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The uniqueness of this textbook lies in the fact that, it is the FIRST book in the field of allergy addressing in detail the various diagnostic and therapeutic procedures. The rationale behind presenting this book is to appraise the reader regarding the underlying principles of such procedures and to identify the limitations as well as usefulness in clinical practice. The chapters do include both traditional and modern methodologies representing the global nature of the specialty. Authors have been drawn across the globe to represent the variety of such procedures used in clinical medicine. This textbook will be appealing to medical students, physicians-in-training as well as consultants.

This completely updated 4th edition now includes two volumes: it retains the easy-to-use handbook format of the previous successful book, while fulfilling the need for a review of the content. Taking into consideration recent advances in systemic and topical treatments, state-of-the-art lasers, and the latest evidence-based recommendations, it now includes biologic agents for psoriasis and their use as off-label treatments in other skin disorders, targeted agents for malignant melanoma and basal cell carcinoma, and new treatment modalities for rosacea, acne, atopic dermatitis, and urticaria, to name but a few. The European Handbook of Dermatological Treatments provides concise, up-to-date overviews of treatment guidelines and clinical pearls for a large number of skin diseases. It is divided into three main sections addressing the many different skin diseases, the drugs available for dermatological treatments, and the various methods applied in dermatology, including fillers, botulinum toxin, lasers, dermoscopy, cryosurgery, and electrosurgery. Written by a recognized expert in the field, each chapter focuses on a particular skin disease, illustrating current treatments while providing a brief synopsis of the etiology and clinical presentation of the disease. Treatment indications and contraindications, modes of action, and dosages are clearly identified and the content is enhanced by a wealth of clinical pictures and tables, making it an engaging tool for professionals, and a valuable learning resource for young practitioners, as well as postgraduate students and residents.

This entirely revised edition of the successful work presents the state of the art in clinics, research and practical management of atopic dermatitis - eczema. The wide variability in clinical morphology including differences between age groups and ethnicities is illustrated by color pictures including the typical minimal manifestations or “stigmata” suggestive of atopy. The dramatic rise in the prevalence of this disease over the last few decades is reflected by detailed analyses of epidemiological data from all over the world. In-depth descriptions of key pathophysiological mechanisms including epidermal barrier, molecular genetics, itch pathophysiology and modern cellular immunology offer readers a deeper understanding of the complex events leading to the often excruciating symptoms. Treatment – and management – comprises all aspects from elicitor avoidance to basic emollient skin care, immuno-modulating treatments both topical and systemic, up to the latest advances in kinase inhibitors and biologics.In turn, the book discusses the role of the microbiome and antimicrobial treatments as well as phototherapy, provides dietary recommendations for individuals with food allergies, and explores psychosocial aspects of the disease. Environmental influences are considered with regard to irritants and allergens. All recommendations are based on current national and international guidelines. The complex management strategies for this disease have led to the emergence of educational programs (Eczema Schools), which the authors have developed and promoted at the national and international level. This new revised edition of Atopic Dermatitis - Eczema will be an invaluable asset for dermatologists, allergists, pediatricians and general practitioners, but also for all related health personnel and patient organizations interested in gaining a fuller understanding of this widespread skin disease.

Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management. - Analyzes the pathophysiology of atopic dermatitis from two distinct fronts: inside out and outside in—an approach that is unique in the field. - Begins with an overview of the disease, then delves into both internal and external pathogenic factors, followed by the Clinician's Corner, which offers practical recommendations for treatment. - Organizes therapeutic discussions by corresponding pathophysiology rather than a one-size-fits-all approach. - Covers recently FDA-approved and emerging medications, as well as atopic comorbidities.

Offering unique, comprehensive coverage of both basic science and clinical scenarios, Clinical Immunology: Principles and Practice, 6th Edition, brings you up to date with every aspect of this fast-changing field. It examines the molecular, cellular, and immunologic bases of immunologic diseases and their broader systemic implications; it also includes complete coverage of common and uncommon immunologic disorders. Updated with all the latest immunologic research and clinical implications, including breakthrough immunotherapies and molecular-based treatment protocols, this fully revised edition provides authoritative guidance from some of the most respected global leaders in immunology in one complete, well-illustrated volume. - Includes extensive revisions that reflect rapidly expanding research and clinical advances, including breakthrough drug and immunotherapies such as immune checkpoint inhibitors, immunotherapies for cancer, precision medicine, and transfusion medicine. - Contains new chapters on COVID-19, immune responses, and the role of the immune system; immunoregulatory deficiencies; immune checkpoints; CAR T cells, including new cellular-based immunotherapy; gene therapy, including CRISPR and gene selection; and a clinically focused chapter on asthma. - Provides new genetics content focused on data applications. - Addresses notable advances in key areas such as the importance of the microbiota to normal immune system development and to the pathogenesis of immunologic and inflammatory diseases; relationships between the innate and adaptive immune systems; progress in rapid and cost-effective genomics; cell signaling pathways and the structure of cell-surface molecules; and many more. - Covers hot topics such as the role of genetics and genomics in immune response and immunologic disease, atherosclerosis, recurrent fever syndromes, aging and deficiencies of innate immunity, the role of microbiota in normal immune system development and in the pathogenesis of immunologic and inflammatory diseases, and novel therapeutics. - Features a user-friendly format with color-coded boxes highlighting critical information on Key Concepts, Clinical Pearls, Clinical Relevance, and Therapeutic Principles. - Summarizes promising research and development anticipated over the next 5–10 years with'On the Horizon'boxes and discussions of translational research. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

