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Advances in Metabolic Disorders, Volume 3 is a compendium of papers that discusses the regulation of ketogenesis, spontaneous diabetes, ethanol-induced hypoglycemia, and hormonal syndromes associated with neoplasia. One paper discusses the primary role of long-chain fatty acids in synergistically controlling enhanced ketogenesis and gluconeogenesis found in the liver at the cellular level. Another paper notes that in rodent experiments, when hypertrophy and hyperplasia are maintained without exhaustion or degeneration and are sufficient in degree, a new equilibrium emerges leading to near-normalization or compensated diabetes. The opposite occurs when hypertrophy and hyperplasia are limited in degree or in duration: decompensation occurs, diabetes progresses. Some papers describe metabolic disorders of the ovary, erythropoietin, and thyroid diseases. One paper analyzes the pathological conditions arising from impairments of the hypothalamic-pituitary-ovarian-uterine axis that can cause disturbances in normal reproduction Another paper investigates if a competitive relationship exists between thyrotropin (TSH) and long-acting thyroid stimulator (LATS). In vivo and in vitro studies show that the effect of LATS are associated mainly with a delayed onset of action. Biochemists, micro-biologists, endocrinologists, and researchers dealing with microchemistry, bacteriology and immunology will find this collection valuable.

A Synopsis of Endocrinology and Metabolism deals with advances and current thinking on endocrine research. The book describes the diseases of the hypothalamus and adenohypophysis including aetiology, methods of investigation, signs, symptoms, growth disturbances (related to height, bone age, skeletal proportions, sexual development, mental development). The authors also investigate the diseases of the neurohypophysis and of the thyroid such as diabetes insipidus, hypernatraemia (salt imbalance), hypothyroidism, myxedema coma, and malignant exophthalmos. Disorders of the adrenal glands—adrenal cortex include Cushing's disease (excess cortisol production), adrenogenital syndrome, feminizing adrenal tumors (feminization of the male), and hyperaldosteronism. Disorders of sexual function involve main structures, namely, cerebral cortex, hypothalamus, anterior pituitary, or gonads. The book also describes disorders of carbohydrate and fat metabolism, for example, diabetes mellitus, hypoglycemia, coronary artery disease, and hypercholesterolemia. One method for reducing raised serum cholesterol levels is following diets based on corn oils or other unsaturated fat oils. This book is suitable for students of medicine, dieticians, endocrinologists, and general medicine practitioners.

Bone Tumours in Man and Animals covers advances in the understanding of the pathogenesis of bone neoplasia in humans and animals as well as their diagnosis and treatment. In the case of animals, particular emphasis is placed on dogs. This book is comprised of 15 chapters and begins by introducing the reader to the principles of diagnosis, including biopsy and bone scanning, and methods of treatment employed for bone tumors in human and animal patients, including surgery, radiotherapy, and chemotherapy. The following chapters focus on bone cysts and benign tumors of osseous origin; osteosarcoma in humans and animals such as dogs, cats, and mice; and tumors of cartilaginous origin such as solitary enchondroma, enchondromatosis, chondroblastoma, and chondromyxoid fibroma. Tumors arising from fibrous, fatty, neurological, or undifferentiated connective tissue are also considered, along with those arising from bone marrow or lymphoid tissue. This book concludes by offering suggestions for future research. This text is intended for clinicians, radiologists, and pathologists, both medical and veterinary, as well as for biologists, biochemists, and radiation physicists.

Differential Diagnosis of Internal Diseases, Third Edition covers the diagnosis of numerous internal diseases based on symptoms and signs. This edition is organized by symptoms and signs that may be individually different even in the same disease and must be analyzed and understood on a pathophysiological basis within the framework of the individual personality. This book is composed of two main parts encompassing 20 chapters. Part I reviews the leading symptoms of headache, chest and abdominal pain, backache, pain in extremities, general feelings and consciousness disorders, vertigo, nausea, vomitus, cough, dyspnea, diarrhea, constipation, and hemorrhages. Part II examines the leading signs habitus, hyperthermia, fever, infectious disease, respiratory, cardiovascular, digestive, hematopoietic, and uropoietic systems diseases, and glycosuria. This book will be of value to general physicians, clinicians, and pathophysiologists.

Progress in Clinical Endocrinology presents a critical review of role of hormones in metabolism. The book discusses the endocrine regulation of protein metabolism; the etiology of endemic goiter; and the relation of nodular goiter to thyroid carcinoma. Some of the topics covered in the text are the description of hyperparathyroidism; the use of radioactive iodine in the diagnosis, study, and treatment of thyroid diseases; and hypothyroidism in children. The clinical use of antithyroid drugs; the pituitary regulation of adrenal cortical activity; and the influence of the adrenal cortex on the metabolism of food are also considered. The book further tackles the surgical treatment and postoperative care of hyperparathyroidism; the clinical diagnosis of Cushing's syndrome; and the analysis of the diagnosis and treatment of Addison's disease. A study of the theory and practice of diabetes treatment is also presented. A chapter is devoted to the diagnostic significance of pregnandiol excretion. The book can provide useful information to endocrinologists, doctors, students, and researchers.

