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Cardiovascular disease is the major cause of mortality and morbidity around the world. While significant progress has been made in treating a major sub-category of cardiac disease and arrhythmias, significant unmet needs remain. Every day, thousands of patients die due to arrhythmias in the U.S. alone, and atrial fibrillation is the most common arrhythmia that affects millions of Americans at any given time. Therefore, there is an urgent public need to continue to develop new and better therapies for arrhythmias. This book reviews key research methods and protocols in cardiac electrophysiology with a focus on advantages and pitfalls. It will discuss new developments as well as traditional treatments and methods. Chapters will focus on practical implementation and collaborative cross-functional research methods. The book will contain contributions from scientists and clinicians from various academic and industrial research institutions. The inclusion of industrial experts expands the scope and potential audience of this book, and provides important perspective beyond basic science. Contributors will include researchers and clinicians from academic institutions such as the University of Minnesota, Harvard, Washington University, Case Western, Indiana University, and Manchester University. Methods and Models in Cardiac Electrophysiology will be a must-have resource for clinical academic scientists, engineers from industry (Biotech, Pharma, and Medical Device), undergraduate and graduate students, physicians, biomedical engineers, and high school and college teachers interested in studying cardiac electrophysiology and cardiac function. The book may also be of interest to students in the fields of physiology, molecular biology, cellular biology, biomedical engineering, mechanical engineering, electrical engineering, and related areas.

The third edition of Psychiatric Care of the Medical Patient brings a classic reference text into the twenty-first century. It combines critical scholarship with the voice of expert clinicians who work at the interface of psychiatry with medical specialties. It is meant to be read for pleasure as well as consulted as a reference. The editors have worked with the authors to bring a consistent perspective to the book - one that sees the medical psychiatrist as an agent for bringing a more comprehensive perspective to medical care. Even seasoned and knowledgeable practitioners will find much that is new to them in this book. The volume covers topics in depth that other books in the field may not cover at all, such as the use of herbal and nutritional therapies for medical-psychiatric symptoms and syndromes, and the choice of questionnaires to supplement history-taking. It looks at old topics in a new way: The chapter on the physical examination applies psychometric considerations to the Babinski sign, describes the method and application of quantitative bedside olfactory testing, and discusses smartphone apps to improve the sensitivity of the examination. Psychiatric Care of the Medical Patient, 3rd Edition provides concepts and information to facilitate the dialogue between psychiatrists and general medical specialists - minimizing psychiatric jargon and speaking in the common language of caring and curious physicians.

This book is an essential guide to the medical treatment of the cardiac patient and presents core principles of cardiovascular therapeutics as well as drug recommendations. Major classes of drugs are featured, including beta-blockers, ACE inhibitors, calcium antagonists, diuretics, and antiplatelet agents and unique insights into the controversies surrounding the use of specific drugs are explored, with answers given to the question: do beta blockers and diuretics really cause diabetes? Properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs are examined. This revised edition is thoroughly updated and addresses the entire spectrum of heart disorders, such as hypertension, angina, myocardial infarction, heart failure, arrhythmias, cardiac arrest, and dyslipidemias. New chapters include endocrine heart diseases, management of cardiomyopathies, and newer agents. In addition, topics such as cardiac drugs in pregnancy and lactation and drug interactions are covered. Cardiac Drug Therapy, Eighth Edition, is an authoritative and clinically relevant resource for cardiologists, cardiology fellows, and internists.

Over the past decade, research on the epidemiology, nature, and meaning of the comorbidity between trauma, PTSD, and substance abuse has burgeoned. Changes in the political and social climate of the United States during this time have brought with them new challenges. Changes in the definitions of both posttraumatic stress disorder (PTSD) and substance abuse have been proposed by those involved with diagnosing and treating people with these issues; some of these changes are expected to be reflected in future diagnostic systems. Trauma and Substance Abuse offers a broad overview of current trends in the field of co-occurring substance abuse and PTSD from both clinical and research perspectives. The goal of this volume, newly revised to include special settings, such as court systems and disasters, and special populations, such as veterans, is to clarify issues specific to trauma, PTSD, and substance abuse and to translate both quantitative and qualitative data into specific recommendations for clinicians, researchers, and administrators.

