sympathectomy, each written by leading experts in those treatment methods. Key Features:Focuses on the medical as well as the surgical aspects of angiology Complete coverage of all three treatment options: conservative treatment, endovascular therapy, and surgery Interdisciplinary approach that includes outpatient medicine, vascular medicine, cardiology, and radiologyAll medical specialists involved in vascular medicine, as well as interventional specialists and vascular surgeons, will find this book to be an invaluable reference throughout their careers.

Das Repetitorium entstand in Zusammenarbeit mit dem Bundesverband Deutscher Internisten e.V. (BDI) und basiert auf den Weiterbildungskursen des BDI. Es enthält nur unmittelbar prüfungsrelevantes Wissen für die Facharztprüfung Innere Medizin. Allgemeininternistisches Wissen aus den Schwerpunktbereichen Angiologie, Kardiologie, Endokrinologie, Gastroenterologie, Hämatologie/Onkologie, Nephrologie, Pneumologie, RheumatologieZur Prüfung notwendiges Wissen aus Infektiologie, Intensivmedizin und Sonografie in jeweils eigenen KapitelnÜbersichtliche Darstellung der prüfungsrelevanten Krankheitsbilder helfen, sich alles Wichtige einzuprägenAlle Lerninhalte abgestimmt mit den aktuellen LeitlinienExtra hervorgehobene Praxisempfehlungen Die Inhalte dieses Titels sind auch im Online-Produkt Innere-Medizinwelt.de. Diese und allen anderen Medizinwelten finden Sie auf www. Elsevier-Medizinwelten.de. Von dort haben Sie Zugriff auf weitere Informationen zu den Produkten, können sich einen kostenfreien Testzugang einrichten oder „Ihre Welt'direkt kaufen.

Hypertension, also referred to as high blood pressure, is a disease afflicting almost 1 billion people worldwide. Some 70 million adults in the United States are affected by hypertension. The condition also affects about two million teens and children. It is called the'silent killer'due to the deleterious damaging effects, such as stroke, myocardial infarction, renal dysfunction, visual problems, among others, derived from hypertension. It is noteworthy that one-third of patients in this condition are not even aware they are hypertensive, as this disease is usually asymptomatic for many years, even decades, until it finally damages certain critical organs and the only reliable way to detect its occurrence is to regularly check blood pressure. Therefore, considerable effort has been devoted to ascertain the causes of hypertension, as well as the mechanisms damaging the organ function. Nevertheless, about 95% of cases have unknown causes and represent the primary or essential hypertension. This book presents an update of research advances contributing to a better understanding of relevant clinical models of hypertension, particularly; the involvement of the role of oxidative stress in various forms of hypertension as a still emerging subject. This paradigm could be applied to account for blood pressure elevation in the metabolic syndrome, renovascular disease, preeclampsia and chronic kidney disease, among others. These examples are discussed in the light of recent clinical and experimental studies providing a rational base for diagnosis and treatment of the diseases. Each chapter includes a synthesis of the mechanistic approach supported by the accumulated evidence to facilitate its comprehension.

Core Concepts in Parenchymal Kidney Disease provides comprehensive and state-of-the-art information on the diagnosis, treatment, classification and pathogenesis of glomerular and tubulointerstitial diseases. Chapters feature various clinical scenarios and are authored by a team of renowned experts in the field. Experienced clinicians and trainees alike will find this authoritative reference to be a valuable resource and contribution to the literature.

Differentialdiagnose rheumatischer Erkrankungen stellt das gesamte vielfältige Diagnosespektrum der rheumatischen Erkrankungen von der Methodik bis zur endgültigen Evaluierung und Abgrenzung zu anderen Erkrankungen dar. Neben Früh- und Spätdiagnose der häufig vorkommenden Erkrankungen werden auch selten vorkommende Formen ausführlich beschrieben. Dem Leser werden Entscheidungswege zur vollständigen Differentialdiagnose gegeben, die ihm erlauben, die notwendigen Therapien einzuleiten. Somit ist das Buch ein wertvolles Referenzwerk für Rheumatologen aber auch für Orthopäden, Radiologen und Sportmediziner.