Joll's Diseases of the Thyroid Gland, Second Edition provides information pertinent to the fundamental aspects of thyroid diseases. This book discusses the physiology structure, and development of the thyroid gland. Organized into 29 chapters, this edition begins with an overview of the function of the thyroid gland to trap and concentrate iodine, harness it in organic combination, and then to secrete it into the blood. This text then discusses the evolutionary scheme showing the development of thyroid gland as a special organ for the control of iodine metabolism. Other chapters consider the various types of thyroid diseases, including simple goiter, acute inflammations, Grave's disease, and granulomatous diseases of the thyroid. This book discusses as well the etiological or clinico-pathological basis of the classification of simple goiter. The final chapter deals with the post-operative complications of thyroidectomy and their treatment. This book is a valuable resource for physicians, surgeons, and clinical researchers.

High Blood Pressure: Its Variations and Control, A Manual for Practitioners covers aspects and consideration of blood pressure estimation and control. The book discusses the advantages and limitations of sphygmomanometry in clinical medicine and the best practical method of taking arterial pressures. The text describes the instruments employed in the estimation of arterial pressure; the fundamental physiological and physical factors on which clinical variations of blood pressure depend; and the physiological variations in arterial pressure. The classification of hyperpiesis; the nature, clinical features, types, and the pathology of hyperpiesia; and hypertonia are also considered. The book then tackles the causes and pathology of arteriosclerosis and the causation, significance, symptomatology, diagnosis, prognosis, prevention, and control of high arterial pressure. Simultaneous arterial pressures (brachial) in pulmonary tuberculosis; the relation of arterial pressure to life assurance; and the epochs in the clinical estimation of blood pressure are also looked into. Practitioners, teachers, and students of medicine will find the book invaluable.

Advances in Metabolic Disorders, Volume 6 covers the developments in the study of metabolic disorders. The book discusses the role of the skin in carbohydrate metabolism; the transmission of Alloxan diabetes and other diabetogenic influences; and the association between glucagon levels and diabetes mellitus. The text also describes the recent contributions to the study of diabetic angiopathy and neuropathy; the disorders due to enzyme defects in the red blood cell; and the pineal gland as a neuroendocrine inducer. The basic aspects of the biology and physiology of calcitonin in relation to its hitherto acknowledged significance in clinical metabolic disorders are also considered. Endocrinologists, biochemists, pharmacologists, physicians, physiologists and medical students will find the book invaluable.

Vitamins in Endocrine Metabolism covers the problems of nutritional diseases in the fields of endocrinology, pathology, enzymology, and vitamin research. This book is divided into 11 chapters that discuss the conditions affecting vitamin requirements. The introductory chapters deal with the intracellular localization, synthesis, molecular structure, and reaction rate of enzymes. The succeeding chapters examine the methods of analysis and mode of action of hormones; pathology of vitamin A deficiency in man and animals; description of vitamin B complex; and diseases of vitamin C deficiency. Other chapters explore the modifying effects of the diet and availability of enzymic activators, as well as the biochemical aspects of isoenzymes, pre-enzymes, coenzymes, and enzyme cofactors. A chapter highlights the characteristics of vitamin, while another chapter is devoted to the chemical structure of vitamin E and the essential fatty acids. The final chapters focus on the exogenous chemical carcinogen. The book can provide useful information to doctors, nutritionists, students, and researchers.

Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U. S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tumor growth. Discussions focus on rapid development of mammary cancer, pituitary functions, androgens, estrogens, and progestins. The book also ponders on the binding of steroid hormones by plasma proteins; the effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serum protein-bound iodine; and the metabolism of dehydroisoandrosterone. The text evaluates studies on estrogen metabolism, biochemical parameters of estrogen action, and enzymatic transport of hydrogen by estrogenic hormones. The manuscript also elaborates on the fate of steroid estrogens in target tissues, effect of steroids on calcium dynamics, and steroids and experimental mammary cancer. The selection is a valuable source of information for readers interested in the use of steroids in treating cancer.

Advances in Metabolic Disorders, Volume 1 presents the application of biochemistry to the pathogenesis of human diseases. This book discusses the parathormone physiology and its deviations, as well as the origins and course of osteoporosis. The introductory chapters deal with the catabolism of glycogen; physiology of parathyroids; multiple enzymic defects; biochemical technology of glycogen storage disease; assay of parathyroid hormone; mechanisms of mitochondrial respiratory control; pathogenesis of primary osteoporosis; and nature of bone change. The subsequent chapters consider the definition and physiology of insulin antagonists and chemistry of parathyroid hormone. These topics are followed by discussions of the physiologic effects of aldosterone and the metabolic interrelationship between folate and vitamin B12 are presented. A chapter is devoted to the definition and treatment of hypoparathyroidism and hyperparathyroidism. The remaining chapters focus on the diagnosis of insulin antagonists in tissues, plasma, and serum. The book can provide useful information to doctors, students, and researchers.

Endocrinology presents the study of the endocrine system, including a number of specialized organs found in the different areas of the body. The book enumerates the different endocrine glands of the endocrine system, and then details how each gland functions and the parts they play in the metabolism and normal function of the human body. The book also cited disorders of the endocrine system and their treatments. Physicians, nurses, pathologists, endocrinologists, and students of medicine will find this book a good reference.