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This book aims to illuminate the causes, incidence, and treatments of Hepatocellular Carcinoma(HCC) or liver cancer in the politically important and societally diverse region of the Middle East. Taking a flexible and inclusive view, it examines the influences of geography, crops and diet, ethnicity, and local behavior on both diagnosis and outcomes of this disease. Understanding the different causes of liver cancer enables effective strategies for both prevention and early diagnosis while knowledge of the different treatment modalities, their uses and limitations, availability and costs, works to inform rational treatment provision and selection. Divided into four sections, this book considers the causes and clinical syndromes associated with HCC, provides a detailed overview of clinical HCC and treatment modalities, describes country-specific clinical HCC experience and practice, and considers future needs and the potential for HCC collaborations across the region. Liver Cancer in the Middle East is a useful resource for clinicians seeking insight into the second highest cause of death from cancer worldwide, governments planning social and medical services for their peoples, as well as for international aid agencies prioritizing donations.

•Hepatocellular carcinoma (HCC) used to be regarded as a rare disease. However, the increasing numbers of chronic HCC carriers in the U.S. and subsequent increased incidences of HCC seen in most large medical centers means that it is no longer an uncommon disease for gastroenterologists or oncologists to encounter and its incidence and epidemiology are changing. During this exciting time in the field of HCC basic science and clinical management, many changes are simultaneously occurring at multiple levels of our understanding and management of the disease. Suddenly, there are several new choices of therapy to offer patients. Hepatocellular Carcinoma, 3rd edition addresses this fast-changing disease and gives the reader a clearer understanding of the many mechanisms involved in carcinogenesis of the liver. This comprehensive and detailed review of how to diagnose and treat hepatocellular carcinoma is written by international leaders in the field, covering both clinical treatment choices and the basic science underlying HCC development. Updated and enhanced from the last edition in 2009, Hepatocellular Carcinoma, 3rd edition features 12 new chapters including discussion of molecular markers, molecular hepatocarcinogenesis, microenvironment, heterogeneity, the new and exciting contributions of immunotherapy, and updates on the major effective hepatitis therapies that will transform HCC incidence and perhaps also the therapy. This cutting-edge text is a vital resource and must-have for today's hepatologists and medical and surgical oncologists.'This is a well written text and should be a good reference book for those who see patients with HCC..'- Practical Gastroenterology'...a useful tool for both physicians and surgeons with a specific interest in the management of patients with HCC.'- Digestive and Liver Disease

This comprehensive resource covers the current thoughts and trends on narcolepsy, as well as cutting-edge evidence-based research. Updates from the previous edition include advances in diagnostic guidelines, treatments, protocols and clinical and psychosocial considerations. Aspects of narcolepsy relating to sleep medicine, neurology, psychiatry and public health are featured throughout the text. Narcolepsy, 2nd Edition provides clinicians and allied health professionals with patient management modalities, clinical and quality of life issues and best practices for health care delivery.

Die gesamte Onkologie – verlässliches Wissen für Ihre Kompetenz!'Die Onkologie'stellt sich der Herausforderung, das ständig wachsende Wissen über Tumorerkrankungen in seiner Gesamtheit zu vermitteln. Sowohl inhaltlich als auch didaktisch auf höchstem Niveau: Fundiertes Grundlagenwissen zum umfassenden Nachschlagen Praxisrelevantes Know-how für Diagnostik und Therapie Systematischer Aufbau für das Verständnis der komplexen Zusammenhänge Angesehene Experten aus Klinik, Forschung und Praxis liefern Ihnen in Teil1 Klinisches Grundlagenwissen zu den Grundprinzipien der Therapie, Epidemiologie, Ätiologie und Pathogenese, sowie zu Komplikationen des malignen Wachstums. Teil 2 enthält umsetzbare und aktuelle Empfehlungen zu Diagnostik und Therapie aller relevanten soliden Tumoren und malignen Systemerkrankungen. Zum Nachschlagen und Anwenden: Finden Sie alle Optionen - auch für Ihren schwierigsten Fall. Der übersichtliche Aufbau und die exzellenten Abbildungen erleichtern Ihnen das schnelle Auffinden und Verständnis der gesuchten Informationen. Für den Alltag onkologisch tätiger Ärzte ist Die Onkologie ein unentbehrlicher Meilenstein.

Comprehensive and state of the art, the second edition of Pharmacotherapy of Depression offers major revisions of every chapter and the addition of new chapters by expert contributors. The first chapter reviews the neurobiology of depression, which lays the groundwork for understanding the mechanisms of action of antidepressants. In the next chapter, a review of the general principles guiding the diagnosis and medication treatment of unipolar depression is provided. The clinical pharmacology of antidepressants is reviewed in some detail, supplemented by tables that provide information on dosing, indications, and metabolism. Augmentation strategies are reviewed, including the use of non-traditional agents. The chapters that follow next address the use of antidepressants in special populations, such as the elderly and depressed individuals with psychosis, bipolar disorder, substance abuse, and post traumatic stress disorder. The complex issues involving the diagnosis and treatment of depression during pregnancy is thoroughly reviewed in Chapter 8 and provides a synthesis of the scientific literature in the area, one that is noted for contradictory and controversial findings, as well as guidelines for prescribing. The next chapter then provides an overview of the treatment of depression in the pediatric population, highlighting clinical concerns such as suicide risk. The book concludes with two chapters at the interface of medicine and psychiatry in the treatment of mood disorders: managing depression in primary care settings and depression associated with medical illnesses. The outstanding clinician-scientists who have contributed to this volume are all leaders in their fields and represent a broad spectrum of renowned institutions. A timely contribution to the literature, The Pharmacotherapy of Depression, Second Edition, offers busy clinicians from many disciplines a strong scientific foundation that seamlessly transitions into practical recommendations for clinicalpractice. The result is another gold-standard guide to the safe and effective use of the latest antidepressant medications.

Extensively revised since the third edition in 1995, this comprehensive text covers all common and rare malignant blood cancers and is an essential reference for hematologists and oncologists. The sixty-two chapters are divided into sections on Chronic Leukemias and Related Disorders, Acute Leukemias, Myeloma and Related Disorders, Lymphomas, and Supportive Care.