Systemic sclerosis or scleroderma is an autoimmune disease characterized by widespread microangiopathy, immune system alterations and fibrosis of the skin and internal organs. This book presents current research in the study of the symptoms, diagnosis and treatment of scleroderma. Topics discussed include the identification and treatment of the pulmonary manifestations of systemic sclerosis; interstitial lung disease in systemic sclerosis; nailfold capillaroscopy and early diagnosis of systemic sclerosis; localized scleroderma; evaluation of a new CENPB epitope array for systemic sclerosis-associated centromere autoantibodies; and iloprost in the treatment of Raynaud phenomenon secondary to scleroderma.

Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea­ cher, and the unswerving commitment of the investigator. Fass­ bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam­ ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor­ mous achievements made in molecular biology, genetics, struc­ tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis­ eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century.

Das Buch mit namhaften Autoren soll Medizinstudenten und Allgemeinmedizinern ebenso wie niedergelassenen und klinisch tätigen Internisten und Rheumatologen den derzeitigen Wissensstand über molekulare und zelluläre Grundlagen rheumatischer Erkrankungen und den sich daraus entwickelnden Therapieprinzipien vermitteln.

A huge number of therapeutic studies has been published in rheumatology and clinical immunology. This number grows substantially by the year. As such, it becomes increasingly difficult to keep track of this multitude of studies and the ensuing therapeutic trends. Further to this, a particular study can be referred to in a variety of ways, either as a shortened version of the title or an acronym, adding to the confusion. The book Clinical Trials in Rheumatology, Second Edition, provides an updated summary of the important studies in the field for easy reference. Every study is shown with name, acronym (if in existence), authors, complete citation, study design, and a short overview of the trial's data and main conclusions. An acronym finder is supplied at the beginning of the book. This book is a valuable reference tool for rheumatologists and other clinical specialties, as well as for research scientists interested in immunomodulatory and selected other drug therapies in rheumatologic diseases.

This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

Aging trends in the United States and Europe continue to demonstrate an increasingly older society, a trend that is unlikely to change for decades to come. This trend renders it prudent for health care providers to better prepare for the changes in society and their health needs. The current number of older adults (aged over 65), about 13% of the U.S. population, is expected to grow to over 20% in the next 20 years. Preparation for the changes in society involves provision of training for current and future generations of physicians to deal with health problems of older adults.Training programs in internal medicine and gastroenterology are required to deal with disorders of aging in the present day hospitalized, long-term care and community older adults. Physiological changes and disease processes in older adults differ significantly from those of the young; these are aspects that trainees and practicing physicians need to have an understanding of. Yet texts devoted to gastrointestinal illness in the elderly are scant at this stage and are clearly in demand.This text provides a comprehensive overview of gastrointestinal disease and disorders in older adults. Divided into sixteen sections, this major reference work covers all aspects of gastroenterology as it pertains to older adults, including epidemiology, gastrointestinal physiology, motility disorders, luminal disorders, hepatobiliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, and gastrointestinal cancer. In addition to fully revised chapters from the previous edition of Geriatric Gastroenterology, the latest edition features new chapters on drug injury to the GI tract, gut microbiota and aging, dysphagia, diabetes and its manifestations, and nursing for GI disorders. Nutrition and related disorders, as well as capsule endoscopy and its utility in the geriatric population, are also highlighted in the text. Presented in a simple, easy to read format, the volume includes numerous figures, tables, and key points to enable ease of understanding.

This Monograph aims to provide an in-depth overview of our current understanding of the various forms of pulmonary hypertension, their diagnosis and their treatment.

