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THE authoritative guide for clinical laboratory immunology For nearly 50 years, the Manual of Molecular and Clinical Laboratory Immunology has been the premier resource for laboratories, students, and professionals involved in the clinical and technical details of diagnostic immunology testing. The 9th Edition continues its tradition of providing comprehensive clinical and technical information on the latest technologies used in medical and diagnostic immunology. Led by a world-renowned group of authors and editors, this new edition reflects substantial changes aimed at improving and updating the Manual's utility while reflecting the significant transformations that have occurred since the last edition, including the revolution of gene editing and the widespread adoption of molecularly engineered cellular therapies. Topical highlights include: Laboratory Management: three new chapters cover essential aspects of quality assurance, quality improvement, and quality management, aligning with the increasingly stringent and demanding regulatory environment.Inborn Errors of Immunity: the primary immunodeficiency section has been completely updated to align with the latest International Union of Immunological Societies'classifications of inborn errors of immunity.Functional Cellular Assays: expanded content includes detailed discussions on various functional assays critical for modern immunologic testing.Autoimmune Diseases: expanded chapters on systemic and organ-specific autoimmune disorders, including new chapters on Sjögren's syndrome and deficiency of ADA2, as well as significant updates on organ-specific autoimmune diseases.Transplantation Immunology: updated chapters detail the assessment of immune reconstitution and ABO testing, reflecting latest practices. The 9th Edition of the Manual of Molecular and Clinical Laboratory Immunology serves as an invaluable resource for laboratory directors, clinicians, laboratory managers, technologists, and students. It provides critical insights into the selection, application, and interpretation of immunologic tests, offering practical guidance on troubleshooting, clinical application, and an understanding of test limitations. This comprehensive and up-to-date manual remains an essential tool for anyone involved in the diagnosis, evaluation, and management of immune-mediated and immune system-related disorders.

This concise practical guide is designed to facilitate the clinical decision-making process in the management of atopic dermatitis by reviewing a number of cases and defining the various diagnostic and management decisions open to clinicians. It is well illustrated and diverse in scope, enabling the reader to obtain relevant information regarding both standard and unusual cases in a rapid, easy to digest format. Each case includes a narrative description and patient management tips along with a relevant board review question. This book covers exciting updates in the diagnosis and management of AD such atopic dermatitis spectrum disorder and the effects of internal vessel inflammation in AD patients. It also highlights the newest oral, biologic and topical therapies (along with pipeline therapies) in the treatment of atopic dermatitis. Clinical Cases in Atopic Dermatitis is a must-have resource for dermatologists, dermatology residents, fellows, medical students, nurse practitioners and physician assistants, as well as allergists and immunologists.

The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. - Provides new research on autoimmune diseases, their diagnosis, prevention, and therapy - Covers a complete range of all common, rare and new autoimmune diseases, including cancer and COVID - Extensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseases - Supplemented with a website that hosts a Podcast per chapter

In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual. The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic. Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus. - Fully revised and updated by a global group of experts, dedicated to and in honor of Noel Rose - Includes 52 completely updated chapters with the latest developments in the field - Is the only book directed specifically at the interactions between infectious agents and autoimmunity - Describes the prevalence and incidence of global issues and current therapeutic approaches - Addresses in full, details of the mechanisms behind the emergence of autoimmune diseases secondary to infections - Brings the reader up-to-date and allows easy access to individual topics in one place

This comprehensive book thoroughly covers the spectrum of rhinitis conditions and related comorbidities. Rhinitis and Related Upper Respiratory Conditions is a unique resource that delivers essential clinical information, addressing the varying patient populations which might be encountered in different types of clinical settings. Chapters range from topics such as pediatric, adult, geriatric, and occupational rhinitis, while also covering the full array of rhinitis subtypes and their complications. Later chapters address secondary causes of rhinitis such as systemic diseases manifesting as rhinitis, drug-induced rhinitis, and CSF leak. Written by experts in the field, every chapter is structured to contain clinical cases which illustrate the typical patient presentation, and their diagnostic work-up and treatment, providing the knowledge needed to further improve diagnosis and care for the patient with rhinitis. Rhinitis and Related Upper Respiratory Conditions is an ideal resource for allergists, primary care physicians, and health care extenders, to help them recognize and further improve care of patients with rhinitis.

There are many principles and applications of recombinant antibodies for infectious diseases. The preferred technology associated to recombinant antibody generation is mainly phage display. The adaptation of antibodies for infectious diseases is an area lacking information as most literature is focused on oncology or autoimmunity. This project highlights the power and potential of antibody phage display for infectious diseases. In addition to that, supplementary information regarding technologies associated to antibody generation and engineering in the context of infectious disease will also help to provide greater insight to the potential of recombinant antibodies for infectious diseases.

Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

Clinical Mycology offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.