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Certain diseases may involve organ systems that cross the boundaries of specialties. For instance, a patient with scleroderma can develop interstitial lung disease, or a patient with relapsing polychondritis can have the clinical manifestation of subglottic stenosis. This book represents a collaboration between specialties, helping clinicians recognize the implications of disease both within their own specialty and in the overlapping specialty. Here, leading experts from the fields of rheumatology and pulmonology provide a masterclass in the care of patients with systemic illnesses that involve the immune system and the lungs.Key Features: Provides an evidence-based clinical approach to the patient with pulmonary manifestations of rheumatic disease Details cutting-edge research with input from the world's leading experts Discusses possible future directions for research and advancement

This reference work aims to be the primary resource in the field of heart disease in children and adult congenital heart disease. It contains nearly 100 chapters covering all aspects of heart disease in three populations: fetus with acquired and congenital heart diseases, children with acquired and congenital heart diseases, and adults with congenital heart diseases. Divided into five main sections, the book provides a comprehensive, up-to-date, and continuously revised overview of what is known in the field as well as resources for practical use such as normal values, medication information, and review of published guidelines. The first section of the book includes historical background on congenital heart disease and the evolution of medical, surgical, and catheter therapeutics. The fetal heart disease section comes next and covers cardiovascular embryogenesis, etiological mechanisms, diagnostic tools, presentation and management, cardiomyopathies, arrhythmias, perinatal management, and emergencies. The bulk of the book lies in the third section on pediatric cardiology, which examines not only basic science, assessment, and therapies but also a wide variety of specific acquired and congenital diseases such as valvular lesions, arterial diseases, cyanotic heart diseases, cardiomyopathies, cardiac tumors, and pulmonary hypertension. This is followed by the section on adult congenital heart diseases, discussing echocardiography, electrophysiology, neurodevelopment, and a variety of unique aspects of congenital heart disease in the adult years. The final section of the book focuses on pharmacology with chapters on inotropes, vasopressors, diuretics, and more. Pediatric Cardiology: Fetal and Pediatric Heart Diseases & Adult Congenital Heart Diseases is an essential reference for physicians, residents, fellows, medical students, nurse-practitioners, and allied health professionals in cardiology, pediatrics, cardiac surgery, and imaging/radiology.

This book examines the development and applications of system biology approaches for the prevention, diagnosis, and understanding of disease mechanisms. It explores the applications of system biology in infectious diseases, including host-pathogen interaction, and the identification of targets for new therapeutics and intervention strategies. It covers the use of system biology for understanding and treating metabolic disorders towards personalized and precision medicine. The book further discusses the systems biology approaches for understanding the mechanisms of tumor progression and designing more effective cancer therapies. The chapter also reviews the current strategies in autoimmune disease treatment and highlights the opportunity that systems biology represents for the development of better and safer treatments. Importantly, the book discusses the current state of the systems-level understanding of diseases and both the therapeutic and adverse mechanisms of drug actions usingsystem biology approaches. Cutting across the disciplines, this book is a valuable source for researchers in genetics, molecular biology, cell biology, microbiology, and biomedical sciences.​

This book comprehensively reviews the understanding of a disorder that continues to challenge primary care clinicians and specialists. Raynaud's phenomenon is an inappropriate and exaggerated response of the digital and cutaneous circulation to cold environmental temperatures. It is common, often causing significant morbidity and it is a major challenge for physicians at every level and specialty. A comprehensive review of Raynaud's is now timely because of the incredible progress in understanding the molecular mechanisms of the normal regulation of cutaneous blood flow and how disease can disrupt the function of these specialized vessels. Likewise, the clinical implications of Raynaud's phenomenon are better appreciated with studies defining its prevalence, the associated diseases, and new treatment approaches for patients suffering from it. The nomenclature used to classify cases has changed over the years and is important to understand these terms both for clinical care andresearch. This fully updated second edition comprehensively discusses various causes of Raynaud's phenomenon including childhood Raynaud's phenomenon, Raynaud's phenomenon secondary to connective tissue disease, occupational causes, and a variety of other associated disorders. Careful consideration is given to the diagnosis of Raynaud's phenomenon with state of the art discussion of nailfold capillary examination, non-invasive imaging, angiography, and appropriate serological testing. The concept that Raynaud's phenomenon is associated with systemic disease or can be the manifestation of a systemic vasospastic disorder is also presented. In addition to reviewing both non-drug and drug therapy for patients with Raynaud's phenomenon, this volume provides a practical approach in specific clinical situations by presenting problematic cases and the authors'expert opinions on therapy. It also discusses mechanisms contributing to the vascular dysfunctionof primary Raynaud's phenomenon and the vascular disease of secondary Raynaud's phenomenon. Engaging readers with case vignettes and a plethora of visual aids, Raynaud's Phenomenon: From Pathogenesis to Management is a state-of-the-art, authoritative reference and invaluable contribution to the literature that will be of interest to adult and pediatric physicians, rheumatologists, and clinical and basic researchers.