Depression is frequently associated with other psychiatric disorders and is often related to chronic health problems. Depressive symptoms are also common in chronically distressed close relationships and severe interpersonal difficulties in families and at work. The topic of depressive comorbidity is clearly very important, and while recent research in this area has been methodologically sophisticated, well presented, and inherently interesting, there has not been a comprehensive, academic resource that covers recent developments in this area. The Oxford Handbook of Depression and Comorbidity brings together scholarly contributions from world-class researchers to present a careful and empirically based review of depressive comorbidity. Cutting-edge chapters address theory, research, and practice, while capturing the diversity, evidence-base, and importance of depressive comorbidity. Specific topics include the comorbidity between depression and PTSD, alcohol use, and eating, anxiety, panic, bipolar, personality, and sleep disorders, as well as schizophrenia, suicide, cardiovascular disease, cancer, pain, obesity, intimate relationships, and many more. The Oxford Handbook of Depression and Comorbidity is a unique and much-needed resource that will be helpful to a broad range of researchers and practitioners including clinical and counseling psychologists, psychiatrists, marital and family therapists, social workers, and counselors working in mental-health and general health-care settings, as well as students in these areas.

The Fifth Annual Washington Spring Symposium on Health Sciences attracted over 400 scientists from 20 countries. It was held at the Lisner Auditorium of the George Washington University in Washington. D.C. The theme of the meeting was neural and endocrine peptides and receptors. The meeting emphasized basic and clinical research on neural and endocrine peptides and receptors. The six plenary sessions emphasized pituitary peptides, releasing factors, brain peptides, growth factors, peripheral peptides, and clinical applications. The chapters in this volume are derived from each of these six scientific sessions plus the poster and special sessions. The Abraham White Distinguished Scientist A ward was presented to Dr. Julius Axelrod for his numerous contributions to the field of neurochemistry. He presented the keynote address, which was entitled'The Regulation of the Release of ACTH.'Dr. Axelrod discussed numerous factors, such as the peptides CRF, VIP, and somatostatin, that regulate hormone secretion from pituitary cells. The Distinguished Public Service Award was presented to Senator Lowell Weicker, Jr., in recognition of his leadership and outstanding achievements in the United States Senate and for his legislative support for biomedical research and education. In the symposium banquet address, Senator Weicker stressed the need for continued federal support of biomedical science research.

As researchers have developed increasingly more effective interventions aimed at relieving trauma symptoms, trauma therapists have come to understand that the success of these approaches is highly contingent on personal factors. Whether affected by natural disaster or sexual assault, by trauma-related symptoms like PTSD, substance abuse, or depression, each victim of psychological trauma has undergone a uniquely personal experience. Recovery too is highly variable and deeply dependent upon an individual's distinctive history and cultural context. This book examines several current clinical approaches to trauma-focused treatment. Rather than describe theoretical approaches in isolation, the editors have integrated these interventions into a broader clinical context. Chapter authors emphasize basic therapeutic skills such as empathic listening, instilling resilience, and creating meaning, in the service of empirically-supported, highly efficacious trauma interventions. Throughout, they focus on the real-life challenges that arise in typical therapy sessions to deepen our understanding and application of evidence based interventions. This book is intended for all clinical mental health professionals who work with trauma survivors, particularly those who seek to broaden their understanding of the way various approaches interact to inform a holistic understanding of trauma treatment.

Esta popular referencia presenta los conocimientos esenciales en diagnóstico físico y valoración de la salud en un formato de pregunta-respuesta práctico y atractivo. Esta obra guía al lector a través de uno de los desafíos más importantes involucrados en el diagnóstico de cualquier paciente: la realización de la historia clínica y el examen físico. Este planteamiento de preguntas y respuestas, propio de la conocida serie'Secretos'hace que sea fácil llegar a controlar todos aquellos aspectos más importantes que debe saber un profesional sobre diagnóstico físico. Los capítulos de esta obra están ordenados por sistema de órganos, lo que hace que sea muy sencillo localizar la información mediante palabras clave. Esta segunda edición ofrece cambios importantes respecto a la primera edición; incluye un listado de los 100 Secretos del examen físico para que puedan ser revisados de manera rápida por el lector, un nuevo capítulo sobre la interpretación de los síntomas y los hallazgos físicos para facilitar el diagnóstico y 100 nuevos dibujos para aclarar aquellos conceptos más relevantes. Este libro va acompañado por un acceso online al'Taller de sonido de Corazón y Pulmón', y a través del Student Consult se podrán consultar archivos de sonido procedentes de pacientes reales, junto a comentarios del Dr. Mangione.Presenta los conocimientos esenciales en diagnóstico físico y valoración de la salud en un formato de pregunta-respuesta práctico y atractivo, y organizado por sistemas de órganos. Incluye un listado de los 100 Secretos del examen físico para que puedan ser revisados de manera rápida por el lector y 100 nuevos dibujos para aclarar aquellos conceptos más relevantes. Contiene un acceso online al'Taller de sonido de Corazón y Pulmón', y a través del Student Consult se podrán consultar archivos de sonido procedentes de pacientes reales, junto a comentarios del Dr. Mangione.

