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Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach.This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options.Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research.This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.

Explore what's new in the new edition!Trusted for four decades by university faculty and relied on by thousands of professionals from diverse fields, Children with Disabilities is the gold-standard text on working effectively with children and families. Now this authoritative resource is in its eighth edition, enhanced with new chapters on critical topics, the latest evidence-based practices, updated instructor materials, and guidance on working with a wide range of professionals to address every aspect of child health and well-being.Spearheaded by senior editor Mark Batshaw, M.D., Chief Academic Officer at Children's National Health System, this new edition is an unparalleled compendium of information about developmental, clinical, family, education, and intervention issues, from birth through adolescence. Every chapter has been meticulously peer-reviewed, and content has been updated throughout to reflect important new research and developments in diverse fields. Comprehensive coverage of contemporary issues makes this volume an indispensable reference for practicing professionals, and the student-friendly features and multimedia instructor materials make it the ultimate textbook for courses on disability.A treasury of essential knowledge from a who's who of today's leading experts and innovators, Children with Disabilities is a cornerstone resource that professionals will use year after year to support their important work and ensure that every child and family thrives.WHAT'S NEWExpanded focus on interdisciplinary care, including practical guidance on how professionals from different fields can effectively collaborateNew chapters on key topics: sleep disorders, assessment of physical disabilities, the senses, rehabilitative services, interdisciplinary care, the role of medication, and the effect of health care disparities on child outcomesNew Evidence-Based Practice boxes throughout the text, for easy review of recent studies and recommended practices Updated nomenclature based on new developments in the field and recommendations from respected organizationsSTUDENT-FRIENDLY FEATURES: Students will benefit from chapter overviews, a helpful glossary, case studies that bring key concepts to life, thought questions, a test bank with more than 200 questions for faculty members, resource lists for further reading, and 200+ downloadable illustrations. And with the complete package of multimedia instructor materials, instructors will use this textbook effectively in their courses and prepare students for years of successful practice.Explore what's new in the new edition!

Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. - Discusses the multiple processes governing gastrointestinal function - Presents new information on the brain-gut axis and microbiome - Edited by preeminent scientists in the field - Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more

4th Asian School-Conference on Physics and Technology of Nanostructured Materials (ASCO-Nanomat 2018)Selected, peer reviewed papers from the Fourth Asian School-Conference on Physics and Technology of Nanostructured Materials (ASCO-Nanomat 2018), September 23-28, 2018, Vladivostok, Russia

Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all