This book, Sunscreens for Skin of Color, provides a complete and comprehensive overview of all the aspects of sunscreens and their role in clinical practice. Tracing the evolution of sunscreens from the early days to the current exploration of plant-based sun screening agents, this book provides an in-depth update on sun protection. Chapters on UV filters, toxicology, ecological and environmental impact, and the relevance of sunscreens in the skin of color provide a balanced understanding of these essential personal care products. The book addresses the questions arising at the interface of patient-physician interaction: from what benefits sunscreens confer on the skin, to ways to circumvent potential health and environmental hazards. The unique role of sunscreens in SOC for the prevention of photo pigmentation and skin aging, the paradigm shift in sunscreen use arising from both sunscreen durability on skin, and potential for systemic absorption, and emerging questions like frontal fibrosing alopecia have been discussed in the context of sunscreen usage in the present day and age. The chapters are easy to understand, and the progressive information unfolding enables the student to assimilate the subject efficiently.

The Diabetes Textbook: Clinical Principles, Patient Management and Public Health Issues (2nd Edition) addresses diabetes from a comprehensive, multidisciplinary perspective. Its purpose is to integrate state-of-the-art information on diabetes from specialists in various disciplines, including epidemiology, public health, pathophysiology, non-pharmacologic and pharmacologic treatment, patient support, acute and chronic complications, new and unproven therapies, and prevention. The main benefit of “The Diabetes Textbook” is its integrative approach. The book is therefore intended for three main types of readers: 1) physicians and health professionals seeking a comprehensive approach to diabetes; 2) those with previous expertise in a specific professional area who want to expand their knowledge; and 3) those interested in learning about topics not previously covered, who will find the contents of “The Diabetes Textbook” both enriching and innovative. The Diabetes Textbook is intended for a broad readership, including professors of medicine and related disciplines (nursing, nutrition, psychology); general physicians; internists and specialists, e.g. in ophthalmology, endocrinology, cardiology, obstetrics and gynecology, pediatrics, geriatrics, epidemiology and public health. To address these readers'needs, the second edition is divided into the following eleven sections: 1) Magnitude of the Problem from an Individual and Social Context, 2) Diagnosis, Classification and Mechanisms of Disease, 3) Global Experiences in Diabetes Care, 4) Basic Components of Management: Patient-Centeredness, Evidence-Based Medicine, and Outcomes, 5) Resources of Support for Persons with Diabetes, 6) Drug Therapy, 7) Cardiovascular Risk Factors, 8) Acute Complications, 9) Chronic Complications, 10) Diabetes in Special Populations, and 11) Novel Therapeutic Approaches: Evidence-Based and Non-Proven, and Diabetes Prevention.

This new edition discusses classical aspects of cellular physiology and the metabolism of physical exercise, as well as novel topics like exercise in transplantation and exercise in beta-cell failure, which mark the frontiers of research in sport-related sciences and research. The team of authors together with the editor are world-renowned experts in the field of physiology and metabolism applied to sport sciences. In order to make the book answering also to current pandemic clinical issue, this second edition includes new chapters, specifically dealing with COVID-related issues.Exercise physiologists, biologists and physicians will benefit from this book. However, the comprehensive nature of the content makes this publication suitable also for university classes of graduate and undergraduate student.

The ESC Textbook of Heart Failure is the latest addition to the European Society of Cardiology (ESC) publications portfolio and is fully supported by the European Heart Failure Association. The textbook brings together internationally renowned experts in the field of heart failure to present an up-to-date understanding of all aspects of this chronic condition that worsens with time. It is estimated that the worldwide population of patients suffering from heart failure is approximately 26 million. This clinically oriented work reflects contemporary European guidelines from the ESC and the European Heart Failure Association and summarizes the latest evidence from clinical trials. Made up of eighteen different sections the textbook covers the epidemiology, etiology, prevention, pathophysiology, and clinical phenotypes of heart failure. The assessment and management of chronic, acute, and advance heart failure are all discussed in detail. As well as chapters dedicated to self-care and patient education, the multidisciplinary approach to heart failure management, and clinical trial design and interpretation. The future direction of the field is discussed throughout with separate chapters on digital health, big data, and telemedicine/remote monitoring in heart failure also included. A must read for cardiovascular healthcare specialists in Europe and across the world it should also appeal to those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, and specialist nurses too.

The extensively revised third edition of this text offers an in-depth practical guide to clinical conditions encountered in pediatric nephrology. Extensively updated disease-specific chapters offer detailed coverage of relevant basic science, diagnostic work-up, laboratory evaluation methods, appropriate management options and potential complications. Topics covered include disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, chronic kidney disease, dialysis, kidney transplantation and hypertension. Information is also provided on important related issues, including the genetic origins of diseases, the role of complement in the pathogenesis of kidney disease, and pharmacological aspects related to the kidney. Pediatric Kidney Disease comprehensively reviews a range of clinical conditions encountered in pediatric nephrology, assisting the reader to develop their skills and improve their clinical decision-making. It is a vital resource for trainees and practicing clinicians alike and a useful reference for those preparing for pediatric nephrology board examinations.

This book provides a practically applicable guide to the management of liver metastases in cases of colorectal cancer. It features detailed reviews of the latest diagnostic and therapeutic options. Instruction on how to appropriately apply surgical techniques including two stage hepatectomy as well as both laprascopic and open resection in a variety of scenarios is covered. The use of systemic therapies involving oxaliplatin, immunotherapy and infusional therapy are also described along with a range of surveillance strategies. Vauthey and Adam Colorectal Liver Metastasis comprehensively covers the latest advances in how to successfully diagnose and treat colorectal liver metastases and is an indispensable resource for all trainee and practicing medical professionals who encounter these patients within their clinical practice.

