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Malaria: Volume 2, Pathology, Vector Studies, and Culture is a collection of papers that deals with erythrocyte destruction mechanism in malaria, the pathology of malaria, colonization of laboratory mosquitoes, and their transmission of plasmodia. Other papers describe the culture of the invertebrate stages of plasmodia, of mosquito tissues, and also of erythrocytic and exoerythrocytic stages of plasmodia. One paper constructs a model to show the roles of the different destructive and regenerative processes in the mechanisms of erythrocyte destruction in malaria. Another paper describes the organ changes and physiopathological mechanism connected with Plasmodium infection. These organs concern the spleen, liver, heart, and vascular system. One paper reviews the procedures involved in malaria transmission by mosquitoes, as well as some specialized procedures unique in avian, rodent, simian, and human malarias. Another paper discusses the benefits and drawbacks of a culture medium based on the composition of adult anopheline hemolymph. This medium should lead to a rapid growth rate in primary cultures of mosquito cells and a shorter interval of adaptation for continuous cell lines. The collection can prove useful for pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in mosquito borne diseases or tropical medicine research.

This ebook describes the pathogenesis of malaria and the major consequences of the parasitism to the vertebrate host. Malaria is one of the oldest infectious diseases of mankind, which still exerts a high burden on human health and society. It is caused by parasites of the genus Plasmodium, and transmitted by Anopheline mosquitoes. Despite several decades of intensive control efforts, malaria remains widely distributed with an estimated 3.3 billion of the world's population at risk of infection. The malaria life cycle is extremely complex and the blood stage parasites are responsible for all the symptoms and pathology of malaria. Because of this strict association between the parasites and red cells, there are numerous consequences to the host's blood extending far beyond the direct effect of parasitized RBCs.

Malaria has ravaged Sub-Saharan Africa, having 90 percent of the world's cases. This guidebook provides essential information on Malaria, but also serves as a historical survey, by providing information on the controversies surrounding its causes, and first-person narratives by people coping with Malaria. Readers will learn from the words of patients, family members, or caregivers. The symptoms, causes, treatments, and potential cures are explained in detail. Alternative treatments are also covered. Each essay is carefully edited and presented with an introduction, so that they are accessible for student researchers and readers.

Malaria: Volume 3, Immunology and Immunization is a collection of papers dealing with malaria parasites, the methods for measuring the immunological response to plasmodia, and the vertebrates host's immune response to plasmodia. Some papers discuss immunization against sporozoites, against the exoerythrocytic stages of malaria parasites, against asexual blood-inhabiting stages of plasmodia, as well as gamete immunization in malaria. One paper describes various separation methods to isolate malaria parasites and their constituents. Another paper discusses in detail the theory and practice of methods used in measuring antibody responses which occur during plasmodial infections, including the antibody response against sporozoites, exoerythrocytic forms, and in the different blood stages. Another paper explains the vertebrate host's immune response to plasmodial infection as a homeostatic physiological response changing along with the progression of the disease. The changes in the dynamic cellular cascade are different as the disease progresses causing death, than when these lead to recovery. Another paper enumerates the parameters which determine malarial infectiousness from one individual to another such as the time of onset, duration, intensity of the blood infections, as well as the maturity, longevity, and rate of production of gametocytes. Pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in malarial research will find the collection very useful.

Rodent Malaria reviews significant findings concerning malaria parasites of rodents, including their taxonomy, zoogeography, and evolution, along with life cycles and morphology; genetics and biochemistry; and concomitant infections. This volume is organized into eight chapters and begins by sketching out the history of the discovery of rodent as well as aspects of parasitology, immunology, and chemotherapy. These concepts are investigated two decades following Ignace Vincke's major discovery and Meir Yoeli's successful establishment of the method of cyclical transmission of the parasite. The following chapters focus on the taxonomy and systematics of the subgenus Vinckeia, with reference to the concepts of species and subspecies of animals and the degree to which they apply to malaria parasites, in particular to those of rodents. The discussion then shifts to how the rodent malaria parasites provide a unique insight into the subcellular organization of Plasmodium species, the use of rodent malaria as an experimental model to study immunological responses, and infectious agents that interact with malaria parasites. The book concludes with a chapter on malaria chemotherapy, with emphasis on the value of rodent malaria in antimalarial drug screening and the use of antimalarial drugs as biological probes. This book will be of interest to protozoologists and physicians as well as those from other disciplines including biochemistry, immunology, pharmacology, cell biology, and genetics.