The Handbook of Cancer Control and Behavioral Science is an expert synthesis of what is known, what is suspected, and what is still unknown about core behavioral and sociocultural aspects of cancer control. Editors Suzanne Miller, Deborah Bowen, Robert Croyle, and Julia Rowland present a thought-provoking overview of the key areas of research, from primary prevention, to early cancer detection, to the clinical treatment of cancer, to survivor experience and bereavement, to future directions for research. Senior researchers provide jargon-free descriptions of current approaches while identifying the most effective behavioral interventions in use for preventing and treating cancer. Yet, the focus is not limited to cancer patients; the relationship between doctor and patient, and the effects of cancer on families are also examined. In its broad scope and detailed examination of the entire continuum of cancer incidence, the Handbook is an essential, cross-disciplinary resource that will be of great use for researchers, health care providers, and mental health professionals in the fight against cancer.

It gives me great pleasure to witness continued growth in the application of cognitive and behavioral theories and therapies to more diverse populations – including, in this volume, their application to the mental health problems of later life. Evidence continues to accumulate, demonstrating that these are effective in treating a broad range of elderly patient groups. This is the first book to examine a number of these evidence-based interventions currently in use with older adults. The editors have assembled chapters developed in many of the leading clinical and clinical research programs focusing on elderly patients, both in this country and in the UK. Since the emphasis of this volume is primarily on clinical appli- tion, each author group was asked to discuss the empirical data for the treatment strategies it is using with the specific patient group selected. Typically, this was followed by a detailed description of treatment procedures that were then ill- trated by one or more clinical examples. The book begins by examining the treatment of depressive and anxiety dis- ders and then moves on to more complicated and/or serious disorders, including schizophrenia and other psychoses, suicidal behavior, personality disorders, bipolar disorders, dementia, and complicated bereavement. A chapter on the problems and issues in training therapists to use evidence-based interventions effectively is also included, along with a chapter discussing the implications of Medicare policies and guidelines for service delivery.

This popular reference presents essential knowledge on physical diagnosis and health assessment in a practical and engaging question-and-answer format. A wealth of high-quality illustrations guide you through the first and most important of challenges involved in diagnosing any patient: performing the history and physical exam. Assessment techniques are highlighted and weighted based on their clinical importance. This detailed, highly focused and practical guide will equip you with the skills you need to confidently evaluate your patients! - The proven question-and-answer format of the highly acclaimed Secrets Series® makes it easy to master all of the most important'need-to-know'information on physical diagnosis. - Chapters are arranged by body system for practical, easy retrieval of key information. - Author pearls, tips, memory aids, and'secrets'provide concise answers to the common questions encountered in everyday practice. - The'Top 100'Secrets of History Taking and Physical Examination are conveniently listed in one place for quick review. - A new chapter on interpreting presenting symptoms and physical findings to facilitate diagnosis. - Key Points boxes in each chapter place essential information at your fingertips.100 new line drawings clarify key concepts. - The Secrets Heart and Lung Sounds Workshop—both in CD-ROM and online format—is available for purchase with the book, and through Student Consult online access, and features audio clips from actual patients, along with Dr. Mangione's commentary and a 32-page downloadable manual, to help you obtain the maximum diagnostic benefit from listening to heart and lung sounds. - STUDENT CONSULT access allows you to view the complete contents of the book online, anywhere you go...perform quick searches...and add your own notes and bookmarks.