This book discusses the clinical management of adolescents with liver disease bridging the gap between pediatric and adult hepatology patient management. Expert views on liver disease in adolescence are discussed and specific differences for this patient subset are highlighted and examined in depth. The reader will gain the specific knowledge required on pathophysiology and treatment, but also about additional aspects such as psychological difficulties and cultural differences including use of social media.Information is presented in a manner relevant to clinical practice, and is fully up-to-date in terms of development and integration of new communication technologies in the society. This book offers a fresh insight to this transitional period which will be a great benefit to hepatologists both in pediatric and adult setting. Edited by two experts in the field and authored by international experts in the area using a multidisciplinary approach, this book is a helpfultool in managing these complex patients and will help minimise their complication rates and improve outcomes by the end of their transition periods.

This text consists of neoplastic and non-neoplastic lung pathology. It discusses frequently encountered issues and diagnostic problems using a Q&A format and case presentations. Emphasis is placed on differentiating one from another based on the histopathological features, ancillary tests including immunohistochemical and molecular analyses, and clinical and radiologic correlation. In particular, clinical-radiologic-pathologic correlation is emphasized in the diagnosis of interstitial lung disease (ILD). This text addresses the issues and diagnostic criteria in segregating a reactive process from adenocarcinoma, poorly differentiated adenocarcinoma from poorly differentiated squamous cell carcinoma, small cell carcinoma from other types of neuroendocrine tumors, large cell carcinoma from large cell neuroendocrine carcinoma, spindle cell/sarcomatoid carcinoma from sarcomatoid mesothelioma, and carcinoma from epithelioidmesothelioma in small biopsy specimens. It also discusses key features useful for differentiating usual interstitial pneumonia (UIP) pattern from non-UIP patterns of ILD such as hypersensitivity pneumonitis, nonspecific interstitial pneumonia, and organizing pneumonia patterns in wedge biopsy specimens as well as highlights the differential diagnosis in the granulomatous inflammation. As a whole, this text answers many of the difficult questions relevant to daily practice of lung pathology. Each chapter addresses a specific diagnostic question significantly related to patients'treatment options.

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importancefor maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.

This'patient-oriented'book was written as a meeting ground for practicing clinicians, allied health professionals, and clinical researchers to provide a practical guide for the contemporary assessment and management of patients with heart failure and cardiomyopathy. It revolves around broad patient scenarios to elegantly (or expertly) guide diagnostic and management strategies. Combining the talents of over one-hundred experts in the field, the book also endeavors to challenge the reader with areas of current controversies and opportunities for clinical investigation with the goals of both orienting clinicians and stimulating their research passions. Key Features Provides practical guidance based on real-life heart failure scenarios Discusses both acute and chronic care patient-oriented scenarios Covers up-to-date and novel concepts in heart failure Features the perspectives of current debates and controversies in heart failure Highlights the opportunities for research in this field

The emphasis in this book is on providing evidence-based basic understanding of the subject. The pathophysiology of diseases has been simplified. Modes of presentation and approach to investigations are given in a clinically applicable manner. Therapeutic plan, as given in guidelines, is summarized and presented in a way it has to be used in practice. Each chapter has been written by an expert in the field. Language is simple to comprehend. Enriched with graphs and tables for easy understanding. Effects of COVID-19 on various systems have been included. Provides an Indian perspective of the diseases in each chapter. Includes MCQs in the chapters for revision. Selected readings can be used for more information on the topic.

Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science. - New focus on high-yield, core knowledge necessary for clerkships or residencies in medicine, with concise, complete coverage of the core principles of medicine and how they apply to patient care. - Each section describes key physiology and biochemistry, followed by comprehensive accounts of the diseases of the organ system or field covered in the chapters. - Full-color design enhances readability and retention of concepts, while numerous imaging videos cover cardiovascular disease, endoscopy, sphincterotomy, and more. - Superb images and photographs vividly illustrate the appearance and clinical features of disease. - New chapters cover Women's Cancer and Transitions in Care from Children to Adults with Pulmonary Disease.

This book discusses all aspects of non-pharmacologic approaches to primary and secondary CVD prevention. It highlights the strength of evidence for particular diet styles in CVD prevention, including plant-based diets, the Mediterranean diet, the DASH diet, and low-carbohydrate diets. Chapters present evidence and future directions for diet and nutrition in diseases related to CVD, such as dyslipidemia, cardiometabolic disease (pre-diabetes, the metabolic syndrome, type-2 diabetes mellitus), and obesity. Finally, the book reviews novel and emerging aspects of dietary intervention in CVD prevention, such as dietary approaches to inflammation and the role of the microbiome in CVD. Up-to-date, evidence-based, and clinically oriented, Prevention and Treatment of Cardiovascular Disease: Nutritional and Dietary Approaches is an essential resource for physicians, residents, fellows, and medical students in cardiology, clinical nutrition, family medicine, endocrinology, and lipidology.