••Selected for Doody's Core Titles® 2024 in Allergy/Clinical Immunology••Allergic and Immunologic Diseases: A Practical Guide to the Evaluation, Diagnosis and Management of Allergic and Immunologic Diseases is a valuable resource for researchers and others involved in the day-to-day practice of allergy and immunology, with specific information, protocols and algorithms to guide their thinking. The book provides practical information and an explanation of why and how we do things, while also addressing the limitations of testing and treatment. Other sections focus on scientific based practices and the known pathophysiology of allergic and immunologic diseases, along with mechanisms of action in various treatment modalities. This book is unique in that it explains the rationale behind everything we do in allergy and immunology, hence it offers readers specific information on procedures and how to order tests and treat allergic and immunologic diseases. - Contains useful information on allergic and immunologic diseases, from why we do things the way we do, to methodologies, interpretation of the results and management of diseases - Provides information that can be immediately downloadable for any specific procedure or treatment algorithm for immediate use - Evaluates scientific merit and evidence or lack thereof

Get a quick, expert overview of the use of current and novel immunotherapies for use in the management and treatment of allergic reactions and diseases. This concise resource by Dr. Linda Cox covers the full range of allergic disease, including aeroallergens, asthma, food allergies, atopic dermatitis, and stinging insects. With essential coverage of allergen immunotherapies in addition to key topics on emerging allergen-associated immunomodulators, this succinct, comprehensive reference consolidates today's available information on this timely topic into a single convenient resource. - Discusses timely topics such as food tolerance, allergy, and allergen unresponsiveness; biologics for COPD and pediatric asthma; and adherence and pharmacoeconomics. - Summarizes practical guidelines and recommendations for use of immunotherapies in clinical practice. - Provides insight into the background and history of immunotherapies as a treatment for allergic disease. - Includes developments on the horizon, including alternative immunotherapy routes and modified allergens.

In the two decades since the elusive'slow reacting substance of anaphylaxis'(SRS-A) was identified as a product of the action of the 5-lipoxygenase enzyme on arachidonic acid, it has been well established that the leukotrienes are key mediators of both alIergy and inflammation. Their release by alIergen or other challenge has been demonstrated in the lungs of asthmatic subjects, and measurement of urinary leukotriene concentrations in such patients has been shown to be a valuable, non­ invasive indicator. Significant progress has been made towards the characterization of the leukotriene receptor subtypes, exemplified by the cloning of the LTB4 receptor earlier this year. Coupled with this there has been a continued elucidation of signal transduction mechanisms underlying receptor activation. Consequent upon these advances has been the development of potent antagonists of the CysLT receptor, J and both these and inhibitors of leukotriene biosynthesis have entered clinical practice in the therapy of asthma. In this clinical setting antagonists of the CysLTJ receptor have been shown to be an effective therapy in chronic asthmatics, against antigen- and exercise-induced bronchoconstriction, and in aspirin-intolerant asthmatics. The advent of this new class of agents promises to change the way in which asthmatic patients are currently treated.

Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance. Despite an explosion of discovery in this area over the last decade, this is the only up-to-date resource on eosinophils and eosinophilia exists. This full-color volume provides an essential collection of world class information that is a must-have for any immunologist's workbench or bookshelf. - The only updated, comprehensive source of information on eosinophils on the market - Written by over 80 leaders in the field - Holistic view of the subject, including basic science, disease-specific chapters, therapeutic options and emerging areas of research

When I entered the field of allergy in the early 1970s, the standard textbook was a few hundred pages, and the specialty was so compact that texts were often authored entirely by a single individual and were never larger than one volume. Compare this with Allergy Frontiers: Epigenetics, Allergens, and Risk Factors, the present s- volume text with well over 150 contributors from throughout the world. This book captures the explosive growth of our specialty since the single-author textbooks referred to above. The unprecedented format of this work lies in its meticulous attention to detail yet comprehensive scope. For example, great detail is seen in manuscripts dealing with topics such as “Exosomes, naturally occurring minimal antigen presenting units” and “Neuropeptide S receptor 1 (NPSR1), an asthma susceptibility gene.” The scope is exemplified by the unique approach to disease entities normally dealt with in a single chapter in most texts. For example, anaphylaxis, a topic usually confined to one chapter in most textbooks, is given five chapters in Allergy Frontiers. This approach allows the text to employ multiple contributors for a single topic, giving the reader the advantage of being introduced to more than one vi- point regarding a single disease.