Revisada y con nuevos colaboradores provenientes de todos los campos relacionados con el dolor, esta nueva edición recoge cada aspecto de la medicina del dolor. Documenta cualquier conocimiento sobre la neurofisiología, la psicología, la valoración y el tratamiento de cada tipo de dolor, y describe todas las opciones disponibles hoy día en farmacología, cirugía, electroestimulación, fisioterapia y tratamiento psicológico. Los más de 125 autores, verdaderas autoridades en la medicina del dolor, garantizan que esta obra es la referencia más actual, experta y completa en dolor, recogiendo la útlima información de un campo en rápido crecimiento.Entre las innovaciones de esta edición, se encuentran avances en este campo como los descubrimientos que siguieron a la identificación de la estructura molecular del receptor de la capsaicina TRPV1 y las sólidas pruebas derivadas de estudios epidemiológicos que han puesto de manifiesto la magnitud del problema clínico del dolor. En correspondencia con estos avances, se han añadido nuevos capítulos que tratan contenidos que van desde la adicción a analgésicos hasta la medicina del dolor basada en la evidencia y los ensayos clínicos. Otra novedad es la inclusión de recientes avances en farmacología que afectan a anticonvulsivantes, antidepresivos, relajantes musculares y derivados del cannabis. Asimismo, la sección dedicada al dolor a sido ampliada de 1 a 4 capítulos. También las técnicas anestésicas han sido ampliadas.En esta nueva edición, las opciones terapéuticas se presentan en un formato llamativo para que puedan localizarse rápidamente, y se ofrecen nuevas ilustraciones en color para facilitar la representación gráfica de los conceptos más importantes.E-dition con acceso a la página web de la obra en inglés, donde se pueden encontrar: el libro completo, actualizado cada semana bajo la supervisión de los autores; imágenes descargables para su uso en presentaciones, y una base de datos, Mosby's Drug Consult, con la información farmacológica disponible más actual, completa y precisa. Revisada y con nuevos colaboradores provenientes de todos los campos relacionados con el dolor, esta nueva edición recoge cada aspecto de la medicina del dolor. Documenta cualquier conocimiento sobre la neurofisiología, la psicología, la valoración y el tratamiento de cada tipo de dolor, y describe todas las opciones disponibles hoy día en farmacología, cirugía, electroestimulación, fisioterapia y tratamiento psicológico. Los más de 125 autores, verdaderas autoridades en la medicina del dolor, garantizan que esta obra es la referencia más actual, experta y completa en dolor, recogiendo la útlima información de un campo en rápido crecimiento. Entre las innovaciones de esta edición, se encuentran avances en este campo como los descubrimientos que siguieron a la identificación de la estructura molecular del receptor de la capsaicina TRPV1 y las sólidas pruebas derivadas de estudios epidemiológicos que han puesto de manifiesto la magnitud del problema clínico del dolor. En correspondencia con estos avances, se han añadido nuevos capítulos que tratan contenidos que van desde la adicción a analgésicos hasta la medicina del dolor basada en la evidencia y los ensayos clínicos. Otra novedad es la inclusión de recientes avances en farmacología que afectan a anticonvulsionantes, antidepresivos, relajantes musculares y derivados del cannabis. Asimismo, la sección dedicada al dolor ha sido ampliada de 1 a 4 capítulos. También las técnicas anestésicas han sido ampliadas. En esta nueva edición, las opciones terapéuticas se presentan en un formato llamativo para que puedan localizarse rápidamente, y se ofrecen nuevas ilustraciones en color para facilitar la representación gráfica de los conceptos más importantes. E-dition con acceso a la página web

An estimated 40 million Americans and millions of others worldwide suffer from some type of sleep disruption or disorder, and these numbers are rapidly increasing. As biomedical technologies advance our understanding of sleep, a wave of developments in sleep research and the emergence of new technologies offer hope and help for a good night‘s

Methods of Animal Experimentation, Volume VI is a compendium of papers that defines which animals will prove most useful in biological experiments using the best methods in an environment of complex technologies and therapies. One paper reviews the genetic methods in animal experimentation including tests of Mendelian ratios, chromosomes crossing-over, chromosome anomalies, and gene transfer that produces congenic strains. Another paper explains the concepts and methodologies used in animals in ophthalmic research, particularly in ocular pharmacology, aqueous humor dynamics, glaucoma, and animal models of non-infectious uveitis. One paper analyzes the neural mechanisms of pain in an intact nervous system following ethical and moral principles of human treatment. For example, the use of different stimuli to elicit pain is applied only in situations where the stimuli is more appropriate, whether in behavioral or physiological experiments. The paper provides a list of requirements for the ideal pain stimulus. Another paper describes the methods in using standard animal models when an unknown agent is to be given as a general or local anesthesia. This book can prove beneficial to researchers, scientists, and laboratory technicians dealing with animals in relation to pharmacological, biological, chemical, and physiological research.