This unique work presents one of the most significant organ failure condition – cardiocirculatory shock – and the prominent role of Methylene Blue (MB). Through their extensive experience, the authors'consider that the lifesaving feature of MB is still underestimated. For this reason they outline key concepts of MB, mentioning essential experimental data, yet focusing mainly on its application in the care of critically ill patients. In an easy-to-read format, the 18 chapters were organized in a didactically structured order, distributed in four parts. The first part introduces the general conceptual aspects and physiology of the endothelium. The second part presents the particularities of endothelial dysfunction in different types of shock. Methylene blue is discussed in detail in the third part. In the fourth part, particular situations of endothelial dysfunction, such as heart surgery and organ transplantation, are described. Additionally, the two complementary subjects of acid-base balance and the therapeutic use of inhaled nitric oxide are mentioned. Finally, looking for therapeutic alternatives for what we classify as'vasoplegic endothelial dysfunction', MB remains promising as an adjuvant to sympathomimetic amines. The combination of three recently proposed concepts may be useful in obtaining better results against the high mortality rates in critically ill patients. These three concepts are'wide-spectrum vasopressors', vasopressor economy strategies, and microcirculation protection against the harmful effects of using high concentrations of amines. This book´s translational approach will appeal to a variety of readers within the health specialties of medicine, biomedicine, physiotherapy, nursing, odontology, and basic science.

Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

This book offers an extensive review of the most recent data on the pathophysiological role of structural and functional alterations in the microcirculation, particularly focusing on hypertension and diabetes. It covers several relevant and innovative aspects, including the possible mechanisms involved in the development of microvascular remodeling and rarefaction, the technical approaches available for the detection of microvascular alterations, including non-invasive evaluations, the prognostic role of changes in small resistance artery structure, the possibility of preventing or regressing such alterations with appropriate treatment, and the potential clinical advantages of such intervention. A number of innovative areas of research are considered, including the role of the immune system, inflammation and oxidative stress in the development of microvascular alterations. Lastly, it examines the availability of recent non-invasive methods for the evaluation of small resistance artery morphology in the retina, which in the near future may provide a useful tool for the stratification of cardiovascular risk and even for clinical decisions regarding drug treatment, thus providing physicians with a clinically relevant instrument for improving and optimizing the management of hypertensive and diabetic patients. The book provides valuable, clinically relevant information for specialists (cardiology, internal medicine, and endocrinology) and general practitioners, and also offers novel and stimulating data to basic and clinical researchers.

Dieses Buch beschreibt umfassend das aktuelle immunologische, neurologische, biochemische, molekularbiologische und pharmakotherapeutische Wissen über allergische und pseudoallergische Reaktionen. Ausgehend von den immunologischen und neuroimmunologischen Ursachen der allergischen und pseudoallergischen Reaktionen des Menschen werden die klinischen Bilder der allergischen Reaktionen, deren Diagnosen und Differentialdiagnosen und deren therapeutische und prophylaktische Möglichkeiten dargestellt. Einzeln beschrieben sind die unterschiedlichen allergischen Reaktionen, im Besonderen diejenigen vermittelt durch Antikörper und durch Chemokine die immunologischen Mechanismen zur Entwicklung einer Toleranz gegen Allergene die Rolle des Nervensystems bei der Entwicklung und Auslösung von allergischen und pseudoallergischen Reaktionen der allergische Formenkreis (akute allergische und pseudoallergische Reaktionen) Neurodermatitiden asthmatische Reaktionen gastrointestinale Reaktionen und Lebensmittelunverträglichkeiten allergische Schockreaktionen chronische allergische Reaktionen allergische Reaktionen und Unfruchtbarkeit allergische Erkrankungen und das Auftreten von Tumorerkrankungen

This volume reviews current and potential future therapies for arrhythmias. It is a highly practical guide for the use of pharmaceuticals in the management of the discipline, and has been written in a simple quick-access format.Antiarrhythmic Drugs builds on the current understanding of pathophysiological mechanisms and insights gained from previous studies of therapeutic interventions. It is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis.

INTRODUCTION: Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage including left-ventricular hypertrophy and congestive heart failure, which in turn increases the risk of cardiovascular morbidity and mortality. While studies of hypertension have been performed worldwide in a variety of epidemiological settings such as diabetes, renal function, obesity and thyroid disorders, there is a need to identify appropriate treatment strategies Novel Strategies and Approaches in Hypertension introduces the reader to different aspects of hypertension treatment (environmental and occupational factors and different clinical settings that can trigger the disease). The book also covers special topics related to the use of new diagnostic biomarkers for hypertension patients, as well as endocrine and nutrition-focused approaches to treat the condition. This reference book will be useful for medical professionals involved in the management and care of patients affected with hypertension. [Series Introduction] Frontiers in Hypertension presents reference works, textbooks and monographs on both fundamental and advanced topics related to the pathophysiology, diagnosis and treatment of hypertension. The series is essential reading for medical students and professionals involved in hypertension and allied subspecialty treatment programs.

