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Reviewing current strategies and methods to treat and manage patients suffering with ventilatory dysfunction, this reference provides a critical overview of the epidemiology, pathophysiology, diagnosis, and outcomes of COPD-describing techniques to prevent and reduce the development of symptoms, improve patient quality of life, and slow the progres

This book is comprised of twelve selected chapters on advances in health and disease. Chapter one covers applications of nano-formulations in drug delivery for skin disease treatments. Chapter Two examines the use of dipeptidyl peptidase-4 inhibitors in the clinical management of diabetes mellitus. Chapter Three reviews the role of sex hormones in asthma therapy. Chapter Four looks at therapies for critically ill COVID-19 patients. Chapter Five examines resistance plasmids; the key to the adaptation of pathogenic microorganisms in hospital environments. Chapter Six shows how oleic acid prevents oxidative stress by inhibiting metabolic pathways in clinical disorders. Chapter Seven reviews the question of post-COVID-19 reactive arthritis, and whether it is a myth or reality. Chapter Eight examines the diagnosis and treatment of dermoid ovarian cysts in children and adolescents. Chapter Nine reviews the beneficial effects of testosterone replacement therapy in older individuals. Chapter Ten covers the state of the art in difficult to treat rheumatoid arthritis. Chapter Eleven provides therapeutic updates on the condition of juvenile psoriatic arthritis. Chapter Twelve examines the underdiagnosed pathology of sinus tarsi syndrome.

This book providesa practical approach to bronchoalveolar lavage (BAL) and its analyses, which are used worldwide in both research and clinical settings. It includes useful guidelines with a theoretic background and provides details on microscopic and flow cytometric measurements for all known differential diagnostics made with BAL analyses, from chronic diseases like COPD and ILD via infectious diseases to inherited illnesses like cystic fibrosis. It includes BAL in both adult and pediatric medicine. The text is supported throughout by illustrations and clinical cases, serving as an invaluable resource for respiratory medicine and infectious disease clinicians and trainees.Key features: Uses BAL in the infectious diseases field and the search for respiratory viruses using the reverse transcription polymerase chain reaction (RT-PCR) technique. Presents contributions from worldwide experts. Clarifies the BAL technique and its diagnostic utility to respiratory physicians, cytologists, and pathologists involved in the diagnosis of pulmonary disease. Provides an updated perspective on the future applications of BAL techonology to research and clinical medicine.

This sixth edition of the Oxford Textbook of Palliative Medicine takes us now into the third decade for this definitive award-winning textbook. It has been rigorously updated to offer a truly global perspective, highlighting the best current evidence-based practices, and collective wisdom from more than 200 experts around the world. This leading textbook covers all the new and emerging topics, updated and restructured to reflect major developments in the increasingly widespread acceptance of palliative medicine as a fundamental public health need. The sixth edition includes new sections devoted to family and caregiver issues, cardio-respiratory symptoms and disorders, and genitourinary symptoms and disorders. In addition, the multi-disciplinary nature of palliative care is emphasized throughout the textbook, covering areas from ethical and communication issues, the treatment of symptoms, and the management of pain. The Oxford Textbook of Palliative Medicine is a truly comprehensive text. No hospital, hospice, palliative care service, or medical library should be without this essential source of information. This sixth edition of the Oxford Textbook of Palliative Medicine is dedicated to the memory of Professor Kenneth Fearon husband of Professor Marie Fallon and a surgeon who became a world leader in the research and management of anorexia and cachexia. He modeled a work-life balance that is so critical in our field, with devotion to both his patients and his family.

In the past, elderly patients were given artificial airway technologies, such as a tracheostomy tube, to assist with their breathing. However, thanks to the advances in medical technologies, older patients now may receive respiratory care while enjoying the comfort of their own home. Noninvasive Ventilation Technologies and Healthcare for Geriatric Patients is a pivotal reference source that provides vital research on the models and processes of care for elderly subjects that require noninvasive ventilation as well as the development of technological solutions. While highlighting topics such as elderly care, respiratory failure, and home care, this publication explores healthcare management as well as the methods of professional homecare medical services. This book is ideally designed for physicians, nurses, pharmacists, senior health technicians, hospital administrators, clinical directors, laboratories, medical practitioners, nurses, and medical students.

Inflammatory Cells and Mediators in Bronchial Asthma provides reviews and summaries regarding state-of-the-art articles that examine the role of various inflammatory cells and their mediators in the pathogenesis of asthma. Topics include pharmacological and biochemical regulation of the airways; involvement of key inflammatory cells and the release and effect of their mediators in airway function; and the characteristics of receptors for leukotriene B4, C4, and D4, adenosine, platelet-activating factor, sensory and inflammatory peptides, and the effect of various anti-asthmatic drugs on airway inflammation. Physicians, allergists, immunologists, and pulmonary disease research scientists will find this book to be an invaluable reference resource.

Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.

Aging, despite its dismal reputation, is actually one of the great mysteries of the universe. Why don't we just reproduce, then exit fast, like salmon? Could aging just be one big evolutionary accident? Is senescence, the gradual falling apart of our bodies, at least partially avoidable? Can we extend the healthy lifespan and reduce the lingering, debilitating effects of senescence? In this book, investigative health journalist Judy Foreman suggests that we actually can, and the key element is exercise, through its myriad effects on dozens of molecules in the brain, the muscles, and other organs. It's no secret, of course, that exercise is good for you and that exercise can extend longevity. What Foreman uncovers through extensive research into evolutionary biology, exercise physiology, and the new field of geroscience is exactly why exercise is so powerful - the mechanisms now being discovered that account for the vast and varied effects of exercise all over the body. Though Foreman also delves into pills designed to combat aging and so-called exercise'mimetics,'or pills that purport to produce the effects of exercise without the sweat, her resounding conclusion is that exercise itself is by far the most effective, and safest, strategy for promoting a long, healthy life. In addition to providing a fascinating look at the science of exercise's effects on the body, Foreman also provides answers to the most commonly asked practical questions about exercise.