The pulmonary circulation is by nature difficult to evaluate for the clinician and a challenge to investigate by radiographic and hemodynamic methods. In recent years, the field has been revolutionized by major improvements in diagnostic approaches and therapies. Tools for the classification, diagnosis, and management of pulmonary embolism and pulmonary hypertension have been developed and optimized, providing clinicians with detailed and updated guidelines. This volume provides the latest information on the fast-growing and challenging field of acute and chronic pulmonary vascular disorders from some of the field's major leaders in research, education, and care. The topics discussed are relevant to chest physicians, thoracic surgeons, nurses, students, and teachers, and a well-balanced mix of contributions ensures that doctors, clinicians, and institutions from all around the world will find the information presented to be both informative and useful to their situations.

This book provides a practical and secure guide through the complexity of Autoimmune Diagnostics and Diagnostic Pathways. It contains an overview of significant aspects of Autoimmune Diagnostics, a standard procedure for indirect immunofluorescence and describes all important autoimmune diseases in terms of their diagnostic. In step with actual practice the innovative concept of Diagnostic Pathways leads from symptoms through all steps and branches to diagnosis.

Edizione italiana a cura di: Vincenzo Eusebi Considerato il testo internazionale di riferimento per studenti e medici per lo studio della patologia generale e specialistica, il “Robbins” giunge, aggiornato e rivisto, alla sua ottava edizione. Gli Autori, tutti opinion leader del settore, spiegano la correlazione tra la patogenesi delle malattie e la clinica, utilizzando tutti gli strumenti a disposizione: la morfologia, la biologia cellulare e la genetica. Punti di forza •I 29 capitoli che costituiscono il libro sono suddivisi in due sezioni: Patologia generale e Malattie degli organi e degli apparati. •Particolarmente aggiornati il capitolo 3 con nuove informazioni sulla biologia cellulare e sui fattori di crescita; il capitolo 5 con dati recenti sulla diagnosi molecolare che riflette le nuove conoscenze fondamentali per lo studio di malattie come cancro e diabete; il capitolo 9 che fa il punto sulla sempre maggiore importanza del fattore ambientale nello sviluppo delle varie patologie; il capitolo 17 propone nuove nozioni sulla patogenesi della malattia infiammatoria intestinale e dei tumori gastrointestinali; Il capitolo 22, tratta le malattie dell'apparato genitale femminile, include la discussione delle basi molecolari del cancro, dell'endometriosi e della preeclampsia. •L'opera è corredata da oltre 1600 figure a colori.di alta qualità. •Il Pin Code consente l'accesso al sito Student Consult che contiene il testo completo in lingua originale, casi clinici, tutte le immagini che sono scaricabili, un microscopio virtuale per esaminare le immagini selezionate a diversi livelli di ingrandimento e le voci bibliografiche singolarmente consultabili via Pub Med.

A huge number of therapeutic studies has been published in rheumatology and clinical immunology. This number grows substantially by the year. As such, it becomes increasingly difficult to keep track of this multitude of studies and the ensuing therapeutic trends. Further to this, a particular study can be referred to in a variety of ways, either as a shortened version of the title or an acronym, adding to the confusion. The book Clinical Trials in Rheumatology provides a summary of the important studies in the field for easy reference. Every study is shown with name, acronym (if in existence), authors, complete citation, study design, results, and summary. An acronym finder is supplied at the beginning of the book. This book is a valuable reference tool for rheumatologists and other clinical specialties, as well as for research scientists interested in immunomodulatory and selected other drug therapies in rheumatologic diseases.

A 50 anni dalla prima pubblicazione il “Robbins” continua a essere il testo internazionale di riferimento di patologia per studenti di Odontoiatria e Protesi Dentaria, Biologia, Farmacia, Veterinaria e per medici. In questa ottava edizione gli Autori, tutti opinion leader del settore, spiegano la correlazione tra la patogenesi delle malattie e la clinica, utilizzando tutti gli strumenti a disposizione: la morfologia, la biologia cellulare e la genetica. Punti di forzaAlcuni dei 10 capitoli in cui è suddiviso il libro sono stati aggiornati e riscritti: in particolare il capitolo 3 con nuove informazioni sulla biologia cellulare e sui fattori di crescita; il capitolo 5 con dati recenti sulla diagnosi molecolare che riflette le nuove conoscenze fondamentali per lo studio di malattie come cancro e diabete; il capitolo 9 che fa il punto sulla sempre maggiore importanza del fattore ambientale nello sviluppo delle varie patologie.L'opera è corredata da oltre 800 figure a colori.di alta qualità.