The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data.FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere.The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area.The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Bereits seit Jahrzehnten ist in den Industrieländern das multiple Organversagen die dritthäufigste Todesursache, - nach den Herz-Kreislauferkrankungen und den vielfältigen Krebserkrankungen. In Deutschland sind dem multiplen Organversagen mehr als 70.000 Todesopfer/Jahr zuzuschreiben. Die häufigsten Ursachen sind Sepsis, Polytraumata, kritisch verlaufende Virusinfektionen wie auch toxische Einwirkungen. Ausgangspunkt ist eine Zellschädigung gleich in welchem Organ, welche zur lokalen Aktivierung der Abwehr und Reparatursysteme des Körpers führt. Hierzu gehören das Kinin-, das Komplement-, das Gerinnungs- und das Fibrinolysesystem wie auch das unspezifische und spezifische Entzündungs- und Immunsystem. Diese aktivierten Systeme dienen einerseits der Begrenzung und Ausheilung der ursprünglichen Schädigung, können bei persistierendem oder sich verstärkendem Schaden aber auch in eine sich selbstverstärkende Aktivierungsspirale münden, in einen Teufelskreis, welcher im primär betroffenen Organ dessen teilweise oder vollständige Funktionsunfähigkeit bewirkt, bei Versagen der lokalen Regulationsmechanismen die Abwehrsysteme auch in anderen Organen aktiviert und dort zu weiteren Zellschädigungen und Funktionsbeeinträchtigungen führt, in den Blutkapillaren aller betroffenen Organe in eine verstärkte Gerinnung bei mangelnder oder fehlender Fibrinolyse mündet und letztlich im multiplen Organversagen als katastrophale Folge endet. Zu verhindern sind die schwerwiegenden Folgen des multiplen Organversagens nur durch eine frühe Diagnostik von aktivierten Faktoren der Abwehrsysteme, durch eine Kompensation der durch die Abwehrsysteme bedingten Schäden und durch eine Stärkung derjenigen Faktoren, welche die Gerinnung hemmen und die Fibrinolyse fördern. Im vorliegenden Buch wird auf die Ursachen der Zellschädigung in den unterschiedlichen Organen eingegangen, der Prozess der hierdurch bedingten lokalen Aktivierung der unterschiedlichen Abwehrsysteme näher geschildert, die inhibierenden Mechanismen der Aktivierungen näher dargestellt und der Übergang von der lokalen Organ-Schädigung hin zum multiplen Organversagen im einzelnen beschrieben.

pproaches to and therapy for many cardiovascular disorders have changed greatly over the past several decades, but perhaps none have changed so greatly as the understanding of and therapy for heart failure. Advances have occurred in the understanding of the varying physiology for this clinical syndrome, including pharmacologic therapy, device therapy, and therapy for truly advanced stages of the syndrome. Future developments may well involve gene or stem cell therapy. Clinical trials continue to define the roles of newer approaches. Clearly, this highly prevalent syndrome and the evolution of its clinical appreciation and treatment have become too extensive; it is a rapidly evolving subject that until now has not been adequately covered in a standard medical textbook. Heart Failure: What a Non-Heart Failure Specialist Needs to Know has been created to reflect the growth and expansion of the clinical field of heart failure and is aimed at non-specialists (primary care physicians, ER staff, general cardiologists, trainees, etc.) who encounter these patients on a daily basis. The authors hope that this book will provide the background for practitioners to develop rational therapeutic regimens designed to alleviate symptoms and improve the quality and quantity of life for patients with heart failure.

MASTER MODERN MEDICINE! Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state-of-the art radiographic images, therapeutic approaches and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison's Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible. Essential for practice and education, the landmark 20th Edition features: Thoroughly revised content—covering the many new breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison's. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care. State-of-the-art coverage of disease mechanisms: Harrison's focuses on pathophysiology with rigor, and with the goal of linking disease mechanisms to treatments. Improved understanding of how diseases develop and progress not only promotes better decision-making and higher value care, but also makes for fascinating reading and improved retention. Harrison's summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system's role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease. Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals. All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include: Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine—Plus, a new Part covering cutting-edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro-Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine. Important and timely new chapters—such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more—offer the very latest, definitive perspectives on must-know topics in medical education and practice. Updated clinical guidelines, expert opinions, and treatment approaches from world-renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient outcomes. End-of-chapter suggested readings reinforce the text material and provide a robust platform for further study and research.

Herbal Medicine: Back to the Future compiles expert reviews on the application of herbal medicines (including Ayurveda, Chinese traditional medicines and alternative therapies) to treat different ailments. The book series demonstrates the use of sophisticated methods to understand traditional medicine, while providing readers a glimpse into the future of herbal medicine.This volume presents reviews of traditional Chinese medicine and other nutritional therapies useful for treating cardiovascular diseases, including:-cardiovascular benefits of the European Olive and bottle gourd-a review of the cardiovascular benefits of Naoxintong-herbal and micronutrient supplements for cardiovascular disease patients-herbal remedies for atherosclerosis-cardio-protective alkaloidsThis volume is essential reading for all researchers in the field of natural product chemistry and pharmacology. Medical professionals involved in cardiovascular care who seek to improve their knowledge about herbal medicine and alternative therapies will also benefit from the contents of the volume.