Because progressive advancements to healthcare practices are leading to longer lifespans, an increased number of aging individuals now require constant care from practiced caregivers. The financial costs of in-home care can be quite high; therefore, many families are opting to stand in as caregivers, and this can lead to various impacts on their own social and psychological wellbeing. The Mental Health Effects of Informal Caregiving: Emerging Research and Opportunities provides autobiographical accounts and statistical data associated with the caregiving experience, as well as the methods to discern the positive psychological forces that shape the subjective wellbeing of informal caregivers. Highlighting topics such as institutional vs. informal caregiving, special healthcare needs, and veteran care, this book is ideally designed for psychologists, therapists, researchers, medical institutions, academia, and students seeking current research on the subjective wellbeing of informal caregivers.

This authoritative text on occupational lung disorders builds upon the fundamentals, including clinical, epidemiological, and predictive approaches. It discusses interstitial and malignant diseases, airways diseases, and other respiratory issues, such as diving, working at high altitudes, and abnormal sleep conditions. It also covers related long-term conditions, such as asthma and COPD. This edition has been completely revised and brought up to date for all physicians dealing with pulmonary disorders caused by the environment or the workplace.Print Versions of this book also include access to the ebook version.

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoverie

For some years, international guidelines on the management of asthma have stressed the importance of early intervention with anti-inflammatory drugs to prevent acute asthma exacerbations and to avert chronic inflammatory damage to the airway. Introduced by a broad survey of the targets for anti-inflammatory drugs, this book proceeds to bring together the most recent research into the mechanisms and clinical benefits of presently available anti-inflammatory treatments including corticosteroids, cromones, and theophylline. For the first time, these drugs are discussed alongside the newly introduced leukotriene modifier drugs, and in the context of frontline research into anti-inflammatory drugs of the future. Leading authorities in their fields evaluate the prospects of novel anti-IgE agents and cytokine antagonists, and examine recent developments in immunosuppressant compounds, protease inhibitors, and selective phosphodiesterase inhibitors. This book is an up-to-date and authoritative survey which will be invaluable to university and pharmaceutical company researchers working on anti-asthma and anti-allergy drugs and to respiratory physicians keeping abreast of developments in their specialty.

Respiration is an area of the medical study that undergoes fast developments. A better understanding of the neural and cellular mechanisms underlying respiratory disorders and lung function is essential for the evidence-based pharmacotherapy and for optimizing the patient care and prophylactic measures to improve the health and quality of life. This comprehensive book is a blend of basic and clinical research. The book is thought to promote the translation of science into clinical practice. The book presents an update on the areas of current research and clinical interest in the neurobiology of the respiratory system. Recent innovations in detection and management of respiratory diseases are described. The book will be a base of reference in the field of respiration for years to come and a source of future research ideas. This book is a required text for respiratory scientists, neuropathologists, and for clinicians searching for ‘bench to bedside'treatments of lung diseases.

Today's consumer can send a company a DNA sample and receive a detailed set of genetic test results in return all without ever visiting a health care provider. Although knowing one's personal risk for serious disease may lead some individuals to make more informed health choices, an ever-growing set of questions remains: Are predictive genetic tests meaningful? Can the results be harmful as well as helpful? In what ways can genetic information be used by health care providers to predict disease risk and optimize medical management within concerned families? Most important, how might the landscape of genetic testing affect the care of children's health?Although there are no easy answers, the Handbook of Genomics and the Family details in one authoritative volume the challenges entailed by the latest genetic advances and offers insights into the potential translation of this knowledge in pediatric and family practice and public health. This timely and comprehensive reference introduces readers to the study of how genes, singly and in combination with each other and the environment, affect health and behavior; summarizes current findings on genetics and genomics in disease etiology and prevention; and provides family-focused perspectives relating to genetic counseling and education.Key features of the Handbook include:- In-depth background in genetics and genomics in relationship to disease etiology and epidemiology.- Integrative frameworks for understanding genetics and genomics in the context of families.- Considerations for communicating genetic and genomic information.- Individual chapters on genetic and familial risks for specific diseases and conditions, including cancer, obesity, and Type 1 diabetes among children and adolescents.- Training, ethics, and other emerging issues and controversies.- Contemporary policies on genetic testing in children and families.The Handbook of Genomicsand the Family is essential reading for clinical child and pediatric psychologists and psychiatrists, pediatricians and nurses, clinical geneticists and genetic counselors, and public health specialists as advances in genetics lead the way to more personalized models of health.

An authoritative, state-of-the-art reference collection, bringing together international experts to examine the key issues and core debates related to gender and healthcare. A vital resource for a wide range of academics, researchers, practitioners and policymakers.

Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source sp

The literature on cytokine genetics is vast, so vast that it is now practically beyond the time or logistical constraints of most scientists to successfully keep pace with it. A compilation of the latest research, Cytokine Gene Polymorphisms in Multifactorial Conditions brings together, reviews, and structures up-to-date information on polymorphism