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This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups. This second volume provides up-to-date, concise yet ample knowledge on the genome evolution of modern humans. It comprises twelve chapters divided into two parts discussing “Non-neutral Evolution on Human Genes” (Part I) and “Evolution of Modern Human Populations” (Part II.) The most significant feature of this book is the continent-wise discussion of modern human dispersal using human genomic data in Part II. Recent results such as introgression of paleogenomes to modern humans, new methods such as computer simulation of global human dispersals, and new information on genes for humanness will be of particular interest to the readers. Since the euchromatin regions of the human genome was sequenced in 2003, a huge number of research papers were published on modern human evolution for a variety ofpopulations. It is now time to summarize these achievements. This book stands out as the most comprehensive book on the modern human evolution, focusing on genomic points of view with a broad scope. Primary target audiences are researchers and graduate students in evolutionary biology.

This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic.The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2,covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing.Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Molekulare Sport- und Leistungsphysiologie ist die Lehre der Genetik und Signaltransduktion im Kontext körperlicher Aktivität. Ihre grundlegenden Ansprüche liegen in der Erforschung des Einfluss der Genetik auf die sportliche Leistungsfähigkeit und der Anpassungsprozesse durch Bewegungs- oder Trainingsreize auf molekularer und zellulärer Ebene.Dieses Werk vermittelt Grundlagenwissen in Genetik, Molekular- und Zellbiologie, stellt molekulare Mechanismen in leistungsphysiologischen Systemen dar und verbindet sportmedizinische mit -wissenschaftlichen Aspekten der körperlichen Leistungsfähigkeit. Der Brückenschlag zwischen theoretischem Wissen und praktischer Umsetzung gelingt durch Einbindung methodischer Aspekte in die sog. „Tooltipps“.Das Buch richtet sich an Sportmediziner, Sportwissenschaftler und sonstige im sportmedizinischen oder -wissenschaftlichen Bereich tätigen Berufsgruppen und Studenten, die sich fundiertes Wissen über moderne Erkenntnisse der körperlichen Leistungsfähigkeit aneignen möchten.

This book reviews the human genome from an evolutionary perspective. No such book has ever been published before, although there are many books on human genomes. There are two parts in this book: Overview of the Human Genome (Part I) and The Human Genome Viewed through Genes (Part II). In Part I, after a brief review of human evolution and the human genome (by Naruya Saitou), chapters on rubbish or junk DNA (by Dan Graur), GC content heterogeneity (by Satoshi Oota), protein coding and RNA coding genes (by Tadashi Imanishi), duplicated genes (by Takashi Kitano), recombinations (by Montanucci and Bertranpetit), and copy number variations including microsatellites (by Naoko Takezaki) are discussed. Readers can obtain various new insights on the human genome from this part. In Part II, genes in X and Y chromosomes (by Yoko Satta and others), HLA genes (by Timothy A. Jinam), opsin genes (by Shoji Kawamura and Amanda D. Melin), genes related to phenotypic variations (by RyosukeKimura), transcription factors (by Mahoko Takahashi and So Nakagawa), diabetes-related genes (by Ituro Inoue), disease genes in general (by Ituro Inoue and Hirofumi Nakaoka), and microbial genomes (by Chaochun Wei) are discussed. The human genome sequences were determined in 2004, and after more than 10 years we are now beginning to understand the human genome from an evolutionary point of view. This book furnishes readers with a good summary of current research in the field.

The fourth, completely revised edition of this classic reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences.The fourth edition has been extensively expanded by new chapters on timely topics such as epigenetics, pharmacogenetics, gene therapy, cloning, and genetic epidemiology, and databases for basic and clinical genetics. In addition a multi/chapter section giving an overview on the main model organisms (mouse, dog, worm, fly, fish) used in human genetics research has been introduced.This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field.

This publication reviews past, current and future applications of genetic research in the fields of exercise science and sports medicine. It highlights ethical concerns, potential clinical applications and exploitation of genetic information. The authors, an interdisciplinary group of experts comprising clinicians, exercise scientists, human geneticists and other biological scientists, present an integrated and holistic understanding of the field to the reader. Several chapters of the book address the issue of nature and nurture in determining athletic ability and etiology of sports injuries. Other chapters are dealing with genetics and performance research during premolecular and molecular biology eras, gene-lifestyle interactions and their consequences on health, as well as genetic risk factors in musculoskeletal soft tissue injuries. Finally, the possible application of gene therapy in athletes, gene doping and genetic testing of athletes are discussed. The book is highly recommended to exercise scientists, sports clinicians, human geneticists, athletes, coaches and to all those interested in the relatively new area of genetic research within the fields of exercise science and sports medicine.

A riveting scientific detective story crossed with a provocative and controversial re-examination of the meaning of race, ethnicity, and religion.Could our sense of who we are really turn on a sliver of DNA? In our multiethnic world, questions of individual identity are becoming increasingly unclear. Now in Abraham's Children bestselling author Jon Entine vividly brings to life the profound human implications of the Age of Genetics while illuminating one of today's most controversial topics: the connection between genetics and who we are, and specifically the question'Who is a Jew?'Entine weaves a fascinating narrative, using breakthroughs in genetic genealogy to reconstruct the Jewish biblical tradition of the chosen people and the hereditary Israelite priestly caste of Cohanim. Synagogues in the mountains of India and China and Catholic churches with a Jewish identity in New Mexico and Colorado provide different patterns of connection within the tangled history of the Jewish diaspora. Legendary accounts of the Hebrew lineage of Ethiopian tribesmen, the building of Africa's Great Zimbabwe fortress, and even the so-called Lost Tribes are reexamined in light of advanced DNA technology. Entine also reveals the shared ancestry of Israelites and Christians.As people from across the world discover their Israelite roots, their riveting stories unveil exciting new approaches to defining one's identity. Not least, Entine addresses possible connections between DNA and Jewish intelligence and the controversial notion that Jews are a'race apart.'Abraham's Children is a compelling reinterpretation of biblical history and a challenging and exciting illustration of the promise and power of genetic research.