The aim of this unique book is to provide an overview of recent advances bridging the gap between psychiatry and neuroscience, allowing a fruitful dialogue between both sciences. The emerging interactions and mutual contributions between neuroscience and psychiatry are here recognized. This book is designed to identify the borders, trends and implications in both fields today.Comprehensive and developed by a renowned group of experts from both fields, the book is divided into four parts: Epistemological Considerations About the Study of Normal and Abnormal Human Behaviors; From Basic Neurosciences to Human Brain; Neurosciences, Learning, Teaching and the Role of Social Environment; and Explaining Human Pathological Behaviors: From Brain Disorders to Psychopathology. A unique and invaluable addition to the literature in psychiatry and neuroscience, Psychiatry and Neuroscience Update – Vol. II: A Translational Approach offers an important and clearer understanding of the relationship between these two disciplines. This book is directed to students, professionals and researchers of medicine, psychology, psychopedagogy and nursery.

Stroke, a brusque interruption of blood supply in an area of the brain, has a sudden and frequently devastating impact on both patients and their families. Although stroke is most common in older people, it can occur in individuals of any age, including young adults and children. Fortunately, the prospects for preventing and treating stroke are far better than they were just a few decades ago. However, a lot of challenges await physicians and researchers in terms of prevention, pathogenesis and treatment. Stroke remains a high priority medical condition for our society; globally, about 15 million people suffer of cerebrovascular diseases, with stroke being the most frequent life-threatening neurological disease and the third cause of death and disability. The authors of Advances and Challenges in Stroke hope to guide readers through the complexity of stroke pathogenesis, from the molecular basis to the most recent advances in terms of pathophysiological cascade leading to cell death. Through the expert opinion of Italian and European researchers, multiple aspects will be explored, including the etiology of juvenile or cryptogenic stroke, correlations between the heart and brain, state-of-the-art telemedicine in reducing door to needle and decision-making time, and the contribution of modern neuroimaging techniques and surgical/endovascular treatment in the hyperacute stroke phase.

Chronic liver disease is one of the most prevalent diseases in the developed world. The large amount of new knowledge has resulted in subspecialities, even in issues such as hepatology. Thus everyday, it is more difficult to access all relevant information that is being published. Additionally, biomolecular techniques lead to a level of complexity that is only beneficial when dealt with by professionals. This book attempts to give a broad overview of the molecular biology of the liver, emphasizing how this knowledge is the basis of further treatment. Thus, pathophysiology and therapies are updated in viral hepatitis, hepatic encephalopathy and portal hypertension, among others. However, appended issues that apparently are less relevant such as the stem cell and endocannabinoids are included. These two issues will soon be of importance due to their close relationship with the liver tissue and especially with liver disease. There are also new paradigms such as cell death and the implication of the extracellular matrix, which are also addressed. In addition, important issues such as the stellate cells and their intimate relationship with fibrogenesis are treated in-depth. Also the fundamental role of endothelin in chronic liver disease is examined. Because of its prevalence, NASH was discussed with special interest, with a focus on the process from fatty liver to molecular biology of liver cells and metabolism in chronic liver disease. The authors believe that this is a broad vision that describes the basic pathophysiological mechanisms shared by many liver diseases, giving rational support for specific therapies.

The aim of this book is to focus on the otorhinolaryngology. Otorhinolaryngology is the medical discipline involving the assessment, diagnosis, treatment, and management of diseases, abnormalities, and other health problems affecting the ears, nose and throat, as well as the head and neck, mouth, sinuses, and voice box (larynx). Also referred to as ENT, otorhinolaryngology is considered as one of the oldest medical practices in the United States. Aside from medical management, they are also trained to perform surgeries that involve the above-mentioned body parts, including plastic or reconstructive surgeries. Otorhinolaryngologists training can take up to 15 years. This book comprises of 6 sections following as head & neck, cranial base and oncology, laryngology, rhinology, endoscopic sinus surgery, facial plastic and otology which consists of 166 chapters. It includes transsphenoidal pituitary surgery, fibrous dysplasia of the skull base, epidemiology of head and neck cancer, training of a head and neck surgeon, molecular markers in head and neck cancers, chemotherapy in head and neck cancers, thyroid cancer, oral cavity cancer, cancer of the temporal bone, tumors of the parathyroid gland, congenital anomalies of larynx and trachea, anatomy of the lateral nasal wall, diagnostic audiology and facial nerve testing, squamous cell carcinoma etc. Advances in the management of head and neck cancers take place on a continuous basis and this compendium provides an exhaustive overview of current practices in the field of head and neck cancer.

The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive reference book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

This issue of Medical Clinics, guest edited by Dr. Edward Frohlich, is devoted to Hypertension. Articles in this outstanding issue include The Kidney in Hypertension; Heart: Fibrosis, Apoptosis, and Cardiac Failure; Myocardial Ischemia; Oxidative Stress and Hypertensive Diseases; Adherence to Antihypertensive Therapy; Aging and Hypertension; Target Organs and Microbiological Considerations in Hypertensive Diseases; Obesity and Sodium Considerations; Diabetes, Hypertension and Cardiorenal Syndrome; Renal Arterial Disease; Cardiac Transplantation and Hypertensive Diseases; Cardiac Failure: Old and New Challenges; Diastolic Dysfunction and Hypertension; Stiffening of Large Arteries; Genetics and Mechanisms; New Guidelines for Hypertensive Diseases; and Local Renin Angiotensin Systems.