A new pathophysiology textbook specifically for Australian and New Zealand nursing studentsUnderstanding Pathophysiology provides nursing students with the optimal balance between science, clinical case material and pharmacology. With entrenched bio-medical terminology that can be difficult to relate to nursing practice, pathophysiology is a complex, though essential, component of all undergraduate nursing courses. Understanding Pathophysiology: ANZ Edition overcomes this difficulty by presenting the topic in an accessible manner appropriate to undergraduate nursing students in Australia and New Zealand. The book prioritises diseases relevant to nursing students and presents them according to prevalence and rate of incidence in Australia and New Zealand. This focused approach prepares students for the presentations they will experience in a clinical setting. Understanding Pathophysiology: ANZ Edition explores each body system first by structure and function, then by alteration. This establishes the physiology prior to addressing the diseases relative to the system and allows students to analyse and compare the normal versus altered state. This local edition of Understanding Pathophysiology incorporates a lifespan approach and explores contemporary health with specific chapters on stress, genes and the environment, obesity and diabetes, cancer, mental illness and Indigenous health issues. Clinical case studies are included in each chapter, with each patient case study highlighting the relevant medical symptoms of a given disease within a clinical setting. This is then analysed with respect to the relevancy of each symptom, their respective affect on body systems and the best course of pharmacological treatment. Elsevier's Evolve website provides extensive support materials for students and lecturers. Also available for purchase with this textbook is an e-book, Pathophysiology Online – a set of online modules, and a mobile study guide application.• pathophysiology presented at an appropriate level for undergraduate nursing students in Australia and New Zealand• an adaptation of a US edition – Understanding Pathophysiology, 4th Edition • diseases are addressed according to prevalence, incidence and relevance• a ‘systems'approach is incorporated with a ‘lifespan'approach within the alterations chapters• a new section on contemporary health issues examines the effects of an aging population and lifestyle choices on a society's overall health• new chapters on topics including homeostasis; genes and the environment; obesity and diabetes; mental health and Indigenous health issues• chapter outlines and key terms appear at the beginning of each chapter• concept maps provide visual representation of the key concepts addressed in each chapter• clinical case studies feature in each chapter to bring pathophysiology into practice• helpful ‘focus on learning'boxes in each chapter• key terms are bolded in the text and listed in the glossary• summaries of main points feature in each chapter• review questions at chapter end are accompanied by answers provided online

Although dermatomyositis is a rare connective tissue disease, many physicians are confronted with the diagnosis and treatment of patients affected by this condition. Based on the vast personal experience of the authors, who have diagnosed, treated, and managed many dermatomyositis patients, this clinical guide provides dermatologists, rheumatologists, pediatricians, neurologists, and general practitioners with the keys to interpreting the clinical symptoms of dermatomyositis. Also included are algorithms to help the reader to make the correct diagnosis, as well as guidance on new diagnostic methods and treatment schemes.

Die Zahl der möglichen Differenzialdiagnosen rheumatischer Erkrankungen ist außerordentlich hoch. Dieser Umstand macht die Diagnostik zu einem schwierigen Feld mit zahlreichen Fallstricken. Die korrekte und vollständige Diagnose ist aber Voraussetzung für die richtige Therapie. Dieses Buch erleichtert dem Leser diesen Weg vom Symptom zur Diagnose: Einer ausführlichen Darstellung der Grundlagen (Anamnese, Untersuchungsbefund, Labordiagnostik und Bildgebung) folgt eine detaillierte Beschreibung aller wichtigen Differenzialdiagnosen. Die mittlerweile vierte Auflage dieses Standardwerks wurde komplett überarbeitet und aktualisiert. Ein unverzichtbarer Ratgeber für alle, die Patienten mit Erkrankungen aus dem rheumatologischen Formenkreis behandeln.