Sleep and Psychosomatic Medicine presents an overview of sleep medicine and the management of common sleep disorders seen in a wide variety of practice settings.Chapters have been written by experts in the field in order to provide physicians of a wide range of interests and abilities with a highly readable exposition of the principal results, including numerous well articulated examples and a rich discussion of applications.The second edition has been revised to further broaden the scope with the inclusion of several new chapters such as Sleep and Dermatology, Fatigue in Chronic Medical Conditions, Occupational Sleep Medicine, Restless Legs Syndrome and Neuropsychiatric Disorders and Sleep Dysfunction after Traumatic Brain Injury, to name a few.This second edition of Sleep and Psychosomatic Medicine is an interdisciplinary, scholarly, authoritative, evidence-based review of the field designed to meet the needs of a wide range of health care professionals, including psychiatrists, psychologists, nurses, medical students, and social workers in health care settings.

This issue of Medical Clinics of North America, guest edited by Drs. David A. Sass and Alden M. Doyl, is devoted to Care of the Liver and Kidney Transplant Recipient. Articles in this issue include: Liver and kidney transplantation: a half-century historical perspective; From Child's-Pugh to MELD: Deciding who really needs a liver transplant; When to consider renal transplantation in your advanced CKD patients; Management of the liver transplant recipient: approach to allograft dysfunction; Acute and chronic allograft dysfunction in renal transplant recipients; The ABC's of Immunosuppression: a primer for the primary care physician; Managing cardiovascular risk in the post solid organ transplant recipient; Diabetes care after transplant: definitions, risk factors, and clinical management; De novo malignancies after transplantation: risk and surveillance strategies; Metabolic bone disease in the post-transplant population: preventative and therapeutic measures; Infectious complications and vaccinations in the post-transplant population; Selection and post-operative care of the living donor; and Long-term functional recovery, quality of life and pregnancy following solid organ transplantation.

Ischemic cardiomyopathy is considered as the main cause of heart failure in industrialized countries. The condition can occur at any age, but its prevalence increases with age. In general, careful evaluation of the patient's history and physical examinati

Significant progress has been acquired in the treatment of rheumatic conditions with the introduction of biologic therapies, which has enabled better control of disease activity and improved patients'long-term outcome. Apart from several biologic treatments already licensed for use in autoimmune rheumatic conditions, numerous other agents are currently under investigation. This rapid expansion of the therapeutic armamentarium requires a critical analysis of individual biologic options and their clinical indications, in order to facilitate the optimal use of these new therapies. The authors felt that a comprehensive book revisiting all the evidence available regarding the efficacy, cost-effectiveness and health implications of the use of biologics in rheumatology was needed in order to integrate the clinical, ethical and socio-economic aspects related to their use. This book is aimed at specialist doctors, trainees, nurses and health professionals working in the field of rheumatology. It critically appraises the level of evidence behind the use of biologic agents in diverse autoimmune diseases, comprising separate chapters which focus on rheumatoid arthritis, systemic lupus erythematosus, myositis, systemic sclerosis, Sjogren's syndrome, seronegative spondyloarthropathies, psoriatic arthritis and psoriasis, small, medium and large vessel vasculitis, osteoporosis, and interstitial lung disease associated with rheumatic conditions. In addition, the book explores aspects related to the use of biologic agents, such as ethical considerations of consenting patients to take part in clinical trials with biologics, and adolescent and adult rheumatology nurse perspectives related to patients'benefits of biologic therapies. Particular interest is given to the use of biologics during pregnancy and assessment of their infectious risks. A separate chapter explores the off-target benefits associated with the use of anti-TNF therapies. Several chapters include data about cost-effectiveness, and national and international guidelines for the use of biologic agents in different rheumatic conditions.

Food and Parkinson's Disease focuses on the alternative therapeutic approach for managing Parkinson's disease. This manuscript analyzes the curative properties of natural ingredients and bioactive compounds — known as “nutraceuticals” — from natural foods, herbs, spices and plant extracts. Scientific revelations supported by conducted research concerning these remedies are presented. For example, consuming foods from natural sources that are rich in amino acids, antioxidants, vitamins and alkaloids may reduce the chances of onset of Parkinson's disease, and suggests that nutrition and diet have an impact on disease management. In addition, epigenetic modifications in conjunction with Parkinson's disease are also discussed in this book.

Pulmonary Circulation provides physicians with a better understanding of the structure, function and pathophysiology of the pulmonary circulation. It provides comprehensive coverage from diagnosis and clinical evaluation of patients with pulmonary hypertension to imaging techniques, disorders and treatment.This new edition incorporates the latest clinical, pathophysiological and pathological research on pulmonary circulatory disorders. In particular, it provides greater emphasis on the role of the right ventricle in pulmonary vascular disease, updated knowledge on pathobiology and genetics, and includes new material related to imaging and other diagnostic modalities. This edition also reflects new classifications and all the recommendations from the 2013 World Conference on Pulmonary Circulation as well as current guidelines from the European Society of Cardiology and the European Respiratory Society.Thoroughly updated to keep up with the brisk pace of discovery and emerging therapies, the book remains an essential resource by providing a balance between scientific review and clinically relevant guidelines for the busy practicing physician.

This book is a practical guide to the evidence-based medicine (EBM) research methods that are applicable to Chinese medicine (CM). It includes 3 parts: clinical research, healthcare data research and laboratory research. In each chapter, it explains how to acquire, analyze and evaluate a specific kind of CM research result. Authors exemplify the most important methods with successful cases in transforming reliable data into new knowledge of CM. This book emphasizes the requirements for CM researchers to design and conduct CM studies by following the best available principles, standards and guidelines.

This book provides readers with the latest developments in cardiovascular research. Topics covered include an analysis of the effectiveness of newer drugs when compared to Warfarin in reducing the mortality and complications from atrial fibrillation; the epidemiological differences and evolution of high-risk acute coronary syndrome in men and women; cardiovascular control via the vestibular system; an alternative view on inflammation and the endothelium, which plays a crucial role for different substantial vascular functions; the epidemiology, physiopathology and the diagnosis and treatment of renovascular hypertension; a therapeutic approach to treating hypovolemic shock; pathological findings, diagnostic strategies and treatment of left ventricular pseudoaneurysm (LVPA); the structure, development and functions of sarcalumenin, a glycoprotein involved in skeletal and cardiac muscles; hybrid coronary revascularization and the dietary factors that play an important role in the modulation of hypertension - the fourth contributor to premature death in developed countries and the seventh in developing countries.

Frontiers in Clinical Drug Research - Anti-Cancer Agents is an eBook series intended for pharmaceutical scientists, postgraduate students and researchers seeking updated and critical information for developing clinical trials and devising research plans in anti-cancer research. Reviews in each volume are written by experts in medical oncology and clinical trials research and compile the latest information available on special topics of interest to oncology researchers.The third volume of the eBook series begins with a detailed review of the molecular biology of inhibitors that target EGF-family receptors. This review is divided into two parts that covers extracellular and intracellular molecules. Other reviews cover targeted therapies for cancers such as melanoma, follicular lymphoma and topics such as cancer immunotherapy, apoptosis targeting and the Warburg Effect.

I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world's leading scientific centers. In the book, I summarize the intricacies of the pineal gland (“the stone of madness”) as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of his scientific career impacts the life of a scientist throughout their entire life. Today we know that in humans pineal melatonin is released every day late in the evening, and there is evidence that it is the trigger for the sleep process. But the most exciting aspect of melatonin is that it is a substance that is present in all living creatures, from unicellular organisms to plants and higher mammals, a fact that evinces its importance for life. Further, the neuroprotective action of melatonin promises to be crucial for the control of neurodegenerative diseases we face as a pandemic in this century. The discoverer of melatonin, Aaron Lerner, based its name on melano, the Greek word for black, because of its effect on the pigment cells of the skin. As in'La vie en rose', the immortal Edith Piaf song written in 1946, my lifelong work with melatonin could well be called'Ma vie en noir'.

Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos.'..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology.'Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015'..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice.'Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015'I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders.'Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

This book provides a detailed overview of the current state of knowledge regarding the pathophysiology of both primary headaches – migraine, tension-type headache (TTH), and cluster headache – and the very important and frequent type of secondary headache, medication overuse headache (MOH). After an introductory chapter describing relevant neuroanatomy and vascular anatomy, the evidence gained from animal models regarding the pathophysiology of migraine and the other primary headaches is reviewed. Knowledge of the genetic component in the different types of headache is then examined with reference to recent evidence, for example regarding the implication of the trigeminovascular system and cortical spreading depression in migraine. Detailed information is provided on insights into primary headaches from imaging studies, including functional magnetic resonance imaging and positron emission tomography and on their neurophysiology and biochemistry. A further series of important chapters describe present knowledge of the pathophysiology of each specific type of headache and consider future directions. Written by acknowledged experts in their fields from Europe and the United States, clinicians and students will find Pathophysiology of Headaches to be an excellent source of up-to-date information on why patients experience headaches. In addition, it will be of value for pain researchers investigating the underlying mechanisms of headache.

For many years, the study and treatment of orofacial pain have been considered as separate from the study and treatment of headaches, but the editors of this updated award-winning textbook take the philosophical stance that orofacial pain and headache must be considered together. The authors integrate knowledge across these disciplines to improve diagnostic accuracy and clinical management of chronic pain conditions and foster a beneficial collaboration between headache specialists and orofacial pain experts. The first chapters cover the diagnostic process, psychosocial modifying factors, and the anatomy and neurophysiology of the trigeminal nerve, but the bulk of the book is given over to a comprehensive review of the major clinical families of craniofacial pain. In this new edition, the authors place a focus on presenting clinical features and outlining treatment strategies, and the clinical case reports offer insight into the complexity of orofacial pain diagnosis and management. Because pharmacotherapy remains the primary treatment for most craniofacial pain, two chapters detail the pharmacology, efficacy, and side effects of commonly used drugs, although treatment options for neurosurgical and complementary and alternative medicine are also included. Finally, a new chapter addressing facial pain, headache, and sleep provides much-needed insight to this often-overlooked topic. The authors interweave an impressive body of scientific evidence with solid clinical experience to provide a timely and instructive addition to the pain literature.